News Archive - 2013

News Archive - 2013

Genetics defines a distinct liver disease

Genetics defines a distinct liver disease

Large-scale genetic study defines relationship between primary sclerosing cholangitis and other autoimmune diseases

Researchers have newly associated nine genetic regions with a rare autoimmune disease of the liver known as primary sclerosing cholangitis (PSC). This brings the total number of genetic regions associated with the disease to 16.

Evolving genes lead to evolving genes

Evolving genes lead to evolving genes

Selection in European populations of genes regulated by FOXP2, a key factor in development and language

Researchers have designed a method that can universally test for evolutionary adaption, or positive (Darwinian) selection, in any chosen set of genes, using re-sequencing data such as that generated by the 1000 Genomes Project. The method identifies gene sets that show evidence for positive selection in comparison with matched controls, and thus highlights genes for further functional studies.

Coelacanth genome surfaces

Coelacanth genome surfaces

Unexpected insights from a fish with a 300-million-year-old fossil record

An international team of researchers has decoded the genome of a creature whose evolutionary history is both enigmatic and illuminating: the African coelacanth. A sea-cave dwelling, five-foot-long fish with limb-like fins, the coelacanth was once thought to be extinct.

Fishing for solutions

Fishing for solutions

Examining function of all genes in the zebrafish genome to benefit human health

Equipped with the zebrafish genome, researchers have designed a method to assay the function of each and every gene and to explore the effects genetic variation has on zebrafish. So far the team has generated one or more mutations in almost 40 per cent of all zebrafish genes.

Family ties: Relationship between human and zebrafish genomes

Family ties: Relationship between human and zebrafish genomes

Completion of the zebrafish reference genome yields strong comparisons with the human genome

Researchers demonstrate today [17 March 2013] that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. Their study highlights the importance of zebrafish as a model organism for human disease research.

Biology behind blood trait signals

Biology behind blood trait signals

One step closer to understanding the biology behind genetic variants linked to blood cell traits

Researchers at the Wellcome Trust Sanger Institute and University of Cambridge have unpicked genetic variants that affect the formation of blood cells. They found that around a third of the variants play a role in gene regulation, and that the action of these variants is specific to individual cell types. The discovery is an important step towards unravelling the biological mechanisms behind variants identified in genome-wide scans of blood traits.

Wanted: your views on genetics

Wanted: your views on genetics

The world's largest survey on genetics aims to grow

With more than 3000 people taking part to date, genomethics already leads the world. But the organiser, social scientist Dr Anna Middleton, wants more views from Jo Public, from young people, from old folks, from mums and dads.

Sanger Institute - EBI single cell genomics centre

Sanger Institute - EBI single cell genomics centre

New centre to provide a whole-genome view of variation and expression at a single-cell level

New centre to provide a whole-genome view of variation and expression at a single-cell level

Finding genes for childhood obesity

Finding genes for childhood obesity

Genome-wide study identifies genetic variants associated with childhood obesity

Researchers have identified four genes newly associated with severe childhood obesity. They also found an increased burden of rare structural variations in severely obese children.

Final chapter to 60 year old blood group mystery

Final chapter to 60 year old blood group mystery

Gene that underlies Vel blood group and influences red blood cell traits will lead to safer blood transfusion

Researchers have uncovered the gene at the root of a human blood group that has remained a mystery for the past 60 years. They showed that a genetic deletion on this gene is responsible for the lack of this blood group in some people.

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