The major theme of our research is the study of genome variation: naturally occurring and engineered, inherited and somatic, in humans, pathogens, human cells and mice.
Our science is organised into five Scientific Programmes, each defining a major area of research with a particular biological, disease or analytic focus.
In all cases, the studies provide insights into human, pathogen, cellular evolution, the phenotypic and hence biological consequences of genome variation and the processes which cause mutations.
We aim to carry out studies that are of a design and scale that cannot be conducted in most biomedical research institutes.
Explore our programmes below
Cancer, Ageing and Somatic Mutation
The Cancer, Ageing and Somatic Mutation Programme pioneers data aggregation and informatics innovation, develops high-throughput cellular models of cancer for genome-wide ...
We are focused on using single-cell approaches: cell atlas technologies and understanding human genetics at the cellular level. The team combines ...
The Human Genetics Programme is driving a step-change in our understanding of genetic causes and biological mechanisms of disease susceptibility and ...
Parasites and Microbes
We use genomics to study important problems in infectious disease, with a strong desire to develop and refine tools for disease ...
In the Computational Genomics programme, novel computational methods were developed, both for managing and analyzing large datasets.
The Infection Genomics Programme investigates the common underpinning mechanisms of evolution, infection and resistance to therapy in viruses, bacteria and parasites. ...
We develop and enhance high-throughput tools and technologies for malaria research to enable us to understand specific biological problems relevant for ...
COVID-19 Research and Surveillance
We are committed to tracking, understanding and combatting COVID-19. We are sequencing thousands of virus genomes and using the data to trace transmission, inform public health measures and are monitoring for new variants. We are also working to understand how the virus interacts with our cells, and to develop new diagnostics
Associate Research Programmes
Our Associate Research Programmes enable the Sanger Institute to pioneer new approaches to studying health and disease.
Through innovative public and private initiatives, we seek to speed the delivery of healthcare and societal impact from research discoveries.
Find out more below
Health Data Research UK (HDR UK)
The Health Data Research (HDR) UK Cambridge site is part of the national institute for health data science (HDR UK) ...
The high-throughput, large-scale biological research undertaken at the Sanger Institute is a central defining characteristic distinguishing our science from that of most research institutes and universities.
This ability is critically dependent upon major core facilities and platforms organised into complex pipelines. These require substantial infrastructure, expert organisation and professional management. The Institute’s data production platforms are organised into a single management structure. This ensures that we have refined processes and ensures that we have appropriate levels of investment and manning, with robust forward-planning and realistic targets.
Explore our facililties and platforms below
Cellular Operations provide cell biology support and expertise to the institute.
The DNA Sequencing area teams of the Wellcome Sanger Institute support the research of all scientists in their use of ...
The IT infrastructure at the Sanger Institute is one of the most extensive in the life sciences sector. It supports the entire workflow of data through the Institute, from data generation to storage in databases and archival systems, research analysis by Faculty teams and publication on our website.
To service the demand from DNA sequencing and analysis, the Institute has approximately 75 petabytes of online storage which is increasing at about 30 per cent annually. The Institute has several high-performance Linux compute clusters with a total capacity of 45,000 CPU cores.
The facility is housed in the Wellcome Genome Campus Data Centre which the Sanger Institute IT teams continually maintain, support and upgrade in response to demands from all teams and organisations across the Genome Campus.
Find out more about the work of our IT teams below
Informatics and Software Development
The IT Informatics and Software Development teams provide essential support to the Sanger Institute Scientific Operations's core platforms of sequencing ...