CM Da Silva, Pixabay

Research programmes

The major theme of our research is the study of genome variation: naturally occurring and engineered, inherited and somatic, in humans, pathogens, human cells and mice.

Our science is organised into five Scientific Programmes, each defining a major area of research with a particular biological, disease or analytic focus.

In all cases, the studies provide insights into human, pathogen, cellular evolution, the phenotypic and hence biological consequences of genome variation and the processes which cause mutations.

We aim to carry out studies that are of a design and scale that cannot be conducted in most biomedical research institutes.

Explore our programmes below

Associate Research Programmes

Our Associate Research Programmes enable the Sanger Institute to pioneer new approaches to studying health and disease.

Through innovative public and private initiatives, we seek to speed the delivery of healthcare and societal impact from research discoveries.

Find out more below

Scientific Operations

The high-throughput, large-scale biological research undertaken at the Sanger Institute is a central defining characteristic distinguishing our science from that of most research institutes and universities.

This ability is critically dependent upon major core facilities and platforms organised into complex pipelines. These require substantial infrastructure, expert organisation and professional management. The Institute’s data production platforms are organised into a single management structure. This ensures that we have refined processes and ensures that we have appropriate levels of investment and manning, with robust forward-planning and realistic targets.

Explore our facililties and platforms

Information Technology

The IT infrastructure at the Sanger Institute is one of the most extensive in the life sciences sector. It supports the entire workflow of data through the Institute, from data generation to storage in databases and archival systems, research analysis by Faculty teams and publication on our website.

To service the demand from DNA sequencing and analysis, the Institute has 65-70 petabytes of online storage which is increasing at about 30 per cent annually. The Institute has several high-performance Linux compute clusters with a total capacity of 45,000 CPU cores.

The facility is housed in the Wellcome Genome Campus Data Centre which the Sanger Institute IT teams continually maintain, support and upgrade in response to demands from all teams and organisations across the Genome Campus.