News – Wellcome Sanger Institute

Elmentaite et al. Nature DOI: 10.1038/s41586-021-03852-1

8 Sep 2021

Development study reveals origins of Inflammatory Bowel Disease

Creating Cell Atlas of Human Development will transform understanding of health and disease

1 Sep 2021

International research consortium to tackle tumour drug resistance using single-cell sequencing

Sanger Institute scientists join a new collaborative research project that will use single-cell sequencing to tackle drug resistance and develop smarter ...

31 Aug 2021

Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases

Projects will create cell atlases of the paediatric ovary, skin and brain to better understand human biology and provide reference datasets ...

27 Aug 2021

Loss of gene linked to differences in brain size

Inactivation of the MAGEE2 gene, seen widely across East Asia, results in enlarged brains in men and decreased brain size in ...

25 Aug 2021

Researchers discover individual variation in how our bodies develop and acquire mutations

Studies will help to establish baseline for human development and acquisition of mutations during life in the soma and the germline

23 Aug 2021

Defining Success

Five inspirational speakers share their journeys, definitions of success, and lessons learnt in the space of diversity and inclusion.

23 Aug 2021

Link between amino acid and a range of common diseases could help predict personal risk

Researchers have identified a link between mitochondrial DNA variants, amino acid fMet, and a range of common, late-onset diseases

10 Aug 2021

Fighting the spread of drug-resistant malaria with genetic surveillance

In-depth genomic surveillance of the malaria parasite over multiple countries has tracked regions of drug resistance

9 Aug 2021

From Mild to Mortal

Why is it that some people infected with a virus don’t get any symptoms at all, while others tragically, may ...

5 Aug 2021

Researchers track how microbiome bacteria adapt to humans via transmission

New research has shed light on how transmission of gut bacteria influences its evolution and functions

4 Aug 2021

Genetic study reveals ancient human adaptation to agriculture and climate change in Middle East

The most comprehensive study so far of genetic diversity in the Middle East has given a glimpse into the lives of ...

4 Aug 2021

New therapeutic target discovered for a number of aggressive cancers

An RNA-modifying protein elevated in some aggressive cancers has been shown to be a promising target for new drug development

4 Aug 2021

The evolutionary history of humans

Mohamed Almarri has recently completed a PhD studying population history and global genetic diversity.

2 Aug 2021

OKRs: Strategic planning the Google way

We’re refreshing the way we do strategic planning, using Objectives and Key Results (OKRs)

21 Jul 2021

A forgotten disease

How genomics is helping to understand melioidosis - a neglected, often fatal, bacterial disease.

16 Jul 2021

Reflections on race and equity in research: One year on...

One year on from the murder of George Floyd, we take a step back to reflect on our reactions and ...

29 Jun 2021

Covid Connections – Variant or Villain

The second COVID connections talk brought together experts from COG-UK to discuss SARS-CoV-2 variants.

28 Jun 2021

Bacterial Biomes

"we are well aware that what we know about already is just a small percentage of the diversity that ...

24 Jun 2021

Water vole genome will help boost conservation of one of UK's most endangered mammals

The water vole genome is published as part of the Darwin Tree of Life Project to assemble the genomes of 70, ...

23 Jun 2021

Cellular signatures of kidney tumours discovered

This method of identification holds promise as a tool for diagnosing patients with rare cancers

18 Jun 2021

Getting to the heart of the matter

Exploring the genomics of inherited cardiomyopathies.

17 Jun 2021

Study identifies trigger for ‘head-to-tail’ axis development in human embryo

Researchers have mapped, in new detail, the genetic changes that a human embryo goes through as it develops.

14 Jun 2021

Computer method to help predict outcomes and tailor treatments for patients with inherited heart diseases

Clinicians and scientists analysed how individual genetic changes affect the heart muscle and created a new computer tool to integrate genomic ...

8 Jun 2021

Sanger Institute human genetics researcher honoured by EMBO

Professor Matthew Hurles, Head of Human Genetics, becomes an elected member of the European Molecular Biology Organization

8 Jun 2021

Winning Cambridgeshire students design card game inspired by the Human Cell Atlas

Game will be developed and feature in nationwide exhibition

3 Jun 2021

New genetic variants lead to diagnoses for children with developmental disorders

By analysing parts of the genome that do not code for proteins, researchers have identified seven variants linked to developmental disorders.

28 May 2021

Genetic study identifies risk for some childhood cancer patients developing secondary leukaemia and will help inform treatment plan

New study used whole genome sequencing to gain further understanding of why some children develop secondary leukaemia after neuroblastoma treatment

27 May 2021

Atlas of malaria parasite gene activity provides new targets for drugs and vaccines

Researchers have mapped in fine detail the genetic changes malaria parasites go through as they prepare to infect people.

27 May 2021

Genomics in a pandemic – Shedding light on the invisible

Experts from the COVID-19 Genomics UK Consortium discuss sequencing SARS-CoV-2, variants, and viral fitness landscapes.

27 May 2021

‘Rescue mutations’ that suppress harmful DNA changes could shed light on origins of genetic disorders

The biological phenomenon may play an important role in genetic diseases such as cancer or rare developmental disorders, and explain why ...

26 May 2021

Discovery of vaccine target for devastating livestock disease could change lives of millions in sub-Saharan Africa

The findings raise the possibility of identifying vaccine targets for trypanosome species that cause the deadly human infections sleeping sickness and ...

18 May 2021

Car manufacturing, cellular biology and COVID

Rachel Nelson, head of the Cellular Generation and Phenotyping (CGaP) facility, reflects on managing science at scale, including the lessons ...

18 May 2021

Unparallelled insights into how our bodies develop from a single cell

Knowing what happens during normal development could help us to understand genetic diseases that arise during pregnancy

13 May 2021

Maturation Block – Redefining Childhood Cancers

Using the latest genome sequencing techniques, Dr Sam Behjati is revealing the journey that cells take on their way to ...

11 May 2021

Identifying the rise of multi-drug resistant E. coli

Largest genomic study of E. coli has tracked the rise of multi-drug resistance (MDR) in Norway.

10 May 2021

Dyslexia and neurodiversity in the workplace

Staff share their experiences of dyslexia and how it has affected their careers in science.

4 May 2021

Diversity and Inclusion in Science

The Equality in Science group and the Race Equity Network at the Wellcome Genome Campus welcomed inspirational speakers last year. ...

30 Apr 2021

Championing Team Science

Professor Muzlifah Haniffa shares her thoughts achieving large-scale science.

30 Apr 2021

New genetic target for blood cancer treatment

Researchers have identified a vulnerability in some cases of acute myeloid leukaemia that could be harnessed for targeted treatment of these ...

29 Apr 2021

New era of quality and scale in genome sequencing will drive biological discovery

Publication of 16 high-quality vertebrate reference genomes establishes standards for biodiversity genomics

28 Apr 2021

Major advance enables study of genetic mutations in any tissue

Analysis of blood, colon, brain and muscle tissue indicates cell division is not the primary cause of somatic mutations

27 Apr 2021

From investment banking to genomics and health

Meet Olivier Seret, Principal Software Developer working in the Infection Genomics team.

26 Apr 2021

Novel drug type for blood cancer entering clinical trials

First drug to target a specific RNA-modifying protein will start clinical trials in 2022 against acute myeloid leukaemia

22 Apr 2021

Taking lockdown baking to a whole new level

New exhibition explores the science of cancer and ageing, through the medium of food and cooking.

20 Apr 2021

Differing immune reponses discovered in asymptomatic cases versus those with severe COVID-19

Using data from the Human Cell Atlas, researchers have identified the differences in immune cells’ response in those who had no ...

16 Apr 2021

Genetic variants identified that impact immune cells' functioning

Researchers have combined genome-wide sequencing and functional profiling of immune cells to understand more about the impact of genetic variants on ...

12 Apr 2021

New genetic drug target for treatment resistant colorectal cancer

Researchers have identified a new potential drug target for treating some types of advanced colorectal cancers.

7 Apr 2021

‘Patchwork’ tumours prevalent across multiple cancer types

Scientists have confirmed that tumour evolution is driven by changes that benefit the cancer, and these lead to a wide range ...

31 Mar 2021

New DERMATLAS project will create world's most comprehensive public resource of rare skin tumour genomes

This project will document the genomes of around 70 rare skin tumours to build a map of how these cancers form ...

30 Mar 2021

Genetic link to male infertility identified

Men who carry a certain subtype of Y chromosome are more likely to experience genetic mutations that lead to low sperm ...

29 Mar 2021

Fighting Pathogens with Data and Partnerships

"Data analysis in genomics means that you can work in something that is meaningful."

25 Mar 2021

Salivary gland cells revealed as sites of COVID-19 infection

Human Cell Atlas findings point to role for saliva in SARS-CoV-2 transmission

24 Mar 2021

New addition to COSMIC database will collate available drugs to target cancer mutations

The Actionability resource identifies relationships between types of cancer, specific mutations and available drugs

23 Mar 2021

CRISPR study identifies gene that plays key role in metastasis of cancers to the lungs

Over-expression of LRRN4CL was linked to cancer spread in colon, breast and bladder cancers in humans

18 Mar 2021

Project to understand beginnings of rare childhood cancer awarded innovation funding

Sam Behjati and collaborators at University College London hope to identify new treatment targets by uncovering foetal origins of rhabdomysarcoma.

17 Mar 2021

SARS-CoV-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

These findings offer a molecular explanation for the reported differences in disease severity for COVID-19 patients depending on age, gender and ...

16 Mar 2021

From Scorpions to Skin Cancer

Dr Daniela Robles-Espinoza recently joined the Sanger Institute as an International Fellow. She works on acral melanoma, a deadly form ...

11 Mar 2021

Genomic surveillance – the world’s binoculars focused on infectious diseases

Monitoring the microorganisms that cause COVID-19, malaria, cholera and a whole range of other diseases enables researchers to track outbreaks, ...

10 Mar 2021

Placenta is a dumping ground for genetic defects

The study is the first high-resolution survey of the genomic architecture of the human placenta, revealing specific patterns of mutation that ...

9 Mar 2021

Full evolutionary journey of hospital superbug mapped for the first time

Sanger Institute researchers and their collaborators have published the full genetic timeline of the bacterium, Enterococcus faecalis showing the influence of ...

8 Mar 2021

Students invited to create a card game inspired by the Human Cell Atlas

How to build a Human: Design a card game challenge

8 Mar 2021

Virtual event celebrates Equality and Diversity Champions from the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

5 Mar 2021

Reverse mentoring: Promoting diversity and positive culture change

Alice Matimba and Martin Dougherty reflect on their experiences of reverse mentoring, and how it can play a key role ...

3 Mar 2021

Genomics study identifies routes of transmission of coronavirus in care homes

Genome sequencing was combined with detailed epidemiological information to examine the impact of COVID-19 on care homes and to discover how ...

3 Mar 2021

New search engine for single cell atlases

New software tool allows researchers to rapidly search datasets from single-cell sequencing

3 Mar 2021

Origin of childhood cancer malignant rhabdoid tumour discovered

Researchers identified two drugs that could be used to overcome the genetic root of the disease, resuming normal development and bringing ...

3 Mar 2021

Sanger Institute researcher wins Pezcoller Foundation EACR Rising Star Award

Congratulations to Dr Sam Behjati, who receives the Award in recognition of his potential to make significant contributions to cancer research

24 Feb 2021

Open data on malaria genomes will help combat drug resistance

The release represents the world’s largest resource of genomic data on malaria parasite evolution and drug resistance

23 Feb 2021

Gene that helps control egg’s journey sheds light on why ectopic pregnancy may occur

Study details the first evidence of gene regulation in the transit of eggs from the ovaries to the uterus in mammals

18 Feb 2021

Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first

For the first time, this new study has successfully created ‘mini-organs’ in the lab, that could help patients with liver damage

18 Feb 2021

Scientists identify over 140,000 virus species in the human gut, half of which are new to science

The results form the basis of the highly-curated Gut Phage Database (GPD) which will be an invaluable resource for those studying ...

12 Feb 2021

New COVID-19 saliva testing strategy could translate into easy-to-use home device

The new testing approach would be easier to collect and simpler to process in the laboratory than the current nasal-swab process.

11 Feb 2021

International Day of Women & Girls in Science 2021

Just 30 per cent of researchers worldwide, only 35 per cent of all students enrolled in STEM-related fields of study ...

5 Feb 2021

New drug targets for childhood cancer neuroblastoma identified

All neuroblastomas arise from developmental cells not normally found in children, making them a promising target for drug development

5 Feb 2021

Sequencing COVID: our latest stats

As the sequencing hub of COG-UK, the Sanger Institute is sequencing the genomes of coronavirus samples from across the country. ...

28 Jan 2021

Sanger Institute joins Wellcome Leap Global Network dedicated to accelerated breakthroughs in human health

Charter group of 21 world-class institutions representing a network of over 150,000 researchers across six continents sign agreement that sets ...

25 Jan 2021

Looking Down a Microscope and Seeing Discoveries Happen

Andy Russell is a PhD Student in the Voet, Lawniczak, and Billker groups at the Sanger Institute, studying cancer and ...

21 Jan 2021

Developmental origins of eczema and psoriasis discovered

Skin Cell Atlas points to new drug targets for inflammatory diseases

11 Jan 2021

Snail hotels, 3D printed robots and custom clips

Engineering solutions to genomic research

21 Dec 2020

20 Things We Learned in 2020

This has been a year that none of us will forget in a hurry. The Institute is immensely proud of ...

18 Dec 2020

Cell atlas of tropical disease parasite may hold key to new treatments

The atlas of 13 distinct cell types at the start of the Schistosoma mansoni's development will aid vaccine and treatment ...

18 Dec 2020

Darwin Tree of Life: Looking back on 2020

Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at

15 Dec 2020

Ten artists to create artworks for global research project mapping the human body

Human Cell Atlas explored through art science collaboration

7 Dec 2020

Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease

Gut Cell Atlas reveals gut development mechanisms

1 Dec 2020

Dr Sam Behjati selected as an EMBO Young Investigator

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work on the developmental origins of ...

19 Nov 2020

COG-UK computing effort wins collaboration award for COVID-19 work

HPCwire award recognises consortium's sequencing of tens of thousands of viral genomes

16 Nov 2020

Wellcome Sanger Institute and COG-UK receive £12.2M UK Government investment for COVID-19 real-time genomic surveillance system

Institute researchers will support the COVID-19 Genomics UK consortium's work by providing high-throughput virus genome sequencing, creating surveillance software to ...

11 Nov 2020

Sanger Faculty to co-lead new Italian Genomics Research Centre

Nicole Soranzo will join the Human Technopole Institute to establish its dual programmes of Population and Medical Genomics and Functional Genomics ...

10 Nov 2020

Stand up science

Join us for an evening of science comedy

4 Nov 2020

Uncovering the origin of rare childhood cancer guides treatment

Bilateral neuroblastoma cancers in a patient can arise independently from each other, at the very earliest stages of life

4 Nov 2020

Why protecting the brain against infection takes guts

Gut microbes educate antibody producing cells that guard the brain

3 Nov 2020

Sequencing COVID – what now?

Helping to track coronavirus outbreaks.

28 Oct 2020

Human Cell Atlas projects increase diversity of sample donors

Funding from the Chan Zuckerberg Initiative enables tissue samples from more diverse ethnic backgrounds

26 Oct 2020

Sanger Institute welcomes Wellcome's new science strategy

Director Mike Stratton outlines the opportunities and continuing support that Wellcome's new strategy provides for Sanger researchers

22 Oct 2020

Sequencing COVID-19 at the Sanger Institute

This photo essay goes behind the scenes of the effort to sequence the genome of the COVID-19 virus at the ...

14 Oct 2020

Study linking 28 genes to developmental disorders will mean diagnoses for around 500 families

Researchers estimate that approximately another 1,000 genes linked to developmental issues have yet to be found

14 Oct 2020

Update to COSMIC drives precision oncology

The Cancer Mutation Census combines biological, biochemical and population data to enable users to understand which DNA mutations drive human cancers

12 Oct 2020

Equity, diversity and inclusion in science

To celebrate Black History Month, Your Digital Mentor Podcast released a special episode. Academics from across the globe discuss inequalities ...

12 Oct 2020

Novel map reveals how immune cells fight and remember infections

Mouse immune study gives pointers for development of vaccines and immune therapies

7 Oct 2020

Comeback of drug-resistant neglected tropical disease tracked through genomic surveillance

Study shows that re-emergence was likely caused by latent infections in untreated asymptomatic people

5 Oct 2020

Song Chen to lead research group in Cellular Genetics Programme

This new group will develop powerful, cutting-edge technologies to map individual cells in the brain and other tissues, to understand how ...

1 Oct 2020

Cause of 1990s Argentina cholera epidemic uncovered

Work influenced Argentine health policy, where the national alert surveillance system now uses whole-genome sequencing to distinguish between pandemic and non-pandemic ...

1 Oct 2020

DNA changes in healthy bladder provide clues on how cancer arises

The research reveals a huge diversity in the number and types of changes between individuals, indicating that a wide range of ...

1 Oct 2020

Xylem, Mentoring, and the Worldwide Fantasy Food Tour

Dr Christine Boinett talks about Black History Month, her new international podcast on mentoring and her research on drug-resistant bacteria.

24 Sep 2020

Highly detailed map of human heart could guide personalised heart treatments

Heart Cell Atlas will illuminate our understanding of heart health and disease

24 Sep 2020

Key genetic clue missing in fight against superbugs

Analysis shows importance of including plasmids when tracking antibiotic resistance in bacterial populations

23 Sep 2020

Ambitious genomics project seeks to understand how aquatic species thrive together

The Aquatic Symbiosis Project will empower researchers to answer important questions about the ecology and evolution of symbiosis

21 Sep 2020

Key discovery in psoriatic arthritis points way for developing targeted treatments

Genetic evidence points to potential single cause for the disease

18 Sep 2020

A day in the life of a cell technician: CRISPR, teamwork, and character cells

Life in the cellular generation and phenotyping labs at the Sanger Institute.

18 Sep 2020

Fire on Wellcome Genome Campus detected and extinguished quickly

The fire was contained to one room and the Campus is safe and fully operational

17 Sep 2020

Future of genomic research at risk without greater public trust in how genetic data is shared

Survey finds lack of familiarity with genomics and how it can benefit society

16 Sep 2020

How Dantu blood group protects against malaria - and how all humans could benefit

Red blood cells have a higher surface tension that prevents them from being invaded by Plasmodium parasite

3 Sep 2020

Genetic information can predict predisposition to blood diseases

Studies identify bulk of genetic variation that influences blood cell traits

28 Aug 2020

Unprecedented national effort by UK immunologists to search for answers on COVID-19

Sanger Institute researchers join national research projects to investigate the role of our immune system in tackling COVID-19

27 Aug 2020

Mosquito immune system mapped to help fight malaria

Atlas will be valuable resource for understanding and controlling mosquito-borne diseases such as malaria, Dengue and Zika

25 Aug 2020

Inspiring prisoners and their families with genomics

“I want to inspire kids, let them know that though they are having a really tough time now, there ...

19 Aug 2020

The race to sequence SARS-CoV-2

The Sanger Institute is built for high-throughput science – but the project to sequence coronavirus demanded more samples were handled more ...

11 Aug 2020

Former Sanger Institute Head of Pathogens receives the 2020 Albert B. Sabin Gold Medal

Professor Gordon Dougan awarded Sabin Vaccine Institute prize for his contributions to vaccinology

6 Aug 2020

From locked down to reaching out: re-inventing public engagement for the “new normal”

Since the Campus closed to visitors in March, staff have been finding new ways of engaging with people who want ...

4 Aug 2020

New podcast to provide digital mentoring tips for early career researchers

Your Digital Mentor launches with first episode on the mentoring experience

3 Aug 2020

Genomes within Genomes

Hiding in the genome of a newly-sequenced red colobus monkey, there was a second species - a parasite descended from ...

30 Jul 2020

New drug targets for lethal brain cancer discovered

Researchers engineered a new mouse model for studying glioblastoma, the most aggressive type of brain cancer

27 Jul 2020

Artificial intelligence finds patterns of mutations and survival in tumour images

AI detects patterns of 167 different mutations and predicts patient survival in 28 cancer types

27 Jul 2020

Impact of The Technician Commitment

Kelly Vere, Programme Director of the Technician Commitment, explores the progress of the scheme across the UK.

21 Jul 2020

Chronic inflammation alters the evolution of cells in the colon, study finds

Researchers have compared diseased colon with healthy tissue to better understand how inflammatory bowel disease (IBD) is linked to an increased ...

17 Jul 2020

Building an inclusive culture in all we do

Launching a new Behavioural Competency Framework.

16 Jul 2020

From bacterial behaviours to COVID-19

Sushmita Sridhar has paused her work on a gastroenteritis-causing bacterium to help diagnose the virus that causes COVID-19.

13 Jul 2020

Explore COVID-19 science in action with new Human Cell Atlas animation

Mapping COVID-19: How the Human Cell Atlas enhances our understanding of the disease

13 Jul 2020

International Common Disease Alliance releases action plan to drive next phase of genetic understanding of common disease

Report defines priorities, proposes international collaborations to accelerate progress from genetic maps to biological mechanisms to medical treatments

8 Jul 2020

Launch of virtual Sanger Seminar series

Join us for a new series of virtual seminars, open to all, which will present the latest research from the Sanger ...

7 Jul 2020

Drug screens and CRISPR combine to help make better cancer drugs

Improved understanding of the biological mechanisms underpinning drug response will enable faster, more efficient drug development

2 Jul 2020

Sarah Teichmann, an international pioneer of single cell research

We spoke to the Head of Cellular Genetics at the Sanger Institute about her life, career and the Human Cell ...

26 Jun 2020

The first draft human genome at 20

A revolution powering today’s advances in genomics, biology and medicine

26 Jun 2020

‘It had better be good’

We reflect on what followed the publication of the human genome sequence for the Sanger Institute, and what the future ...

24 Jun 2020

Restarting Science

Staff are starting to return to the Wellcome Genome Campus.

18 Jun 2020

Update to DECIPHER brings power to clinical genomics

Update to rare disease database allows researchers and clinicians to input, interpret and share all types of genomic variants in all ...

16 Jun 2020

Supporting Pride Month at the Wellcome Genome Campus

We are celebrating Pride Month with virtual events, and we are pleased to have joined the Stonewall Diversity Champions programme. ...

11 Jun 2020

Denisovan DNA influences immune system of modern day Oceanian populations

Previously-unknown variations in medically-important genes will be valuable resource for the field of precision medicine

10 Jun 2020

My postdoc and my dad’s dementia

This carers week, postdoctoral fellow Lia Chappell shares her experiences.

8 Jun 2020

Genomic surveillance of antibiotic resistance in the Philippines established

Bacterial resistance to last-line antibiotic mapped in the Philippines

8 Jun 2020

Sanger researcher wins prize from European Society for Human Genetics

Gosia Trynka awarded 2020 Leena Peltonen Prize for her outstanding research into human immune diseases

1 Jun 2020

From cancer, stem cells and organoids to COVID-19

Sanger scientists speak about their new roles in sequencing SARS-CoV-2 genomes.

28 May 2020

4,000 years of contact, conflict and cultural change had little genetic impact on Near East

Only three periods had lasting effect on genetics of local people in Beirut

22 May 2020

Analysis of COVID-19 Genomes reveals large numbers of introductions to the UK in March

The data reports, published by the COVID-19 Genomics UK Consortium (COG-UK), show the value in mapping COVID-19 lineages across the UK ...

18 May 2020

An automated method for cell type discovery

Identifying cell types from single-cell RNA sequencing data is now more efficient than ever

18 May 2020

Honour with Athena SWAN Silver Award

The Wellcome Sanger Institute and its associated organisations have been awarded by Athena SWAN for commitment to advancing women's careers ...

18 May 2020

Potentially cancerous cells kept in check by competitive neighbours, study of oesophagus finds

Hope that understanding of the 'rules of the game' of clonal competition will lead to new therapies

18 May 2020

Welcoming Athena SWAN Silver

"We are deeply committed to our values of equality, diversity and inclusion and these are fundamental to our work."...

13 May 2020

Sanger scientists recognised by the Academy of Medical Sciences

Six Sanger researchers – past and present – have been welcomed into Fellowship of the prestigious organisation

13 May 2020

‘These lowly organised creatures’: Earthworm sample collecting at the Sanger Institute

Few organisms have, as Darwin himself wrote, played such an important role in the history of the world.

7 May 2020

Sanger scientist receives Chan Zuckerberg Initiative support for COVID-19 study

Roser Vento-Tormo will use single-cell technologies to understand human immune response to SARS-CoV-2 infection and the progression of the disease

6 May 2020

New computational method unravels single-cell data from multiple people

Souporcell could assist personalised medicine and malaria research

4 May 2020

Prising open the scallop genome

As part of the Sanger Institute’s 25 Genomes Project, the king scallop, Pecten maximus, had its genome sequenced.

29 Apr 2020

Head of Cellular Genetics elected Fellow of the Royal Society

Sarah Teichmann is recognised for her pioneering computational biology and genomics work, leading to the Human Cell Atlas initiative

28 Apr 2020

New tools to tackle malaria: translating from cutting edge research to real-world applications

This World Malaria Day we look at three ambitious projects, backed by the Sanger Institute Technology Transfer Office, which are ...

27 Apr 2020

Puzzles and Parasites

Dr Stephen Doyle, in the Sanger Institute’s Parasites and Microbes Programme, has just been awarded a new UKRI Future ...

27 Apr 2020

Sanger researcher backed through flagship fellowship

Dr Stephen Doyle has been awarded a UKRI Future Leaders Fellowship to explore the evolution of drug responses in parasitic worms

24 Apr 2020

Sanger Institute to extend funding for Postdoctoral Fellows affected by COVID-19 shutdown

Funding will be extended for six months, including for those funded by third parties

23 Apr 2020

Key nose cells identified as likely COVID-19 entry points

Study with Human Cell Atlas could help understand transmission of the virus

22 Apr 2020

Normal human uterus is colonised by clones with cancer-driving mutations that arise early in life, study finds

Hope that insights into earliest stages of uterine cancer development will help to tackle one of most common female cancers

21 Apr 2020

Tackling COVID-19 at the Sanger Institute

Staff at the Sanger Institute have joined the fight against the global COVID-19 pandemic.

14 Apr 2020

Experience matters for immune cells - discovery of T cells response spectrum could help understand immune diseases

Study could help find better drug targets for asthma and rheumatoid arthritis

8 Apr 2020

Mapping the Human Cell Atlas – charting the body’s cellular world

The Human Cell Atlas is being used to guide future research into human development, biology, health, and disease.

3 Apr 2020

Raising Awareness of Neurodiversity in the Scientific Workplace

By Catherine Gater, Equality Diversity and Inclusion Programme Manager, Wellcome Sanger Institute In February, we welcomed Sara Rankin, Professor of

23 Mar 2020

Sanger Institute scientist wins 2021 Biochemical Society award

Roser Vento-Tormo awarded an Early Career Research Award

23 Mar 2020

UK launches whole genome sequence alliance to map spread of coronavirus

The Wellcome Sanger Institute will collaborate with expert groups across the country to analyse the genetic code of COVID-19 samples circulating ...

20 Mar 2020

Sanger Institute and Wellcome Genome Campus temporarily closed to all but critical research

In response to the rapidly changing COVID-19 pandemic, the Sanger Institute and its neighbours on the Wellcome Genome Campus will close ...

19 Mar 2020

Global human genomes reveal rich genetic diversity shaped by complex evolutionary history

Study will help identify the susceptibility of different populations to disease

19 Mar 2020

The duty of care: a genetic balancing act?

Genetic testing is becoming a standard part of UK healthcare, with plans to expand its use. But who does this ...

16 Mar 2020

New research on brain structure highlights cells linked to Alzheimer’s and autism

Astrocytes organised into layers in similar way to neurons

13 Mar 2020

Being an LGBT+ Ally and Supporting Diversity

Jim Smith joined us at the Wellcome Genome Campus last year as part of the LGBT+ Network and Equality in ...

9 Mar 2020

Dinosaurs and the high seas

Eugene Gardner is a Postdoctoral Fellow in the Human Genetics Programme. His research focuses on the genetics of developmental disorders.

6 Mar 2020

Equality and Diversity Champions celebrated at the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

20 Feb 2020

Origins of immune system mapped, opening doors for new cancer immunotherapies

Cell atlas of human thymus could help engineer improved therapeutic T cells

19 Feb 2020

Otter genome to help understand genetic legacy of pollution crisis and secure species’ future

Genome will unlock wealth of data stored in DNA archives in bid to understand response to environmental changes

17 Feb 2020

Gut bacteria’s interactions with immune system mapped

Cell atlas could reveal why some gut diseases affect specific areas

16 Feb 2020

Cancer across the animal kingdom

Cancer, ageing and somatic mutation rates across species.

16 Feb 2020

Sepsis and precision medicine: is it all in your genes?

Using gene expression data to stratify patients.

15 Feb 2020

Sequencing and the Tree of Life

Progress and promise of the Earth Biogenome Project - a mission to sequence all known eukaryotic species.

11 Feb 2020

The Human Cell Atlas: Understanding health to combat disease

Dr Kerstin Meyer, Principal Staff Scientist at the Sanger Institute, explains what it’s like to work on a such ...

5 Feb 2020

Background information about the ICGC/TCGA Pan-Cancer Project

Overview of the Pan-Cancer Project

5 Feb 2020

Cancer-causing culprits will be caught by their DNA fingerprints

Study within Pan-Cancer Project will help research into cancer prevention, diagnosis and treatments

5 Feb 2020

Comprehensive study finds mutations in non-coding genome are infrequent drivers of cancer

Findings suggest efforts to develop new cancer treatments should primarily focus on protein-coding genes

5 Feb 2020

Genomics in the cloud

The huge, international Pan-Cancer project is the first large-scale use of distributed cloud computing in genomics. As genomics becomes a ...

5 Feb 2020

Unprecedented exploration generates most comprehensive map of cancer genomes charted to date

Pan-Cancer Project discovers causes of previously unexplained cancers, pinpoints cancer-causing events and zeroes in on mechanisms of development

4 Feb 2020

Red and grey squirrel genomes could hold the key to the survival of reds in Britain and Ireland

Susceptibility to squirrel pox and genetic fitness of fragmented populations are key questions for red squirrel researchers

3 Feb 2020

Tailor-made vaccines could almost halve rates of serious bacterial disease

Innovative study points the way to more effective vaccine design

31 Jan 2020

Statement on Brexit by the Wellcome Sanger Institute, the European Molecular Biology Laboratory (EMBL) and the Francis Crick Institute

Statement on Brexit

29 Jan 2020

Never too late to quit: protective cells could cut risk of lung cancer for ex-smokers

Ex-smokers have four times more genetically healthy cells than smokers, helping to protect them against lung cancer

10 Jan 2020

2020 vision: supporting the people behind our science

Read about our ongoing and upcoming work to ensure that all our staff and students from all backgrounds can thrive

5 Jan 2020

“If you know, there is a Nobel prize for you!” – Searching for the causes of cancer in Czechia

In a study spanning five continents, researchers are hunting for tell-tale ‘signatures’ left in DNA by the unknown causes of ...

24 Dec 2019

#SangerAdvent

For our advent calendar on Twitter, this year we celebrated our staff from around the world. Each day, someone told ...

20 Dec 2019

Analysis of CRISPR-Cas9 datasets leads to largest genetic screen resource for cancer research

Study will help narrow down the list of targets for the next generation of cancer treatments

16 Dec 2019

Dr Konstantinos Tzelepis receives ASH–BSH Abstract Achievement Award for leukaemia target research

Award-winning abstract on METTL3 presented at American Society of Hematology meeting

16 Dec 2019

Researchers identify over 140 genes linked to immune system regulation

First extensive immune profiling of mice reveals a vast catalogue of genes that regulate the immune system and model human disease

9 Dec 2019

Appointments and changes to the Genome Research Limited Board

At the GRL Board meeting on 2 December 2019, David Willetts announced his intention to step down as Chair because of ...

5 Dec 2019

Researchers identify new possibilities for the treatment of inflammatory bowel disease

Two molecular pathways found to be integral to maintaining balance in the digestive system

5 Dec 2019

Root of childhood kidney cancer discovered

Pre-cancerous signatures found in healthy tissue point the way towards new treatment options

3 Dec 2019

Causality and the genetic thesaurus

Manuel Tardaguila is a postdoctoral research scientist in Nicole Soranzo’s group. The group focuses on the application of large-scale ...

25 Nov 2019

Best of both worlds

A degree apprenticeship offers the opportunity to earn whilst studying.

19 Nov 2019

From childhood cancer to mapping human development: Pioneering scientist awarded 2019 Foulkes Foundation medal

Congratulations to Professor Muzlifah Haniffa, who has been recognised for her work on the immune system and childhood cancer

18 Nov 2019

Dr Sam Behjati wins Liddy Shriver Early Career Research Award

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work in sarcoma cancer genomics

14 Nov 2019

New malaria drug targets identified in liver stage of life cycle

Hope that new liver-stage drugs will help to counter the threat of antimicrobial resistance to current blood-stage medicines

8 Nov 2019

Ambitious project to map genomes of all life on British Isles funded by Wellcome

An unprecedented insight to the diverse range of species on the British Isles will be made possible by Wellcome funding to ...

31 Oct 2019

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Research explains why children often catch other infections after measles, and highlights the importance of vaccination

31 Oct 2019

Perfume, jazz and immunogenetics

Dr Velislava Petrova is a Postdoctoral Fellow working in immunogenetics in Dr Carl Anderson’s group at the Sanger Institute. ...

28 Oct 2019

Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

Researchers will examine both healthy and diseased intestinal tissue to identify key cell types involved in Crohn’s disease

23 Oct 2019

Accumulation of DNA mutations found in healthy liver leads to disease

Largest study of its kind seeks to better understand how liver disease and hepatocellular carcinoma develop

23 Oct 2019

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

15 Oct 2019

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

15 Oct 2019

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

14 Oct 2019

Science on a bike

One man, one bike, and lots of genomics.

11 Oct 2019

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

9 Oct 2019

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early ...

9 Oct 2019

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

8 Oct 2019

Pioneering Computer Science

Celebrating Ada Lovelace Day and the achievements of women in science, technology, engineering and maths.

8 Oct 2019

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use ...

3 Oct 2019

A dangerous new Salmonella strain is emerging in sub-Saharan Africa

Researchers have discovered the first extensively drug resistant non-typhoidal Salmonella in the Democratic Republic of the Congo

26 Sep 2019

Human kidney map charts our growing immune defence

New cell atlas reveals immune cells present in zones of human kidney

25 Sep 2019

The biology of the brain

Studying mouse brain development can give insights into human neurodevelopmental and psychiatric disorders, as well as help diagnose rare genetic ...

23 Sep 2019

Scientists hone in on DNA differences behind immune diseases

Search could help find drug targets for developing new treatments

19 Sep 2019

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Strain of dangerous pathogen shown to have developed resistance to last-line-of-defence drug

18 Sep 2019

Babies' gut bacteria affected by delivery method, Baby Biome project shows

Vaginal delivery promotes mother's gut bacteria in baby's gut

18 Sep 2019

Health implications of the baby biome?

The method of a baby’s birth affects its collection of gut microbes – its microbiome. But we still don’t ...

16 Sep 2019

Coding the Future

You’re never too young to start learning about DNA sequencing, software development and 3D printing.

11 Sep 2019

500,000 whole human genomes will be a game-changer for research into human diseases

Following on from a successful pilot at the Sanger Institute, we are leading a project to sequence the genomes of all ...

11 Sep 2019

Powering discovery in blood disorders and depression

The wealth of information available to researchers through UK Biobank is powering studies into human health and disease

5 Sep 2019

Brown trout genome will help explain species' genetic superpowers

Eagerly awaited reference genome will allow conservationists to understand how the fish adapts to marine and freshwater environments

5 Sep 2019

Fishing for answers in the brown trout genome

Brown trout are highly adaptable and its genetic make up may hold key answers to helping species survive climate change

4 Sep 2019

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab has launched an exciting programme of events for Friday 27 and Saturday 28 September 2019, transforming parts of Cambridge, Peterborough ...

30 Aug 2019

Flying to the Future

Dr Sophie Adjalley is a Postdoctoral Fellow in Marcus Lee's research group at the Wellcome Sanger Institute. Her research ...

28 Aug 2019

Decoding first of 60,000 British species as Darwin Tree of Life branches out

The mission to map the genetic code of all known British species is underway

22 Aug 2019

Malaria Cell Atlas: mapping a murderous parasite’s life cycle

Malaria - and the parasite that causes it - is complicated. Not only does the single-celled parasite move between humans ...

22 Aug 2019

Malaria control success in Africa at risk from spread of multi-drug resistance

Regional populations of Plasmodium falciparum parasites in Africa are sharing genetic material in all directions – including genes that can confer resistance ...

22 Aug 2019

Map of malaria behaviour set to revolutionise research

The Malaria Cell Atlas gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites ...

16 Aug 2019

A lasting legacy

Meet the next generation of genomic scientists who are benefiting from our founder's generosity

12 Aug 2019

Diarrhoea-causing bacteria adapted to spread in hospitals

Gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals

8 Aug 2019

The modern rise of an ancient disease

Sanger scientists have sequenced the largest number of Treponema pallidum bacterial genomes to date. The bacterium causes syphilis, a sexually ...

2 Aug 2019

Vaccines: Life savers against infectious diseases

Smallpox has been stamped out and various other diseases are declining, thanks to vaccination. But not all diseases have vaccines ...

29 Jul 2019

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Research emphasises importance of ongoing genomic surveillance and infection control

29 Jul 2019

Outbreaks and Antibiotic Resistance

Sophia David talks about her life as a postdoctoral researcher at the Sanger Institute.

25 Jul 2019

Cancer drug data release set to power next wave of therapeutic discovery

Unique data comparing almost 1,000 cancer cell lines’ responses to 453 licensed and experimental drugs is now freely available to ...

23 Jul 2019

Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

Medical student working in the Cancer Genome Project wins prize for colon cancer research

22 Jul 2019

2019 Chief Medical Officer’s Report published

Sanger Institute researchers contribute to Professor Dame Sally Davies' eleventh annual report

22 Jul 2019

Multi-drug resistant malaria spreading in Asia

Study reveals importance of ongoing genomic surveillance for malaria control strategies

18 Jul 2019

Low doses of radiation promote cancer-capable cells

New research in mice helps to understand the risks around exposure to low doses of radiation, such as CT scans and ...

17 Jul 2019

COSMIC: setting the path for tomorrow’s cancer treatments

From gene discovery, to database, to cancer treatment. COSMIC celebrates 15 years of fuelling cancer research.

9 Jul 2019

Cancer, Caveman and Art

Thoughts on life as a postdoctoral researcher, combining science and art.

3 Jul 2019

DECIPHER: Fuelling Rare Disease Research

More than 15 years ago, a hospital doctor realised that bringing people’s genetic data together could provide answers for ...

27 Jun 2019

Connecting With Science

Staff at the Wellcome Genome Campus are supported to connect people with their science - find out more

25 Jun 2019

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Seed Networks projects will focus on specific tissues, such as the thymus, lung, liver, kidney and immune system

24 Jun 2019

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Genomic analysis shows that a significant number of strains are susceptible to penicillin combined with clavulanic acid

20 Jun 2019

Melanoma, Personalised Medicine and the Middle Ages

Saskia Rudat talks about her life as a postdoctoral researcher at the Sanger Institute.

17 Jun 2019

First lung map uncovers new insights into asthma

Understanding lung cells and their signals could help towards finding new asthma drug targets

17 Jun 2019

What if medicine could be tailored ‘just for you’?

The information in our genomes is helping doctors diagnose and treat disease. But how far can personalised medicine go?

12 Jun 2019

Tracking a deadly shapeshifter

A global child killer constantly changes its coat to evade destruction, but a worldwide network of scientists is using genetics ...

11 Jun 2019

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo becomes an elected member of the European Molecular Biology Organization

10 Jun 2019

Pneumonia mapped in largest genomic survey of any disease-causing bacterium

Study will help predict strains important for new vaccines

6 Jun 2019

Breaking the mould – the story of penicillin

From a contaminated dish in London to saving lives on the D-Day beaches of Normandy (via dedicated scientists in Oxford ...

3 Jun 2019

Day in the life: Software Developer – making research happen

Meet the people building software to enable high-throughput genomics at the Sanger Institute.

3 Jun 2019

Major stem cell discovery to boost research into development and regenerative medicine

Expanded Potential Stem Cell lines of pig and human cells established

30 May 2019

Equality and Diversity – not just about fairness

We've come a long way, but the journey isn't finished yet...

28 May 2019

We’ve got the power

Running one of the largest biosciences data centres in Europe as efficiently as possible requires cool heads and even cooler ...

27 May 2019

Global Strep A vaccine one step closer

Streptococcus genomes reveal potential vaccine targets present in over 20 countries worldwide

23 May 2019

Infectious diseases make a comeback in Venezuela following healthcare crisis

The experiences of a friend of a Sanger Institute researcher reveal how parasites and bacteria are now threatening the country'...

16 May 2019

CRISPR catches out critical cancer changes

Researchers reveal which gene fusions are critical for the growth of cancer cells and identify a new drug target for multiple ...

16 May 2019

Sanger Institute animal research facility to close

Following a full review, the Sanger Institute will be closing its animal research facility

15 May 2019

Caring for children with cancer

We explore the world of award-winning cancer scientist, Dr Sam Behjati

15 May 2019

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

The 2019 recipient of the Dr Simon Newell Early Career Investigator Award has been announced as Dr Sam Behjati, whose career ...

8 May 2019

Lead cancer researcher elected to Academy of Medical Sciences

Dr Peter Campbell receives prestigious Fellowship for his work in cancer genomics

1 May 2019

Sanger’s super-sized sequencing scales new heights

We're celebrating: we've just read the same amount of DNA in one year as we achieved in the ...

24 Apr 2019

More than just malaria

Researchers can change children's futures in many more ways than just helping to beat a killer disease...

18 Apr 2019

Crusaders made love and war, genetic study finds

Sanger Institute researchers have produced whole-genome sequences from skeletons discovered in a 13th Century burial pit in Sidon, Lebanon

18 Apr 2019

Rare genetic change provides clues to pancreas development

Understanding pancreas formation could aid research into type 1 diabetes treatments

17 Apr 2019

Head of Human Genetics elected Fellow of the Royal Society

Matthew Hurles is recognised for his pioneering work in identifying the genetic basis of undiagnosed developmental disorders and paving the way ...

12 Apr 2019

Six surprising animal cancer facts

Some creatures never get cancer, while others can catch it from the sea. Find out more in our list of ...

11 Apr 2019

Mice reveal 38 new genes involved in hearing loss

Molecular pathways revealed could identify potential drug targets for restoring hearing

10 Apr 2019

Cracking cancer with CRISPR

How Sanger scientists are using genetic surgery to understand the blueprint of life

10 Apr 2019

Genetic code of WWI soldier's cholera mapped

The bacterium was isolated from a British soldier and stored for over 100 years before being revived and sequenced

10 Apr 2019

New cancer drug targets accelerate path to precision medicine

Researchers discovered thousands of genes essential for cancer’s survival and ranked which ones show the most promise as drug targets ...

29 Mar 2019

CRAM-ming it in

An impending flood of genomic data threatens to overwhelm scientists' abilities to store and share it. Next-generation compression seeks to ...

28 Mar 2019

Sanger Institute scientist wins 2020 Biochemical Society award

Head of Cellular Genetics Programme wins GlaxoSmithKline prize

25 Mar 2019

Tea-time News

Hot tea has been linked to oesophageal cancer - but it's not clear if it's the cause. Studying ...

21 Mar 2019

Darwin Tree of Life sets down roots

Planning for the Darwin Tree of Life Project is underway. We welcome Professor Mark Blaxter, from the University of Edinburgh, who ...

21 Mar 2019

Glass: The Poetry of Science

Dr Kate Carruthers Thomas explores gender in the workplace through the poetry of the Glass Ceiling, Glass Escalator, Glass Cliff ...

14 Mar 2019

Catching pneumonia with caterpillars

Using caterpillars to investigate how human pneumonia works.

14 Mar 2019

Commitment to collaborate on using genomics for pathogen surveillance across Europe

Combining the strengths of the European Centre for Disease Prevention and Control, the Wellcome Sanger Institute and the Centre for Genomic ...

8 Mar 2019

A Day in the Life: Bioinformatician – collaboration, cancer and all life on Earth

Understanding the nature of life on Earth has been revolutionised by DNA sequencing. In the past we could only observe ...

8 Mar 2019

Champions of equality and diversity celebrated

The winners were nominated by staff working at the Wellcome Genome Campus for their actions to advance equality, diversity and inclusion, ...

7 Mar 2019

Major mutation pattern in cancer occurs in bursts

New resource could help understand origins of cancer

5 Mar 2019

Cambridge heart research boosted by £6 million British Heart Foundation Research Excellence Award

Funding will allow Sanger Institute researchers and collaborators to apply cutting-edge genomics to help develop new heart disease diagnostics and treatments

4 Mar 2019

Getting smart about artificial intelligence

Sanger researchers are harnessing the power of AI to extract new knowledge from the ever increasing flood of genomic data. ...

4 Mar 2019

Roser Vento-Tormo leads single-cell research team at the Sanger Institute

The new group will identify the cells involved in the human female reproductive system, how they work, organise and communicate with ...

27 Feb 2019

Improving global surveillance of antibiotic resistance

A WHO Technical Note has been published that will enable health authorities to make informed choices on the most appropriate molecular ...

20 Feb 2019

Establishing the molecular blueprint of early embryo development

By studying the genetic activity of 116,312 single cells from 6.5 to 8.5 days after fertilisation, researchers have ...

12 Feb 2019

Cancer comparison across species highlights new drug target

Scientists discover key genes for mucosal melanoma in humans, dogs and horses that help prioritise targets for new cancer therapies

11 Feb 2019

Almost 2,000 unknown bacteria discovered in the human gut

Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America

11 Feb 2019

I’ve never had chickenpox, what’s your superpower?

Gary Dillon, Business Development Manager at the Sanger Institute gives us his view on some of the powers and pitfalls ...

11 Feb 2019

Sanger Institute steps up commitment to Equality, Diversity and Inclusion in Science

The Institute has joined a new coalition to remove biases in all aspects of life science research, including staff, experiment design, ...

5 Feb 2019

Study reveals how immune cells target different tissues

Tissue-specific receptors and adaptations enable localisation of T regulatory cells

4 Feb 2019

100 cancer organoid models developed by Sanger Institute scientists

The organoids developed by the Sanger Institute lead the UK effort as part of the international Human Cancer Model Initiative (HCMI) ...

4 Feb 2019

More than 100 new gut bacteria discovered in human microbiome

Study will help understand role of microbiome in health and disease

4 Feb 2019

The weird and wonderful world of organoids

Mini organs grown in the lab are boosting cancer research and drug discovery.

31 Jan 2019

Genetic testing gives answers on developmental disorders during pregnancy

Researchers identified new diagnoses of known genetic disorders for 52 of the 610 pregnancies they genome sequenced

31 Jan 2019

Immune master regulator orchestrates responses to parasite infection

Receptor IL-10R is vital to coordinating the body's immune response to whipworms, preventing uncontrolled infection and gut lining damage

30 Jan 2019

GARFIELD classifies disease-relevant changes in the genome

New approach reveals role of genomic changes in a disease, both within and outside genes

30 Jan 2019

Genetic Disability, Experience and the Sorting Society

Our genetic information is more accessible to us than ever before. But what do we want to know? Dr Felicity ...

29 Jan 2019

Huge step forward in decoding genomes of small species

Scientists from the Wellcome Sanger Institute and Pacific Biosciences use just ‘half a mosquito-worth’ of DNA to produce a whole, high ...

23 Jan 2019

Ian Dunham appointed as Open Targets Director

Open Targets is the public-private partnership on the Wellcome Genome Campus that aims to transform drug discovery through the systematic identification ...

21 Jan 2019

Genetic study reveals possible new routes to treating osteoarthritis

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines

18 Jan 2019

The importance of public engagement on antibiotic resistance

Nicole Wheeler talks antibiotics, antibiotic resistance and public engagement - and letting people use real software on real data to ...

17 Jan 2019

Developing a view on Brexit

Sarion Bowers, Policy Lead at the Sanger Institute, reflects on how Brexit will affect science.

14 Jan 2019

Disability, Inclusion and Science

Distinguished disability rights campaigner, David Ruebain, joined us last month at the Wellcome Genome Campus. He spoke on disability and ...

10 Jan 2019

CRISPR study reveals new immune system regulators

Map of T cell regulation could aid development of drugs that could activate the immune system

2 Jan 2019

Mystery of Yemen cholera epidemic solved

Bacteria's genomes reveal that the most likely source of the disease came from Eastern Africa and entered Yemen with the ...

2 Jan 2019

Science in a conflict zone: Investigating cholera in Yemen

In addition to the civil war, Yemen is experiencing the worst epidemic of cholera ever recorded. We spoke to Ankur ...

21 Dec 2018

Bird migration and conservation clues in robin and Turtle dove genomes

The genomes were read by the Sanger Institute and its partners, in celebration of Sanger’s 25th anniversary

21 Dec 2018

Statement from GRL Board accepting the findings of the independent investigation into a whistleblowing claim

Genome Research Limited Chair and Director of the Wellcome Sanger Institute outline steps the Institute will put in place to improve ...

20 Dec 2018

Human genome editing – the issues explored

Hayley Clissold from the Sanger Institute's policy team team explores the issues surrounding gene editing and human embryos

19 Dec 2018

From eye drops to potential leukaemia treatment

Ingredient in pre-clinical treatment for retinal neovascular disease targets gene associated with acute myeloid leukaemia

18 Dec 2018

Hasta la VISA, genomes!

From ragworts that are too common and the tricky toughness of truffles to the trials of getting DNA samples a ...

17 Dec 2018

New strains of hepatitis C found in Africa

Study could inform hepatitis C treatment and vaccine development worldwide

11 Dec 2018

Scientific Evidence in Policy Making

Evidence is a vital part of policy-making - but it's by no means the only part. We look at ...

7 Dec 2018

Chernobyl: chasing a ‘catching’ cancer

Sanger researcher Alex Cagan travelled to Chernobyl’s nuclear exclusion zone for samples of cancer. But he isn’t investigating ...

6 Dec 2018

Claims of genome edited babies shock the world

Our Policy Lead, Sarion Bowers, explores the extraordinary claims that the world’s first genome edited babies have been born.

6 Dec 2018

Sanger’s cloud computing wins award

High performance computing community recognises pioneering work of Sanger’s scientific IT teams

29 Nov 2018

Human Embryo Editing: science fiction or science fact?

Anna Middleton, Head of the Society and Ethics research group at Wellcome Genome Campus Connecting Science, reports on Prof He ...

29 Nov 2018

Wellcome Genome Campus wins silver watermark to recognise its support for public engagement

Award reflects work to nurture a culture where public engagement is supported and encouraged

27 Nov 2018

Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing

Prediction resource could make CRISPR-Cas9 editing more reliable

14 Nov 2018

Dr Cordelia Langford wins BioBeat award

The ‘50 Movers and Shakers in BioBusiness 2018’ report identifies outstanding women who are developing revolutionary bioscience. Dr Cordelia Langford, ...

14 Nov 2018

Human cell atlas study reveals how the maternal immune system is modified early in pregnancy

Cell map of healthy pregnancy could also help understand miscarriages or preeclampsia

12 Nov 2018

Darwin Tree of Life: focusing on fungi and probing plants

We have much to thank fungi and plants for, and the Darwin Tree of Life project will help us to ...

9 Nov 2018

Science as a human right

The idea that we should benefit from scientific advancement is something we may never have thought of as human right, ...

8 Nov 2018

Recessive genes explain only small fraction of undiagnosed developmental disorders

Study will guide research and help estimate risk for future pregnancies

5 Nov 2018

Largest parasitic worm genetic study hatches novel treatment possibilities

Study helps understand how parasitic worms cause disease and uncovers potential new de-worming drugs

1 Nov 2018

Genetic code of 60,000 UK species to be sequenced

The Darwin Tree of Life Project, led by the Wellcome Sanger Institute, plans to read the genomes all known species of ...

1 Nov 2018

Launch of global effort to read genetic code of all complex life on earth

The project aims to create a new foundation for biology to drive solutions for preserving biodiversity and sustaining human societies

1 Nov 2018

Sequencing All Life On Earth – Facts and Figures

Scientists have announced an ambitious goal to sequence all of life on earth. Here are 10 top facts that help ...

1 Nov 2018

The quest to sequence all life

What will reading the genomes of all life on earth uncover? And how does the Sanger Institute intend to lead ...

30 Oct 2018

Result of independent investigation into whistleblowing allegations released

Independent barrister's report concludes that no wrongdoing took place, but that Institute procedures could be improved

29 Oct 2018

Long live bats

The bat genome sequence could help us understand how these remarkable creatures are are reisitant to cancer, Ebola and SARS.

29 Oct 2018

Sanofi joins Open Targets

Unique public-private consortium to identify and prioritise therapeutic targets for new medicines using genomics, bioinformatics and traditional pharmaceutical research gains a ...

24 Oct 2018

Largest census of cancer genes to help understand drug targets

Cancer Gene Census paves the way for improvements in personalised medicine

24 Oct 2018

Study reveals how gene activity shapes immunity across species

More than 250,000 single cells studied to chart evolution of antiviral and antibacterial immunity

18 Oct 2018

Mutant cells colonise our tissues over our lifetime

Scientists may need to rethink the role of some cancer genes in the light of sequencing normal tissues

16 Oct 2018

Milestone reached in major developmental disorders project

Eight years after launch, the Deciphering Developmental Disorders project has identified 49 completely new disorders and provided diagnoses to 4,500 ...

16 Oct 2018

Solving the mysteries of developmental disorders: The DDD study

Alison Cranage talks to one family who have been helped by the Deciphering Developmental Disorders study

10 Oct 2018

Genetics allows personalised disease predictions for chronic blood cancers

The approach could help doctors identify which patients may benefit from specific treatments or clinical trials

4 Oct 2018

10 surprises from sequencing 25 new species

From exploding worms to cannibal crickets and adored arachnids to bewildering blackberries, Alison Cranage picks out the more bizarre discoveries ...

4 Oct 2018

25 Genomes: The Common Starfish

The Starfish genome could offer new approaches to wound healing and into surgical glue, if only we can get enough ...

4 Oct 2018

25 UK species' genomes sequenced for first time

The high-quality genomes will be made freely available to scientists to use in their research

1 Oct 2018

25 years of pushing the scientific boundaries

From one human genome to hundreds of thousands, to every single cell in the body, to the genome of every ...

1 Oct 2018

Journey to precision cancer treatment takes off with new passports tool

Cell Model Passports website offers 'one-stop shop' of information about cancer cell models covering their genetics, clinical history and drug sensitivities, ...

1 Oct 2018

Newly sequenced mouse genomes unearth unknown genes

Sixteen newly sequenced mouse strains reveal unexpected diversity that could impact disease research

27 Sep 2018

Skin is a battlefield for mutations

Our skin is a microcosm of Darwinian evolution where only the cells with the most useful characteristics survive

26 Sep 2018

Rare genetic disorders more complex than thought

Study reveals that common genetic variants could affect the risk of rare developmental disorders

25 Sep 2018

25 Genomes at New Scientist Live

Alongside robots, slime and VR machines, Sanger researchers were at New Scientist Live last week – talking genomes, Alison Cranage reports

21 Sep 2018

Building capacity for genomic surveillance of malaria mosquitoes in Africa

Funding from the Bill and Melinda Gates Foundation will enable the Pan African Mosquito Control Association (PAMCA) to launch nine ...

19 Sep 2018

Wellcome Sanger Institute at 25: how the genomic revolution is changing medicine

Leaps forward in knowledge have allowed scientists and doctors to start to bringing advances out of the lab and into the ...

17 Sep 2018

The Beast from the East? Vespa velutina

Words and pictures by: Alex Cagan Date: 17.09.18 Prelude: Death from above Today, you are a honeybee and today you

14 Sep 2018

LifeLab - Free events highlight discovery on your doorstep

Events include pop-up labs, a puppet show with a difference, story-telling and retro gameshows

13 Sep 2018

International Vertebrate Genomes Project releases first 15 high-quality reference genomes

Publicly available data will impact studies on life, disease, and conservation efforts

5 Sep 2018

Family tree of blood production reveals hundreds of thousands of stem cells

Humans have 10 times more blood-making stem cells than previously thought

3 Sep 2018

Regulator protein key to malaria parasite’s lifecycle

Discovery of AP2-G master switch could help find new ways to prevent malaria

3 Sep 2018

The golden eagle genome has landed

The golden eagle genome is the first sequence completed as part of the 25 Genomes Project. Kat Arney talks to ...

31 Aug 2018

Newly sequenced golden eagle genome will help its conservation

The golden eagle is the first of 25 UK species to be completed as part of the 25 Genomes Project

30 Aug 2018

Children’s bone cancers could remain hidden for years before diagnosis

Complex genetic rearrangements found in many Ewing sarcomas could help inform diagnosis and treatment

9 Aug 2018

Human Cell Atlas gets a boost with first funding from Wellcome

Injection of £7 million will help to create a cellular 'Google map' of the human body, which could revolutionise health and ...

9 Aug 2018

Kidney cancer's developmental source revealed

Study reveals that kidney cancers may arise from cells that haven't fully developed, offering a new target for treatment

30 Jul 2018

Explore nature's genetic secrets in new exhibition

Curious Nature exhibition explores the Wellcome Sanger Institute’s 25th anniversary project to sequence the genomes of 25 UK species for ...

23 Jul 2018

Gene study pinpoints superbug link between people and animals

The research could help with designing more effective ways to prevent bacterial transfer in farms and better antibiotic practices

23 Jul 2018

Omer Bayraktar to lead new research group in the Cellular Genetics Programme

The Faculty appointment, starting in August 2018, will develop high-throughput pipelines to map human tissues one cell at a time

16 Jul 2018

Genome damage from CRISPR/Cas9 gene editing higher than thought

Caution required for using CRISPR/Cas9 in potential gene therapies

9 Jul 2018

Roots of leukaemia reveal possibility of predicting people at risk

Mutations in blood identify individuals at high risk of developing leukaemia

25 Jun 2018

Cholera spread tracked at household level

The results could be used by public health officials to improve cholera control strategies

20 Jun 2018

A new deal on data – articulating the contract between science and people

Now is the time for scientists to strike a deal everyone that benefits society as well as research, argue Anna ...

19 Jun 2018

Wellcome Sanger Institute calls for the free movement of scientists across European borders following Brexit

The Institute has provided evidence for the UK Government Science and Technology Committee’s inquiry into an immigration system that works ...

18 Jun 2018

Genomics offers new treatment options for infants with range of soft tissue tumours

Scientists uncover the genetic changes causing a group of related infant cancers

12 Jun 2018

25 Genomes update. Yes, it’s been a while ...

More than half of the species' genomes have now been sequenced and assembled. But starfish, flatworms and truffles are a ...

12 Jun 2018

Genetic discovery will help clinicians identify aggressive versus benign bone tumours

A genetic change affecting the transcription factor, FOS is specific to osteoblastoma, distinguishing it from osteosarcoma

8 Jun 2018

Cambridge LIFE LAB project wins place in Europe's largest public science event

LIFE LAB will be led by Wellcome Genome Campus Public Engagement, and delivered by a consortium including the Wellcome Sanger Institute

6 Jun 2018

Microbiotica enters into microbiome collaboration with Genentech

Sanger Institute spin out company signs strategic collaboration to apply its leading microbiome Reference Genome Database and Culture Collection to discover ...

6 Jun 2018

Wellcome Sanger Institute sequences reference genomes of 3,000 dangerous bacteria

Gonorrhoea, deadly plague and dysentery among collection of bacterial genomes now publicly available through collaboration with Pacific Biosciences

29 May 2018

New online course introduces bioinformatics to address skills gap

The free course ‘Bacterial Genomes: From DNA to protein function using bioinformatics’ was developed by researchers from the Wellcome Sanger Institute

21 May 2018

Deadly malaria’s evolution revealed

Study shows Plasmodium falciparum emerged earlier than thought and gives clues to how deadly parasites arise

15 May 2018

Gonorrhoea surveillance study maps antibiotic resistance across Europe

Genomic approach could help doctors monitor emerging resistance and prescribe most effective antibiotics in the future

14 May 2018

A trusty guide for exploring the complexity of cells

Single cell RNA sequencing data can be used to identify cell types. Martin Hemberg and Vladimir Kiselev explain how their ...

14 May 2018

Sanger’s Head of Cancer, Ageing and Somatic Mutation Programme honoured by EMBO

Dr Peter Campbell becomes an elected member of the European Molecular Biology Organization

10 May 2018

Professor Nicole Soranzo and Dr David Adams elected to the Academy of Medical Sciences

Sanger researchers focusing on human genetics and cancer are recognised with prestigious Fellowships

9 May 2018

Professor Dominic Kwiatkowski joins the Fellowship of the Royal Society

Head of Sanger’s Parasites and Microbes Programme elected Fellow of the Royal Society

8 May 2018

Machine learning flags emerging pathogens

A new machine learning tool could be useful for flagging dangerous bacteria before they cause an outbreak, from hospital wards to ...

8 May 2018

On Job Satisfaction

Dan Mead is a happy man, here's why ...

7 May 2018

Leukaemia: protective role of Y chromosone gene discovered

Researchers have found that UTY, a gene on the Y chromosome, protects male mice lacking the tumour-suppressing UTX gene on the ...

3 May 2018

Celgene joins Open Targets Initiative

Celgene will expand the Initiative's collective efforts to transform drug discovery through the systematic identification and prioritisation of drug targets

3 May 2018

Deadliest human malaria parasite reveals the genomic chinks in its armour

Study reveals essential genes for Plasmodium falciparum to identify new drug targets

23 Apr 2018

The trouble with Crickets

Crickets' genomes are tricky things, just when you think you know how big they are, they just get a whole ...

20 Apr 2018

Emma Davenport and Hilary Martin to lead research groups in the Human Genetics Programme

The faculty appointments, starting in Autumn 2018, will help the Sanger Institute establish foundational knowledge of how variation in DNA contributes ...

19 Apr 2018

New Sanger Institute Human Cell Atlas projects funded by the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation

Projects will build computational tools to support the global Human Cell Atlas initiative to map every cell type in the body

13 Apr 2018

Advance access to data: Researchers post genetic profiles of human and mouse cells on Human Cell Atlas online portal before publication

Prior to publishing their results, researchers compile and make raw data openly accessible on the preview version of the HCA Data ...

12 Apr 2018

First seeds of kidney cancer sown in adolescence

Insights from this study present an opportunity to develop approaches for early detection and early intervention in kidney cancer

11 Apr 2018

Single cell technology and organoids reveal every bowel tumour and bowel cancer cell have unique genetic fingerprints

Study could help researchers target cancer-specific processes for cancer prevention or to develop treatments

9 Apr 2018

20 year-old mystery of malaria vaccine target solved

Discovery of human receptor for TRAP protein could help improve development of an effective malaria vaccine

6 Apr 2018

New computational method reveals where genes are expressed

06.04.18 Valentine Svensson explains how the new computational method SpacialDE interprets single-cell data to identify which genes are switched on ...

6 Apr 2018

Whole genome sequencing will ‘transform the research landscape for a wide range of diseases’

UK Biobank enters exciting new phase of genetics research

27 Mar 2018

Malaria Cell Atlas launched: Parasite development mapped in unprecedented detail

The Malaria Cell Atlas will allow researchers to identify weak points in the parasite’s lifecycle for intervention with drugs

27 Mar 2018

New online course launched to help doctors and nurses better understand how genomics can battle bacterial diseases

Free three week course on Bacterial Genomes: Disease Outbreaks and Antimicrobial Resistance starts on April 30th

22 Mar 2018

NUCLEUS project welcomes new consortium member: Wellcome Genome Campus in Cambridge

The ambitious HORIZON 2020 NUCLEUS project has been further strengthened by the joining of the Wellcome Genome Campus in Cambridge, UK ...

21 Mar 2018

First 'non-gene' mutations behind neurodevelopmental disorders discovered

The study is a positive step towards providing an explanation for children with undiagnosed neurodevelopmental disorders

21 Mar 2018

Sanger Institute opens up its life sciences leadership development courses

Five bespoke courses tailored to the needs of leaders at all levels, from new supervisors to established managers, are being offered ...

20 Mar 2018

Switch discovered to convert blood vessels to blood stem cells during embryonic development

Findings could aid research into creating new blood cells for transplants and understanding cancer metastasis

19 Mar 2018

New osteoarthritis genes discovered

The results could open the door to new targeted therapies for this debilitating disease in the future

14 Mar 2018

Placenta defects critical factor in prenatal deaths

Research in mice reveal genes whose roles appear to be vital in developing healthy placentas

9 Mar 2018

A cautionary tale about blackberries [2/2]

Dan Mead discovers that conferences can be a great way to build fruitful research collaborations...

9 Mar 2018

John Sulston (1942-2018) – Founding Director of the Wellcome Sanger Institute

We are deeply saddened to announce the death of Professor Sir John Sulston, Founding Director of the Wellcome Sanger Institute

8 Mar 2018

A cautionary tale about blackberries...[1/2]

Finding a blackberry bush was as easy a pie, but then Dan discovered that there are 300 different species... and ...

8 Mar 2018

Human Cell Atlas takes first steps towards understanding human development: First 250 thousand developmental cells sequenced

The Human Developmental Cell Atlas programme will create genomic reference maps of all the cells that are important for human development

8 Mar 2018

Supporters of women in science shine

Role models from across the Wellcome Genome Campus have been recognised for their work in promoting gender equality

5 Mar 2018

Genomic Expressions: Express yourself at new exhibition

The exhibition is part of the Wellcome Genome Campus’ Open Saturdays programme dates include 24 March, 21 April, 19 May and ...

2 Mar 2018

Genetic roots of major depression: three new genetic risk markers discovered

New research taking people's life histories into account finds new genetic regions that may increase the risk of major depression

28 Feb 2018

Missing link found between pathways involved in cell development

The new mechanism could be essential for processes that need a rapid response - such as organ repair, immune response or cancer ...

22 Feb 2018

UK Bioindustry Association (BIA) launches new Genomics Advisory Committee at annual Committee Summit

The UK Bioindustry Association (BIA) launched its newest Advisory Committee, focused on the issue of genomics, chaired by Adrian Ibrahim from ...

20 Feb 2018

Sequencing a superbug: How typhoid became extensively drug-resistant

20.02.18 Gordon Dougan and Elizabeth Klemm report how their laboratory has been sequencing the DNA of Salmonella Typhi strains that ...

20 Feb 2018

Typhoid outbreak: genetic cause of extensive drug resistance found

The results suggest that treatment options for typhoid treatment are running out and preventative strategies are needed

16 Feb 2018

Getting a hold of samples... [part 2]

Dan Mead continues his hunt to collect all 25 species to sequence...

7 Feb 2018

Major funding for Cambridge to transform health through data science

Cambridge is amongst six sites across the UK to be awarded a total of £30M funding by Health Data Research UK, ...

5 Feb 2018

Is food love-hate coded in your DNA?

This Valentine’s special is the first of an exciting new programme of monthly Café Sci events in Cambridge

1 Feb 2018

Multidrug resistant malaria spread under the radar for years in Cambodia

Study suggests that ongoing genomic surveillance is vital to inform malaria control strategies

29 Jan 2018

Getting a hold of some samples...

Sequencing new species is hard enough, but finding out where you can get a sample to work with can be ...

29 Jan 2018

Hidden genetic effects behind immune diseases may be missed, study suggests

For the first time immune cells created from human induced pluripotent stem cells (HiPSCs) have been used to model immune response ...

29 Jan 2018

Sarah Teichmann awarded the Genetics Society’s 2018 Mary Lyon Medal

Award recognises Dr Teichmann’s “outstanding research” in understanding how the immune system works by using genomics and bioinformatics approaches

22 Jan 2018

BioBright, Sanger Institute aim to cut drug-development time

Collaboration promises better, more reproducible biomedical data

8 Jan 2018

On choosing the 25 species for the 25 Genomes Project

From 2 billion species to just 25 - how the Sanger Institute chose which species to sequence

20 Dec 2017

Big data for mosquito control

20.12.17 Alistair Miles explains how the Anopheles gambiae 1000 Genomes project is helping to understand the evolution and spread of ...

20 Dec 2017

We let the public decide five of our species....

5,000 people participated and there were over 150,000 page views - and 5 winners

14 Dec 2017

Concerning spiders, and where to find them

Dan Mead, our 25 Genomes Project Coordinator, is on the search for spiders that like to walk on water

14 Dec 2017

Giant Hogweed sampling, a retrospective

Armed with a mobile phone, 4G signal, orange protective gloves, a tyvek suit, face shield and Google Maps, Dan Mead ...

8 Dec 2017

25 species revealed for 25 Genomes Project

Blackberry to robin, bush cricket to brown trout - the 25 species all reside in the UK

8 Dec 2017

£3.9m project to support elimination of the world’s leading infectious cause of blindness

A major new research project that aims to accelerate the elimination of trachoma has been launched

4 Dec 2017

Takeda joins drug target discovery initiative

Takeda will expand the skills and scientific background of Open Target's existing partners by bringing expertise in gastroenterology, central nervous ...

1 Dec 2017

Life in the fast lane: rapid reproduction in malaria parasites

1.12.17 Brandon Invergo investigates how quickly malaria parasites can prepare to sexually reproduce once they are picked up by a ...

29 Nov 2017

Largest genetic study of mosquitoes reveals spread of insecticide resistance across Africa

Genetic resource will help develop new tools to support the campaign against malaria in Africa

27 Nov 2017

Unforeseen new drug target discovered for acute myeloid leukaemia (AML)

Scientists find that inhibiting the METTL3 gene destroys AML cells without harming non-cancerous blood cells

13 Nov 2017

Alzheimer’s Disease: The puzzle we’re so desperate to solve

13.11.17 Fiona Calvert is using stem cells to study Alzheimer's Disease. Read her shortlisted article for the Max Perutz ...

9 Nov 2017

Risk of cholera epidemics estimated with new rule book

Researchers from across the world have studied cholera outbreaks in Africa, Latin America and the Caribbean from the last 60 years

6 Nov 2017

25 new genomes to celebrate 25 years of the Sanger Institute

Blackberry to robin, bush cricket to brown trout - the 25 species all reside in the UK

31 Oct 2017

A step towards an effective, multi-target vaccine for malaria

Gareth Powell and Leyla Bustamante helped to find five targets on the parasite that could be the basis of a ...

26 Oct 2017

Professor Sharon Peacock to be awarded the 2018 Microbiology Society Unilever Colworth Prize

This Prize is awarded for significant contributions in the field of microbiology

25 Oct 2017

Study shows routine genomic surveillance of MRSA can detect unsuspected outbreaks

Catching outbreaks early could prevent further spread and reduce the number of people involved

23 Oct 2017

Five new malaria targets that could lead to an effective vaccine

Scientists have identified five targets that reduce the parasite’s ability to invade red blood cells

19 Oct 2017

1 to 10 mutations are needed to drive cancer, scientists find

The results show the number of mutations driving cancer varies considerably across different cancer types

18 Oct 2017

The international Human Cell Atlas publishes strategic blueprint; announces data from first one million cells

Blueprint describes path forward for cataloging every cell in the human body; cell data release to be available to research community

17 Oct 2017

Results of the Chordoma Genome Project reveal genetic changes that drive chordoma

DATE: 12/09/17 By: Chordoma Foundation Team Editor’s Note: This blog is reproduced from The Chordoma Foundation blog, a charity ...

17 Oct 2017

Yeast spotlights genetic variation’s link to drug resistance

Study shows that genetic diversity influences which adaptive mutations cause antimicrobial resistance

16 Oct 2017

Genomics reveals how competition between bacteria affects the impact of vaccination

Study identifies the consequences of fierce competition between bacterial strains surviving after vaccine introduction.

12 Oct 2017

New drug hope for patients with rare bone cancer

Patients with a rare bone cancer of the skull and spine – chordoma – could be helped by existing PI3K inhibitor drugs, researchers ...

11 Oct 2017

New type of stem cell line produced offers expanded potential for research and treatments

Scientists have created Expanded Potential Stem Cells (EPSCs) that, for the first time, can produce all three types of blastocyst stem ...

10 Oct 2017

Helping apprentices lead the field in big data

Anglia Ruskin and Wellcome Trust Sanger Institute team up to deliver new training

28 Sep 2017

UK students working with scientists to help prevent childhood parasite infection

Genome Decoders, a UK-wide schools project to help solve a global parasite problem by decoding the whipworm genome, has launched

20 Sep 2017

Genome editing reveals role of gene important for human embryo development

CRISPR-Cas9 genome editing shows that the protein OCT4 is essential in very early days of human embryo development

14 Sep 2017

Huge genetic diversity among Papuan New Guinean peoples revealed

Genetic diversity found to mirror linguistic and cultural diversity among Papuan New Guinean people

13 Sep 2017

Immunotherapy treatment option for selected breast cancer patients, genetic study suggests

Opens up the possibility of another therapy option for approximately 1,000 breast cancer patients in the UK

12 Sep 2017

Type 2 diabetes is being misdiagnosed in African Americans, genetic study suggests

Around 650,000 African Americans in the US have a unique genetic variant that significantly reduces the accuracy of the HbA1c ...

7 Sep 2017

Sanger Institute responds to UK Government's position paper on future EU and UK science collaboration

Government’s position paper offers ideas for negotiating a special status for UK research with European Union funding bodies

7 Sep 2017

The Brain Tumour Charity grants WINDOW Consortium £1.5 million for new research into combination therapies to treat brain cancer

The Dutch/British consortium will study glioblastoma

30 Aug 2017

The Wellcome Trust Sanger Institute responds to the Life Sciences Industrial Strategy

The Life Sciences Industrial Strategy recognises the key role genomics and genetics will play in future healthcare provision

29 Aug 2017

Bowel cancer study reveals impact of mutations on protein networks

The results offer clearer picture of the cellular processes behind bowel cancer, and may enable future tailoring of drug treatments to ...

14 Aug 2017

New genetic analysis reveals late spread of breast cancer and backs key role of early diagnosis

These results show that catching and treating breast cancer before it spreads is a realistic goal

3 Aug 2017

Editing embryos – Could you? Would you? Should you? Views from Genetic Counsellors

03.08.17 This week the American Society of Human Genetics issued a policy on the application of germline editing – the ability ...

1 Aug 2017

Mystery epidemic that crossed species in Iceland is solved

Scientists have identified and tracked the bacteria that caused an epidemic respiratory disease in Iceland’s native horse population

27 Jul 2017

Present-day Lebanese descend from Biblical Canaanites, genetic study suggests

Scientists sequenced the genomes of 4,000-year-old Canaanite individuals and compared these to other ancient and present-day populations

21 Jul 2017

New global health initiative for genomic surveillance of antimicrobial resistance funded by NIHR

The Centre for Genomic Pathogen Surveillance to house the Global Health Research Unit to monitor antibiotic resistant bacteria around the globe

20 Jul 2017

MRSA emerged years before methicillin was even discovered

Study shows that Staphylococcus aureus acquired the mecA methicillin resistance gene in the mid-1940s

18 Jul 2017

'Superbugs' study reveals complex picture of E. coli bloodstream infections

Genetic study of E. coli showed that drug resistant ‘superbugs’ don't always out-compete other strains.

18 Jul 2017

Placing drug-resistant strains of E. coli into a broader context

18.7.17 Samples of E. coli were isolated from patients with bloodstream infections over eleven years. Teemu Kallonen, Julian Parkhill and ...

18 Jul 2017

Richard Durbin awarded the Royal Society’s Gabor Medal

Award recognises more than 25 years of developing computational biology and genomic science

13 Jul 2017

Largest study of malaria gene function reveals a finely tuned genome full of potential drug targets

Scientists discover that two thirds of the malaria parasite’s genes studied are essential for growth, meaning there are many more ...

13 Jul 2017

Malaria parasites: more susceptible to a knock-out blow than we thought?

13.7.17 Theo Sanderson and Ellen Bushell explain how characterising the role of many of the malaria parasite’s five thousand ...

5 Jul 2017

Malaria parasites able to sense their host's calorie intake

Scientists have found that the odds of dying with a malaria infection are lower when the host eats lower amounts of ...

4 Jul 2017

The Wellcome Trust Sanger Institute responds to the Chief Medical Officer's annual report 2016: Generation Genome

The UK Chief Medical Officer's report has highlighted the key role genomics and genetics will play in future healthcare provision. ...

3 Jul 2017

Artificial bile ducts successfully grown in lab and transplanted into mice could help treat liver disease in children

New method opens the way to develop future treatments and reduce the need for liver transplants

3 Jul 2017

Chief Medical Officer’s annual report 2016: Generation Genome highlights the potential for pathogen genomics in patient diagnosis and infection control

04.07.17 The UK Chief Medical Officer's Report has highlighted the vital role genetics and genomics will play in UK ...

29 Jun 2017

‘Like sugar in milk’: Parsi populations from India and Pakistan

29.06.17 Qasim Ayub explains the results of a genetic analysis of the Parsi population.

28 Jun 2017

Inflammatory Bowel Disease: Scientists zoom in on genetic culprits

Scientists produced a high-resolution map to investigate which genetic variants have a causal role in the disease

28 Jun 2017

Professor Eleftheria Zeggini honoured as Young Scientist by World Economic Forum

Professor Eleftheria Zeggini, Group Leader in the Human Genetics programme, has been recognised by the World Economic Forum for her contributions ...

26 Jun 2017

Study reveals how sex 'blindspot' could misdirect medical research

Scientists have shown that the differences between male and female mice impact on biomedical research

23 Jun 2017

Existing drugs could benefit patients with bone cancer, genetic study suggests

New research suggests a subset of bone cancer patients are likely to respond to IGF1R inhibitors based on their genetic profile

19 Jun 2017

Babies' DNA affects mothers' risk of pre-eclampsia in pregnancy

Strong evidence found for a number of genetic variations near to the FLT1 gene being linked to increased risk of pre-eclampsia

12 Jun 2017

Hidden lives revealed in a new exhibition at the Wellcome Genome Campus

The Hidden Lives exhibition offers an exciting insight into the lives and origins of our East Anglian ancestors, greatly enriched from ...

1 Jun 2017

Chan Zuckerberg Initiative supports Human Cell Atlas data platform

The Data Coordination Platform will check, share and analyse the vast amounts of diverse information generated

26 May 2017

Isolated Greek villages reveal genetic secrets that protect against heart disease

A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute ...

18 May 2017

Natural resistance to malaria linked to variation in human red blood cell receptors

First study to identify protective effect of glycophorin gene rearrangements on malaria

10 May 2017

Scientists unveil the UK’s largest resource of human stem cells from healthy donors

Powerful resource created for scientists studying human development and disease

9 May 2017

Cancer drug design targeted by COSMIC's new 3D system

Collaboration between Wellcome Trust Sanger Institute and Astex Pharmaceuticals brings together COSMIC (Catalogue of Somatic Mutations In Cancer) and wwPDB (worldwide ...

8 May 2017

Dr Matt Hurles elected to the Academy of Medical Sciences

Head of the Human Genetics Programme recognised with prestigious Fellowship

25 Apr 2017

Genetics and environment combine to give everyone a unique sense of smell

Genetically identical mice develop different smell receptors in response to their environments

25 Apr 2017

New chlamydia drug targets discovered using CRISPR and stem cells

Scientists have created an innovative technique for studying how chlamydia invades our immune system

13 Apr 2017

Mouse’s internal clock could reveal the secrets of ageing

Researchers have discovered that mice’s DNA ages in a similar way to humans

12 Apr 2017

Some genes are less helpful than others

Some people are naturally missing one of their 20,000 genes - and sometimes the results can be beneficial, pointing to new ...

11 Apr 2017

How genetic mutations affect development more complex than previously thought

Turning off the same gene in mice can result in different physical changes, despite similar genetic backgrounds

11 Apr 2017

New deep learning technique offers a more accurate approach to single-cell genomics

Scientists are using the emerging technology of deep learning to fill in the missing gaps of single-cell genomic analysis

2 Apr 2017

Sanger parasite researcher recognised by British Parasitology Society

Dr Matthew Berriman awarded the 2017 CA Wright Medal for his leading role in understanding protozoan and helminthic parasites through genomics

30 Mar 2017

Single-cell sequencing reveals immune cell coordination breaks down with ageing

T cells from older mice were more variable and less coordinated

27 Mar 2017

New tool allows analysis of single-cell RNA data in pre-malignant tumours

Single Cell Consensus Clustering (SC3) tool more accurate and robust than previous methods for sorting cells into groups

23 Mar 2017

New stem cell method produces millions of human brain and muscle cells in days

The new platform technology, OPTi-OX, optimises the way of switching on genes in human stem cells

22 Mar 2017

First mutations in human life discovered

Archaeological traces of embryo development seen in adult cells

20 Mar 2017

Novel genes identified that help suppress prostate and other cancers

Study reveals possible drug targets for cancers with a faulty PTEN gene

13 Mar 2017

1 in 5 patients with breast cancer could benefit from existing treatment, genetic study reveals

Study shows that a greater number of breast cancers are genetically similar to rarer cases with faulty BRCA1 or BRCA2 genes

8 Mar 2017

Role models recognised for supporting women in science

Eleftheria Zeggini of the Wellcome Trust Sanger Institute and Helen Parkinson of the European Bioinformatics Institute (EMBL-EBI) have been recognised for ...

7 Mar 2017

Matt Hurles appointed as new Head of Human Genetics Programme

Dr Matt Hurles, leader of the DDD Programme and co-founder of Institute spin-out Congenica, has been confirmed as the new Head ...

3 Mar 2017

Latest genomic technology uncovers secrets of immune system's response to malaria

Scientists reveal how mouse T cells develop

27 Feb 2017

Sanger Institute clinical analysis spin-out goes from strength to strength

20 Feb 2017

Sanger Institute's COSMIC database expands cancer cloud capabilities at the Institute for Systems Biology

The Institute for Systems Biology has embedded the COSMIC data within their Cancer Genomics Cloud (CGC), which is a cloud-based platform ...

10 Feb 2017

Malaria vaccine target’s invasion partner uncovered

This could help develop a more effective malaria vaccine

10 Feb 2017

Sanger scientists win £20 million ‘Grand Challenge’ funding from Cancer Research UK

Professor Sir Mike Stratton will lead an international team to help transform our understanding of what causes cancer

6 Feb 2017

Genes linked to malaria parasites’ ability to persist in the body

The ability of malaria parasites to persist in the body for years is linked to the expression of a set of ...

30 Jan 2017

Largest genetic study of inflammatory bowel disease provides clues on new drug targets

Genetic variant identified that doubles an individual’s risk of developing ulcerative colitis

30 Jan 2017

Tracking the movement of a deadly pathogen and biothreat agent

30.01.17 Sharon Peacock and Claire Chewapreecha reveal how the bacterium responsible for Melioidosis has spread across the globe.

25 Jan 2017

Genetic study identifies 14 new developmental disorders in children

Study shows 400,000 children with developmental disorders born each year globally

25 Jan 2017

Genome secrets of elusive human malaria species revealed

Improved surveillance and diagnosis of rarer malaria parasites possible

23 Jan 2017

Study reveals new genetic mechanism driving breast cancer

This new mechanism found in 33 mutation hotspots in the genome.

20 Jan 2017

Sarah Teichmann given Helmholtz International Fellow Award

Head of Cellular Genetics recognised with 20,000 Euros to further her research and an invitation to a research stay at ...

16 Jan 2017

Best treatment option written in cancer’s genetic script

Acute myeloid leukaemia study finds personalised therapy is possible

11 Jan 2017

New genes identified that regulate the spread of cancers

Study reveals Spns2 gene as a new drug target

20 Dec 2016

In search of the hidden reservoir of Malaria

20.12.16 Arthur Talman explains how his field work in Mali could help understand the behaviour of malaria parasites.

19 Dec 2016

Cambridge Innovation Capital plc and IP Group plc announce the creation of Wellcome Trust Sanger Institute spin-out company, Microbiotica

Based on ground-breaking research at the Wellcome Trust Sanger Institute into the role of the human microbiome in disease. Goal is ...

19 Dec 2016

Largest ever genetic study of Primary Sclerosing Cholangitis reveals potential drug target

International collaboration finds associations with four regions of the genome in PSC patients

30 Nov 2016

Online epidemic tracking tool embraces open data and collective intelligence to understand outbreaks

Researchers from the Wellcome Trust Sanger Institute and Imperial College London have developed Microreact, a free, real-time epidemic visualisation and tracking ...

29 Nov 2016

Enhanced CRISPR lets scientists explore all steps of health and disease in every cell type

Two new methods will allow researchers world-wide to rapidly and accurately explore the changing role of genes as the cells develop ...

24 Nov 2016

Sanger spin-out secures $100 million

Company founded on Institute technology goes from strength to strength.

23 Nov 2016

River blindness worm’s genome reveals unique fatal flaws

In Nature Microbiology, Wellcome Trust Sanger Institute researchers revealed the whole genome of Onchocerca volvulus, and within it key differences to ...

21 Nov 2016

Prime Minister opened £42M Biodata Innovation Centre and new Sequencing Facility

The UK Prime Minister Rt Hon Theresa May today (21 November) joined key stakeholders from across the life sciences sector to ...

17 Nov 2016

Landmark project shows heart disease and rheumatoid arthritis risk raised by genetic changes in blood cells

As part of BLUEPRINT, Wellcome Trust Sanger Institute led two of the six papers published in the journal Cell

10 Nov 2016

Multi-drug resistant infection spreading globally among cystic fibrosis patients

Study reveals challenge to infection control practices in hospitals

10 Nov 2016

Newton's apple seeds to grow on Wellcome Genome Campus

Wellcome Genome Campus Connecting Science celebrate International Science Centre Day

3 Nov 2016

Genetic marker found for resistance to malaria treatment in Cambodia

Resistance to the key anti-malarial drug piperaquine has recently emerged in Cambodia, this research will help health officials to monitor its ...

3 Nov 2016

Smoking a pack a day for a year causes 150 mutations in lung cells

Genetic damage caused by smoking measured in different organs of the body

27 Oct 2016

Ancient interbreeding between chimpanzees and bonobos revealed

Genome study creates new conservation opportunities

20 Oct 2016

Sanger Institute Researcher Sam Behjati given the inaugural St. Baldrick’s Foundation Robert J Arceci International Award

The revolutionary award will allow Dr Behjati to focus on finding treatments for childhood cancers without typical research restrictions

18 Oct 2016

Vulnerabilities of leukaemia cells revealed using genome editing technique

Researchers have uncovered approximately 500 genes that are essential for cancer cell survival, including more than 200 for which drugs could ...

14 Oct 2016

International Human Cell Atlas Initiative

An ambitious global initiative to create a Human Cell Atlas - a description of every cell in the human body as a ...

29 Sep 2016

New drug target for asthma

PD-1 marker found in immune cells that can trigger asthma

26 Sep 2016

New genetic links for heart disease risk factors identified

17 rare genetic variants found

26 Sep 2016

Out of Africa: more data must give us definite answers, soon ....

26.09.2016 Dr Yali Xue shares her hopes and dreams of using the world's genomes to understand our evolution and ...

23 Sep 2016

Richard Durbin awarded the International Steven Hoogendijk Award

Sanger Institute Faculty member is recognised for his contribution to bioinformatics

21 Sep 2016

The genetic history of Aboriginal Australians and Papuans

Evidence found for a single major 'Out of Africa' migration event

16 Sep 2016

Childhood cancer targeted by Sanger Institute and St Jude Children’s Research Hospital data-sharing agreement

Regular updates and exchanges of cancer data in childhood cancer will help both institutions and will be made freely available to ...

12 Sep 2016

How ionising radiation damages DNA and causes cancer

Two characteristic patterns of DNA damage found

22 Aug 2016

How oesophageal cancers grow

Oesophageal cancers driven by 'marginal gain' rather than speed

22 Aug 2016

New types of African Salmonella associated with lethal infection

Two novel African types differ genetically to Western Salmonella Enteritidis

1 Aug 2016

Largest genomic study of heart disease in children reveals inherited genetic roots and new disorders

The international study sequenced and analysed the protein-coding segments of the genome of 1,900 congenital heart disease patients and their ...

21 Jul 2016

New intellectual disability syndrome caused by damage to single gene

Study explains genetic effect on cognition

12 Jul 2016

Red hair gene variant drives up skin cancer mutations

The burden of mutations is comparable to an extra 21 years of sun exposure

11 Jul 2016

Dr Sarah Teichmann awarded Fellowship by the International Society for Computational Biology

Head of the Cellular Genetics Programme at the Wellcome Trust Sanger Institute is honoured for her work in computational biology and ...

11 Jul 2016

International collaboration to create new cancer models to accelerate research

Human Cancer Models Initiative (HCMI) will create globally accessible bank of around 1,000 cancer cell models.

7 Jul 2016

Cancer cell lines predict drug response

Large-scale study could increase success rate of developing personalised cancer treatments

6 Jul 2016

Anatomy of a decision: mapping early development

A new atlas of gene expression during the earliest stages of life boosts studies of development

29 Jun 2016

Companion: a new tool to generate and visualize annotation of parasite genomes

29.06.16 Sascha Steinbiss & Thomas D. Otto explain how this new software tool and web server will allow people to ...

27 Jun 2016

Monitoring malaria parasite reveals evolving drug resistance and infection history

Plasmodium vivax study shows genomic surveillance could guide health strategies

22 Jun 2016

Understanding historical population movements and the study of malaria

22.06.16 Past migrations within sub-Saharan Africa revealed in a post by George Busby

9 Jun 2016

Acute myeloid leukaemia is at least 11 different diseases

Landmark study shows genetic changes explain differences in survival for young AML patients.

9 Jun 2016

GA4GH presents vision for genomic and clinical data sharing

The Global Alliance for Genomics and Health (GA4GH) calls for a federated data ecosystem for sharing genomic and clinical data, in ...

31 May 2016

Adrian Bird awarded 2016 Shaw Prize in Life Science and Medicine

Associate Faculty member recognised for research into the genomics of autism spectrum disorder Rett Syndrome

26 May 2016

Nicole Soranzo named among Italy’s Top 38 Women Scientists in biomedicine

Award recognises the impact of Sanger Institute researcher’s work in driving forward biomedical science

24 May 2016

Closing the Evidence Gap on Public Attitudes Toward Genetic Data Handling

The Global Alliance for Genomics and Health (GA4GH) and the Wellcome Genome Campus have launched a new project to explore global ...

24 May 2016

Personalised medicine – how to stand out in a crowd

25.05.16 Personalised medicine is the promise of genomic research, but to make it a reality will take a community of ...

18 May 2016

Tracking the last Ebola cases in Sierra Leone

Ebola virus genomes were sequenced in a temporary laboratory at the outbreak treatment centre

17 May 2016

X-Men Inheritance - research project launched to discover how families understand genetics

A new study at the Wellcome Genome Campus will use popular films such as the X-Men series to explore how stories ...

5 May 2016

Karma Bacterium: New additions to the Culture Club

05.05.16 Hilary Browne explains how growing previously 'unculturable' microbiota helps determine the role of bacteria in human health

5 May 2016

Superbug infections tracked across Europe

The Centre for Genomic Pathogen Surveillance has developed a new web-based tool that can track the spread of MRSA

4 May 2016

Bugs as drugs

Harnessing novel gut bacteria for human health

2 May 2016

Five new breast cancer genes found

Discovery of mutations paves the way for personalised treatment of breast cancer

25 Apr 2016

Modern DNA reveals ancient male population explosions linked to migration and technology

Y chromosomes bear the marks of a series of explosive increases in male numbers linked to human development

19 Apr 2016

Open Targets: new name, new data

The Centre for Therapeutic Target Validation - now called ‘Open Targets’ - releases its first experimental datasets from consortium experiments and a new ...

17 Apr 2016

International Cancer Genome Consortium for Medicine (ICGCmed) will link genomics to clinical information and health

New Orleans – (April 17, 2016) The International Cancer Genome Consortium (ICGC) today announced plans to launch the International Cancer Genome Consortium ...

7 Apr 2016

Test run finds no cancer risk from stem cell therapy

Therapeutic stem cells can be made without introducing genetic changes that could later lead to cancer, a study in PLoS Genetics ...

6 Apr 2016

Scientists and conservation charities join forces to track Spanish bluebell invasion

Volunteers will use some of the latest genomic technologies to help understand the spread of the Spanish bluebell

29 Mar 2016

Early-stage embryos with abnormalities can still develop into healthy babies

Study shows that abnormal cells within embryos can be killed off by programmed cell death, and replaced by normal cells for ...

24 Mar 2016

Embryo development: Some cells are more equal than others even at four-cell stage

Although they seem to be identical, the cells of a two-day-old embryo are already beginning to display subtle differences

23 Mar 2016

Launch of new European Stem Cell Bank

Sanger Institute's stem cells pipeline contributes HiPSCi cell lines to international resource.

22 Mar 2016

Black fever beats drugs by adding just two DNA bases to its genome

For drug resistance, sometimes it just takes two (extra DNA base pairs)

22 Mar 2016

Genomes of chimpanzee parasite species reveal evolution of human malaria

Whole-genome sequencing and analysis has been used to explore and understand the origins of human malarial disease.

21 Mar 2016

Genomic study of epidemic dysentery reveals how Europe exported a scourge worldwide

Largest genetic study of the bacterium responsible for epidemic dysentery has revealed that the Shigella dysenteriae pathogen, which remains a real ...

16 Mar 2016

Editing the Debate

Editing the genome is a grand endeavour. Discussions on the aims and regulation of genome editing need to reflect the ...

14 Mar 2016

Politicians want to make the most of personalised medicine for the NHS

More than one hundred stakeholders will join parliamentarians to discuss the nature of personalised medicine and implications for the NHS.

14 Mar 2016

Socialising the Genome

Anna Middleton explains how bringing together an Advertising Executive, a Genetic Counsellor and the power of Internet Videos is tackling ...

14 Mar 2016

Strongest single gene conclusively implicated in schizophrenia

Single-letter changes to the DNA code of one gene have been shown to have a substantial effect on the risk of ...

8 Mar 2016

Leading the way for gender equality

Sumana Sharma of the Wellcome Trust Sanger Institute and Robert Petryszak of the European Bioinformatics Institute (EMBL-EBI) have been recognised for ...

7 Mar 2016

Evolution of artemisinin-resistant malaria

07/03/2016: Roberto Amato shows how mutations in the malaria gene kelch13, associated with artemisinin resistance in Southeast Asia, are far ...

7 Mar 2016

Immunology meets single-cell sequencing

A new computational approach in single-cell genomics reveals how different types of T cells detect, destroy and remember invaders.

4 Mar 2016

Studying gene function through natural gene knockouts in humans

Studying the genome sequences of natural gene knockouts in humans has shown that only a small fraction of our genes ...

25 Feb 2016

Casting light on the neglected tropical disease Trachoma

Genomic sequencing reveals link between STIs and leading cause of infectious blindness

25 Feb 2016

Genetic study reveals 50 thousand years of independent history of Aboriginal Australian people

Researchers worked with Aboriginal Australian communities to explore heritage

16 Feb 2016

Slavery carried bilharzia parasites from West Africa to the Caribbean, genomics confirms

The bilharzia-causing parasite, Schistosoma mansoni, first infected humans as they fished in lakes in East Africa and was spread, first to ...

8 Feb 2016

Biogen joins pioneering target validation collaboration CTTV

The Centre for Therapeutic Target Validation welcomes new member Biogen, expanding its efforts to accelerate drug discovery research

1 Feb 2016

How do parasites worm their way in?

Adam Reid has worked with researchers around the world to discover the genes that let the Strongyloides nematode set up ...

28 Jan 2016

Super-speed Salmonella evolution

28/01/2016: Thousands of years’ worth of evolution in just one person: Elizabeth Klemm explains how a Salmonella Enteritidis infection evolved ...

21 Jan 2016

Turning DREAM into reality

21.01.16 David Wedge reports the launch of a new DREAM Challenge that aims to identify the different cells that make ...

19 Jan 2016

Ancient genomes reveal that the English are one third Anglo-Saxon

DNA from ancient British skeletons reveals immigrant history

11 Jan 2016

Parallel single-cell profiling now possible

New protocol allows links between DNA methylation and gene expression to be studied in the same cells

18 Dec 2015

“Darwin’s puddle” shows how new species can emerge without geographic separation

Cichlid fish from a tiny volcanic crater have been caught in the act of sympatric speciation

14 Dec 2015

Sperm mutation rate varies between fathers

Risk of having two children with the same genetic disorder is determined by mutation timing

11 Dec 2015

Periodic table of protein complexes

New tool helps to visualise, understand and predict how proteins combine to drive biological processes

8 Dec 2015

Target Validation Platform launches

A web interface to help researchers find therapeutic targets for new and repurposed medicines is launched by the Centre for Therapeutic ...

7 Dec 2015

Skin cells play ‘dice games’

Movies of cell growth explain skin graft success and may help understand cancer

9 Nov 2015

Molecular clocks control mutation rate in human cells

Cancer and ageing could be predetermined by the speed of molecular clocks

29 Oct 2015

Targeted therapy for gastric cancer possible

Genomic fingerprint can highlight which breast, ovarian, pancreatic and gastric cancers are likely to respond to treatment

26 Oct 2015

CRISPR/Cas9 used for rapid functional study of cancer-causing genes

Novel high-throughput approach finds combinations of genes that induce cancer

19 Oct 2015

Location, location, location: Site of inflammatory bowel disease crucial

Genetic similarity suggests Crohn's disease and ulcerative colitis form a continuum of subtypes in the bowel

5 Oct 2015

Sharing of genetic data empowers discovery of new disorders in children

Four new genetic disorders identified

2 Oct 2015

1000 genomes for mankind

Completed project creates largest catalogue of global genomic diversity

2 Oct 2015

Gene expression: a snapshot of stem cell development

New genes found that regulate development of stem cells

1 Oct 2015

Genes that protect African children from developing malaria identified

New resistance locus lies close to gatekeeper genes involved in malaria invasion of red blood cells

30 Sep 2015

Lessons from Ebola: Better disease surveillance needed

Technology could help counter risk of next Ebola crisis

14 Sep 2015

10,000 UK genomes project explores the contribution of rare variants to human disease and its risk factors

Landmark study confirms complexity and informs the next stages of research

10 Sep 2015

Great balls of cells: Using intestinal organoids to study Salmonella

10.09.15 It is difficult to study Salmonella infections in the body. Jessica Forbester explains how newly created balls of intestinal ...

17 Aug 2015

Immunotherapy: the latest way to treat cancer

Yong Yu talks about his research in immunotherapy, an emerging cancer treatment that exploits the biology of innate lymphoid cells

7 Aug 2015

Shigella flexneri persists in environment and switches serotypes

Clean water, not vaccines, will be most effective against dysentery, genomics reveal

31 Jul 2015

Analysis of horse pathogen sheds light on persistent infections

Bacteria that lost diversity around WWI provides insight into HIV and TB

30 Jul 2015

Major European study reveals role of genes in disease

EUMODIC consortium studies functions of over 300 mouse genes

20 Jul 2015

Host-targeted antibodies effective against malaria

20 Jul 2015

Inflammatory Bowel Disease (IBD) genetically similar in Europeans and non-Europeans

15 Jul 2015

Stealth and sabotage

15.07.15 Abigail Perrin explains how malaria parasites trick our immune system

13 Jul 2015

Scientists create mini liver segments for drug discovery

2 Jul 2015

New antimalarial compound discovered

1 Jul 2015

Fellowship renamed in honour of Janet Thornton

1 Jul 2015

“Being a scientist is fantastic”

Former EBI Director Janet Thornton talks to Saher Ahmed about life and science - and finding a balance between the ...

23 Jun 2015

Genome of emerging antibiotic resistant bacteria decoded

22 Jun 2015

A breath of fresh air for oxygen-starved tissue

22.06.15 Artificial membrane could transform the way we treat heart disease, says Rameen Shakur

18 Jun 2015

Sarah Teichmann receives EMBO Gold Award

3 Jun 2015

Ebola sequencing data released to global research community

1 Jun 2015

CRISPR genome editing far safer than previously thought

1 Jun 2015

Out of Africa via Egypt

27 May 2015

It’s all about reproducibility

To check results, experiments need to be repeated. In animal research, this hasn’t been easy but, as Natasha Karp ...

21 May 2015

Using healthy skin to identify cancer's origins

12 May 2015

Drug target for asthma discovered

11 May 2015

Antibiotic resistant typhoid detected in countries around the world

7 May 2015

Patient cancer cells help to test treatments

29 Apr 2015

Most people eager to know the secrets of their genetics

28 Apr 2015

Action against antibiotic resistance begins with the community

27 Apr 2015

Single cells seen in unprecedented detail

24 Apr 2015

Keeping pace with changing parasite genetics

25.04.15 Malaria parasites adapt at a frightening rate. A global collaboration has compiled a large collection of P. falciparum genomes ...

15 Apr 2015

Helping computers to read symptoms

15.04.15 Big data can help us find the causes of rare diseases. But, says Anika Oellrich, computers must first understand ...

13 Apr 2015

Being part of the herd saves lives

13.04.15 Stopping the leading cause of child death starts with you. Rebecca Gladstone explains how widespread vaccination protects the vulnerable

9 Apr 2015

Mountain gorillas enter the genomic age

4 Apr 2015

A world without smell

02.04.15 Fresh bread, your newborn baby, a gas leak; Darren Logan imagines life without these smells and explains his work ...

1 Apr 2015

Following cancer’s journey

01.04.15 How do tumours move between organs? Are they competing when they spread or do they work cooperatively? David Wedge ...

1 Apr 2015

Is the playing field level in prostate cancer?

01.04.15 Between competing prostate tumours there are often areas of normal tissue. David Wedge asks whether these healthy cells are ...

1 Apr 2015

Prostate cancer study overturns thinking on cancer's spread

30 Mar 2015

The bacteria that’s as smart as a whip

30.03.15 In the rest of the world, Salmonella Typhi has only one type of flagellin, the whip-like structure that helps ...

18 Mar 2015

From bench to bedside

18.03.15 Some scientific discoveries become life-changing technologies while others never make it to the clinic. Sarion Bowers introduces an initiative ...

17 Mar 2015

Parliamentary Group seeks bioscience health benefits

13 Mar 2015

Patience is a virtue for tolerant bacteria

13.03.15 How do microbes develop a tolerance to antibiotics? Research into the genetic mechanisms suggest it’s something of a ...

13 Mar 2015

Sanger Institute PhD student wins prestigious prize

9 Mar 2015

Answering age-old questions

09.03.15 Why do we age? What’s happening to us at a cellular level? While exploring competing theories, Tamir Chandra ...

8 Mar 2015

Supporting Women in Science

6 Mar 2015

The home of genetic sequencing

05.03.15 Fred Sanger, who unlocked life’s code, will be honoured at a ceremony this weekend. Anita Sedgewick explains how ...

4 Mar 2015

Two return-to-research fellows appointed at the Sanger Institute

2 Mar 2015

SMRTer sequencing

02.03.15 We’re beginning to understand how bacterial DNA adapts and evolves. John Lees explains the long and short of ...

27 Feb 2015

Dr Jeffrey Barrett to lead Centre for Therapeutic Target Validation

26 Feb 2015

Leukaemia-associated mutations almost inevitable as we age

25 Feb 2015

Teaching old dogs new tricks

25.02.15 An unassuming small molecule derived from Vitamin A has the potential to make cell-reprogramming more efficient than ever, explains ...

19 Feb 2015

The mosaic of life

19.02.15 Structural changes to the intricate pattern of DNA after fertilisation could be the cause of as yet undiagnosed developmental ...

4 Feb 2015

Wondrous diversity

04.02.15 Malaria-transmitting mosquito populations harbour an extraordinary potential for adaptation, says Alistair Miles

2 Feb 2015

Cancer cells and the quest for immortality

02.02.15 Researchers are beginning to understand cancer’s crafty tricks for dodging death, says Daniela Robles-Espinoza

29 Jan 2015

CRISPR collaboration aims to speed drug discovery

28 Jan 2015

Can sharing your personal data protect your freedom?

28.01.15 Proposed EU limits on data use will limit genetic research, which relies on enormous data sets. Does preventing the ...

20 Jan 2015

American Society of Clinical Oncology highlights Sanger Institute research

20 Jan 2015

How can we see our immune system?

19.01.15 By sequencing individual immune cells, scientists can now look at the way our bodies respond to infection and disease. ...

19 Jan 2015

Genetics underpinning antimalarial drug resistance revealed

14 Jan 2015

A molecular archaeologist’s toolkit

14.01.15 Like archaeologists, cancer researchers piece together the shards of past catastrophe. However, as Moritz Gerstung explains, algorithms, not brushes, ...

9 Jan 2015

Novel breast cancer gene found

8 Jan 2015

Revamped website unravels mysteries of DNA

24 Dec 2014

Project finds 12 new genetic causes of developmental disorders

24 Dec 2014

Which bacterium is it anyway?

24.12.14 Microorganisms are everywhere, so how can you be sure they aren’t contaminating the bacteria you are sequencing? Zannah ...

18 Dec 2014

Fast-changing genes help malaria to hide in the human body

18 Dec 2014

Fundamental mechanism for controlling protein function identified

17 Dec 2014

Getting to know you

17.12.14 Your genome can tell you a great deal about your future health but, asks Anna Middleton, how much should ...

17 Dec 2014

Making single-cell biology work

17 Dec 2014

National project paves way for clinical genetic diagnosis

16 Dec 2014

Institute cancer diagnostics spin-out secures £12.5 million

12 Dec 2014

Understanding the impact of genomic data

12.12.14 Genome sequencing is now available to all. Can our current genetic counselling service deal with the fallout, asks Anna ...

10 Dec 2014

Isolating cause and effect with sensitive mice

10.12.14 The smallest environmental change can have an impact on a mouse. Natasha Karp explains how experiments must be carefully ...

8 Dec 2014

Genes that cause pancreatic cancer identified by new tool

3 Dec 2014

Study set to shape medical genetics in Africa

28 Nov 2014

Parasitic worm genomes: largest-ever dataset released

26 Nov 2014

Targeting skin cancers

26.11.14 Many melanomas don’t respond to existing drugs and most eventually become resistant to treatment. Marco Ranzani explains how ...

24 Nov 2014

Battling bacteria: this time it’s personal

24.11.14 Claire Chewapreecha’s research into the genetics of deadly bacteria is motivated by her commitment to improve public health ...

21 Nov 2014

Brain-dwelling worm in UK man's head sequenced

10 Nov 2014

Large-scale study raises hopes for development of E. coli vaccine

7 Nov 2014

World War I soldier helps in fight against dysentery

5 Nov 2014

African genomes yield sickle cell insights

5 Nov 2014

Science and the media – allies or enemies?

05.11.14 Meeting science journalists and hearing from researchers about their media work has encouraged Rebecca Gladstone to stand up for ...

3 Nov 2014

Open season in science

03.11.14 Research has become more publicly available than ever before. Sarion Bowers explores the benefits and dangers of open access

21 Oct 2014

Global Alliance for Genomics and Health Members Meet to Advance Genomic Data Sharing

20 Oct 2014

Sanger Institute researcher collaborates on story of love and flu

13 Oct 2014

Sanger Institute researcher becomes Suffrage Science awardee

13 Oct 2014

The life and death of a B cell

13.10.14 Alena Pance explains how the unforeseen survival of cells in her team’s work led to an unexpected discovery ...

30 Sep 2014

Malaria study raises evolutionary questions

26 Sep 2014

Drawing a BLUEPRINT for blood cells

An EU-funded project is looking beyond genetics to see what governs how our blood cells are created and how they ...

25 Sep 2014

Journey from stem cell to blood cell uncovered

25 Sep 2014

Protein controlling gut's protective force field identified

16 Sep 2014

Gene variant that dramatically reduces 'bad' lipids

16 Sep 2014

Hide and seq: tracking down viruses

16.09.14 The genetic code of a virus is a million times shorter than ours and changes quickly. Velislava Petrova explains ...

12 Sep 2014

Poised and waiting for malaria’s next move

11.09.14 Scientists across Africa have set up a network to track and rapidly respond to the emergence of antimalarial drug ...

10 Sep 2014

The deep end

10.09.14 Stepping out of a science degree and into a communications role was never going to be easy, says Sophia ...

9 Sep 2014

Comparison holds key to human infection

8 Sep 2014

How do animals become domesticated?

08.09.14 Rabbits provide an excellent model for studying the genetics of domestication. Bronwen Aken explains how changes in their genomes ...

5 Sep 2014

Odour, ardour and anger

04.09.14 Why do male and female mice behave differently? As Ximena Ibarra-Soria explains, smell plays a role but it’s ...

29 Aug 2014

Happy Birthday, Sanger Institute Blog!

To celebrate, here are the 10 most popular posts from the blog’s second year

15 Aug 2014

Samtools CRAMS in support for improved compression formats

14 Aug 2014

Do stem cells have memory?

14.08.14 Some stem cells may recall their origins. Daniel Gaffney and Foad Rouhani explain how genetic variation complicates the picture

13 Aug 2014

Why do resistant bacteria succeed?

11 Aug 2014

Fleshing out our knowledge of bone

11.08.14 Bone is regulated by a multitude of pathways and we are only just beginning to see how they all ...

7 Aug 2014

Finding the genetic culprits that drive antibiotic resistance

7 Aug 2014

Mobile DNA elements restructure cancer genomes

5 Aug 2014

Genomics API supports Global Alliance for Genomics and Health

4 Aug 2014

Malaria: the parasite’s perspective

04.08.14 Artist Deborah Robinson wanted to go beyond familiar malaria imagery and create new ways of seeing the disease. Here, ...

1 Aug 2014

Genome Campus will host UK NHS 100,000 genomes project

31 Jul 2014

Urban lifestyle risk factors increase in world's most rural area

30 Jul 2014

New malaria vaccine candidates identified

21 Jul 2014

New technique maps life's effects on our DNA

15 Jul 2014

Chasing the cause of chicken coccidiosis

15.07.14 The secret to a devastating chicken parasite’s success could lie in the uniquely repetitive structure of its DNA, ...

10 Jul 2014

Secrets and secretions of merozoite proteins

10.07.14 If we can understand the function of the proteins displayed on the surface of malaria parasites, we might be ...

8 Jul 2014

The egg enigma

08.07.14 Why did it take a decade to find the perfect partner for sperm’s surface protein?

2 Jul 2014

Agreement will accelerate genetic disease research worldwide

2 Jul 2014

Three shades of fat

02.07.14 If we’re to tackle obesity, it’s important to understand the crucial differences between white, beige and brown ...

29 Jun 2014

Reconstructing the life history of a single cell

25 Jun 2014

Mosquitos swap insecticide-resistance genes

18 Jun 2014

Trials and tribulations of a corresponding author

18.06.14 For Yali Xue, a series of unfortunate events made the process of publishing her paper a rather more stressful ...

15 Jun 2014

Exploring a parasitic tunnel-boring machine

13 Jun 2014

What does it mean to be obese?

13.06.14 Measurements for obesity based on studies conducted in European populations may not be appropriate for African populations, explains Georgina ...

12 Jun 2014

En busca de la epistasia

12.06.14 En la cruzada por entender cómo la genética determina la forma en que funcionamos, Andrew Brown nos cuenta cómo, ...

12 Jun 2014

The search for epistasis

12.06.14 In the quest to understand how genetics determines the way we function, there’s a layer of complexity that, ...

11 Jun 2014

Sanger Institute launches return-to-research fellowship

9 Jun 2014

Pathway between gut and liver regulates bone mass

4 Jun 2014

Superbugs at home

04.06.14 MRSA isn’t just a hospital infection, it can make itself a cosy home in the community. A study ...

3 Jun 2014

Looking further afield

03.06.14 Writing reviews on papers outside your area of expertise can inspire new ideas. Virologist Eva Archer talks about her ...

30 May 2014

Using big data to understand small data

30.05.14 Looking at patterns in vast datasets is helping researchers to pick out individual genes involved in cancer development and ...

29 May 2014

An unexpected discovery

29.05.14 When Susie Cooke stumbled upon a dead gene in cancer DNA, she realised that what she’d found had ...

29 May 2014

Clonal heterogeneity is hidden in the mix

19 May 2014

Beneath the skin

19 May 2014

Getting under the skin of dermatological conditions

19.05.14 Combining large-scale genetic screening with tissue screening has identified genes involved in nine severe skin abnormalities, explains Valerie Vancollie

15 May 2014

Concordat to broaden understanding of animal research

15 May 2014

Is this mosquito a new species?

Have Anopheles sundaicus mosquitoes divided into several different species? One way to find out is to reconstruct their evolutionary history...

11 May 2014

Atlas shows how genes affect our metabolism

8 May 2014

Immune cells use steroids

7 May 2014

Institute supports boost for science participation

7 May 2014

Julian Parkhill and Karen Steel elected to EMBO

6 May 2014

Brief encounters in mass spectrometry

06.05.14 Proteins are transformed in a fleeting but essential process called phosphorylation. Researchers are perfecting techniques to locate these potential ...

1 May 2014

Institute researcher elected Fellow of the Royal Society

30 Apr 2014

Non-allelic homologous recombination: inheritance or chance?

30.04.14 Are deletions and duplications of portions of the genome in sperm due to genetics or is it more random? ...

29 Apr 2014

Two human genomes per hour

28 Apr 2014

Single cell genomics: thinking small

28.04.14 Advances in single-cell genomics are starting to reveal just how much diversity can occur within a single organism, says ...

25 Apr 2014

Seeking causes of osteoarthritis

24 Apr 2014

Origin and evolution of Bordetella pertussis

24 Apr 2014

The enemy within

24.04.14 Virus DNA found within the genome of the disease-spreading tsetse fly could provide researchers with the key to controlling ...

24 Apr 2014

Tsetse fly genome reveals weaknesses

21 Apr 2014

A plague in your family

16 Apr 2014

Sperm meets egg: protein essential for fertilisation discovered

14 Apr 2014

Shoot the messengers

14.04.14 Signalling molecules have been shown to be essential throughout the lifecycle of the malaria parasite. Disrupting them could halt ...

13 Apr 2014

Virus-fighting genes linked to mutations in cancer

11 Apr 2014

Leading questions

11.04.14 Anna Middleton recently emerged victorious in an online competition where young people can ask scientists anything. She explains how ...

8 Apr 2014

An underestimated emergency

08.04.14 Antibiotic-resistant infections are disproportionately affecting the very people who can’t afford alternative treatments. The situation is critical, says ...

8 Apr 2014

Congenital heart disease gene found

1 Apr 2014

The Sanger Institute honoured with Athena SWAN Bronze Award

30 Mar 2014

Genetic mutations warn of skin cancer risk

27 Mar 2014

Where do you start when developing a new medicine?

25 Mar 2014

Battling against resistance

25.03.14 By sequencing and tracking gonorrhea, researchers are hoping to reduce the spread of strains resistant to antibiotic treatment, explains ...

23 Mar 2014

Leukaemia caused by chromosome catastrophe

17 Mar 2014

Sanger Institute spinout Kymab announces therapeutic antibody discovery technology

16 Mar 2014

Cancer therapy may be too targeted

13 Mar 2014

COSMIC celebrates its 10th anniversary

10 Mar 2014

Genome Campus appoints Director of Scientific Conferences and Engagement

8 Mar 2014

Celebrating inspirational female scientists

5 Mar 2014

Our genetics is not necessarily our destiny

05:03:14 It’s becoming clear that both nature, our genes, and nurture, the way our environment affects the ...

4 Mar 2014

The Global Alliance of Genomics and Health holds first partnership meeting

3 Mar 2014

Continued advances in HIV treatment and diagnosis require shared resources

03.03.14 Complete genomes of the Human Immunodeficiency Virus 1 are being sequenced and shared to create important reference material, explains ...

2 Mar 2014

A crisper CRISPR: safer genome modification

26 Feb 2014

Strained relations

26.02.14: After 63 years of separation, two widely used mouse strains have developed a few important differences, explains Jacqui White

24 Feb 2014

Genetic screening: the voices that need to be heard

24.02.14: If implemented, opportunistic genomic screening could transform genetic practice. Anna Middleton explains the Association of Genetic Nurses and Counsellors’ ...

24 Feb 2014

Protein essential to the spread of malaria uncovered

21 Feb 2014

Out of Africa the evolution of Plasmodium vivax

21 Feb 2014

Sequencing improves rates of prenatal diagnosis

21.02.14: Exome sequencing could be the answer to tracking down small genetic changes that cause fetal abnormalities, says Keren Carss

20 Feb 2014

Harmless bacterium could be source of antibiotic resistance

19 Feb 2014

Massive DNA sequencing reveals disease-causing mutations

19.02.14: The terabytes of genetic data collected by the UK10K project is a valuable resource that will be used by ...

6 Feb 2014

Hunting for mutations in cancers

06.02.14: Shearwater, a new method of finding the various mutations that can develop within cancers, is inspired by the hunting ...

5 Feb 2014

Finding what's important in our genome

4 Feb 2014

Is social media the future of social science research?

04.02.14: Anna Middleton was dubious about recruiting research participants through Facebook and Twitter but her first experience of social media ...

30 Jan 2014

Know your enemy

20.01.14: Some types of Salmonella evolve to perfect their attack, others simply exploit human weakness. To defeat them, you have ...

28 Jan 2014

All creatures great and small

28.01.14: Whole-genome amplification allows researchers to sequence even microscopic creatures. However, as Tom Huckvale explains, it’s important to be ...

24 Jan 2014

Understanding the origins of cancer

24.01.14: What makes that first cell mutate, leading to a life-threatening tumour? Ludmil Alexandrov explains how large-scale studies are helping ...

23 Jan 2014

11,000-year-old living dog cancer reveals its secrets

22 Jan 2014

Should we really be scared of bats?

22.01.14: Kate Baker and Alison Peel explain how sequencing can help us to gauge the risk bats really pose to ...

20 Jan 2014

How does adipose tissue cope with excess fat?

20.01.14: Some people can store excess fat while avoiding adverse metabolic effects – understanding how could help researchers in the fight ...

12 Jan 2014

Immune system development linked to leukaemia

10 Jan 2014

A genomic revolution in malaria research

10.01.14: Increasingly, sequencing is playing a vital role in the race to detect and contain drug-resistant strains, says Olivo Miotto

9 Jan 2014

Why is type 2 diabetes an increasing problem?

8 Jan 2014

Keeping our little friends happy

08.01.14: Intestinal microbiota can play a crucial role in keeping us healthy but first we need to look after them, ...

6 Jan 2014

Sanger Institute scientist makes Forbes' Top 30 under 30

3 Jan 2014

Throwing a spanner in the works

03.01.14: Causing genes to malfunction can help us to understand liver cancer’s complex genetic networks, explains Alistair Rust.

23 Dec 2013

Library that can determine resistance

21 Dec 2013

Genetics that protects your heart

20 Dec 2013

Review of our blogs – 2013

20.12.13: Over the past year, Wellcome Trust Sanger Institute researchers have shared their passion and enthusiasm for their work to ...

17 Dec 2013

How should we use clinical genomic data?

17.12.14: The Government's plan to sequence 100,000 people raises concerns about how genomic data is used in a ...

13 Dec 2013

Lost in translation

13.12.13: Mice are thought to share around 95 per cent of genes with humans. Despite this conservation and many successful ...

10 Dec 2013

New test for chronic blood cancers

9 Dec 2013

Getting to the heart of coronary artery disease

09.12.13: When searching for the genetic causes of heart disease, Deepti Gurdasani explains, it’s important to distinguish between the ...

8 Dec 2013

Gene promotes one in a hundred of tumours

5 Dec 2013

Finding functions for DUF proteins

05.12.13: A group of scientists is working to characterise some of the millions of proteins designated ‘Domain of Unknown Function’...

3 Dec 2013

How malaria parasites choose between us and our evolutionary cousins

03.12.13: Madushi Wanaguru talks about the challenges of studying the host-specificity of great ape malaria parasites, and the approach used ...

2 Dec 2013

What makes the deadliest form of malaria specific to people?

28 Nov 2013

The rare diseases of mice and men

28.11.13: The daunting task of searching a genome to find the variation responsible for producing a genetic disease from among ...

25 Nov 2013

Understanding the known unknowns of human gene annotation

25.11.13: Annotating the human genome is not a short-term endeavour and, currently, it’s difficult even to know how much ...

21 Nov 2013

Anti-fungal drug increases flu susceptibility

20 Nov 2013

Fred Sanger, 1918-2013

19 Nov 2013

A multi-pronged attack on malaria parasites

19.11.13: Targeting multiple life stages of the malaria parasite could help in the development of reliable vaccines, explains Madushi Wanaguru

14 Nov 2013

Exploring the other 98 per cent of the genome

14.11.13: The majority of the genome has long been seen as ‘non-coding’. Vincenza Colonna explains how large data sets ...

8 Nov 2013

Methylation linked to metabolic disease

31 Oct 2013

Scratching the surface in malaria vaccine development

31.10.13: Extracellular regions of parasites are being targeted for vaccine development. Cecile Crosnier explains how they could lead researchers to ...

30 Oct 2013

Stem cells could set up future transplant therapies

29 Oct 2013

New building set to drive translational medicine

28 Oct 2013

The enemy of my enemy is my friend

28.10.13: Some viruses are able to kill bacteria, making them helpful for scientists tackling cholera. Ana Toribio explains how a ...

27 Oct 2013

Novel mutations define two types of bone tumour

24 Oct 2013

Cutting-edge new build for Genome Campus

24 Oct 2013

Genetic variants decrease rate of metabolism

21 Oct 2013

Fighting fat with fat

21.10.13: Brown fat could offer a solution to the obesity epidemic. Stefania Carobbio explains how stem cells are helping to ...

15 Oct 2013

Sex in Science launches web presence on Ada Lovelace Day

10 Oct 2013

Big data getting to the heart of disease

10 Oct 2013

Disrupting genes and sequencing machines

10.10.13: The Sequencing Research and Development team have their work cut out making TraDIS work on Illumina’s next-generation sequencing ...

10 Oct 2013

When does a cell decide which direction to take?

8 Oct 2013

Target practice with malaria parasites

08.10.13: New Methods are being used to speed the process of identifying genes in malaria strains such as Plasmodium falciparum ...

3 Oct 2013

New technique identifies novel class of cancer's drivers

1 Oct 2013

New study paves the way for single-cell genomics

01.10.13: Statistical method overcomes computational challenges at molecular biology’s new frontier

24 Sep 2013

Identifying the random mutations that make us truly unique

24.09.13: Searching for mutations that originate in sperm and egg cells is a tricky business. Art Wuster explains why and ...

20 Sep 2013

MERS Co-V genomes reveal complex transmission patterns

18 Sep 2013

£25m to kick start industrial revolution in regenerative medicine

12 Sep 2013

The contribution of local animal populations to human drug resistant Salmonella infections may previously have been overstated

29 Aug 2013

Developing a method to tease pathogen genomes apart

29.08.13: There has been an explosion in genomic data, jumping genes may offer a way for researchers to keep up

28 Aug 2013

Parasitic worm genome uncovers potential drug targets

14 Aug 2013

Cancer's origins revealed

13 Aug 2013

Finding pearls in swine: how a worldwide community annotated the pig genome

13.08.13: Pigs' immune systems are similar to ours, making them a great model to understand human health and disease. But ...

9 Aug 2013

Protein that accelerates age, brakes cancer

8 Aug 2013

Zebrafish helping fight against muscle disorders

08.08.13: Muscular dystrophy is a group of muscle wasting disorders that affects more than 70,000 children and adults in ...

4 Aug 2013

Distinct brain disorders biologically linked

29 Jul 2013

Malaria’s Flaws of attraction

29.07.13: Finding malaria vaccine targets means looking for parasite proteins that bind to red blood cells. Discovering these weak and ...

22 Jul 2013

Institute scientist to give prestigious Royal Society lecture

22 Jul 2013

Why is it hard to detect disease association in African populations?

22.07.13: Over 600,000 people die from malaria each year, mainly children under the age of five in Africa. Katja ...

18 Jul 2013

How mice teach us about disease

11 Jul 2013

Unique route to stem cells

8 Jul 2013

New opportunities to treat bowel cancer

4 Jul 2013

Going Beyond the Genome at the Royal Society

04.07.13: The ‘Beyond the Genome’ exhibit got people to question what they wanted to know about their DNA; could you ...

1 Jul 2013

Talking DNA and disease at the Royal Society

27 Jun 2013

Relentless killer captured by art

23 Jun 2013

Getting to grips with migraine

19 Jun 2013

Sequencing the MERS coronavirus outbreak in Saudi Arabia

16 Jun 2013

Cartilage gene linked to bone cancers

14 Jun 2013

Professor Mike Stratton Knighted in the Birthday Honours list

10 Jun 2013

Cracking the secrets of the turtle’s shell

10.06.13: How researchers cracked the secrets of the turtle’s shell and answered some of evolution’s most intriguing puzzles

5 Jun 2013

Alliance will build data-sharing future

4 Jun 2013

Picking cancer apart, one cell at a time

03.06.13: We can learn much about how cancer develops by studying the genomes of individual cancer cells, explains Peter Van ...

29 May 2013

Malaria's severity reset by mosquito

21 May 2013

Discovering how we evolved – Evolving genes lead to more evolving genes

21.05.13: Qasim Ayub explains how a new technique he helped to develop is finding signatures of selection in human genomes ...

17 May 2013

Cocktail parties and cancer genomes: Separating out the mutational processes behind cancer development

17.05.13: Cancer genomes contain an archaeological record of the genetic events that have led to their formation. Ludmil Alexandrov talks ...

15 May 2013

Tackling the looming epidemic of non-infectious diseases in sub-Saharan Africa

14.05.13: Non-communicable diseases (NCDs) such as obesity, heart disease and cancer are a substantial and rapidly growing problem in sub-Saharan ...

5 May 2013

Vaccine reduces pneumococcal disease but not bacterial population

1 May 2013

New frontiers for Chlamydia sequencing

1 May 2013: Using attractive magnetic beads to capture Chlamydia from clinical samples is a rapid and effective way to ...

28 Apr 2013

Fingerprinting malaria parasite drug resistance

25 Apr 2013

A brief history since 1953: 60 years after Crick and Watson’s discovery

25 April 2013: In a break from our traditional blog style, we celebrate the 60th anniversary of Crick and Watson’...

25 Apr 2013

Two cultures: Artists and scientists inspire each other

23 Apr 2013

Does science need to be entertaining for mass-market entertainments?

23 April 2013: ‘How much ‘creative licence’ should scientists allow creatives?’ asks Darren Logan, a Faculty member of the Sanger ...

23 Apr 2013

Science and games - inspiring one another

21 Apr 2013

Genetics defines a distinct liver disease

18 Apr 2013

Evolving genes lead to evolving genes

17 Apr 2013

Coelacanth genome surfaces

17 Apr 2013

Family ties: Relationship between human and zebrafish genomes

17 Apr 2013

Fishing for solutions

16 Apr 2013

Biology behind blood trait signals

16 Apr 2013

Wanted: your views on genetics

12 Apr 2013

Sanger Institute - EBI single cell genomics centre

7 Apr 2013

Final chapter to 60 year old blood group mystery

7 Apr 2013

Finding genes for childhood obesity

4 Apr 2013

Unravelling the spread of a cystic fibrosis pathogen

4 April 2013: Mycobacterium abscessus infection is on the rise in CF patients. Josie Bryant talks about her research tracking ...

29 Mar 2013

Rise in CF patient infections explained

27 Mar 2013

Is arthritis due to DNA’s dark matter?

27 March 2013: Steven Witte explains how his fascination with the cause of autoimmune diseases such as arthritis has brought ...

13 Mar 2013

Tapeworm DNA contains drug weak spots

12 Mar 2013

No more free rides for tapeworms?

13 March 2013: Tapeworm’s leave all the hard work to their hosts. But their laziness could be their undoing. ...

27 Feb 2013

Mouse jumping genes don’t always land where they should

27 Feb 2013: piggyBac is a jumping gene that normally leaps from TTAA sequence to TTAA sequence. But, sometimes, it ...

17 Feb 2013

Dental decay: the evolution of oral diversity

15 Feb 2013

Resisting malaria

15 Feb 2013: Susana Campino explains how her lab works in partnerships to uncover the genes that make people resistant ...

13 Feb 2013

Cause of selective male deafness discovered

13 Feb 2013: For one family at least, selective male deafness is true. A team at the Sanger Institute has ...

4 Feb 2013

Chlamydia: Silent, Treacherous, Invisible?

04 Feb 2013: Bacteria that cause the sexual diseases Chlamydia and Gonorrhoea can swap DNA between their peers and hide ...

30 Jan 2013

Fighting against the flu

29 Jan 2013

How our computers crack flu’s evolution

29 Jan 2013: Using genome sequences and computer analysis, we are able to understand the rapid evolution of the influenza ...

25 Jan 2013

Why Malaria’s Magnus is celebrated by Wales’ Wikipedia Day

25 Jan 2013: Fellow Wikipedian, Darren Logan, explains why one of our malaria researchers is honoured by Jimmy Wales with ...

22 Jan 2013

Director awarded prestigious prize

14 Jan 2013

Chronic disease research awarded funding

10 Jan 2013

Finding cancer culprits' fingerprints

10 Jan 2013

How do we talk to parasites?

10 Jan 2013: Adam Reid explains how his new approah to understand how genes control host-parasite interactions could be used ...

9 Jan 2013

A recipe for better fry and better fish

9 Jan 2013: A simple addition to Zebrafish food that boosts survival and can reduce numbers of animals in research, ...

7 Jan 2013

One small piece of a genetic puzzle

7 Jan 2013: Jacqui White explains how the Institute work on blood tests has helped to pick out a gene ...

2 Jan 2013

Even great mutations need a little help from their friends

21 Dec 2012

A key to a promising malaria vaccine

21 Dec 2012: A search for key interactions between the malaria parasite and human red blood cells has thrown up ...

20 Dec 2012

Getting to the guts of IBD

20 Dec 2012: Alan Walker discusses his recent work demonstrating the mechanism by which the transcription factor, T-bet, regulates immue ...

13 Dec 2012

Getting to the root of transposable elements in mice

13 Dec 2012; Thomas Keane talks about his recent study developing a near complete catalogue of transposable element variation across ...

11 Dec 2012

No need to prepare

10 Dec 2012

Single gene defect wipes out immunity

9 Dec 2012

Bugs without borders

6 Dec 2012

Nobody's perfect

6 Dec 2012

Resetting genetic instructions

5 Dec 2012

A leap forward for red blood cell formation

2 Dec 2012

Insights into the genetic causes of coronary artery disease and heart attacks

30 Nov 2012

Making messengers work hard for their money

30 Nov 2012: Selected segments of genes used in distinct tissues can play an important role in tissue integrity, in ...

29 Nov 2012

Biology behind brain development disorder

23 Nov 2012

One for all, all for one

23 Nov 2012: Astrid Gall talks about her research into HIV and her recent study into designing the first universal ...

19 Nov 2012

The pig genome

16 Nov 2012

Transforming Tuberculosis control

14 Nov 2012

Bacterial DNA sequence used to map an infection outbreak

6 Nov 2012

New national stem cell resource

2 Nov 2012

How did humankind conquer the globe?

02 Nov 2012: Wei Wei discusses her interest into variation within the Y chromosome and her recent study on the ...

31 Oct 2012

Gut reaction: The evolution of IBD

31 Oct 2012

The fruit of 1000 genomes

29 Oct 2012

The biggest expansion of man in prehistory?

25 Oct 2012

C'est difficile

11 Oct 2012

Alex Bateman takes on protein sequence services at the European Bioinformatics Institute

8 Oct 2012

Award puts Africa diabetes under the microscope

4 Oct 2012

Babies learn the smell of mum

4 Oct 2012

Genetic Analysis of Eating Disorder Related Symptoms, Behaviours and Personality Traits

04 Oct 2012: Vesna Boraska talks about her recent study, identifying possible genetics variants associated with eating disorder related symptoms, ...

30 Sep 2012

Novel pathogen epidemic identified in sub-Saharan Africa

25 Sep 2012

A Cornucopia of Candidates for Deafness

25 Sept 2012: Morag Lewis talks about a review she has had published in Cell. The study looked at genes ...

21 Sep 2012

Chipping away at the genetics of PBC

21 Sept 2012: Jimmy Liu disscusses his recent research discovering and refining genetic regions linked to susceptibility for primary biliary ...

21 Sep 2012

Royal Society recognises Institute International Researcher

19 Sep 2012

Sanger paper is 2011 best of Journal of Biological Chemistry

19 Sept 2012: A team from the Wellcome Trust Sanger Institute have identified a seventh, unusual proteolytic enzyme in an ...

14 Sep 2012

Is it as plain as the nose on one’s face?

13 Sept 2012: Have you ever considered whether we all sense the world the same way? Darren Logan at the ...

12 Sep 2012

Walking a thousand miles starts with one step

11 Sept 2012: The Malaria Programme at the Wellcome Trust Sanger Institute is carrying out research addressing questions about the ...

9 Sep 2012

Genetic clues to the causes of primary biliary cirrhosis

7 Sep 2012

Muscle cells’ social etiquette: are they aloof, friendly or just good talkers?

7 Sept 2012: In the embryo, muscle cells grow and knit together to eventually make up the size and shape ...

5 Sep 2012

Google Earth of Biomedical Research

5 Sep 2012

Human genome far more active than thought

3 Sep 2012

Handle with care: animal husbandry’s virtuous circle

3 Sept 2012: Jacqui White, from the Institute's Mouse Genetics team, describes how our researchers are committed to treating ...

2 Sep 2012

Near and far, nature and nurture

29 Aug 2012

Genetic clues to ‘Hair today, gone tomorrow’ found

29 Aug 2012: Stavroula Kanoni, a researcher in Human Genetics, describes the hunt for genes associated with male pattern baldness

17 Aug 2012

Seq and ye shall find...

25 Jul 2012: Malaria researcher, Lia Chappell, spreads the word on how choosing the right approach can make your experiments ...

13 Aug 2012

Knowing zebrafish, knowing you – understanding zebrafish genomes, unlocking human health

30 Jul 2012: Understanding how the zebrafish genome works allows us to understand human health and disease

12 Aug 2012

Metabolic MAGIC

5 Aug 2012

Out of Europe

2 Aug 2012

Close to the bone

19 Jul 2012

Sanger Institute discussed the value of EU funding with local MEP Vicky Ford

19 Jul 2012: Institute researchers and administrators met with Vicky Ford MEP to influence the shape of future EU funding ...

18 Jul 2012

Colin’s Colony Collecting “Colinator” minimises mindless monotony

A new robot created at the Wellcome Trust Sanger Institute will spare the hands, eyes and minds of researchers from ...

10 Jul 2012

Royal Society recognises Institute researcher

3 Jul 2012

New genetic culprits found in world-leading study of osteoarthritis

26 Jun 2012

Sanger Institute Scientist receives the Eppendorf Award for Young European Investigators

Dr Elizabeth Murchison has been given the award for her ongoing research into the deadly transmissible facial cancer that is ...

25 Jun 2012

Cause of rare growth disease discovered

21 Jun 2012

Exploring Salmonella’s deadly sub-Saharan adaptation

A distinct strain of Salmonella Typhimurium, has emerged as a new pathogenic group in sub-Saharan Africa, and might have adapted ...

21 Jun 2012

Four Institute researchers have made it to Reuters most influential list

Four of the Wellcome Trust Sanger Institute researchers been cited by Thomson Reuters as being among the top 15 most ...

21 Jun 2012

Gene responsible for diarrhoeal disease transmission identified

Researchers identify a key gene that allows C. difficile – a diarrhoea-causing bacterium found in hospitals and across the developing world – ...

21 Jun 2012

Genomics and African Queens

19 Jun 2012

Creating a gold-standard, not a rotten, tomato genome

We shared our experiences and knowledge from producing animal reference genomes to enable plant genomes researchers to deliver high-quality, standardised ...

18 Jun 2012

Fourth Institute bioinformatician wins open access award

A fourth Wellcome Trust Sanger Institute alumnus – Heng Li – has won the Benjamin Franklin Award for Open Access in the ...

13 Jun 2012

New build for bioinformatics

13 Jun 2012

Putting parasites on the world map

13 Jun 2012

Tracking MRSA in real time

11 Jun 2012

Moving towards mitigating migraines

8 Jun 2012

Why resist insulin?

17 May 2012

Deciphering the life history of 21 breast cancers

17 May 2012

Mutational processes behind breast cancer

17 May 2012

Untangling the development of breast cancer

16 May 2012

Understanding breast cancer

11 May 2012

Institute researcher is sequence-squeezing champ

29 Apr 2012

Gene against pancreatic cancer discovered

23 Apr 2012

Rare muscular dystrophy gene mutations discovered

20 Apr 2012

Sanger Institute scientist elected Fellow of the Royal Society

19 Apr 2012

Key genes that switch off with ageing identified

28 Mar 2012

The path to personalised cancer treatment

25 Mar 2012

Genetics of flu susceptibility

22 Mar 2012

Subtle differences can lead to major changes in parasites

12 Mar 2012

Institute researcher awarded Brain Prize

11 Mar 2012

Tracing the UK's No1 sexually transmitted infection

8 Mar 2012

Sanger's shining stars

7 Mar 2012

What have we got in common with a Gorilla?

28 Feb 2012

Improvements for animal research

26 Feb 2012

Elusive platelet count and limb development gene discovered

19 Feb 2012

Director discusses cancer evolution at prestigious conference

16 Feb 2012

Preventing the devil's downfall

16 Feb 2012

When is a gene not a gene?

7 Feb 2012

Sanger researcher awarded the ISTT Prize

2 Feb 2012

Paths to Cardiovascular Diseases and Type 2 Diabetes

31 Jan 2012

What are your views on what happens to your genomic information?

25 Jan 2012

Genetic screens bring new hope for tackling sleeping sickness

12 Jan 2012

New light on human evolution

16 Dec 2011

International Consortium for future pandemics

13 Dec 2011

The mystery behind the building of muscle

12 Dec 2011

European Research Council Award to Institute Researcher

2 Dec 2011

Celebrating the Wellcome Trust's 75th Anniversary

30 Nov 2011

From gene to function

9 Nov 2011

Malaria's Achilles' heel revealed?

6 Nov 2011

Researchers discover genes involved in colorectal cancer

27 Oct 2011

Different paths to drug resistance in Leishmania

26 Oct 2011

Genetic cause for hearing impairment discovered

20 Oct 2011

Sanger Institute researcher honoured by EMBO

12 Oct 2011

Clean correction of a patient's genetic mutation

12 Oct 2011

Data centre shutdown for green power source upgrade

10 Oct 2011

Seeking superior stem cells

7 Oct 2011

Scientists identify cause of severe hypoglycaemia

3 Oct 2011

Cutting to the heart of swine genomics

29 Sep 2011

Genetic library will speed up disease research

27 Sep 2011

Researchers uncover gene associated with blood cancers

14 Sep 2011

Researchers develop mouse genetic blueprint

31 Aug 2011

New biochemical discoveries into developing disease

25 Aug 2011

Third genetic link to osteoarthritis discovered

24 Aug 2011

Cholera pandemic's source discovered

22 Aug 2011

Real-time genomics applied to fatal outbreak

16 Aug 2011

Molecular relay race drives cell cycle

15 Aug 2011

Unique immune system in Atlantic cod

8 Aug 2011

New resource to unlock the role of microRNAs

25 Jul 2011

Elusive gene discovered that makes platelets grey

18 Jul 2011

Dr Richard Durbin awarded Fellowship by the International Society for Computational Biology

15 Jul 2011

Institute researcher awarded Cancer Research UK Fellowship

13 Jul 2011

New elegant technique used for genomic archaeology

11 Jul 2011

ICGC releases new genomic data on cancer ahead of schedule

1 Jul 2011

New approach to link genome-wide association signals to biological function

15 Jun 2011

A knockout resource for mouse genetics

14 Jun 2011

Many migraines may have a common genetic basis

12 Jun 2011

We are all mutants

8 Jun 2011

Bone cancer, from lab to clinic

3 Jun 2011

New strain of MRSA discovered

19 May 2011

'Master switch' gene for obesity and diabetes discovered

27 Apr 2011

Zebrafish provide insight into congenital muscular dystrophies

21 Apr 2011

A User's Guide to the Encyclopaedia of DNA Elements

27 Mar 2011

The gene processes that drive acute myeloid leukaemia

24 Mar 2011

Professor Seth Grant honoured by election to the Fellowship of the Royal Society of Edinburgh

22 Mar 2011

Deciphering Developmental Disorders

13 Mar 2011

Consortium finds chronic liver cirrhosis clues

10 Mar 2011

Diabetes drug boosts survival rate for melioidosis patients

8 Mar 2011

Towards a novel non-invasive prenatal diagnostic test for Down syndrome

6 Mar 2011

Research doubles number of known genetic markers for coronary heart disease

6 Feb 2011

Research links 29 genome regions with common form of inflammatory bowel disease

2 Feb 2011

Study doubles number of known human structural variants

27 Jan 2011

Staying one strep ahead

26 Jan 2011

Filaments, fibres and muscles in transparent embryos

19 Jan 2011

Research provides new kidney cancer clues

6 Jan 2011

Punctuated evolution in cancer genomes

20 Dec 2010

Chronic Fatigue Syndrome is not caused by XMRV

19 Dec 2010

The genetic basis of brain diseases

26 Nov 2010

Genetic markers for blood clot found

21 Nov 2010

39 new genetic associations with Crohn's disease

17 Nov 2010

Sanger Institute researcher among first to receive Rutherford Discovery Fellowship

7 Nov 2010

Sanger researcher awarded Cancer Research UK prize

27 Oct 2010

1000 Genomes Project publishes analysis of completed pilot phase

27 Oct 2010

Forces for cancer spread: genomic instability and evolutionary selection

19 Oct 2010

When one is not enough: finding hyper-sensitive genes

14 Oct 2010

PiggyBac joins armoury in fight against cancer

10 Oct 2010

Apple-shaped or pear-shaped, it's partly down to your genes

29 Sep 2010

Is explaining variation in height a tall order?

22 Sep 2010

Researchers suggest human malignant malaria originated in gorillas

16 Sep 2010

Completed genome is first step to tackling Tasmanian devil facial tumours

9 Sep 2010

New insights into type 1 diabetes risk

1 Sep 2010

Finding variants in the human genome

29 Aug 2010

First genetic link to common migraine exposed

25 Aug 2010

The Leena Peltonen School of Human Genomics

4 Aug 2010

Uncovering the heart of genetic influence on cholesterol and triglyceride levels in the blood

15 Jul 2010

Largest study of genomes and cancer treatments releases first results

12 Jul 2010

Kymab and Wellcome Trust sign £20 million financing agreement

28 Jun 2010

Decoding diabetes

24 Jun 2010

Celebrating a 'decade of discovery' since the Human Genome Project

24 Jun 2010

Wellcome Trust launches study of 10,000 human genomes in UK

21 Jun 2010

1000 Genomes Project releases data from pilot projects on path to providing database for 2,500 human genomes

10 Jun 2010

Making cancer killers

17 May 2010

Professor Mike Stratton appointed new Director

21 Apr 2010

Institute researcher wins Benjamin Franklin award

14 Apr 2010

Cataloguing cancer codes

13 Apr 2010

Sequence is scaffold to study sleeping sickness

12 Apr 2010

Bacterial evolution then and there and here and now

8 Apr 2010

CNVs close up

1 Apr 2010

Proteins at the heart of life

1 Apr 2010

Who speaks to whom in stem cell biology?

31 Mar 2010

CNVs and common disease

31 Mar 2010

From alpaca to zebra finch

31 Mar 2010

Movies for the human genome

31 Mar 2010

Sanger institute papers in Nature

29 Mar 2010

Allan Bradley leads translation opportunity

18 Mar 2010

Sanger Institute Scientist Awarded Cancer Research Prize

11 Mar 2010

Professor Leena Peltonen-Palotie: 1952-2010

10 Mar 2010

Exploring genetic effects in cells

17 Feb 2010

Sorting the drivers from the passengers in the cancer genome

26 Jan 2010

Gentlemen or farmers?

21 Jan 2010

Tracking MRSA evolution and transmission

17 Jan 2010

From biological basics to diabetes discovery

6 Jan 2010

Unravelling kidney cancer

23 Dec 2009

Broken genomes behind breast cancers

22 Dec 2009

Sanger Institute first for impact

16 Dec 2009

Lung Cancer and melanoma laid bare

16 Dec 2009

One mutation every day

16 Dec 2009

Signatures of sunlight

7 Dec 2009

Scientists reveal malaria parasites' tactics for outwitting our immune systems

6 Dec 2009

Genetic studies reveal new causes of severe obesity in childhood

2 Dec 2009

Ten years of 22

30 Nov 2009

Biology of emergent Salmonella exposed

3 Nov 2009

Senior Sanger Institute researcher honoured

2 Nov 2009

First draft of the pig genome

21 Oct 2009

Sanger Institute duo among 66 honoured

16 Oct 2009

TraDIS technique tackles typhoid

11 Oct 2009

Blood counts are clues to human disease

8 Oct 2009

Standards for a new genomic age

7 Oct 2009

Jumping genes, gene loss and genome dark matter

25 Sep 2009

Candida can do less

11 Sep 2009

Sparking debate on data and resource sharing

1 Sep 2009

Senior Sanger Institute Investigator awarded Carter medal

27 Aug 2009

We are all mutants

30 Jul 2009

Genetic variations produce different effects, depending on the tissue

21 Jul 2009

Cdiff spores spread superbug

15 Jul 2009

Complete fluke? Genome sequencers crack parasite genome

10 Jul 2009

Prestigious award for Sanger Institute researcher

8 Jul 2009

Visit by His Royal Highness The Duke of York

14 Jun 2009

Knockout results for mouse genetics

4 Jun 2009

Scientists identify gene for deadly inherited lung disease

31 May 2009

First testicular cancer risk genes found

24 May 2009

Genetic study of malaria

21 May 2009

Chlamydia that avoids diagnosis

20 May 2009

UnMASCing diseases of the brain

15 May 2009

Karen Steel elected Fellow of the Royal Society

13 May 2009

Prestigious awards in microbiology

1 May 2009

Switches, circuits, brain and disease

19 Apr 2009

The genetic X-factor

16 Apr 2009

DECIPHERing human disease

12 Apr 2009

New insights into hearing loss

8 Apr 2009

Adding factors

3 Apr 2009

The lowdown on height genes

29 Mar 2009

Getting down to basics

27 Mar 2009

UK scientific breakthrough to help animals worldwide

19 Mar 2009

Genome-wide association scan reveals the landscape of inherited variability in response to warfarin dose

18 Mar 2009

G2C Online launches

23 Feb 2009

Could Genetics Improve Warfarin Dosing?

11 Feb 2009

Simple yeast leads to understanding ourselves

9 Feb 2009

The genetics of heart disease

5 Feb 2009

The nonsense in our genes

18 Jan 2009

The worst luck in the world?

23 Dec 2008

A new search for cancer treatments

17 Dec 2008

Genetic messages in Wikipedia

16 Dec 2008

£3m funding to decode genomes of 17 mouse strains

14 Dec 2008

Brain Background to Body Mass

7 Dec 2008

Discovery of new gene associated with diabetes risk suggests link with body clock

7 Dec 2008

Genes for nine health indicators

7 Dec 2008

The Genetic Heart of the Lipids

27 Nov 2008

What drives cancer?

24 Nov 2008

Next-generation technology provides human genome sequence

18 Nov 2008

The International Cancer Genome Consortium announces the launch of eight Cancer Genome Projects

6 Nov 2008

DNA chunks, chimps and humans

31 Oct 2008

Oblivious Oblivion

30 Oct 2008

The Alphabet, Tyrian Purple...And Genes

8 Oct 2008

Genome of a monkey human-malaria parasite

17 Sep 2008

Maps of Structural Variation released for Cancer Cell Lines

11 Sep 2008

Making the Most of Genetic Data

27 Jul 2008

Defining DNA Differences to Track and Tackle Typhoid

16 Jul 2008

Sanger Institute to help boost infection research

2 Jul 2008

Fifteen human genomes each week

11 Jun 2008

Three Sequencing Companies Join 1000 Genomes Project

8 Jun 2008

Origins of the brain

16 May 2008

Mike Stratton, co-Head of Cancer Genome Project at the Wellcome Trust Sanger Institute, Elected to the Royal Society

15 May 2008

Connecting Cancer Genes

11 May 2008

Mutant gene causes epilepsy, intellectual disability in women

7 May 2008

Emerging superbug genome sequenced

4 May 2008

Second Genetic Link to Weight and Obesity

1 May 2008

Genome Campus has Top Two in the UK

29 Apr 2008

Global Genetics Consortium Sets Sights On Cancer

29 Apr 2008

Seeing the enemy up close

14 Apr 2008

Largest ever study of genetics of common disease just got bigger

27 Mar 2008

Crusader Y chromosomes in Lebanon

22 Feb 2008

Novel method to reveal drug targets

8 Feb 2008

Scientists reveal a new target to fight bad cholesterol

22 Jan 2008

International Consortium Announces the 1000 Genomes Project

14 Jan 2008

Taking Sequencing Forward

7 Jan 2008

Changing patterns of infection

6 Dec 2007

Thirty years on: one human genome a day

2 Dec 2007

Mutant sperm guide clinicians to new diseases

29 Nov 2007

Inside DNA

24 Oct 2007

Largest-ever Alzheimer's gene study underway

21 Oct 2007

Major genetic breakthrough for ankylosing spondylitis brings treatment hope

17 Oct 2007

Consortium Publishes Phase II Map of Human Genetic Variation

12 Oct 2007

Cambridge scientists in world's first major genome screen for osteoarthritis

9 Oct 2007

Researchers Expand Efforts to Explore Functional Landscape of the Human Genome

16 Sep 2007

Genes and disease? It's what you do with what you have

22 Aug 2007

Leader in Human Genetics to join Wellcome Trust Sanger Institute

6 Jul 2007

Canadian, British and American scientists launch major new genome partnership to catalogue all common copy number variations

17 Jun 2007

Potent possibilities for parasite attack

13 Jun 2007

The Wider View from a Detailed Focus

6 Jun 2007

Largest ever study of genetics of common diseases

23 May 2007

Botulism bug has few genome wrinkles

26 Apr 2007

Minuscule molecules pack a powerful punch

8 Mar 2007

Molecular mechanism of learning

7 Mar 2007

Drivers and Passengers on the Road to Cancer

8 Feb 2007

Which Genome Variants Matter?

11 Jan 2007

Stealth technology maintains fitness after sex

22 Dec 2006

A Hot ACT

10 Dec 2006

The Weapons in Malaria's Evolutionary Arms Race

24 Nov 2006

ABC of a Health Problem: Antibiotics, Bacteria and Carriers

22 Nov 2006

Missing pages from the "Book of Life"

3 Nov 2006

Prime Minister praises 'outstanding contribution'

29 Oct 2006

Towards a Global Map of Epigenetic Variation

4 Oct 2006

Sanger Institute Research Strategy

24 Sep 2006

Molecular Tags to catch Common Killers

7 Sep 2006

Wellcome Trust Sanger Institute receives award from US National Institutes of Health

21 Jul 2006

Hub genes

20 Jul 2006

Giving worms a taste of their own medicine

25 Jun 2006

Looking for weaknesses in difficult difficile

2 Jun 2006

Nodules, nitrogen and nature

1 Jun 2006

International collaboration to boost genome research in developing countries

17 May 2006

Genome doesn't start with 'G'

15 May 2006

Uncovering Gene Functions With A New Vertebrate Model

21 Apr 2006

Mammoths Maketh Man

21 Mar 2006

TraceSearch - Seeking among sequences

10 Mar 2006

Outsmarting the Smartie Bug

9 Mar 2006

When Less is More

24 Feb 2006

Antibiotic Resistance Advance in Asia

27 Jan 2006

Identity Swap

18 Jan 2006

UnMASCing Machines in the Brain

17 Jan 2006

Around the World in 800 Billion Bases

16 Jan 2006

International Partnership to Sequence the Pig Genome

25 Dec 2005

Sifting through the Genome Baggage

21 Dec 2005

Tackling the Basis (and Bases) of Disease

21 Dec 2005

Ubiquitous, Essential ... but Deadly

16 Dec 2005

Using Maps to Find Managers

26 Oct 2005

International Consortium Completes Map Of Human Genetic Variation

14 Oct 2005

Wellcome Trust Genome Campus Extension Opened

14 Oct 2005

Wellcome Trust Sanger Institute has major role in EU initiative to understand the genetic make-up of human diseases

28 Sep 2005

Researchers set to find 'genetic signposts' for eight diseases

11 Aug 2005

A giant among viruses could delay ageing and the effects of terminal diseases

14 Jul 2005

Triple Disease Sequencing

30 Jun 2005

Cattle Parasite Code Cracked

5 May 2005

The Constitution of a New Model Army

4 May 2005

The cryptic past of Madagascar

3 May 2005

New insights into Chlamydial Infection

4 Apr 2005

Deletion, Duplication and Detail

16 Mar 2005

What Sex did to the X - and Why

3 Mar 2005

Genome centres combine forces to validate a gene set for biomedical research

23 Feb 2005

DNA of the tissue destroyer

3 Feb 2005

COSMIC First Anniversary

13 Dec 2004

International HapMap Consortium Releases All Data to the Public

23 Nov 2004

Genomic Bookmarks Uncovered

26 Oct 2004

Top Award to Sanger Scientist

20 Oct 2004

The finished human genome

29 Sep 2004

A Switch for Lung Cancer

14 Sep 2004

Getting a Grip on the Great Mimicker

4 Jul 2004

MICER: a resource to help understand disease

24 Jun 2004

Superbug's Pick'n'Mix DNA

28 May 2004

Richard Durbin, Deputy Director of the Wellcome Trust Sanger Institute, Elected to the Royal Society

27 May 2004

One-tenth of our genome in one day: from sequence to disease to evolution

1 Apr 2004

Number 13 - unlucky for genes?

4 Feb 2004

COSMIC assault on cancer

18 Dec 2003

Mapping A Road To Understanding Human Health

3 Nov 2003

Sanger's Celestial Spiral Staircase

23 Oct 2003

Largest bite at the human genome

15 Oct 2003

New Wellcome Trust Campus Build 'Tops Out'

7 Oct 2003

Epigenomics And The Wellcome Trust Sanger Institute Launch Human Epigenome Project To Follow EU-Pilot Study

14 Apr 2003

The Finished Human Genome - Wellcome To The Genomic Age

21 Feb 2003

Undercover Infective - Cracking the Code of a Quiet Killer

5 Dec 2002

The Measure Of Man

7 Nov 2002

Plans to extend leading Genome Campus get go-ahead

7 Oct 2002

Sir John Sulston awarded the 2002 Nobel Prize for Physiology or Medicine

3 Oct 2002

Double Success In Fight Against Malaria

5 Aug 2002

Maps Of Mice - And Men

9 Jun 2002

Scientists Identify Gene Involved In 70 Percent Of Melanomas

13 May 2002

Wellcome Trust Sanger Institute's Director Honoured: Allan Bradley Elected to Royal Society

9 May 2002

Scientists sequence Nature's antibiotic factory

6 May 2002

International Team of Researchers Assembles Draft Sequence of Mouse Genome

16 Apr 2002

Wellcome Trust Proposal To Extend Genome Campus

20 Mar 2002

MHC Haplotype Consortium Web Resource

1 Mar 2002

The complete genome of Mycobacterium bovis has been sequenced

21 Feb 2002

Humble yeast to help tackle cancer

20 Dec 2001

Dermatitis, Diabetes, Dementia:

25 Oct 2001

Typhoid fever bug sequence raises hope of complete eradication

15 Oct 2001

Wellcome Trust Sanger Institute moves to new era

4 Oct 2001

Black Death unveiled

16 May 2001

Top international award for British genome champion

8 May 2001

Of mice and men - First phase of mouse genome sequencing project completed

26 Apr 2001

Wellcome Trust promotes open door policy of human genome treasure chest

21 Feb 2001

Leprosy genome shows massive gene decay

15 Feb 2001

Mouse genome data available in public databases

11 Feb 2001

British science targets nearly half of world's genetic diseases

11 Feb 2001

Comparison of draft human sequence versions from the public and private domain

11 Feb 2001

Human Genome Project Centres

11 Feb 2001

Human Genome Project shows the wonder and the mystery of humankind

11 Feb 2001

Ten facts from the Human Genome Project

8 Jan 2001

Dr John Sulston Knighted in the New Year Honours list

21 Nov 2000

Sanger Centre to sequence zebrafish genome in new Wellcome Trust Initiative

6 Oct 2000

Public-Private Consortium to Accelerate Sequencing of Mouse Genome

20 Jul 2000

Wellcome Trust Announces Major Investment in Genome Bioinformatics

26 Jun 2000

Commentators' Views on the Announcement of the First Draft of the Human Genome

26 Jun 2000

Completion of draft human genome: press pack

26 Jun 2000

Human Genome Project Centres

26 Jun 2000

Human Genome Project Helps Child Birth Defects

26 Jun 2000

Human Genome Project Helps Identify Skin Disease Genes

26 Jun 2000

Human Genome Project may help find treatment for muscular dystrophy

26 Jun 2000

International Human Genome Sequencing Consortium Announces "Working Draft" of Human Genome

26 Jun 2000

Past Great Discoveries

26 Jun 2000

The Future's Genomic

26 Jun 2000

The History of the UK Genome Project

26 Jun 2000

The first draft of the Book of Humankind has been read

17 May 2000

Wellcome Trust Appoints New Sanger Centre Director

8 May 2000

A collaboration between the Sanger Centre and the EBI adds critical annotation to sequence data from the Human Genome Project

8 May 2000

Public Consortium Launches Final Phase of Human Genome Sequencing: 85 percent of Human Genome Sequence Assembled and Available to the Public

3 May 2000

Largest grant to study horse disease

26 Apr 2000

Beowulf announces £3 million of new funding for pathogen sequencing

13 Apr 2000

The complete genome of the leprosy bacillus has been sequenced

29 Mar 2000

Meningitis Bacterium Code Cracked

29 Mar 2000

Two-thirds of Human Genome Given to Researchers Worldwide

14 Mar 2000

Wellcome applauds USA and UK governments' commitment to free sequence data

7 Mar 2000

Genome talks collapse over commercial ownership

10 Feb 2000

Scientists reveal clues to food poisoning bug

6 Jan 2000

New research will tackle causes of disease from the UK to the tropics

1 Dec 1999

Scientists open first chapter of the book of life with decoding of human chromosome

20 Oct 1999

A Revolutionary Project To Identify Cancer Genes

15 May 1999

UK & America accelerate Human Genome Project for year 2000

10 Dec 1998

The first sequence of an animal genome is essentially complete

1 Oct 1998

Genome of typhoid strain to be tackled

13 May 1998

Development study reveals origins of Inflammatory Bowel Disease

International research consortium to tackle tumour drug resistance using single-cell sequencing

Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases

Loss of gene linked to differences in brain size

Researchers discover individual variation in how our bodies develop and acquire mutations

Year

Type

Topic/ focus

Search

Development study reveals origins of Inflammatory Bowel Disease

International research consortium to tackle tumour drug resistance using single-cell sequencing

Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases

Loss of gene linked to differences in brain size

Researchers discover individual variation in how our bodies develop and acquire mutations

Defining Success

Link between amino acid and a range of common diseases could help predict personal risk

Fighting the spread of drug-resistant malaria with genetic surveillance

From Mild to Mortal

Researchers track how microbiome bacteria adapt to humans via transmission

Genetic study reveals ancient human adaptation to agriculture and climate change in Middle East

New therapeutic target discovered for a number of aggressive cancers

The evolutionary history of humans

OKRs: Strategic planning the Google way

A forgotten disease

Reflections on race and equity in research: One year on...

Covid Connections – Variant or Villain

Bacterial Biomes

Water vole genome will help boost conservation of one of UK's most endangered mammals

Cellular signatures of kidney tumours discovered

Getting to the heart of the matter

Study identifies trigger for ‘head-to-tail’ axis development in human embryo

Computer method to help predict outcomes and tailor treatments for patients with inherited heart diseases

Sanger Institute human genetics researcher honoured by EMBO

Winning Cambridgeshire students design card game inspired by the Human Cell Atlas

New genetic variants lead to diagnoses for children with developmental disorders

Genetic study identifies risk for some childhood cancer patients developing secondary leukaemia and will help inform treatment plan

Atlas of malaria parasite gene activity provides new targets for drugs and vaccines

Genomics in a pandemic – Shedding light on the invisible

‘Rescue mutations’ that suppress harmful DNA changes could shed light on origins of genetic disorders

Discovery of vaccine target for devastating livestock disease could change lives of millions in sub-Saharan Africa

Car manufacturing, cellular biology and COVID

Unparallelled insights into how our bodies develop from a single cell

Maturation Block – Redefining Childhood Cancers

Identifying the rise of multi-drug resistant E. coli

Dyslexia and neurodiversity in the workplace

Diversity and Inclusion in Science

Championing Team Science

New genetic target for blood cancer treatment

New era of quality and scale in genome sequencing will drive biological discovery

Major advance enables study of genetic mutations in any tissue

From investment banking to genomics and health

Novel drug type for blood cancer entering clinical trials

Taking lockdown baking to a whole new level

Differing immune reponses discovered in asymptomatic cases versus those with severe COVID-19

Genetic variants identified that impact immune cells' functioning

New genetic drug target for treatment resistant colorectal cancer

‘Patchwork’ tumours prevalent across multiple cancer types

New DERMATLAS project will create world's most comprehensive public resource of rare skin tumour genomes

Genetic link to male infertility identified

Fighting Pathogens with Data and Partnerships

Salivary gland cells revealed as sites of COVID-19 infection

New addition to COSMIC database will collate available drugs to target cancer mutations

CRISPR study identifies gene that plays key role in metastasis of cancers to the lungs

Project to understand beginnings of rare childhood cancer awarded innovation funding

SARS-CoV-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

From Scorpions to Skin Cancer

Genomic surveillance – the world’s binoculars focused on infectious diseases

Placenta is a dumping ground for genetic defects

Full evolutionary journey of hospital superbug mapped for the first time

Students invited to create a card game inspired by the Human Cell Atlas

Virtual event celebrates Equality and Diversity Champions from the Wellcome Genome Campus

Reverse mentoring: Promoting diversity and positive culture change

Genomics study identifies routes of transmission of coronavirus in care homes

New search engine for single cell atlases

Origin of childhood cancer malignant rhabdoid tumour discovered

Sanger Institute researcher wins Pezcoller Foundation EACR Rising Star Award

Open data on malaria genomes will help combat drug resistance

Gene that helps control egg’s journey sheds light on why ectopic pregnancy may occur

Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first

Scientists identify over 140,000 virus species in the human gut, half of which are new to science