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  • Three Sanger scientists recieve prestigious fellowships for their work

    Congratulations to Professor Nicholas Thomson and Dr John Marioni who have been recognised by the Academy of Medical Sciences, and Professor ...

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  • Immune cell characteristics mapped across multiple tissues, from early life to adulthood   

    Two new papers from the Human Cell Atlas shed new light on the types and traits of immune cells that can ...

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  • Wellcome Genome Campus staff commended at Cambridge Independent Science and Technology Awards

    The winners were drawn from all aspects of the Campus' world-leading work with genomes: from academic research to commercial application, and ...

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  • Birmingham 2022 Queen’s Baton Relay to visit Wellcome Genome Campus as full England route revealed

    Baton will visit Wellcome Genome Campus in South Cambridgeshire on 9 July 2022 ahead of the Commonwealth Games

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  • Increased mutations in children can be traced back to mistakes in father’s sperm     

    Researchers have traced the cause of increased numbers of mutations in children to a higher rate of random mutations in sperm ...

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17 May 2022

Six unbelievable things you probably didn’t know about DNA

Explore the surprising secrets of DNA, genes and genomes

13 May 2022

Three Sanger scientists recieve prestigious fellowships for their work

Congratulations to Professor Nicholas Thomson and Dr John Marioni who have been recognised by the Academy of Medical Sciences, and Professor ...

Chenqu Suo, Sophie Pritchard, Nadav Yayon for the Wellcome Sanger Institute

12 May 2022

Immune cell characteristics mapped across multiple tissues, from early life to adulthood   

Two new papers from the Human Cell Atlas shed new light on the types and traits of immune cells that can ...

Cambridge Independent / Keith Heppell

12 May 2022

Wellcome Genome Campus staff commended at Cambridge Independent Science and Technology Awards

The winners were drawn from all aspects of the Campus' world-leading work with genomes: from academic research to commercial application, and ...

Wellcome Genome Campus

11 May 2022

Birmingham 2022 Queen’s Baton Relay to visit Wellcome Genome Campus as full England route revealed

Baton will visit Wellcome Genome Campus in South Cambridgeshire on 9 July 2022 ahead of the Commonwealth Games

AdobeStock

11 May 2022

Increased mutations in children can be traced back to mistakes in father’s sperm     

Researchers have traced the cause of increased numbers of mutations in children to a higher rate of random mutations in sperm ...

4 May 2022

Supporting translational research at the Sanger Institute 

Six innovative projects have been selected by the Translation Committee for their potential of delivering novel approaches for the advancement of ...

27 Apr 2022

You can change the world

In conversation with Julia Gillard, who has recently joined Wellcome as Chair of the Board. Wellcome aim to solve the urgent ...

25 Apr 2022

From genome data to malaria control

How MalariaGEN's latest genetic data resources are helping in the fight to eliminate malaria.

22 Apr 2022

Contamination control and walking with dinosaurs

Meet Laura Grout, a Quality Assurance Manager playing a vital role in genomic surveillance and UK Biobank projects at the Sanger ...

Wellcome Sanger Institute:Genome Research Ltd

14 Apr 2022

New bacteria in mice associated with Inflammatory Bowel Disease

Bacteria that cause weight loss and intestinal inflammation discovered in mice should be considered in the interpretation and design of future ...

Alex Cagan, Wellcome Sanger Institute

13 Apr 2022

Mutations across animal kingdom shed new light on ageing

Quantity of mutations acquired similar over lifetime of 16 species, despite vast differences in lifespan and body mass

David Levine / Wellcome Sanger Institute

7 Apr 2022

Take on a coding challenge to build the Tree of Life

Sanger’s Tree of Life programme is taking part in Google Summer of Code, a global online initiative focused on bringing ...

Adobe Stock

6 Apr 2022

Genes linked to disease affect function of rare immune cell type

Study set out to identify how genetic variants modulate function of regulatory T cells

M. Duque-Correa, D. Goulding, F. Rodgers, et al. (2022)

1 Apr 2022

Mini guts used to study early stages of whipworm infection

Researchers have developed a new organoid model of the mouse gut to understand how the gut lining responds to whipworm infection ...

Ernesto del Aguila III, NHGRI

1 Apr 2022

Researchers generate the first complete, gapless sequence of a human genome

Complete genome sequence will significantly add to knowledge of chromosomes, including more accurate maps for five chromosome arms

Adobe Stock

1 Apr 2022

Study sheds light on why immunodeficiency affects only one identical twin

Cell-cell communication and epigenetic problems found to interfere with immune function

31 Mar 2022

Setting the bar higher – the complete human genome sequence

The newly determined sequence covers previously inaccessible regions of chromosomes, bringing a new era for genomics.

28 Mar 2022

Barcoding creatures and building confidence

Meet Leia Zhao, a research assistant working in the Evolutionary Genomics group in the Tree of Life Programme.

AdobeStock

28 Mar 2022

New analysis sheds light on how to uncover causal variants for immune-mediated diseases

Mapping regulatory trait loci can help uncover which genetic variants are most likely to be the cause of immune-mediated diseases.

AdobeStock

23 Mar 2022

Evolutionary pressures on genes associated with childlessness

Genetic variants that damage the genome have a small association with increased childlessness, but free choice and other factors are more ...

18 Mar 2022

LiFTS: Li Fraumeni over Time Study – tracking changes in LFS

March 20th is Li Fraumeni Syndrome (LFS) Awareness Day. People will be on social media, wearing blue, #WearBlueForLFS, to raise awareness ...

AdobeStock

14 Mar 2022

New hope for treatment of infant cancer that has puzzled researchers for decades

Subtle differences detected in immune cell type from which infant leukaemia arises

8 Mar 2022

Making your voice heard

Evolutionary genomics, creepy crawlies and being a woman in science

8 Mar 2022

Women rising in STEM

Reflections on working on genomic surveillance in the pandemic, and being a woman in science.

Petra Korlevic, Wellcome Sanger Institute

8 Mar 2022

Work to promote race equity in science celebrated at Best Practice Awards

The Wellcome Genome Campus holds its annual awards for Best Practice for Supporting Equality and Diversity in Science, in celebration of ...

Wellcome Sanger Institute

4 Mar 2022

Statement on the war in Ukraine

Communication from the Wellcome Sanger Institute

28 Feb 2022

The power of sharing

Three opportunities and challenges in rare disease research

Adobe Stock

24 Feb 2022

Genomic study shows that England’s travel quarantine measures were effective – up to a point

More than half of imported cases during period studied came from just three countries

AdobeStock

23 Feb 2022

Calls to share genetic data fairly and promote conservation

Scientists from 17 countries have published their thoughts on ongoing UN policy discussions around the sharing of digital sequence information to ...

AdobeStock

23 Feb 2022

New drug combinations found for resistant cancers

Sanger researchers have created the world’s largest novel resource using systematic drug testing and genetics analyses to show new potential ...

16 Feb 2022

The diversity of plants

We spoke to some of the Darwin Tree of Life team about their plans to sequence the DNA of every plant ...

11 Feb 2022

International Day of Women & Girls in Science 2022

To celebrate International Day of Women and Girls in Science we asked some of our female staff to tell us about ...

11 Feb 2022

Women rising in STEM

We sat down with Sanger Associate Director, Julia Wilson, to talk about her career so far and being a woman in ...

3 Feb 2022

Engaging everyone with science

Researchers discuss an innovative new training course designed to help them engage the public with science, with a focus on equity ...

AdobeStock

3 Feb 2022

Motivations to take part in research vary around the world   

Being able to receive results is a key motivator that influences participation in research, according to public audiences from the USA, ...

Wellcome Sanger Institute

1 Feb 2022

Professor Sir Mike Stratton to step down from Institute Directorship  

The new Director will be appointed over the coming year, and Sir Mike will remain at the Institute to continue conducting ...

27 Jan 2022

Exploring race, diversity and genomics

A new PhD project will explore structural inequalities in genomic research

AdobeStock

19 Jan 2022

Adult blood cancer-causing mutations occur in early childhood  

Mutations that cause adult blood cancer have been traced to acquisition in childhood, suggesting that cancer causing events can arise in ...

Wellcome Sanger Institute

17 Jan 2022

British and Irish project at forefront of global effort to map genomes of all life on Earth

Activity on Earth BioGenome Project and affiliated initiatives due to ramp up considerably in 2022

Omer Bayraktar

13 Jan 2022

Unprecedented cellular maps of tissues enabled by new tool

Ability to combine cell function and spatial information key to understanding life at molecular level

Michael Sweet, University of Derby

10 Jan 2022

New centre to explore links between organisms and their microbiomes

The £10m Leverhulme Centre for the Holobiont aims to create a green revolution in agriculture, rescue threatened species, and restore habitats

AdobeStock

5 Jan 2022

Superbug MRSA arose in hedgehogs before use of antibiotics

Scientists have found evidence that the antibiotic resistant superbug MRSA arose in nature long before the use of antibiotics, which has ...

Adobe Stock

22 Dec 2021

Rapid immune response in children protects them from COVID-19, genetic study finds

Discovery of importance of interferon response in preventing serious infection will underpin new diagnostics and therapeutics

21 Dec 2021

21 things we’ve learned in 2021

We would like to bring you 21 things that we have learned in the year 2021

20 Dec 2021

Sanger researcher invited to deliver 2022 Balfour Lecture 

The award marks Dr Sam Behjati’s contributions to genetics research, as an outstanding young investigator

20 Dec 2021

Sequencing COVID variants: latest stats

Latest numbers for coronavirus genome sequencing at the Sanger Institute

20 Dec 2021

The Story of Dogs

Dogs, descended from wolves, were the first animals to be domesticated by humans, some 40,000 years ago. New research, using ...

16 Dec 2021

Darwin Tree of Life in 2021: Tireless fieldwork and the first beautiful genomes

Teams have been collecting species across the UK - from the mountains of Scotland, to the sea caves of Wales, and the ...

AdobeStock

10 Dec 2021

Genetic history of British Pakistanis mapped for the first time

Analysis of genomic data from the Born in Bradford study will help to ensure those of Pakistani ancestry benefit from advances ...

Wellcome Connecting Science

9 Dec 2021

New centre to foster global conversations about ethical issues raised by science

The University of Cambridge and Wellcome Connecting Science announce the launch of the Kavli Centre for Ethics, Science, and the Public, ...

AdobeStock

9 Dec 2021

New link between malaria parasites and sickle haemoglobin identified 

Some malaria parasites in sub-Saharan Africa have genetic variants that allow them to infect those with sickle haemoglobin, which is normally ...

AdobeStock

8 Dec 2021

Launch of Fellowship programme to support next generation of Black scientists

The three-year Fellowship is open exclusively to early-stage Black heritage researchers who studied at a UK institution and offers a fully ...

8 Dec 2021

Research Excellence: The Power of Diversity

The Sanger Institute recently hosted three speakers as part of a new series - Research Excellence: The Power of Diversity. Read a ...

Rawlinson et al.

2 Dec 2021

Human parasite’s daily rhythms could be targeted for better treatments

The parasitic worm that causes the neglected tropical disease, schistosomiasis, has daily rhythms in gene expression, including genes that could be ...

2 Dec 2021

Mapping the endometrium, cell by cell

Dr Roser Vento-Tormo tells us about her work to map the cells lining the uterus in space and time, how it ...

2 Dec 2021

Spinning out the science

Much of the Sanger Institute's research has the potential to positively impact people's lives around the world: from a ...

Kenny Roberts, Wellcome Sanger Institute

2 Dec 2021

Uterus study is important step towards understanding diseases that affect one third of women

The study's organoid-based techniques provide a sophisticated model of endometrial function and will form a blueprint for discovering how other ...

Adobe Stock

26 Nov 2021

Syphilis is back and it is global, genetic study suggests

Disease incidence has risen sharply in recent decades

AdobeStock

23 Nov 2021

IBS biomarker identified that could help personalise diet and treatment

Half of people with Irritable Bowel Syndrome have a distinct microbiome compared to healthy people, and they respond better to a ...

22 Nov 2021

A Space for Science

"The most incredible things in research are the incidental findings, the serendipitous connections, moments when you are looking for one thing ...

Wellcome Sanger Institute

19 Nov 2021

Sanger celebrates Highly Cited Researchers

A number of researchers from the Wellcome Sanger Institute have been named on Clarivate's Highly Cited list

Project JAGUAR

17 Nov 2021

Researchers will map immune cells across Latin America with support from CZI

Researchers will sequence immune cell diversity across Latin America for the first time, shedding light on how ancestry impacts the immune ...

17 Nov 2021

Whole Genome Sequencing data on 200,000 UK Biobank participants are made widely available for research through unique public-private partnership

First release from world’s largest whole genome sequencing project could help researchers to understand the genetic determinants of disease and ...

15 Nov 2021

Covid Connections – Big Data in a Pandemic World

Researchers discuss COVID-19 genome data and its complexities, data sharing and security, and their careers in data science

AdobeStock

9 Nov 2021

New database of 660,000 assembled bacterial genomes sheds light on the evolution of bacteria  

A vast, curated collection of bacterial genomes has been created that allows the community unprecedented access to data.

3 Nov 2021

A Cellular Landscape

The connections between the external and internal environments are explored in a new experimental short film ‘Call of the Silent Cell’. ...

Gemma Girdler, University of Cambridge

3 Nov 2021

Sanger researchers to tackle deadly brain cancer with ‘tissue time machine’

Sanger Institute scientists are starting a new project that will integrate information from spatial transcriptomics with single-cell RNA and DNA sequencing, ...

2 Nov 2021

Sanger employee recognised in BioBeat’s top 30 trendsetters in UK life sciences  

Burcu Bronner-Anar is celebrated in BioBeat’s ‘Movers and Shakers in BioBusiness report’ that lists 30 UK trendsetters who are tackling ...

29 Oct 2021

Art and science unite to explore the intricacies of the human body 

The exhibition, One Cell At A Time opens on the 29th October 2021. It combines art and science to explore the ...

Saltanat ebli, Wikimedia Commons, Creative Commons CC0 1.0

25 Oct 2021

Huge global variation in oesophageal cancer incidence not due to a unique pattern of DNA damage 

Major global research collaboration adds new piece to the complex puzzle of oesophageal cancer

22 Oct 2021

A Health Data Research UK Black Internship Programme experience

This Black History Month, we asked Ifeanyi Chukwu to reflect on his recent experiences as an intern within HDR UK’s ...

18 Oct 2021

Marine medicines from the slimiest of worms

“They’re not cute or charismatic. They have toxic mucus. But I like nemerteans because no one is rooting for them – ...

H.S.Vöhringer, et al.

14 Oct 2021

The inside story of England COVID pandemic described in new study

The most detailed analysis of SARS-CoV-2 genomics surveillance to date shows COVID-19 as a series of overlapping epidemics rather than a ...

Dr Bartomeu Colom, Wellcome Sanger Institute

13 Oct 2021

Mutated cells drive out early tumours from the oesophagus

Normal human oesophagus carries a high number of mutations, but tumours are rare, due to mutant cells eliminating early tumours

AdobeStock

13 Oct 2021

Mutations in liver cells linked to liver disease and fat metabolism  

Mutations linking liver disease with obesity and diabetes have been identified, leading to new understanding about how systemic diseases interact

11 Oct 2021

Talent in Diversity

Over this year's Black History Month, we are celebrating the diversity of talent here at the Sanger Institute. For this ...

7 Oct 2021

We are molecular mosaics

Quantifying the mutational landscape of the human body

1 Oct 2021

Talent in Diversity

Over this year’s Black History Month, we are celebrating the diversity of talent here at the Sanger Institute. Here, ...

Wellcome Sanger Institute

30 Sep 2021

Higher rates of mutation alone are not to blame for age related disease  

Researchers have found that cells tolerate many more mutations than previously thought, without impacting their function

Novopath, Newcastle Upon Tyne NHS Trust

29 Sep 2021

Cell atlas reveals how blood and immune systems form in developing bone marrow

Study fills large knowledge gap and has important implications for diagnosis and treatment of immune deficiencies and leukaemia

28 Sep 2021

Genomics for all

In this guest post, Sadye Paez and Marcela Uliano-Silva explore what it takes to sequence the genomes of all life ...

23 Sep 2021

Eimeria: the chicken parasite costing farmers billions

By sequencing the genome of this single-celled coccidian parasite, scientists hope to develop better vaccines to protect poultry from a ...

20 Sep 2021

Celebrating Sanger Postdocs

This week (20th-24th September) is Postdoc Appreciation Week - a time to celebrate the fantastic contribution postdoctoral scientists make.

Mohammad Rahmatullah

14 Sep 2021

Evidence-based national policies are essential to curb local COVID-19 infections

By using genomic surveillance and mobile phone data, researchers have uncovered useful insights into the management of the COVID-19 pandemic in ...

Wellcome Sanger Institute

10 Sep 2021

Wellcome Sanger Institute recognised as Charity Times finalist for outstanding contribution to pandemic response

Staff praised for dedication and excellence as they work to sequence coronavirus genomes, helping to shape the pandemic response

Elmentaite et al. Nature DOI: 10.1038/s41586-021-03852-1

8 Sep 2021

Development study reveals origins of Inflammatory Bowel Disease

Creating Cell Atlas of Human Development will transform understanding of health and disease

Anne Weston, Francis Crick Institute

1 Sep 2021

International research consortium to tackle tumour drug resistance using single-cell sequencing

Sanger Institute scientists join a new collaborative research project that will use single-cell sequencing to tackle drug resistance and develop smarter ...

31 Aug 2021

Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases

Projects will create cell atlases of the paediatric ovary, skin and brain to better understand human biology and provide reference datasets ...

AdobeStock

27 Aug 2021

Loss of gene linked to differences in brain size  

Inactivation of the MAGEE2 gene, seen widely across East Asia, results in enlarged brains in men and decreased brain size in ...

Wellcome Sanger Institute

25 Aug 2021

Researchers discover individual variation in how our bodies develop and acquire mutations 

Studies will help to establish baseline for human development and acquisition of mutations during life in the soma and the germline

23 Aug 2021

Defining Success

Five inspirational speakers share their journeys, definitions of success, and lessons learnt in the space of diversity and inclusion.

AdobeStock

23 Aug 2021

Link between amino acid and a range of common diseases could help predict personal risk

Researchers have identified a link between mitochondrial DNA variants, amino acid fMet, and a range of common, late-onset diseases

AdobeStock

10 Aug 2021

Fighting the spread of drug-resistant malaria with genetic surveillance  

In-depth genomic surveillance of the malaria parasite over multiple countries has tracked regions of drug resistance

9 Aug 2021

From Mild to Mortal

An expert panel discuss some of the latest research into human genetics, immunology and COVID-19

AdobeStock

5 Aug 2021

Researchers track how microbiome bacteria adapt to humans via transmission

New research has shed light on how transmission of gut bacteria influences its evolution and functions

Adobe Stock

4 Aug 2021

Genetic study reveals ancient human adaptation to agriculture and climate change in Middle East

The most comprehensive study so far of genetic diversity in the Middle East has given a glimpse into the lives of ...

AdobeStock

4 Aug 2021

New therapeutic target discovered for a number of aggressive cancers

An RNA-modifying protein elevated in some aggressive cancers has been shown to be a promising target for new drug development

4 Aug 2021

The evolutionary history of humans

Mohamed Almarri has recently completed a PhD studying population history and global genetic diversity.

2 Aug 2021

OKRs: Strategic planning the Google way

We’re refreshing the way we do strategic planning, using Objectives and Key Results (OKRs)

16 Jul 2021

Reflections on race and equity in research: One year on...

One year on from the murder of George Floyd, we take a step back to reflect on our reactions and ...

29 Jun 2021

Covid Connections – Variant or Villain

The second COVID connections talk brought together experts from COG-UK to discuss SARS-CoV-2 variants.

28 Jun 2021

Bacterial Biomes

"we are well aware that what we know about already is just a small percentage of the diversity that ">...

AdobeStock

24 Jun 2021

Water vole genome will help boost conservation of one of UK's most endangered mammals

The water vole genome is published as part of the Darwin Tree of Life Project to assemble the genomes of 70, ...

Kenny Roberts, Bayraktar Lab

23 Jun 2021

Cellular signatures of kidney tumours discovered

This method of identification holds promise as a tool for diagnosing patients with rare cancers

Mole, M.A. et al

17 Jun 2021

Study identifies trigger for ‘head-to-tail’ axis development in human embryo   

Researchers have mapped, in new detail, the genetic changes that a human embryo goes through as it develops.

AdobeStock

14 Jun 2021

Computer method to help predict outcomes and tailor treatments for patients with inherited heart diseases  

Clinicians and scientists analysed how individual genetic changes affect the heart muscle and created a new computer tool to integrate genomic ...

Wellcome Sanger Institute

8 Jun 2021

Sanger Institute human genetics researcher honoured by EMBO

Professor Matthew Hurles, Head of Human Genetics, becomes an elected member of the European Molecular Biology Organization

Human Cell Atlas

8 Jun 2021

Winning Cambridgeshire students design card game inspired by the Human Cell Atlas

Game will be developed and feature in nationwide exhibition

Pixabay

3 Jun 2021

New genetic variants lead to diagnoses for children with developmental disorders

By analysing parts of the genome that do not code for proteins, researchers have identified seven variants linked to developmental disorders.

Adobe Stock

28 May 2021

Genetic study identifies risk for some childhood cancer patients developing secondary leukaemia and will help inform treatment plan

New study used whole genome sequencing to gain further understanding of why some children develop secondary leukaemia after neuroblastoma treatment

AdobeStock

27 May 2021

Atlas of malaria parasite gene activity provides new targets for drugs and vaccines

Researchers have mapped in fine detail the genetic changes malaria parasites go through as they prepare to infect people.

Jolanda van Leeuwen

27 May 2021

‘Rescue mutations’ that suppress harmful DNA changes could shed light on origins of genetic disorders

The biological phenomenon may play an important role in genetic diseases such as cancer or rare developmental disorders, and explain why ...

Harriet Auty, University of Glasgow

26 May 2021

Discovery of vaccine target for devastating livestock disease could change lives of millions in sub-Saharan Africa

The findings raise the possibility of identifying vaccine targets for trypanosome species that cause the deadly human infections sleeping sickness and ...

K Hardy CC BY 4.0

18 May 2021

Unparallelled insights into how our bodies develop from a single cell

Knowing what happens during normal development could help us to understand genetic diseases that arise during pregnancy

11 May 2021

Identifying the rise of multi-drug resistant E. coli

Largest genomic study of E. coli has tracked the rise of multi-drug resistance (MDR) in Norway.

AdobeStock

30 Apr 2021

New genetic target for blood cancer treatment 

Researchers have identified a vulnerability in some cases of acute myeloid leukaemia that could be harnessed for targeted treatment of these ...

AdobeStock

29 Apr 2021

New era of quality and scale in genome sequencing will drive biological discovery

Publication of 16 high-quality vertebrate reference genomes establishes standards for biodiversity genomics

Ludovic Collin / Wellcome Images

28 Apr 2021

Major advance enables study of genetic mutations in any tissue

Analysis of blood, colon, brain and muscle tissue indicates cell division is not the primary cause of somatic mutations

26 Apr 2021

Novel drug type for blood cancer entering clinical trials 

First drug to target a specific RNA-modifying protein will start clinical trials in 2022 against acute myeloid leukaemia

Dr. Kelvin (Zewen) Tuong

20 Apr 2021

Differing immune responses discovered in asymptomatic cases versus those with severe COVID-19

Using data from the Human Cell Atlas, researchers have identified the differences in immune cells’ response in those who had no ...

AdobeStock

16 Apr 2021

Genetic variants identified that impact immune cells' functioning 

Researchers have combined genome-wide sequencing and functional profiling of immune cells to understand more about the impact of genetic variants on ...

12 Apr 2021

New genetic drug target for treatment resistant colorectal cancer 

Researchers have identified a new potential drug target for treating some types of advanced colorectal cancers.

Annie Cavanagh

7 Apr 2021

‘Patchwork’ tumours prevalent across multiple cancer types

Scientists have confirmed that tumour evolution is driven by changes that benefit the cancer, and these lead to a wide range ...

31 Mar 2021

New DERMATLAS project will create world's most comprehensive public resource of rare skin tumour genomes 

This project will document the genomes of around 70 rare skin tumours to build a map of how these cancers form ...

30 Mar 2021

Genetic link to male infertility identified

Men who carry a certain subtype of Y chromosome are more likely to experience genetic mutations that lead to low sperm ...

Paola Perez, PhD, Warner Lab

25 Mar 2021

Salivary gland cells revealed as sites of COVID-19 infection

Human Cell Atlas findings point to role for saliva in SARS-CoV-2 transmission

24 Mar 2021

New addition to COSMIC database will collate available drugs to target cancer mutations

The Actionability resource identifies relationships between types of cancer, specific mutations and available drugs

Anne Weston, Francis Crick Institute

23 Mar 2021

CRISPR study identifies gene that plays key role in metastasis of cancers to the lungs

Over-expression of LRRN4CL was linked to cancer spread in colon, breast and bladder cancers in humans

AdobeStock

18 Mar 2021

Project to understand beginnings of rare childhood cancer awarded innovation funding

Sam Behjati and collaborators at University College London hope to identify new treatment targets by uncovering foetal origins of rhabdomysarcoma.

CDC / Alissa Ecker, MS / Dan_Higgins, MAMS

17 Mar 2021

SARS-CoV-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

These findings offer a molecular explanation for the reported differences in disease severity for COVID-19 patients depending on age, gender and ...

Adobe Stock

10 Mar 2021

Placenta is a dumping ground for genetic defects 

The study is the first high-resolution survey of the genomic architecture of the human placenta, revealing specific patterns of mutation that ...

CDC/Janice Haney-Carr

9 Mar 2021

Full evolutionary journey of hospital superbug mapped for the first time 

Sanger Institute researchers and their collaborators have published the full genetic timeline of the bacterium, Enterococcus faecalis showing the influence of ...

8 Mar 2021

Students invited to create a card game inspired by the Human Cell Atlas

How to build a Human: Design a card game challenge

Alex Cagan

8 Mar 2021

Virtual event celebrates Equality and Diversity Champions from the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

Sabine van Erp, Pixabay.com

3 Mar 2021

Genomics study identifies routes of transmission of coronavirus in care homes

Genome sequencing was combined with detailed epidemiological information to examine the impact of COVID-19 on care homes and to discover how ...

Wellcome Sanger Institute

3 Mar 2021

New search engine for single cell atlases

New software tool allows researchers to rapidly search datasets from single-cell sequencing

L. Custers & J. Drost

3 Mar 2021

Origin of childhood cancer malignant rhabdoid tumour discovered

Researchers identified two drugs that could be used to overcome the genetic root of the disease, resuming normal development and bringing ...

3 Mar 2021

Sanger Institute researcher wins Pezcoller Foundation EACR Rising Star Award

Congratulations to Dr Sam Behjati, who receives the Award in recognition of his potential to make significant contributions to cancer research

Roberto Amato, Wellcome Sanger Institute

24 Feb 2021

Open data on malaria genomes will help combat drug resistance

The release represents the world’s largest resource of genomic data on malaria parasite evolution and drug resistance

AdobeStock

23 Feb 2021

Gene that helps control egg’s journey sheds light on why ectopic pregnancy may occur

Study details the first evidence of gene regulation in the transit of eggs from the ovaries to the uterus in mammals

Dr Fotios Sampaziotis, Dr Teresa Brevini, University of Cambridge

18 Feb 2021

Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first

For the first time, this new study has successfully created ‘mini-organs’ in the lab, that could help patients with liver damage

AdobeStock

18 Feb 2021

Scientists identify over 140,000 virus species in the human gut, half of which are new to science

The results form the basis of the highly-curated Gut Phage Database (GPD) which will be an invaluable resource for those studying ...

Prasesh Shiwakoti Lomash, Unsplash.com

12 Feb 2021

New COVID-19 saliva testing strategy could translate into easy-to-use home device

The new testing approach would be easier to collect and simpler to process in the laboratory than the current nasal-swab process.

Adobe Stock

5 Feb 2021

New drug targets for childhood cancer neuroblastoma identified

All neuroblastomas arise from developmental cells not normally found in children, making them a promising target for drug development

Wellcome Leap

28 Jan 2021

Sanger Institute joins Wellcome Leap Global Network dedicated to accelerated breakthroughs in human health

Charter group of 21 world-class institutions representing a network of over 150,000 researchers across six continents sign agreement that sets ...

Newcastle University

21 Jan 2021

Developmental origins of eczema and psoriasis discovered

Skin Cell Atlas points to new drug targets for inflammatory diseases

Jayhun Lee, Postdoctoral Fellow, Newmark Lab, Morgridge Institute for Research

18 Dec 2020

Cell atlas of tropical disease parasite may hold key to new treatments

The atlas of 13 distinct cell types at the start of the Schistosoma mansoni's development will aid vaccine and treatment ...

boredomresearch

15 Dec 2020

Ten artists to create artworks for global research project mapping the human body

Human Cell Atlas explored through art science collaboration

Kenny Roberts and Sophie Pritchard, Wellcome Sanger Institute

7 Dec 2020

Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease

Gut Cell Atlas reveals gut development mechanisms

1 Dec 2020

Dr Sam Behjati selected as an EMBO Young Investigator

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work on the developmental origins of ...

Dan Ross

19 Nov 2020

COG-UK computing effort wins collaboration award for COVID-19 work

HPCwire award recognises consortium's sequencing of tens of thousands of viral genomes

CDC, Alissa Ecker/MS and Dan Higgins/MAMS

16 Nov 2020

Wellcome Sanger Institute and COG-UK receive £12.2M UK Government investment for COVID-19 real-time genomic surveillance system

Institute researchers will support the COVID-19 Genomics UK consortium's work by providing high-throughput virus genome sequencing, creating surveillance software to ...

Wellcome Sanger Institute

11 Nov 2020

Sanger Faculty to co-lead new Italian Genomics Research Centre

Nicole Soranzo will join the Human Technopole Institute to establish its dual programmes of Population and Medical Genomics and Functional Genomics ...

Adobe Stock

4 Nov 2020

Uncovering the origin of rare childhood cancer guides treatment

Bilateral neuroblastoma cancers in a patient can arise independently from each other, at the very earliest stages of life

Zach Fitzpatrick

4 Nov 2020

Why protecting the brain against infection takes guts

Gut microbes educate antibody producing cells that guard the brain

28 Oct 2020

Human Cell Atlas projects increase diversity of sample donors

Funding from the Chan Zuckerberg Initiative enables tissue samples from more diverse ethnic backgrounds

Wellcome Sanger Institute

26 Oct 2020

Sanger Institute welcomes Wellcome's new science strategy

Director Mike Stratton outlines the opportunities and continuing support that Wellcome's new strategy provides for Sanger researchers

Michael Fallon, Unsplash.com

14 Oct 2020

Study linking 28 genes to developmental disorders will mean diagnoses for around 500 families

Researchers estimate that approximately another 1,000 genes linked to developmental issues have yet to be found

Wellcome Sanger Institute

14 Oct 2020

Update to COSMIC drives precision oncology

The Cancer Mutation Census combines biological, biochemical and population data to enable users to understand which DNA mutations drive human cancers

Adapted from Nature Immunology DOI: 10.1038/s41590-020-0800-8

12 Oct 2020

Novel map reveals how immune cells fight and remember infections

Mouse immune study gives pointers for development of vaccines and immune therapies

Camila G. Beiras (FLSida https://www.flsida.org/en)

7 Oct 2020

Comeback of drug-resistant neglected tropical disease tracked through genomic surveillance

Study shows that re-emergence was likely caused by latent infections in untreated asymptomatic people

5 Oct 2020

Song Chen to lead research group in Cellular Genetics Programme

This new group will develop powerful, cutting-edge technologies to map individual cells in the brain and other tissues, to understand how ...

Dave Goulding, Wellcome Sanger Institute

1 Oct 2020

Cause of 1990s Argentina cholera epidemic uncovered

Work influenced Argentine health policy, where the national alert surveillance system now uses whole-genome sequencing to distinguish between pandemic and non-pandemic ...

1 Oct 2020

DNA changes in healthy bladder provide clues on how cancer arises

The research reveals a huge diversity in the number and types of changes between individuals, indicating that a wide range of ...

Adobe Stock

24 Sep 2020

Highly detailed map of human heart could guide personalised heart treatments

Heart Cell Atlas will illuminate our understanding of heart health and disease

Wellcome Sanger Institute, Genome Research Limited

24 Sep 2020

Key genetic clue missing in fight against superbugs

Analysis shows importance of including plasmids when tracking antibiotic resistance in bacterial populations

Michael Sweet, University of Derby

23 Sep 2020

Ambitious genomics project seeks to understand how aquatic species thrive together

The Aquatic Symbiosis Project will empower researchers to answer important questions about the ecology and evolution of symbiosis

Fiona McQueen, Marissa Lassere and Mikkel Østergaard. CC BY 2.0 Wikimedia Commons

21 Sep 2020

Key discovery in psoriatic arthritis points way for developing targeted treatments

Genetic evidence points to potential single cause for the disease

18 Sep 2020

Fire on Wellcome Genome Campus detected and extinguished quickly

The fire was contained to one room and the Campus is safe and fully operational

Adobe Stock

17 Sep 2020

Future of genomic research at risk without greater public trust in how genetic data is shared

Survey finds lack of familiarity with genomics and how it can benefit society

Adobe Stock

16 Sep 2020

How Dantu blood group protects against malaria - and how all humans could benefit

Red blood cells have a higher surface tension that prevents them from being invaded by Plasmodium parasite

Annie Cavanagh (CC BY-NC 4.0)

3 Sep 2020

Genetic information can predict predisposition to blood diseases

Studies identify bulk of genetic variation that influences blood cell traits

CDC / Alissa Ecker MS; Dan Higgins, MAMS

28 Aug 2020

Unprecedented national effort by UK immunologists to search for answers on COVID-19 

Sanger Institute researchers join national research projects to investigate the role of our immune system in tackling COVID-19

Gianmarco Raddi, Wellcome Sanger Institute

27 Aug 2020

Mosquito immune system mapped to help fight malaria

Atlas will be valuable resource for understanding and controlling mosquito-borne diseases such as malaria, Dengue and Zika

11 Aug 2020

Former Sanger Institute Head of Pathogens receives the 2020 Albert B. Sabin Gold Medal 

Professor Gordon Dougan awarded Sabin Vaccine Institute prize for his contributions to vaccinology

4 Aug 2020

New podcast to provide digital mentoring tips for early career researchers

Your Digital Mentor launches with first episode on the mentoring experience

30 Jul 2020

New drug targets for lethal brain cancer discovered

Researchers engineered a new mouse model for studying glioblastoma, the most aggressive type of brain cancer

Yu Fu, Moritz Gerstung, Spencer Phillips

27 Jul 2020

Artificial intelligence finds patterns of mutations and survival in tumour images

AI detects patterns of 167 different mutations and predicts patient survival in 28 cancer types

21 Jul 2020

Chronic inflammation alters the evolution of cells in the colon, study finds

Researchers have compared diseased colon with healthy tissue to better understand how inflammatory bowel disease (IBD) is linked to an increased ...

Human Cell Atlas

13 Jul 2020

Explore COVID-19 science in action with new Human Cell Atlas animation

Mapping COVID-19: How the Human Cell Atlas enhances our understanding of the disease

13 Jul 2020

International Common Disease Alliance releases action plan to drive next phase of genetic understanding of common disease

Report defines priorities, proposes international collaborations to accelerate progress from genetic maps to biological mechanisms to medical treatments

AdobeStock

8 Jul 2020

Launch of virtual Sanger Seminar series

Join us for a new series of virtual seminars, open to all, which will present the latest research from the Sanger ...

AdobeStock

7 Jul 2020

Drug screens and CRISPR combine to help make better cancer drugs

Improved understanding of the biological mechanisms underpinning drug response will enable faster, more efficient drug development

26 Jun 2020

The first draft human genome at 20

A revolution powering today’s advances in genomics, biology and medicine

18 Jun 2020

Update to DECIPHER brings power to clinical genomics

Update to rare disease database allows researchers and clinicians to input, interpret and share all types of genomic variants in all ...

Ron van der Stappen, Adobe Stock

11 Jun 2020

Denisovan DNA influences immune system of modern day Oceanian populations

Previously-unknown variations in medically-important genes will be valuable resource for the field of precision medicine

Albert Renn, Unsplash.com

8 Jun 2020

Genomic surveillance of antibiotic resistance in the Philippines established

Bacterial resistance to last-line antibiotic mapped in the Philippines

Open Targets

8 Jun 2020

Sanger researcher wins prize from European Society for Human Genetics

Gosia Trynka awarded 2020 Leena Peltonen Prize for her outstanding research into human immune diseases

Directorate General of Antiquities (Lebanon)

28 May 2020

4,000 years of contact, conflict and cultural change had little genetic impact on Near East

Only three periods had lasting effect on genetics of local people in Beirut

22 May 2020

Analysis of COVID-19 Genomes reveals large numbers of introductions to the UK in March

The data reports, published by the COVID-19 Genomics UK Consortium (COG-UK), show the value in mapping COVID-19 lineages across the UK ...

Spencer Phillips/EMBL-EBI

18 May 2020

An automated method for cell type discovery

Identifying cell types from single-cell RNA sequencing data is now more efficient than ever

18 May 2020

Honour with Athena SWAN Silver Award

The Wellcome Sanger Institute and its associated organisations have been awarded by Athena SWAN for commitment to advancing women's careers ...

18 May 2020

Potentially cancerous cells kept in check by competitive neighbours, study of oesophagus finds

Hope that understanding of the 'rules of the game' of clonal competition will lead to new therapies

Big T Images for Academy of Medical Sciences

13 May 2020

Sanger scientists recognised by the Academy of Medical Sciences

Six Sanger researchers – past and present – have been welcomed into Fellowship of the prestigious organisation

Wellcome Sanger Institute, Genome Research Limited

7 May 2020

Sanger scientist receives Chan Zuckerberg Initiative support for COVID-19 study

Roser Vento-Tormo will use single-cell technologies to understand human immune response to SARS-CoV-2 infection and the progression of the disease

Wellcome Sanger Institute, Genome Research Limited

6 May 2020

New computational method unravels single-cell data from multiple people

Souporcell could assist personalised medicine and malaria research

Sebastian Nevols

29 Apr 2020

Head of Cellular Genetics elected Fellow of the Royal Society

Sarah Teichmann is recognised for her pioneering computational biology and genomics work, leading to the Human Cell Atlas initiative

Wellcome Sanger Institute and UKRI

27 Apr 2020

Sanger researcher backed through flagship fellowship

Dr Stephen Doyle has been awarded a UKRI Future Leaders Fellowship to explore the evolution of drug responses in parasitic worms

Wellcome Sanger Institute

24 Apr 2020

Sanger Institute to extend funding for Postdoctoral Fellows affected by COVID-19 shutdown

Funding will be extended for six months, including for those funded by third parties

CDC / Alissa Ecker MS; Dan Higgins, MAMS

23 Apr 2020

Key nose cells identified as likely COVID-19 entry points

Study with Human Cell Atlas could help understand transmission of the virus

Luiza Moore, Wellcome Sanger Institute

22 Apr 2020

Normal human uterus is colonised by clones with cancer-driving mutations that arise early in life, study finds

Hope that insights into earliest stages of uterine cancer development will help to tackle one of most common female cancers

NIH, NIAID

14 Apr 2020

Experience matters for immune cells - discovery of T cells response spectrum could help understand immune diseases

Study could help find better drug targets for asthma and rheumatoid arthritis

23 Mar 2020

Sanger Institute scientist wins 2021 Biochemical Society award

Roser Vento-Tormo awarded an Early Career Research Award

Wellcome Sanger Institute, Genome Research Limited

23 Mar 2020

UK launches whole genome sequence alliance to map spread of coronavirus

The Wellcome Sanger Institute will collaborate with expert groups across the country to analyse the genetic code of COVID-19 samples circulating ...

20 Mar 2020

Sanger Institute and Wellcome Genome Campus temporarily closed to all but critical research

In response to the rapidly changing COVID-19 pandemic, the Sanger Institute and its neighbours on the Wellcome Genome Campus will close ...

Matt Midgley

19 Mar 2020

Global human genomes reveal rich genetic diversity shaped by complex evolutionary history

Study will help identify the susceptibility of different populations to disease

Bayraktar lab, Wellcome Sanger Institute and Rowitch lab, University of Cambridge

16 Mar 2020

New research on brain structure highlights cells linked to Alzheimer’s and autism

Astrocytes organised into layers in similar way to neurons

Wellcome Genome Campus

6 Mar 2020

Equality and Diversity Champions celebrated at the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

Sanger Institute

20 Feb 2020

Origins of immune system mapped, opening doors for new cancer immunotherapies

Cell atlas of human thymus could help engineer improved therapeutic T cells

Adobe Stock

19 Feb 2020

Otter genome to help understand genetic legacy of pollution crisis and secure species’ future

Genome will unlock wealth of data stored in DNA archives in bid to understand response to environmental changes

SciePro, Adobe Stock

17 Feb 2020

Gut bacteria’s interactions with immune system mapped

Cell atlas could reveal why some gut diseases affect specific areas

5 Feb 2020

Background information about the ICGC/TCGA Pan-Cancer Project

Overview of the Pan-Cancer Project

5 Feb 2020

Cancer-causing culprits will be caught by their DNA fingerprints

Study within Pan-Cancer Project will help research into cancer prevention, diagnosis and treatments

Anne Weston, Francis Crick Institute

5 Feb 2020

Comprehensive study finds mutations in non-coding genome are infrequent drivers of cancer

Findings suggest efforts to develop new cancer treatments should primarily focus on protein-coding genes

5 Feb 2020

Unprecedented exploration generates most comprehensive map of cancer genomes charted to date

Pan-Cancer Project discovers causes of previously unexplained cancers, pinpoints cancer-causing events and zeroes in on mechanisms of development

4 Feb 2020

Red and grey squirrel genomes could hold the key to the survival of reds in Britain and Ireland

Susceptibility to squirrel pox and genetic fitness of fragmented populations are key questions for red squirrel researchers

3 Feb 2020

Tailor-made vaccines could almost halve rates of serious bacterial disease

Innovative study points the way to more effective vaccine design

31 Jan 2020

Statement on Brexit by the Wellcome Sanger Institute, the European Molecular Biology Laboratory (EMBL) and the Francis Crick Institute

Statement on Brexit

Wellcome Sanger Institute, Genome Research Limited

29 Jan 2020

Never too late to quit: protective cells could cut risk of lung cancer for ex-smokers

Ex-smokers have four times more genetically healthy cells than smokers, helping to protect them against lung cancer

Adobe Stock

20 Dec 2019

Analysis of CRISPR-Cas9 datasets leads to largest genetic screen resource for cancer research

Study will help narrow down the list of targets for the next generation of cancer treatments

16 Dec 2019

Dr Konstantinos Tzelepis receives ASH–BSH Abstract Achievement Award for leukaemia target research

Award-winning abstract on METTL3 presented at American Society of Hematology meeting

Wellcome Sanger Institute:Genome Research Ltd

16 Dec 2019

Researchers identify over 140 genes linked to immune system regulation

First extensive immune profiling of mice reveals a vast catalogue of genes that regulate the immune system and model human disease

9 Dec 2019

Appointments and changes to the Genome Research Limited Board

At the GRL Board meeting on 2 December 2019, David Willetts announced his intention to step down as Chair because of ...

5 Dec 2019

Researchers identify new possibilities for the treatment of inflammatory bowel disease

Two molecular pathways found to be integral to maintaining balance in the digestive system

5 Dec 2019

Root of childhood kidney cancer discovered

Pre-cancerous signatures found in healthy tissue point the way towards new treatment options

Jooney Woodward, Wellcome CC-BY

19 Nov 2019

From childhood cancer to mapping human development: Pioneering scientist awarded 2019 Foulkes Foundation medal

Congratulations to Professor Muzlifah Haniffa, who has been recognised for her work on the immune system and childhood cancer

18 Nov 2019

Dr Sam Behjati wins Liddy Shriver Early Career Research Award

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work in sarcoma cancer genomics

University of Bern

14 Nov 2019

New malaria drug targets identified in liver stage of life cycle

Hope that new liver-stage drugs will help to counter the threat of antimicrobial resistance to current blood-stage medicines

8 Nov 2019

Ambitious project to map genomes of all life on British Isles funded by Wellcome

An unprecedented insight to the diverse range of species on the British Isles will be made possible by Wellcome funding to ...

CDC/ Molly Kurnit, M.P.H.

31 Oct 2019

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Research explains why children often catch other infections after measles, and highlights the importance of vaccination

28 Oct 2019

Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

Researchers will examine both healthy and diseased intestinal tissue to identify key cell types involved in Crohn’s disease

Nephron, Wikimedia Commons

23 Oct 2019

Accumulation of DNA mutations found in healthy liver leads to disease

Largest study of its kind seeks to better understand how liver disease and hepatocellular carcinoma develop

23 Oct 2019

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

Adobe Stock

15 Oct 2019

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

15 Oct 2019

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

Pixabay

11 Oct 2019

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

Newcastle University

9 Oct 2019

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early ...

Neil Henderson, University of Edinburgh

9 Oct 2019

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

8 Oct 2019

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use ...

Menna Clatworthy, University of Cambridge

26 Sep 2019

Human kidney map charts our growing immune defence

New cell atlas reveals immune cells present in zones of human kidney

Shutterstock

23 Sep 2019

Scientists hone in on DNA differences behind immune diseases

Search could help find drug targets for developing new treatments

Dave Goulding, Wellcome Sanger Institute

19 Sep 2019

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Strain of dangerous pathogen shown to have developed resistance to last-line-of-defence drug

18 Sep 2019

Babies' gut bacteria affected by delivery method, Baby Biome project shows

Vaginal delivery promotes mother's gut bacteria in baby's gut

11 Sep 2019

500,000 whole human genomes will be a game-changer for research into human diseases

Following on from a successful pilot at the Sanger Institute, we are leading a project to sequence the genomes of all ...

5 Sep 2019

Brown trout genome will help explain species' genetic superpowers

Eagerly awaited reference genome will allow conservationists to understand how the fish adapts to marine and freshwater environments

4 Sep 2019

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab has launched an exciting programme of events for Friday 27 and Saturday 28 September 2019, transforming parts of Cambridge, Peterborough ...

28 Aug 2019

Decoding first of 60,000 British species as Darwin Tree of Life branches out

The mission to map the genetic code of all known British species is underway

William Brieger, Jhpiego

22 Aug 2019

Malaria control success in Africa at risk from spread of multi-drug resistance

Regional populations of Plasmodium falciparum parasites in Africa are sharing genetic material in all directions – including genes that can confer resistance ...

Alex Cagan

22 Aug 2019

Map of malaria behaviour set to revolutionise research

The Malaria Cell Atlas gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites ...

12 Aug 2019

Diarrhoea-causing bacteria adapted to spread in hospitals

Gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals

29 Jul 2019

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Research emphasises importance of ongoing genomic surveillance and infection control

25 Jul 2019

Cancer drug data release set to power next wave of therapeutic discovery

Unique data comparing almost 1,000 cancer cell lines’ responses to 453 licensed and experimental drugs is now freely available to ...

23 Jul 2019

Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

Medical student working in the Cancer Genome Project wins prize for colon cancer research

22 Jul 2019

2019 Chief Medical Officer’s Report published

Sanger Institute researchers contribute to Professor Dame Sally Davies' eleventh annual report

Chanaki Amaratunga

22 Jul 2019

Multi-drug resistant malaria spreading in Asia

Study reveals importance of ongoing genomic surveillance for malaria control strategies

Wellcome Sanger Institute

18 Jul 2019

Low doses of radiation promote cancer-capable cells

New research in mice helps to understand the risks around exposure to low doses of radiation, such as CT scans and ...

25 Jun 2019

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Seed Networks projects will focus on specific tissues, such as the thymus, lung, liver, kidney and immune system

David Goulding, Wellcome Sanger Institute

24 Jun 2019

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Genomic analysis shows that a significant number of strains are susceptible to penicillin combined with clavulanic acid

Professor Wim Timens, UMCG

17 Jun 2019

First lung map uncovers new insights into asthma

Understanding lung cells and their signals could help towards finding new asthma drug targets

11 Jun 2019

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo becomes an elected member of the European Molecular Biology Organization

10 Jun 2019

Pneumonia mapped in largest genomic survey of any disease-causing bacterium

Study will help predict strains important for new vaccines

3 Jun 2019

Major stem cell discovery to boost research into development and regenerative medicine

Expanded Potential Stem Cell lines of pig and human cells established

CDC/PHIL

27 May 2019

Global Strep A vaccine one step closer

Streptococcus genomes reveal potential vaccine targets present in over 20 countries worldwide

16 May 2019

CRISPR catches out critical cancer changes

Researchers reveal which gene fusions are critical for the growth of cancer cells and identify a new drug target for multiple ...

16 May 2019

Sanger Institute animal research facility to close

Following a full review, the Sanger Institute will be closing its animal research facility

Wellcome Sanger Institute

15 May 2019

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

The 2019 recipient of the Dr Simon Newell Early Career Investigator Award has been announced as Dr Sam Behjati, whose career ...

8 May 2019

Lead cancer researcher elected to Academy of Medical Sciences

Dr Peter Campbell receives prestigious Fellowship for his work in cancer genomics

18 Apr 2019

Crusaders made love and war, genetic study finds

Sanger Institute researchers have produced whole-genome sequences from skeletons discovered in a 13th Century burial pit in Sidon, Lebanon

18 Apr 2019

Rare genetic change provides clues to pancreas development

Understanding pancreas formation could aid research into type 1 diabetes treatments

17 Apr 2019

Head of Human Genetics elected Fellow of the Royal Society

Matthew Hurles is recognised for his pioneering work in identifying the genetic basis of undiagnosed developmental disorders and paving the way ...

11 Apr 2019

Mice reveal 38 new genes involved in hearing loss

Molecular pathways revealed could identify potential drug targets for restoring hearing

Imperial War Museums (Wikimedia Commons)

10 Apr 2019

Genetic code of WWI soldier's cholera mapped

The bacterium was isolated from a British soldier and stored for over 100 years before being revived and sequenced

10 Apr 2019

New cancer drug targets accelerate path to precision medicine

Researchers discovered thousands of genes essential for cancer’s survival and ranked which ones show the most promise as drug targets ...

28 Mar 2019

Sanger Institute scientist wins 2020 Biochemical Society award

Head of Cellular Genetics Programme wins GlaxoSmithKline prize

21 Mar 2019

Darwin Tree of Life sets down roots

Planning for the Darwin Tree of Life Project is underway. We welcome Professor Mark Blaxter, from the University of Edinburgh, who ...

14 Mar 2019

Commitment to collaborate on using genomics for pathogen surveillance across Europe

Combining the strengths of the European Centre for Disease Prevention and Control, the Wellcome Sanger Institute and the Centre for Genomic ...

8 Mar 2019

Champions of equality and diversity celebrated

The winners were nominated by staff working at the Wellcome Genome Campus for their actions to advance equality, diversity and inclusion, ...

Annie Cavanagh, Wellcome Images and Photoroyalty, freepik.com

7 Mar 2019

Major mutation pattern in cancer occurs in bursts

New resource could help understand origins of cancer

5 Mar 2019

Cambridge heart research boosted by £6 million British Heart Foundation Research Excellence Award

Funding will allow Sanger Institute researchers and collaborators to apply cutting-edge genomics to help develop new heart disease diagnostics and treatments

4 Mar 2019

Roser Vento-Tormo leads single-cell research team at the Sanger Institute

The new group will identify the cells involved in the human female reproductive system, how they work, organise and communicate with ...

27 Feb 2019

Improving global surveillance of antibiotic resistance

A WHO Technical Note has been published that will enable health authorities to make informed choices on the most appropriate molecular ...

20 Feb 2019

Establishing the molecular blueprint of early embryo development

By studying the genetic activity of 116,312 single cells from 6.5 to 8.5 days after fertilisation, researchers have ...

12 Feb 2019

Cancer comparison across species highlights new drug target

Scientists discover key genes for mucosal melanoma in humans, dogs and horses that help prioritise targets for new cancer therapies

11 Feb 2019

Almost 2,000 unknown bacteria discovered in the human gut

Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America

11 Feb 2019

Sanger Institute steps up commitment to Equality, Diversity and Inclusion in Science

The Institute has joined a new coalition to remove biases in all aspects of life science research, including staff, experiment design, ...

Peter Lane and Fiona McConnell, Wellcome Images

5 Feb 2019

Study reveals how immune cells target different tissues

Tissue-specific receptors and adaptations enable localisation of T regulatory cells

Wellcome Sanger Institute, Genome Research Limited

4 Feb 2019

100 cancer organoid models developed by Sanger Institute scientists

The organoids developed by the Sanger Institute lead the UK effort as part of the international Human Cancer Model Initiative (HCMI) ...

Wellcome Sanger Institute, Genome Research Limited

4 Feb 2019

More than 100 new gut bacteria discovered in human microbiome

Study will help understand role of microbiome in health and disease

Dr Wolfgang Moroder, Wikimedia commons

31 Jan 2019

Genetic testing gives answers on developmental disorders during pregnancy

Researchers identified new diagnoses of known genetic disorders for 52 of the 610 pregnancies they genome sequenced

Dave Goulding, Wellcome Sanger Institute

31 Jan 2019

Immune master regulator orchestrates responses to parasite infection

Receptor IL-10R is vital to coordinating the body's immune response to whipworms, preventing uncontrolled infection and gut lining damage

30 Jan 2019

GARFIELD classifies disease-relevant changes in the genome

New approach reveals role of genomic changes in a disease, both within and outside genes

James Gathany, CDC PHIL

29 Jan 2019

Huge step forward in decoding genomes of small species

Scientists from the Wellcome Sanger Institute and Pacific Biosciences use just ‘half a mosquito-worth’ of DNA to produce a whole, high ...

23 Jan 2019

Ian Dunham appointed as Open Targets Director

Open Targets is the public-private partnership on the Wellcome Genome Campus that aims to transform drug discovery through the systematic identification ...

National Institutes of Health

21 Jan 2019

Genetic study reveals possible new routes to treating osteoarthritis

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines

NIAID

10 Jan 2019

CRISPR study reveals new immune system regulators

Map of T cell regulation could aid development of drugs that could activate the immune system

Dave Goulding, Wellcome Sanger Institute

2 Jan 2019

Mystery of Yemen cholera epidemic solved

Bacteria's genomes reveal that the most likely source of the disease came from Eastern Africa and entered Yemen with the ...

Wikimedia Commons

21 Dec 2018

Bird migration and conservation clues in robin and Turtle dove genomes

The genomes were read by the Sanger Institute and its partners, in celebration of Sanger’s 25th anniversary

21 Dec 2018

Statement from GRL Board accepting the findings of the independent investigation into a whistleblowing claim

Genome Research Limited Chair and Director of the Wellcome Sanger Institute outline steps the Institute will put in place to improve ...

19 Dec 2018

From eye drops to potential leukaemia treatment

Ingredient in pre-clinical treatment for retinal neovascular disease targets gene associated with acute myeloid leukaemia

17 Dec 2018

New strains of hepatitis C found in Africa

Study could inform hepatitis C treatment and vaccine development worldwide

Wellcome Sanger Institute, Genome Research Limited

6 Dec 2018

Sanger’s cloud computing wins award

High performance computing community recognises pioneering work of Sanger’s scientific IT teams

29 Nov 2018

Wellcome Genome Campus wins silver watermark to recognise its support for public engagement

Award reflects work to nurture a culture where public engagement is supported and encouraged

Wellcome Sanger Institute, Genome Research Limited

27 Nov 2018

Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing

Prediction resource could make CRISPR-Cas9 editing more reliable

14 Nov 2018

Human cell atlas study reveals how the maternal immune system is modified early in pregnancy

Cell map of healthy pregnancy could also help understand miscarriages or preeclampsia

8 Nov 2018

Recessive genes explain only small fraction of undiagnosed developmental disorders

Study will guide research and help estimate risk for future pregnancies

5 Nov 2018

Largest parasitic worm genetic study hatches novel treatment possibilities

Study helps understand how parasitic worms cause disease and uncovers potential new de-worming drugs

1 Nov 2018

Genetic code of 60,000 UK species to be sequenced

The Darwin Tree of Life Project, led by the Wellcome Sanger Institute, plans to read the genomes all known species of ...

1 Nov 2018

Launch of global effort to read genetic code of all complex life on earth

The project aims to create a new foundation for biology to drive solutions for preserving biodiversity and sustaining human societies

30 Oct 2018

Result of independent investigation into whistleblowing allegations released

Independent barrister's report concludes that no wrongdoing took place, but that Institute procedures could be improved

29 Oct 2018

Sanofi joins Open Targets

Unique public-private consortium to identify and prioritise therapeutic targets for new medicines using genomics, bioinformatics and traditional pharmaceutical research gains a ...

24 Oct 2018

Largest census of cancer genes to help understand drug targets

Cancer Gene Census paves the way for improvements in personalised medicine