From cancer, stem cells and organoids to COVID-19

Sanger scientists speak about their new roles in sequencing SARS-CoV-2 genomes.

4,000 years of contact, conflict and cultural change had little genetic impact on Near East

Only three periods had lasting effect on genetics of local people in Beirut

Analysis of COVID-19 Genomes reveals large numbers of introductions to the UK in March

The data reports, published by the COVID-19 Genomics UK Consortium (COG-UK), show the value in mapping COVID-19 lineages across the UK ...

An automated method for cell type discovery

Identifying cell types from single-cell RNA sequencing data is now more efficient than ever

Honour with Athena SWAN Silver Award

The Wellcome Sanger Institute and its associated organisations have been awarded by Athena SWAN for commitment to advancing women's careers ...

Potentially cancerous cells kept in check by competitive neighbours, study of oesophagus finds

Hope that understanding of the 'rules of the game' of clonal competition will lead to new therapies

Welcoming Athena SWAN Silver

"We are deeply committed to our values of equality, diversity and inclusion and these are fundamental to our work."...

Sanger scientists recognised by the Academy of Medical Sciences

Six Sanger researchers – past and present – have been welcomed into Fellowship of the prestigious organisation

‘These lowly organised creatures’: Earthworm sample collecting at the Sanger Institute

Few organisms have, as Darwin himself wrote, played such an important role in the history of the world.

Sanger scientist receives Chan Zuckerberg Initiative support for COVID-19 study

Roser Vento-Tormo will use single-cell technologies to understand human immune response to SARS-CoV-2 infection and the progression of the disease

New computational method unravels single-cell data from multiple people

Souporcell could assist personalised medicine and malaria research

Prising open the scallop genome

As part of the Sanger Institute’s 25 Genomes Project, the king scallop, Pecten maximus, had its genome sequenced.

Head of Cellular Genetics elected Fellow of the Royal Society

Sarah Teichmann is recognised for her pioneering computational biology and genomics work, leading to the Human Cell Atlas initiative

New tools to tackle malaria: translating from cutting edge research to real-world applications

This World Malaria Day we look at three ambitious projects, backed by the Sanger Institute Technology Transfer Office, which are ...

Puzzles and Parasites

Dr Stephen Doyle, in the Sanger Institute’s Parasites and Microbes Programme, has just been awarded a new UKRI Future ...

Sanger researcher backed through flagship fellowship

Dr Stephen Doyle has been awarded a UKRI Future Leaders Fellowship to explore the evolution of drug responses in parasitic worms

Sanger Institute to extend funding for Postdoctoral Fellows affected by COVID-19 shutdown

Funding will be extended for six months, including for those funded by third parties

Key nose cells identified as likely COVID-19 entry points

Study with Human Cell Atlas could help understand transmission of the virus

Normal human uterus is colonised by clones with cancer-driving mutations that arise early in life, study finds

Hope that insights into earliest stages of uterine cancer development will help to tackle one of most common female cancers

Tackling COVID-19 at the Sanger Institute

Staff at the Sanger Institute have joined the fight against the global COVID-19 pandemic.

Experience matters for immune cells - discovery of T cells response spectrum could help understand immune diseases

Study could help find better drug targets for asthma and rheumatoid arthritis

Mapping the Human Cell Atlas – charting the body’s cellular world

The Human Cell Atlas is being used to guide future research into human development, biology, health, and disease.

Raising Awareness of Neurodiversity in the Scientific Workplace

By Catherine Gater, Equality Diversity and Inclusion Programme Manager, Wellcome Sanger Institute In February, we welcomed Sara Rankin, Professor of

Sanger Institute scientist wins 2021 Biochemical Society award

Roser Vento-Tormo awarded an Early Career Research Award

UK launches whole genome sequence alliance to map spread of coronavirus

The Wellcome Sanger Institute will collaborate with expert groups across the country to analyse the genetic code of COVID-19 samples circulating ...

Sanger Institute and Wellcome Genome Campus temporarily closed to all but critical research

In response to the rapidly changing COVID-19 pandemic, the Sanger Institute and its neighbours on the Wellcome Genome Campus will close ...

Global human genomes reveal rich genetic diversity shaped by complex evolutionary history

Study will help identify the susceptibility of different populations to disease

The duty of care: a genetic balancing act?

Genetic testing is becoming a standard part of UK healthcare, with plans to expand its use. But who does this ...

New research on brain structure highlights cells linked to Alzheimer’s and autism

Astrocytes organised into layers in similar way to neurons

Being an LGBT+ Ally and Supporting Diversity

Jim Smith joined us at the Wellcome Genome Campus last year as part of the LGBT+ Network and Equality in ...

Dinosaurs and the high seas

Eugene Gardner is a Postdoctoral Fellow in the Human Genetics Programme. His research focuses on the genetics of developmental disorders.

Equality and Diversity Champions celebrated at the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

Origins of immune system mapped, opening doors for new cancer immunotherapies

Cell atlas of human thymus could help engineer improved therapeutic T cells

Otter genome to help understand genetic legacy of pollution crisis and secure species’ future

Genome will unlock wealth of data stored in DNA archives in bid to understand response to environmental changes

Gut bacteria’s interactions with immune system mapped

Cell atlas could reveal why some gut diseases affect specific areas

Cancer across the animal kingdom

Cancer, ageing and somatic mutation rates across species.

Sepsis and precision medicine: is it all in your genes?

Using gene expression data to stratify patients.

Sequencing and the Tree of Life

Progress and promise of the Earth Biogenome Project - a mission to sequence all known eukaryotic species.

The Human Cell Atlas: Understanding health to combat disease

Dr Kerstin Meyer, Principal Staff Scientist at the Sanger Institute, explains what it’s like to work on a such ...

Background information about the ICGC/TCGA Pan-Cancer Project

Overview of the Pan-Cancer Project

Cancer-causing culprits will be caught by their DNA fingerprints

Study within Pan-Cancer Project will help research into cancer prevention, diagnosis and treatments

Comprehensive study finds mutations in non-coding genome are infrequent drivers of cancer

Findings suggest efforts to develop new cancer treatments should primarily focus on protein-coding genes

Genomics in the cloud

The huge, international Pan-Cancer project is the first large-scale use of distributed cloud computing in genomics. As genomics becomes a ...

Unprecedented exploration generates most comprehensive map of cancer genomes charted to date

Pan-Cancer Project discovers causes of previously unexplained cancers, pinpoints cancer-causing events and zeroes in on mechanisms of development

Red and grey squirrel genomes could hold the key to the survival of reds in Britain and Ireland

Susceptibility to squirrel pox and genetic fitness of fragmented populations are key questions for red squirrel researchers

Tailor-made vaccines could almost halve rates of serious bacterial disease

Innovative study points the way to more effective vaccine design

Statement on Brexit by the Wellcome Sanger Institute, the European Molecular Biology Laboratory (EMBL) and the Francis Crick Institute

Statement on Brexit

Never too late to quit: protective cells could cut risk of lung cancer for ex-smokers

Ex-smokers have four times more genetically healthy cells than smokers, helping to protect them against lung cancer

2020 vision: supporting the people behind our science

Read about our ongoing and upcoming work to ensure that all our staff and students from all backgrounds can thrive

“If you know, there is a Nobel prize for you!” – Searching for the causes of cancer in Czechia

In a study spanning five continents, researchers are hunting for tell-tale ‘signatures’ left in DNA by the unknown causes of ...

#SangerAdvent

For our advent calendar on Twitter, this year we celebrated our staff from around the world. Each day, someone told ...

Analysis of CRISPR-Cas9 datasets leads to largest genetic screen resource for cancer research

Study will help narrow down the list of targets for the next generation of cancer treatments

Dr Konstantinos Tzelepis receives ASH–BSH Abstract Achievement Award for leukaemia target research

Award-winning abstract on METTL3 presented at American Society of Hematology meeting

Researchers identify over 140 genes linked to immune system regulation

First extensive immune profiling of mice reveals a vast catalogue of genes that regulate the immune system and model human disease

Appointments and changes to the Genome Research Limited Board

At the GRL Board meeting on 2 December 2019, David Willetts announced his intention to step down as Chair because of ...

Researchers identify new possibilities for the treatment of inflammatory bowel disease

Two molecular pathways found to be integral to maintaining balance in the digestive system

Root of childhood kidney cancer discovered

Pre-cancerous signatures found in healthy tissue point the way towards new treatment options

Causality and the genetic thesaurus

Manuel Tardaguila is a postdoctoral research scientist in Nicole Soranzo’s group. The group focuses on the application of large-scale ...

Best of both worlds

A degree apprenticeship offers the opportunity to earn whilst studying.

From childhood cancer to mapping human development: Pioneering scientist awarded 2019 Foulkes Foundation medal

Congratulations to Professor Muzlifah Haniffa, who has been recognised for her work on the immune system and childhood cancer

Dr Sam Behjati wins Liddy Shriver Early Career Research Award

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work in sarcoma cancer genomics

New malaria drug targets identified in liver stage of life cycle

Hope that new liver-stage drugs will help to counter the threat of antimicrobial resistance to current blood-stage medicines

Ambitious project to map genomes of all life on British Isles funded by Wellcome

An unprecedented insight to the diverse range of species on the British Isles will be made possible by Wellcome funding to ...

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Research explains why children often catch other infections after measles, and highlights the importance of vaccination

Perfume, jazz and immunogenetics

Dr Velislava Petrova is a Postdoctoral Fellow working in immunogenetics in Dr Carl Anderson’s group at the Sanger Institute. ...

Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

Researchers will examine both healthy and diseased intestinal tissue to identify key cell types involved in Crohn’s disease

Accumulation of DNA mutations found in healthy liver leads to disease

Largest study of its kind seeks to better understand how liver disease and hepatocellular carcinoma develop

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

Science on a bike

One man, one bike, and lots of genomics.

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early ...

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

Pioneering Computer Science

Celebrating Ada Lovelace Day and the achievements of women in science, technology, engineering and maths.

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use ...

A dangerous new Salmonella strain is emerging in sub-Saharan Africa

Researchers have discovered the first extensively drug resistant non-typhoidal Salmonella in the Democratic Republic of the Congo

Human kidney map charts our growing immune defence

New cell atlas reveals immune cells present in zones of human kidney

The biology of the brain

Studying mouse brain development can give insights into human neurodevelopmental and psychiatric disorders, as well as help diagnose rare genetic ...

Scientists hone in on DNA differences behind immune diseases

Search could help find drug targets for developing new treatments

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Strain of dangerous pathogen shown to have developed resistance to last-line-of-defence drug

Babies' gut bacteria affected by delivery method, Baby Biome project shows

Vaginal delivery promotes mother's gut bacteria in baby's gut

Health implications of the baby biome?

The method of a baby’s birth affects its collection of gut microbes – its microbiome. But we still don’t ...

Coding the Future

You’re never too young to start learning about DNA sequencing, software development and 3D printing.

500,000 whole human genomes will be a game-changer for research into human diseases

Following on from a successful pilot at the Sanger Institute, we are leading a project to sequence the genomes of all ...

Powering discovery in blood disorders and depression

The wealth of information available to researchers through UK Biobank is powering studies into human health and disease

Brown trout genome will help explain species' genetic superpowers

Eagerly awaited reference genome will allow conservationists to understand how the fish adapts to marine and freshwater environments

Fishing for answers in the brown trout genome

Brown trout are highly adaptable and its genetic make up may hold key answers to helping species survive climate change

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab has launched an exciting programme of events for Friday 27 and Saturday 28 September 2019, transforming parts of Cambridge, Peterborough ...

Flying to the Future

Dr Sophie Adjalley is a Postdoctoral Fellow in Marcus Lee's research group at the Wellcome Sanger Institute. Her research ...

Decoding first of 60,000 British species as Darwin Tree of Life branches out

The mission to map the genetic code of all known British species is underway

Malaria Cell Atlas: mapping a murderous parasite’s life cycle

Malaria - and the parasite that causes it - is complicated. Not only does the single-celled parasite move between humans ...

Malaria control success in Africa at risk from spread of multi-drug resistance

Regional populations of Plasmodium falciparum parasites in Africa are sharing genetic material in all directions – including genes that can confer resistance ...

Map of malaria behaviour set to revolutionise research

The Malaria Cell Atlas gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites ...

A lasting legacy

Meet the next generation of genomic scientists who are benefiting from our founder's generosity

Diarrhoea-causing bacteria adapted to spread in hospitals

Gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals

The modern rise of an ancient disease

Sanger scientists have sequenced the largest number of Treponema pallidum bacterial genomes to date. The bacterium causes syphilis, a sexually ...

Vaccines: Life savers against infectious diseases

Smallpox has been stamped out and various other diseases are declining, thanks to vaccination. But not all diseases have vaccines ...

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Research emphasises importance of ongoing genomic surveillance and infection control

Outbreaks and Antibiotic Resistance

Sophia David talks about her life as a postdoctoral researcher at the Sanger Institute.

Cancer drug data release set to power next wave of therapeutic discovery

Unique data comparing almost 1,000 cancer cell lines’ responses to 453 licensed and experimental drugs is now freely available to ...

Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

Medical student working in the Cancer Genome Project wins prize for colon cancer research

2019 Chief Medical Officer’s Report published

Sanger Institute researchers contribute to Professor Dame Sally Davies' eleventh annual report

Multi-drug resistant malaria spreading in Asia

Study reveals importance of ongoing genomic surveillance for malaria control strategies

Low doses of radiation promote cancer-capable cells

New research in mice helps to understand the risks around exposure to low doses of radiation, such as CT scans and ...

COSMIC: setting the path for tomorrow’s cancer treatments

From gene discovery, to database, to cancer treatment. COSMIC celebrates 15 years of fuelling cancer research.

Cancer, Caveman and Art

Thoughts on life as a postdoctoral researcher, combining science and art.

DECIPHER: Fuelling Rare Disease Research

More than 15 years ago, a hospital doctor realised that bringing people’s genetic data together could provide answers for ...

Connecting With Science

Staff at the Wellcome Genome Campus are supported to connect people with their science - find out more

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Seed Networks projects will focus on specific tissues, such as the thymus, lung, liver, kidney and immune system

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Genomic analysis shows that a significant number of strains are susceptible to penicillin combined with clavulanic acid

Melanoma, Personalised Medicine and the Middle Ages

Saskia Rudat talks about her life as a postdoctoral researcher at the Sanger Institute.

First lung map uncovers new insights into asthma

Understanding lung cells and their signals could help towards finding new asthma drug targets

What if medicine could be tailored ‘just for you’?

The information in our genomes is helping doctors diagnose and treat disease. But how far can personalised medicine go?

Tracking a deadly shapeshifter

A global child killer constantly changes its coat to evade destruction, but a worldwide network of scientists is using genetics ...

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo becomes an elected member of the European Molecular Biology Organization

Pneumonia mapped in largest genomic survey of any disease-causing bacterium

Study will help predict strains important for new vaccines

Breaking the mould – the story of penicillin

From a contaminated dish in London to saving lives on the D-Day beaches of Normandy (via dedicated scientists in Oxford ...

Day in the life: Software Developer – making research happen

Meet two people whose software skills enable the Sanger Institute's scientists to make their ground-breaking genomic discoveries

Major stem cell discovery to boost research into development and regenerative medicine

Expanded Potential Stem Cell lines of pig and human cells established

Equality and Diversity – not just about fairness

We've come a long way, but the journey isn't finished yet...

We’ve got the power

Running one of the largest biosciences data centres in Europe as efficiently as possible requires cool heads and even cooler ...

Global Strep A vaccine one step closer

Streptococcus genomes reveal potential vaccine targets present in over 20 countries worldwide

Infectious diseases make a comeback in Venezuela following healthcare crisis

The experiences of a friend of a Sanger Institute researcher reveal how parasites and bacteria are now threatening the country'...

CRISPR catches out critical cancer changes

Researchers reveal which gene fusions are critical for the growth of cancer cells and identify a new drug target for multiple ...

Sanger Institute animal research facility to close

Following a full review, the Sanger Institute will be closing its animal research facility

Caring for children with cancer

We explore the world of award-winning cancer scientist, Dr Sam Behjati

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

The 2019 recipient of the Dr Simon Newell Early Career Investigator Award has been announced as Dr Sam Behjati, whose career ...

Lead cancer researcher elected to Academy of Medical Sciences

Dr Peter Campbell receives prestigious Fellowship for his work in cancer genomics

Sanger’s super-sized sequencing scales new heights

We're celebrating: we've just read the same amount of DNA in one year as we achieved in the ...

More than just malaria

Researchers can change children's futures in many more ways than just helping to beat a killer disease...

Crusaders made love and war, genetic study finds

Sanger Institute researchers have produced whole-genome sequences from skeletons discovered in a 13th Century burial pit in Sidon, Lebanon

Rare genetic change provides clues to pancreas development

Understanding pancreas formation could aid research into type 1 diabetes treatments

Head of Human Genetics elected Fellow of the Royal Society

Matthew Hurles is recognised for his pioneering work in identifying the genetic basis of undiagnosed developmental disorders and paving the way ...

Six surprising animal cancer facts

Some creatures never get cancer, while others can catch it from the sea. Find out more in our list of ...

Mice reveal 38 new genes involved in hearing loss

Molecular pathways revealed could identify potential drug targets for restoring hearing

Cracking cancer with CRISPR

How Sanger scientists are using genetic surgery to understand the blueprint of life

Genetic code of WWI soldier's cholera mapped

The bacterium was isolated from a British soldier and stored for over 100 years before being revived and sequenced

New cancer drug targets accelerate path to precision medicine

Researchers discovered thousands of genes essential for cancer’s survival and ranked which ones show the most promise as drug targets ...

CRAM-ming it in

An impending flood of genomic data threatens to overwhelm scientists' abilities to store and share it. Next-generation compression seeks to ...

Sanger Institute scientist wins 2020 Biochemical Society award

Head of Cellular Genetics Programme wins GlaxoSmithKline prize

Tea-time News

Hot tea has been linked to oesophageal cancer - but it's not clear if it's the cause. Studying ...

Darwin Tree of Life sets down roots

Planning for the Darwin Tree of Life Project is underway. We welcome Professor Mark Blaxter, from the University of Edinburgh, who ...

Glass: The Poetry of Science

Dr Kate Carruthers Thomas explores gender in the workplace through the poetry of the Glass Ceiling, Glass Escalator, Glass Cliff ...

Catching pneumonia with caterpillars

Using caterpillars to investigate how human pneumonia works.

Commitment to collaborate on using genomics for pathogen surveillance across Europe

Combining the strengths of the European Centre for Disease Prevention and Control, the Wellcome Sanger Institute and the Centre for Genomic ...

A Day in the Life: Bioinformatician – collaboration, cancer and all life on Earth

Understanding the nature of life on Earth has been revolutionised by DNA sequencing. In the past we could only observe ...

Champions of equality and diversity celebrated

The winners were nominated by staff working at the Wellcome Genome Campus for their actions to advance equality, diversity and inclusion, ...

Major mutation pattern in cancer occurs in bursts

New resource could help understand origins of cancer

Cambridge heart research boosted by £6 million British Heart Foundation Research Excellence Award

Funding will allow Sanger Institute researchers and collaborators to apply cutting-edge genomics to help develop new heart disease diagnostics and treatments

Getting smart about artificial intelligence

Sanger researchers are harnessing the power of AI to extract new knowledge from the ever increasing flood of genomic data. ...

Roser Vento-Tormo leads single-cell research team at the Sanger Institute

The new group will identify the cells involved in the human female reproductive system, how they work, organise and communicate with ...

Improving global surveillance of antibiotic resistance

A WHO Technical Note has been published that will enable health authorities to make informed choices on the most appropriate molecular ...

Establishing the molecular blueprint of early embryo development

By studying the genetic activity of 116,312 single cells from 6.5 to 8.5 days after fertilisation, researchers have ...

Cancer comparison across species highlights new drug target

Scientists discover key genes for mucosal melanoma in humans, dogs and horses that help prioritise targets for new cancer therapies

Almost 2,000 unknown bacteria discovered in the human gut

Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America

I’ve never had chickenpox, what’s your superpower?

Gary Dillon, Business Development Manager at the Sanger Institute gives us his view on some of the powers and pitfalls ...

Sanger Institute steps up commitment to Equality, Diversity and Inclusion in Science

The Institute has joined a new coalition to remove biases in all aspects of life science research, including staff, experiment design, ...

Study reveals how immune cells target different tissues

Tissue-specific receptors and adaptations enable localisation of T regulatory cells

100 cancer organoid models developed by Sanger Institute scientists

The organoids developed by the Sanger Institute lead the UK effort as part of the international Human Cancer Model Initiative (HCMI) ...

More than 100 new gut bacteria discovered in human microbiome

Study will help understand role of microbiome in health and disease

The weird and wonderful world of organoids

Mini organs grown in the lab are boosting cancer research and drug discovery.

Genetic testing gives answers on developmental disorders during pregnancy

Researchers identified new diagnoses of known genetic disorders for 52 of the 610 pregnancies they genome sequenced

Immune master regulator orchestrates responses to parasite infection

Receptor IL-10R is vital to coordinating the body's immune response to whipworms, preventing uncontrolled infection and gut lining damage

GARFIELD classifies disease-relevant changes in the genome

New approach reveals role of genomic changes in a disease, both within and outside genes

Genetic Disability, Experience and the Sorting Society

Our genetic information is more accessible to us than ever before. But what do we want to know? Dr Felicity ...

Huge step forward in decoding genomes of small species

Scientists from the Wellcome Sanger Institute and Pacific Biosciences use just ‘half a mosquito-worth’ of DNA to produce a whole, high ...

Ian Dunham appointed as Open Targets Director

Open Targets is the public-private partnership on the Wellcome Genome Campus that aims to transform drug discovery through the systematic identification ...

Genetic study reveals possible new routes to treating osteoarthritis

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines

The importance of public engagement on antibiotic resistance

Nicole Wheeler talks antibiotics, antibiotic resistance and public engagement - and letting people use real software on real data to ...

Developing a view on Brexit

Sarion Bowers, Policy Lead at the Sanger Institute, reflects on how Brexit will affect science.

Disability, Inclusion and Science

Distinguished disability rights campaigner, David Ruebain, joined us last month at the Wellcome Genome Campus. He spoke on disability and ...

CRISPR study reveals new immune system regulators

Map of T cell regulation could aid development of drugs that could activate the immune system

Mystery of Yemen cholera epidemic solved

Bacteria's genomes reveal that the most likely source of the disease came from Eastern Africa and entered Yemen with the ...

Science in a conflict zone: Investigating cholera in Yemen

In addition to the civil war, Yemen is experiencing the worst epidemic of cholera ever recorded. We spoke to Ankur ...

Bird migration and conservation clues in robin and Turtle dove genomes

The genomes were read by the Sanger Institute and its partners, in celebration of Sanger’s 25th anniversary

Statement from GRL Board accepting the findings of the independent investigation into a whistleblowing claim

Genome Research Limited Chair and Director of the Wellcome Sanger Institute outline steps the Institute will put in place to improve ...

Human genome editing – the issues explored

Hayley Clissold from the Sanger Institute's policy team team explores the issues surrounding gene editing and human embryos

From eye drops to potential leukaemia treatment

Ingredient in pre-clinical treatment for retinal neovascular disease targets gene associated with acute myeloid leukaemia

Hasta la VISA, genomes!

From ragworts that are too common and the tricky toughness of truffles to the trials of getting DNA samples a ...

New strains of hepatitis C found in Africa

Study could inform hepatitis C treatment and vaccine development worldwide

Scientific Evidence in Policy Making

Evidence is a vital part of policy-making - but it's by no means the only part. We look at ...

Chernobyl: chasing a ‘catching’ cancer

Sanger researcher Alex Cagan travelled to Chernobyl’s nuclear exclusion zone for samples of cancer. But he isn’t investigating ...

Claims of genome edited babies shock the world

Our Policy Lead, Sarion Bowers, explores the extraordinary claims that the world’s first genome edited babies have been born.

Sanger’s cloud computing wins award

High performance computing community recognises pioneering work of Sanger’s scientific IT teams

Human Embryo Editing: science fiction or science fact?

Anna Middleton, Head of the Society and Ethics research group at Wellcome Genome Campus Connecting Science, reports on Prof He ...

Wellcome Genome Campus wins silver watermark to recognise its support for public engagement

Award reflects work to nurture a culture where public engagement is supported and encouraged

Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing

Prediction resource could make CRISPR-Cas9 editing more reliable

Dr Cordelia Langford wins BioBeat award

The ‘50 Movers and Shakers in BioBusiness 2018’ report identifies outstanding women who are developing revolutionary bioscience. Dr Cordelia Langford, ...

Human cell atlas study reveals how the maternal immune system is modified early in pregnancy

Cell map of healthy pregnancy could also help understand miscarriages or preeclampsia

Darwin Tree of Life: focusing on fungi and probing plants

We have much to thank fungi and plants for, and the Darwin Tree of Life project will help us to ...

Science as a human right

The idea that we should benefit from scientific advancement is something we may never have thought of as human right, ...

Recessive genes explain only small fraction of undiagnosed developmental disorders

Study will guide research and help estimate risk for future pregnancies

Largest parasitic worm genetic study hatches novel treatment possibilities

Study helps understand how parasitic worms cause disease and uncovers potential new de-worming drugs

Genetic code of 60,000 UK species to be sequenced

The Darwin Tree of Life Project, led by the Wellcome Sanger Institute, plans to read the genomes all known species of ...

Launch of global effort to read genetic code of all complex life on earth

The project aims to create a new foundation for biology to drive solutions for preserving biodiversity and sustaining human societies

Sequencing All Life On Earth – Facts and Figures

Scientists have announced an ambitious goal to sequence all of life on earth. Here are 10 top facts that help ...

The quest to sequence all life

What will reading the genomes of all life on earth uncover? And how does the Sanger Institute intend to lead ...

Result of independent investigation into whistleblowing allegations released

Independent barrister's report concludes that no wrongdoing took place, but that Institute procedures could be improved

Long live bats

The bat genome sequence could help us understand how these remarkable creatures are are reisitant to cancer, Ebola and SARS.

Sanofi joins Open Targets

Unique public-private consortium to identify and prioritise therapeutic targets for new medicines using genomics, bioinformatics and traditional pharmaceutical research gains a ...

Largest census of cancer genes to help understand drug targets

Cancer Gene Census paves the way for improvements in personalised medicine

Study reveals how gene activity shapes immunity across species

More than 250,000 single cells studied to chart evolution of antiviral and antibacterial immunity

Mutant cells colonise our tissues over our lifetime

Scientists may need to rethink the role of some cancer genes in the light of sequencing normal tissues

Milestone reached in major developmental disorders project

Eight years after launch, the Deciphering Developmental Disorders project has identified 49 completely new disorders and provided diagnoses to 4,500 ...

Solving the mysteries of developmental disorders: The DDD study

Alison Cranage talks to one family who have been helped by the Deciphering Developmental Disorders study

Genetics allows personalised disease predictions for chronic blood cancers

The approach could help doctors identify which patients may benefit from specific treatments or clinical trials

10 surprises from sequencing 25 new species

From exploding worms to cannibal crickets and adored arachnids to bewildering blackberries, Alison Cranage picks out the more bizarre discoveries ...

25 Genomes: The Common Starfish

The Starfish genome could offer new approaches to wound healing and into surgical glue, if only we can get enough ...

25 UK species' genomes sequenced for first time

The high-quality genomes will be made freely available to scientists to use in their research

25 years of pushing the scientific boundaries

From one human genome to hundreds of thousands, to every single cell in the body, to the genome of every ...

Journey to precision cancer treatment takes off with new passports tool

Cell Model Passports website offers 'one-stop shop' of information about cancer cell models covering their genetics, clinical history and drug sensitivities, ...

Newly sequenced mouse genomes unearth unknown genes

Sixteen newly sequenced mouse strains reveal unexpected diversity that could impact disease research

Skin is a battlefield for mutations

Our skin is a microcosm of Darwinian evolution where only the cells with the most useful characteristics survive

Rare genetic disorders more complex than thought

Study reveals that common genetic variants could affect the risk of rare developmental disorders

25 Genomes at New Scientist Live

Alongside robots, slime and VR machines, Sanger researchers were at New Scientist Live last week – talking genomes, Alison Cranage reports

Building capacity for genomic surveillance of malaria mosquitoes in Africa

Funding from the Bill and Melinda Gates Foundation will enable the Pan African Mosquito Control Association (PAMCA) to launch nine ...

Wellcome Sanger Institute at 25: how the genomic revolution is changing medicine

Leaps forward in knowledge have allowed scientists and doctors to start to bringing advances out of the lab and into the ...

The Beast from the East? Vespa velutina

Words and pictures by: Alex Cagan Date: 17.09.18 Prelude: Death from above Today, you are a honeybee and today you

LifeLab - Free events highlight discovery on your doorstep

Events include pop-up labs, a puppet show with a difference, story-telling and retro gameshows

International Vertebrate Genomes Project releases first 15 high-quality reference genomes

Publicly available data will impact studies on life, disease, and conservation efforts

Family tree of blood production reveals hundreds of thousands of stem cells

Humans have 10 times more blood-making stem cells than previously thought

Regulator protein key to malaria parasite’s lifecycle

Discovery of AP2-G master switch could help find new ways to prevent malaria

The golden eagle genome has landed

The golden eagle genome is the first sequence completed as part of the 25 Genomes Project. Kat Arney talks to ...

Newly sequenced golden eagle genome will help its conservation

The golden eagle is the first of 25 UK species to be completed as part of the 25 Genomes Project

Children’s bone cancers could remain hidden for years before diagnosis

Complex genetic rearrangements found in many Ewing sarcomas could help inform diagnosis and treatment

Human Cell Atlas gets a boost with first funding from Wellcome

Injection of £7 million will help to create a cellular 'Google map' of the human body, which could revolutionise health and ...

Kidney cancer's developmental source revealed

Study reveals that kidney cancers may arise from cells that haven't fully developed, offering a new target for treatment

Explore nature's genetic secrets in new exhibition

Curious Nature exhibition explores the Wellcome Sanger Institute’s 25th anniversary project to sequence the genomes of 25 UK species for ...

Gene study pinpoints superbug link between people and animals

The research could help with designing more effective ways to prevent bacterial transfer in farms and better antibiotic practices

Omer Bayraktar to lead new research group in the Cellular Genetics Programme

The Faculty appointment, starting in August 2018, will develop high-throughput pipelines to map human tissues one cell at a time

Genome damage from CRISPR/Cas9 gene editing higher than thought

Caution required for using CRISPR/Cas9 in potential gene therapies

Roots of leukaemia reveal possibility of predicting people at risk

Mutations in blood identify individuals at high risk of developing leukaemia

Cholera spread tracked at household level

The results could be used by public health officials to improve cholera control strategies

A new deal on data – articulating the contract between science and people

Now is the time for scientists to strike a deal everyone that benefits society as well as research, argue Anna ...

Wellcome Sanger Institute calls for the free movement of scientists across European borders following Brexit

The Institute has provided evidence for the UK Government Science and Technology Committee’s inquiry into an immigration system that works ...

Genomics offers new treatment options for infants with range of soft tissue tumours

Scientists uncover the genetic changes causing a group of related infant cancers

25 Genomes update. Yes, it’s been a while ...

More than half of the species' genomes have now been sequenced and assembled. But starfish, flatworms and truffles are a ...

Genetic discovery will help clinicians identify aggressive versus benign bone tumours

A genetic change affecting the transcription factor, FOS is specific to osteoblastoma, distinguishing it from osteosarcoma

Cambridge LIFE LAB project wins place in Europe's largest public science event

LIFE LAB will be led by Wellcome Genome Campus Public Engagement, and delivered by a consortium including the Wellcome Sanger Institute

Microbiotica enters into microbiome collaboration with Genentech

Sanger Institute spin out company signs strategic collaboration to apply its leading microbiome Reference Genome Database and Culture Collection to discover ...

Wellcome Sanger Institute sequences reference genomes of 3,000 dangerous bacteria

Gonorrhoea, deadly plague and dysentery among collection of bacterial genomes now publicly available through collaboration with Pacific Biosciences

New online course introduces bioinformatics to address skills gap

The free course ‘Bacterial Genomes: From DNA to protein function using bioinformatics’ was developed by researchers from the Wellcome Sanger Institute

Deadly malaria’s evolution revealed

Study shows Plasmodium falciparum emerged earlier than thought and gives clues to how deadly parasites arise

Gonorrhoea surveillance study maps antibiotic resistance across Europe

Genomic approach could help doctors monitor emerging resistance and prescribe most effective antibiotics in the future

A trusty guide for exploring the complexity of cells

Single cell RNA sequencing data can be used to identify cell types. Martin Hemberg and Vladimir Kiselev explain how their ...

Sanger’s Head of Cancer, Ageing and Somatic Mutation Programme honoured by EMBO

Dr Peter Campbell becomes an elected member of the European Molecular Biology Organization

Professor Nicole Soranzo and Dr David Adams elected to the Academy of Medical Sciences

Sanger researchers focusing on human genetics and cancer are recognised with prestigious Fellowships

Professor Dominic Kwiatkowski joins the Fellowship of the Royal Society

Head of Sanger’s Parasites and Microbes Programme elected Fellow of the Royal Society

Machine learning flags emerging pathogens

A new machine learning tool could be useful for flagging dangerous bacteria before they cause an outbreak, from hospital wards to ...

On Job Satisfaction

Dan Mead is a happy man, here's why ...

Leukaemia: protective role of Y chromosone gene discovered

Researchers have found that UTY, a gene on the Y chromosome, protects male mice lacking the tumour-suppressing UTX gene on the ...

Celgene joins Open Targets Initiative

Celgene will expand the Initiative's collective efforts to transform drug discovery through the systematic identification and prioritisation of drug targets

Deadliest human malaria parasite reveals the genomic chinks in its armour

Study reveals essential genes for Plasmodium falciparum to identify new drug targets

The trouble with Crickets

Crickets' genomes are tricky things, just when you think you know how big they are, they just get a whole ...

Emma Davenport and Hilary Martin to lead research groups in the Human Genetics Programme

The faculty appointments, starting in Autumn 2018, will help the Sanger Institute establish foundational knowledge of how variation in DNA contributes ...

New Sanger Institute Human Cell Atlas projects funded by the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation

Projects will build computational tools to support the global Human Cell Atlas initiative to map every cell type in the body

Advance access to data: Researchers post genetic profiles of human and mouse cells on Human Cell Atlas online portal before publication

Prior to publishing their results, researchers compile and make raw data openly accessible on the preview version of the HCA Data ...

First seeds of kidney cancer sown in adolescence

Insights from this study present an opportunity to develop approaches for early detection and early intervention in kidney cancer

Single cell technology and organoids reveal every bowel tumour and bowel cancer cell have unique genetic fingerprints

Study could help researchers target cancer-specific processes for cancer prevention or to develop treatments

20 year-old mystery of malaria vaccine target solved

Discovery of human receptor for TRAP protein could help improve development of an effective malaria vaccine

New computational method reveals where genes are expressed

06.04.18 Valentine Svensson explains how the new computational method SpacialDE interprets single-cell data to identify which genes are switched on ...

Whole genome sequencing will ‘transform the research landscape for a wide range of diseases’

UK Biobank enters exciting new phase of genetics research

Malaria Cell Atlas launched: Parasite development mapped in unprecedented detail

The Malaria Cell Atlas will allow researchers to identify weak points in the parasite’s lifecycle for intervention with drugs

New online course launched to help doctors and nurses better understand how genomics can battle bacterial diseases

Free three week course on Bacterial Genomes: Disease Outbreaks and Antimicrobial Resistance starts on April 30th

NUCLEUS project welcomes new consortium member: Wellcome Genome Campus in Cambridge

The ambitious HORIZON 2020 NUCLEUS project has been further strengthened by the joining of the Wellcome Genome Campus in Cambridge, UK ...

First 'non-gene' mutations behind neurodevelopmental disorders discovered

The study is a positive step towards providing an explanation for children with undiagnosed neurodevelopmental disorders

Sanger Institute opens up its life sciences leadership development courses

Five bespoke courses tailored to the needs of leaders at all levels, from new supervisors to established managers, are being offered ...

Switch discovered to convert blood vessels to blood stem cells during embryonic development

Findings could aid research into creating new blood cells for transplants and understanding cancer metastasis

New osteoarthritis genes discovered

The results could open the door to new targeted therapies for this debilitating disease in the future

Placenta defects critical factor in prenatal deaths

Research in mice reveal genes whose roles appear to be vital in developing healthy placentas

A cautionary tale about blackberries [2/2]

Dan Mead discovers that conferences can be a great way to build fruitful research collaborations...

John Sulston (1942-2018) – Founding Director of the Wellcome Sanger Institute

We are deeply saddened to announce the death of Professor Sir John Sulston, Founding Director of the Wellcome Sanger Institute

A cautionary tale about blackberries...[1/2]

Finding a blackberry bush was as easy a pie, but then Dan discovered that there are 300 different species... and ...

Human Cell Atlas takes first steps towards understanding human development: First 250 thousand developmental cells sequenced

The Human Developmental Cell Atlas programme will create genomic reference maps of all the cells that are important for human development

Supporters of women in science shine

Role models from across the Wellcome Genome Campus have been recognised for their work in promoting gender equality

Genomic Expressions: Express yourself at new exhibition

The exhibition is part of the Wellcome Genome Campus’ Open Saturdays programme dates include 24 March, 21 April, 19 May and ...

Genetic roots of major depression: three new genetic risk markers discovered

New research taking people's life histories into account finds new genetic regions that may increase the risk of major depression

Missing link found between pathways involved in cell development

The new mechanism could be essential for processes that need a rapid response - such as organ repair, immune response or cancer ...

UK Bioindustry Association (BIA) launches new Genomics Advisory Committee at annual Committee Summit

The UK Bioindustry Association (BIA) launched its newest Advisory Committee, focused on the issue of genomics, chaired by Adrian Ibrahim from ...

Sequencing a superbug: How typhoid became extensively drug-resistant

20.02.18 Gordon Dougan and Elizabeth Klemm report how their laboratory has been sequencing the DNA of Salmonella Typhi strains that ...

Typhoid outbreak: genetic cause of extensive drug resistance found

The results suggest that treatment options for typhoid treatment are running out and preventative strategies are needed

Getting a hold of samples... [part 2]

Dan Mead continues his hunt to collect all 25 species to sequence...

Major funding for Cambridge to transform health through data science

Cambridge is amongst six sites across the UK to be awarded a total of £30M funding by Health Data Research UK, ...

Is food love-hate coded in your DNA?

This Valentine’s special is the first of an exciting new programme of monthly Café Sci events in Cambridge

Multidrug resistant malaria spread under the radar for years in Cambodia

Study suggests that ongoing genomic surveillance is vital to inform malaria control strategies

Getting a hold of some samples...

Sequencing new species is hard enough, but finding out where you can get a sample to work with can be ...

Hidden genetic effects behind immune diseases may be missed, study suggests

For the first time immune cells created from human induced pluripotent stem cells (HiPSCs) have been used to model immune response ...

Sarah Teichmann awarded the Genetics Society’s 2018 Mary Lyon Medal

Award recognises Dr Teichmann’s “outstanding research” in understanding how the immune system works by using genomics and bioinformatics approaches

BioBright, Sanger Institute aim to cut drug-development time

Collaboration promises better, more reproducible biomedical data

On choosing the 25 species for the 25 Genomes Project

From 2 billion species to just 25 - how the Sanger Institute chose which species to sequence

Big data for mosquito control

20.12.17 Alistair Miles explains how the Anopheles gambiae 1000 Genomes project is helping to understand the evolution and spread of ...

We let the public decide five of our species....

5,000 people participated and there were over 150,000 page views - and 5 winners

Concerning spiders, and where to find them

Dan Mead, our 25 Genomes Project Coordinator, is on the search for spiders that like to walk on water

Giant Hogweed sampling, a retrospective

Armed with a mobile phone, 4G signal, orange protective gloves, a tyvek suit, face shield and Google Maps, Dan Mead ...

25 species revealed for 25 Genomes Project

Blackberry to robin, bush cricket to brown trout - the 25 species all reside in the UK

£3.9m project to support elimination of the world’s leading infectious cause of blindness

A major new research project that aims to accelerate the elimination of trachoma has been launched

Takeda joins drug target discovery initiative

Takeda will expand the skills and scientific background of Open Target's existing partners by bringing expertise in gastroenterology, central nervous ...

Life in the fast lane: rapid reproduction in malaria parasites

1.12.17 Brandon Invergo investigates how quickly malaria parasites can prepare to sexually reproduce once they are picked up by a ...

Largest genetic study of mosquitoes reveals spread of insecticide resistance across Africa

Genetic resource will help develop new tools to support the campaign against malaria in Africa

Unforeseen new drug target discovered for acute myeloid leukaemia (AML)

Scientists find that inhibiting the METTL3 gene destroys AML cells without harming non-cancerous blood cells

Alzheimer’s Disease: The puzzle we’re so desperate to solve

13.11.17 Fiona Calvert is using stem cells to study Alzheimer's Disease. Read her shortlisted article for the Max Perutz ...

Risk of cholera epidemics estimated with new rule book

Researchers from across the world have studied cholera outbreaks in Africa, Latin America and the Caribbean from the last 60 years

25 new genomes to celebrate 25 years of the Sanger Institute

Blackberry to robin, bush cricket to brown trout - the 25 species all reside in the UK

A step towards an effective, multi-target vaccine for malaria

Gareth Powell and Leyla Bustamante helped to find five targets on the parasite that could be the basis of a ...

Professor Sharon Peacock to be awarded the 2018 Microbiology Society Unilever Colworth Prize

This Prize is awarded for significant contributions in the field of microbiology

Study shows routine genomic surveillance of MRSA can detect unsuspected outbreaks

Catching outbreaks early could prevent further spread and reduce the number of people involved

Five new malaria targets that could lead to an effective vaccine

Scientists have identified five targets that reduce the parasite’s ability to invade red blood cells

1 to 10 mutations are needed to drive cancer, scientists find

The results show the number of mutations driving cancer varies considerably across different cancer types

The international Human Cell Atlas publishes strategic blueprint; announces data from first one million cells

Blueprint describes path forward for cataloging every cell in the human body; cell data release to be available to research community

Results of the Chordoma Genome Project reveal genetic changes that drive chordoma

DATE: 12/09/17 By: Chordoma Foundation Team Editor’s Note: This blog is reproduced from The Chordoma Foundation blog, a charity ...

Yeast spotlights genetic variation’s link to drug resistance

Study shows that genetic diversity influences which adaptive mutations cause antimicrobial resistance

Genomics reveals how competition between bacteria affects the impact of vaccination

Study identifies the consequences of fierce competition between bacterial strains surviving after vaccine introduction.

New drug hope for patients with rare bone cancer

Patients with a rare bone cancer of the skull and spine – chordoma – could be helped by existing PI3K inhibitor drugs, researchers ...

New type of stem cell line produced offers expanded potential for research and treatments

Scientists have created Expanded Potential Stem Cells (EPSCs) that, for the first time, can produce all three types of blastocyst stem ...

Helping apprentices lead the field in big data

Anglia Ruskin and Wellcome Trust Sanger Institute team up to deliver new training

UK students working with scientists to help prevent childhood parasite infection

Genome Decoders, a UK-wide schools project to help solve a global parasite problem by decoding the whipworm genome, has launched

Genome editing reveals role of gene important for human embryo development

CRISPR-Cas9 genome editing shows that the protein OCT4 is essential in very early days of human embryo development

Huge genetic diversity among Papuan New Guinean peoples revealed

Genetic diversity found to mirror linguistic and cultural diversity among Papuan New Guinean people

Immunotherapy treatment option for selected breast cancer patients, genetic study suggests

Opens up the possibility of another therapy option for approximately 1,000 breast cancer patients in the UK

Type 2 diabetes is being misdiagnosed in African Americans, genetic study suggests

Around 650,000 African Americans in the US have a unique genetic variant that significantly reduces the accuracy of the HbA1c ...

Sanger Institute responds to UK Government's position paper on future EU and UK science collaboration

Government’s position paper offers ideas for negotiating a special status for UK research with European Union funding bodies

The Brain Tumour Charity grants WINDOW Consortium £1.5 million for new research into combination therapies to treat brain cancer

The Dutch/British consortium will study glioblastoma

The Wellcome Trust Sanger Institute responds to the Life Sciences Industrial Strategy

The Life Sciences Industrial Strategy recognises the key role genomics and genetics will play in future healthcare provision

Bowel cancer study reveals impact of mutations on protein networks

The results offer clearer picture of the cellular processes behind bowel cancer, and may enable future tailoring of drug treatments to ...

New genetic analysis reveals late spread of breast cancer and backs key role of early diagnosis

These results show that catching and treating breast cancer before it spreads is a realistic goal

Editing embryos – Could you? Would you? Should you? Views from Genetic Counsellors

03.08.17 This week the American Society of Human Genetics issued a policy on the application of germline editing – the ability ...

Mystery epidemic that crossed species in Iceland is solved

Scientists have identified and tracked the bacteria that caused an epidemic respiratory disease in Iceland’s native horse population

Present-day Lebanese descend from Biblical Canaanites, genetic study suggests

Scientists sequenced the genomes of 4,000-year-old Canaanite individuals and compared these to other ancient and present-day populations

New global health initiative for genomic surveillance of antimicrobial resistance funded by NIHR

The Centre for Genomic Pathogen Surveillance to house the Global Health Research Unit to monitor antibiotic resistant bacteria around the globe

MRSA emerged years before methicillin was even discovered

Study shows that Staphylococcus aureus acquired the mecA methicillin resistance gene in the mid-1940s

'Superbugs' study reveals complex picture of E. coli bloodstream infections

Genetic study of E. coli showed that drug resistant ‘superbugs’ don't always out-compete other strains.

Placing drug-resistant strains of E. coli into a broader context

18.7.17 Samples of E. coli were isolated from patients with bloodstream infections over eleven years. Teemu Kallonen, Julian Parkhill and ...

Richard Durbin awarded the Royal Society’s Gabor Medal

Award recognises more than 25 years of developing computational biology and genomic science

Largest study of malaria gene function reveals a finely tuned genome full of potential drug targets

Scientists discover that two thirds of the malaria parasite’s genes studied are essential for growth, meaning there are many more ...

Malaria parasites: more susceptible to a knock-out blow than we thought?

13.7.17 Theo Sanderson and Ellen Bushell explain how characterising the role of many of the malaria parasite’s five thousand ...

Malaria parasites able to sense their host's calorie intake

Scientists have found that the odds of dying with a malaria infection are lower when the host eats lower amounts of ...

The Wellcome Trust Sanger Institute responds to the Chief Medical Officer's annual report 2016: Generation Genome

The UK Chief Medical Officer's report has highlighted the key role genomics and genetics will play in future healthcare provision. ...

Artificial bile ducts successfully grown in lab and transplanted into mice could help treat liver disease in children

New method opens the way to develop future treatments and reduce the need for liver transplants

Chief Medical Officer’s annual report 2016: Generation Genome highlights the potential for pathogen genomics in patient diagnosis and infection control

04.07.17 The UK Chief Medical Officer's Report has highlighted the vital role genetics and genomics will play in UK ...

‘Like sugar in milk’: Parsi populations from India and Pakistan

29.06.17 Qasim Ayub explains the results of a genetic analysis of the Parsi population.

Inflammatory Bowel Disease: Scientists zoom in on genetic culprits

Scientists produced a high-resolution map to investigate which genetic variants have a causal role in the disease

Professor Eleftheria Zeggini honoured as Young Scientist by World Economic Forum

Professor Eleftheria Zeggini, Group Leader in the Human Genetics programme, has been recognised by the World Economic Forum for her contributions ...

Study reveals how sex 'blindspot' could misdirect medical research

Scientists have shown that the differences between male and female mice impact on biomedical research

Existing drugs could benefit patients with bone cancer, genetic study suggests

New research suggests a subset of bone cancer patients are likely to respond to IGF1R inhibitors based on their genetic profile

Babies' DNA affects mothers' risk of pre-eclampsia in pregnancy

Strong evidence found for a number of genetic variations near to the FLT1 gene being linked to increased risk of pre-eclampsia

Hidden lives revealed in a new exhibition at the Wellcome Genome Campus

The Hidden Lives exhibition offers an exciting insight into the lives and origins of our East Anglian ancestors, greatly enriched from ...

Chan Zuckerberg Initiative supports Human Cell Atlas data platform

The Data Coordination Platform will check, share and analyse the vast amounts of diverse information generated

Isolated Greek villages reveal genetic secrets that protect against heart disease

A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute ...

Natural resistance to malaria linked to variation in human red blood cell receptors

First study to identify protective effect of glycophorin gene rearrangements on malaria

Scientists unveil the UK’s largest resource of human stem cells from healthy donors

Powerful resource created for scientists studying human development and disease

Cancer drug design targeted by COSMIC's new 3D system

Collaboration between Wellcome Trust Sanger Institute and Astex Pharmaceuticals brings together COSMIC (Catalogue of Somatic Mutations In Cancer) and wwPDB (worldwide ...

Dr Matt Hurles elected to the Academy of Medical Sciences

Head of the Human Genetics Programme recognised with prestigious Fellowship

Genetics and environment combine to give everyone a unique sense of smell

Genetically identical mice develop different smell receptors in response to their environments

New chlamydia drug targets discovered using CRISPR and stem cells

Scientists have created an innovative technique for studying how chlamydia invades our immune system

Mouse’s internal clock could reveal the secrets of ageing

Researchers have discovered that mice’s DNA ages in a similar way to humans

Some genes are less helpful than others

Some people are naturally missing one of their 20,000 genes - and sometimes the results can be beneficial, pointing to new ...

How genetic mutations affect development more complex than previously thought

Turning off the same gene in mice can result in different physical changes, despite similar genetic backgrounds

New deep learning technique offers a more accurate approach to single-cell genomics

Scientists are using the emerging technology of deep learning to fill in the missing gaps of single-cell genomic analysis

Sanger parasite researcher recognised by British Parasitology Society

Dr Matthew Berriman awarded the 2017 CA Wright Medal for his leading role in understanding protozoan and helminthic parasites through genomics

Single-cell sequencing reveals immune cell coordination breaks down with ageing

T cells from older mice were more variable and less coordinated

New tool allows analysis of single-cell RNA data in pre-malignant tumours

Single Cell Consensus Clustering (SC3) tool more accurate and robust than previous methods for sorting cells into groups

New stem cell method produces millions of human brain and muscle cells in days

The new platform technology, OPTi-OX, optimises the way of switching on genes in human stem cells

First mutations in human life discovered

Archaeological traces of embryo development seen in adult cells

Novel genes identified that help suppress prostate and other cancers

Study reveals possible drug targets for cancers with a faulty PTEN gene

1 in 5 patients with breast cancer could benefit from existing treatment, genetic study reveals

Study shows that a greater number of breast cancers are genetically similar to rarer cases with faulty BRCA1 or BRCA2 genes

Role models recognised for supporting women in science

Eleftheria Zeggini of the Wellcome Trust Sanger Institute and Helen Parkinson of the European Bioinformatics Institute (EMBL-EBI) have been recognised for ...

Matt Hurles appointed as new Head of Human Genetics Programme

Dr Matt Hurles, leader of the DDD Programme and co-founder of Institute spin-out Congenica, has been confirmed as the new Head ...

Latest genomic technology uncovers secrets of immune system's response to malaria

Scientists reveal how mouse T cells develop

Sanger Institute's COSMIC database expands cancer cloud capabilities at the Institute for Systems Biology

The Institute for Systems Biology has embedded the COSMIC data within their Cancer Genomics Cloud (CGC), which is a cloud-based platform ...

Malaria vaccine target’s inv