Genome damage from CRISPR/Cas9 gene editing higher than thought
Roots of leukaemia reveal possibility of predicting people at risk
Wellcome Sanger Institute researchers and collaborators found that patients with acute myeloid leukaemia (AML) had genetic changes in their blood years before they suddenly developed the disease. The study published in Nature shows that further research could allow earlier detection and monitoring of people at risk of AML in the future.
Cholera spread tracked at household level
For the first time, the transmission of cholera has been tracked at the household level across Dhaka, Bangladesh, a city with a ‘hyper-endemic’ level of the disease. Researchers from the Wellcome Sanger Institute and their collaborators found that nearly 80 per cent of the cholera transmission in Dhaka occurred between people who shared a household. The results of the large-scale genomic study could be used by public health officials to improve cholera control strategies.
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A cross-sectional analysis of ITN and IRS coverage in Namibia in 2013.
Malaria journal 2018;17;1;264
Increasing nursing capacity in genomics: Overview of existing global genomics resources.
Nurse education today 2018;69;53-59
Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles.
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology 2018
Immune Cell Dynamics Unfolded by Single-Cell Technologies.
Frontiers in immunology 2018;9;1435
An enhanced CRISPR repressor for targeted mammalian gene regulation.
Nature methods 2018