British and Irish project at forefront of global effort to map genomes of all life on Earth

Activity on Earth BioGenome Project and affiliated initiatives due to ramp up considerably in 2022

Unprecedented cellular maps of tissues enabled by new tool

Ability to combine cell function and spatial information key to understanding life at molecular level

New centre to explore links between organisms and their microbiomes

The £10m Leverhulme Centre for the Holobiont aims to create a green revolution in agriculture, rescue threatened species, and restore habitats

Superbug MRSA arose in hedgehogs before use of antibiotics

Scientists have found evidence that the antibiotic resistant superbug MRSA arose in nature long before the use of antibiotics, which has ...

Rapid immune response in children protects them from COVID-19, genetic study finds

Discovery of importance of interferon response in preventing serious infection will underpin new diagnostics and therapeutics

21 things we’ve learned in 2021

We would like to bring you 21 things that we have learned in the year 2021

Sanger researcher invited to deliver 2022 Balfour Lecture 

The award marks Dr Sam Behjati’s contributions to genetics research, as an outstanding young investigator

Sequencing COVID variants: latest stats

Latest numbers for coronavirus genome sequencing at the Sanger Institute

The Story of Dogs

Dogs, descended from wolves, were the first animals to be domesticated by humans, some 40,000 years ago. New research, using ...

Darwin Tree of Life in 2021: Tireless fieldwork and the first beautiful genomes

Teams have been collecting species across the UK - from the mountains of Scotland, to the sea caves of Wales, and the ...

Genetic history of British Pakistanis mapped for the first time

Analysis of genomic data from the Born in Bradford study will help to ensure those of Pakistani ancestry benefit from advances ...

New centre to foster global conversations about ethical issues raised by science

The University of Cambridge and Wellcome Connecting Science announce the launch of the Kavli Centre for Ethics, Science, and the Public, ...

New link between malaria parasites and sickle haemoglobin identified 

Some malaria parasites in sub-Saharan Africa have genetic variants that allow them to infect those with sickle haemoglobin, which is normally ...

Launch of Fellowship programme to support next generation of Black scientists

The three-year Fellowship is open exclusively to early-stage Black heritage researchers who studied at a UK institution and offers a fully ...

Research Excellence: The Power of Diversity

The Sanger Institute recently hosted three speakers as part of a new series - Research Excellence: The Power of Diversity. Read a ...

Human parasite’s daily rhythms could be targeted for better treatments

The parasitic worm that causes the neglected tropical disease, schistosomiasis, has daily rhythms in gene expression, including genes that could be ...

Spinning out the science

Much of the Sanger Institute's research has the potential to positively impact people's lives around the world: from a ...

Uterus study is important step towards understanding diseases that affect one third of women

The study's organoid-based techniques provide a sophisticated model of endometrial function and will form a blueprint for discovering how other ...

Syphilis is back and it is global, genetic study suggests

Disease incidence has risen sharply in recent decades

IBS biomarker identified that could help personalise diet and treatment

Half of people with Irritable Bowel Syndrome have a distinct microbiome compared to healthy people, and they respond better to a ...

A Space for Science

"The most incredible things in research are the incidental findings, the serendipitous connections, moments when you are looking for one thing ...

Sanger celebrates Highly Cited Researchers

A number of researchers from the Wellcome Sanger Institute have been named on Clarivate's Highly Cited list

Researchers will map immune cells across Latin America with support from CZI

Researchers will sequence immune cell diversity across Latin America for the first time, shedding light on how ancestry impacts the immune ...

Whole Genome Sequencing data on 200,000 UK Biobank participants are made widely available for research through unique public-private partnership

First release from world’s largest whole genome sequencing project could help researchers to understand the genetic determinants of disease and ...

Covid Connections – Big Data in a Pandemic World

Researchers discuss COVID-19 genome data and its complexities, data sharing and security, and their careers in data science

New database of 660,000 assembled bacterial genomes sheds light on the evolution of bacteria  

A vast, curated collection of bacterial genomes has been created that allows the community unprecedented access to data.

A Cellular Landscape

The connections between the external and internal environments are explored in a new experimental short film ‘Call of the Silent Cell’. ...

Sanger researchers to tackle deadly brain cancer with ‘tissue time machine’

Sanger Institute scientists are starting a new project that will integrate information from spatial transcriptomics with single-cell RNA and DNA sequencing, ...

Sanger employee recognised in BioBeat’s top 30 trendsetters in UK life sciences  

Burcu Bronner-Anar is celebrated in BioBeat’s ‘Movers and Shakers in BioBusiness report’ that lists 30 UK trendsetters who are tackling ...

Art and science unite to explore the intricacies of the human body 

The exhibition, One Cell At A Time opens on the 29th October 2021. It combines art and science to explore the ...

Huge global variation in oesophageal cancer incidence not due to a unique pattern of DNA damage 

Major global research collaboration adds new piece to the complex puzzle of oesophageal cancer

A Health Data Research UK Black Internship Programme experience

This Black History Month, we asked Ifeanyi Chukwu to reflect on his recent experiences as an intern within HDR UK’s ...

Marine medicines from the slimiest of worms

“They’re not cute or charismatic. They have toxic mucus. But I like nemerteans because no one is rooting for them – ...

The inside story of England COVID pandemic described in new study

The most detailed analysis of SARS-CoV-2 genomics surveillance to date shows COVID-19 as a series of overlapping epidemics rather than a ...

Mutated cells drive out early tumours from the oesophagus

Normal human oesophagus carries a high number of mutations, but tumours are rare, due to mutant cells eliminating early tumours

Mutations in liver cells linked to liver disease and fat metabolism  

Mutations linking liver disease with obesity and diabetes have been identified, leading to new understanding about how systemic diseases interact

Talent in Diversity

Over this year's Black History Month, we are celebrating the diversity of talent here at the Sanger Institute. For this ...

We are molecular mosaics

Quantifying the mutational landscape of the human body

Talent in Diversity

Over this year’s Black History Month, we are celebrating the diversity of talent here at the Sanger Institute. Here, ...

Higher rates of mutation alone are not to blame for age related disease  

Researchers have found that cells tolerate many more mutations than previously thought, without impacting their function

Cell atlas reveals how blood and immune systems form in developing bone marrow

Study fills large knowledge gap and has important implications for diagnosis and treatment of immune deficiencies and leukaemia

Genomics for all

In this guest post, Sadye Paez and Marcela Uliano-Silva explore what it takes to sequence the genomes of all life ...

Eimeria: the chicken parasite costing farmers billions

By sequencing the genome of this single-celled coccidian parasite, scientists hope to develop better vaccines to protect poultry from a ...

Celebrating Sanger Postdocs

This week (20th-24th September) is Postdoc Appreciation Week - a time to celebrate the fantastic contribution postdoctoral scientists make.

Evidence-based national policies are essential to curb local COVID-19 infections

By using genomic surveillance and mobile phone data, researchers have uncovered useful insights into the management of the COVID-19 pandemic in ...

Wellcome Sanger Institute recognised as Charity Times finalist for outstanding contribution to pandemic response

Staff praised for dedication and excellence as they work to sequence coronavirus genomes, helping to shape the pandemic response

Development study reveals origins of Inflammatory Bowel Disease

Creating Cell Atlas of Human Development will transform understanding of health and disease

International research consortium to tackle tumour drug resistance using single-cell sequencing

Sanger Institute scientists join a new collaborative research project that will use single-cell sequencing to tackle drug resistance and develop smarter ...

Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases

Projects will create cell atlases of the paediatric ovary, skin and brain to better understand human biology and provide reference datasets ...

Loss of gene linked to differences in brain size  

Inactivation of the MAGEE2 gene, seen widely across East Asia, results in enlarged brains in men and decreased brain size in ...

Researchers discover individual variation in how our bodies develop and acquire mutations 

Studies will help to establish baseline for human development and acquisition of mutations during life in the soma and the germline

Defining Success

Five inspirational speakers share their journeys, definitions of success, and lessons learnt in the space of diversity and inclusion.

Link between amino acid and a range of common diseases could help predict personal risk

Researchers have identified a link between mitochondrial DNA variants, amino acid fMet, and a range of common, late-onset diseases

Fighting the spread of drug-resistant malaria with genetic surveillance  

In-depth genomic surveillance of the malaria parasite over multiple countries has tracked regions of drug resistance

From Mild to Mortal

An expert panel discuss some of the latest research into human genetics, immunology and COVID-19

Researchers track how microbiome bacteria adapt to humans via transmission

New research has shed light on how transmission of gut bacteria influences its evolution and functions

Genetic study reveals ancient human adaptation to agriculture and climate change in Middle East

The most comprehensive study so far of genetic diversity in the Middle East has given a glimpse into the lives of ...

New therapeutic target discovered for a number of aggressive cancers

An RNA-modifying protein elevated in some aggressive cancers has been shown to be a promising target for new drug development

The evolutionary history of humans

Mohamed Almarri has recently completed a PhD studying population history and global genetic diversity.

OKRs: Strategic planning the Google way

We’re refreshing the way we do strategic planning, using Objectives and Key Results (OKRs)

Reflections on race and equity in research: One year on...

One year on from the murder of George Floyd, we take a step back to reflect on our reactions and ...

Covid Connections – Variant or Villain

The second COVID connections talk brought together experts from COG-UK to discuss SARS-CoV-2 variants.

Bacterial Biomes

"we are well aware that what we know about already is just a small percentage of the diversity that ">...

Water vole genome will help boost conservation of one of UK's most endangered mammals

The water vole genome is published as part of the Darwin Tree of Life Project to assemble the genomes of 70, ...

Cellular signatures of kidney tumours discovered

This method of identification holds promise as a tool for diagnosing patients with rare cancers

Getting to the heart of the matter

Exploring the genomics of inherited cardiomyopathies.

Study identifies trigger for ‘head-to-tail’ axis development in human embryo   

Researchers have mapped, in new detail, the genetic changes that a human embryo goes through as it develops.

Computer method to help predict outcomes and tailor treatments for patients with inherited heart diseases  

Clinicians and scientists analysed how individual genetic changes affect the heart muscle and created a new computer tool to integrate genomic ...

Sanger Institute human genetics researcher honoured by EMBO

Professor Matthew Hurles, Head of Human Genetics, becomes an elected member of the European Molecular Biology Organization

Winning Cambridgeshire students design card game inspired by the Human Cell Atlas

Game will be developed and feature in nationwide exhibition

New genetic variants lead to diagnoses for children with developmental disorders

By analysing parts of the genome that do not code for proteins, researchers have identified seven variants linked to developmental disorders.

Genetic study identifies risk for some childhood cancer patients developing secondary leukaemia and will help inform treatment plan

New study used whole genome sequencing to gain further understanding of why some children develop secondary leukaemia after neuroblastoma treatment

Atlas of malaria parasite gene activity provides new targets for drugs and vaccines

Researchers have mapped in fine detail the genetic changes malaria parasites go through as they prepare to infect people.

Genomics in a pandemic – Shedding light on the invisible

Experts from the COVID-19 Genomics UK Consortium discuss sequencing SARS-CoV-2, variants, and viral fitness landscapes.

‘Rescue mutations’ that suppress harmful DNA changes could shed light on origins of genetic disorders

The biological phenomenon may play an important role in genetic diseases such as cancer or rare developmental disorders, and explain why ...

Discovery of vaccine target for devastating livestock disease could change lives of millions in sub-Saharan Africa

The findings raise the possibility of identifying vaccine targets for trypanosome species that cause the deadly human infections sleeping sickness and ...

Car manufacturing, cellular biology and COVID

Rachel Nelson, head of the Cellular Generation and Phenotyping (CGaP) facility, reflects on managing science at scale, including the lessons ...

Unparallelled insights into how our bodies develop from a single cell

Knowing what happens during normal development could help us to understand genetic diseases that arise during pregnancy

Maturation Block – Redefining Childhood Cancers

Using the latest genome sequencing techniques, Dr Sam Behjati is revealing the journey that cells take on their way to ...

Identifying the rise of multi-drug resistant E. coli

Largest genomic study of E. coli has tracked the rise of multi-drug resistance (MDR) in Norway.

Dyslexia and neurodiversity in the workplace

Staff share their experiences of dyslexia and how it has affected their careers in science.

Diversity and Inclusion in Science

The Equality in Science group and the Race Equity Network at the Wellcome Genome Campus welcomed inspirational speakers last year. ...

Championing Team Science

Professor Muzlifah Haniffa shares her thoughts achieving large-scale science.

New genetic target for blood cancer treatment 

Researchers have identified a vulnerability in some cases of acute myeloid leukaemia that could be harnessed for targeted treatment of these ...

New era of quality and scale in genome sequencing will drive biological discovery

Publication of 16 high-quality vertebrate reference genomes establishes standards for biodiversity genomics

Major advance enables study of genetic mutations in any tissue

Analysis of blood, colon, brain and muscle tissue indicates cell division is not the primary cause of somatic mutations

From investment banking to genomics and health

Meet Olivier Seret, Principal Software Developer working in the Infection Genomics team.

Novel drug type for blood cancer entering clinical trials 

First drug to target a specific RNA-modifying protein will start clinical trials in 2022 against acute myeloid leukaemia

Taking lockdown baking to a whole new level

New exhibition explores the science of cancer and ageing, through the medium of food and cooking.

Differing immune responses discovered in asymptomatic cases versus those with severe COVID-19

Using data from the Human Cell Atlas, researchers have identified the differences in immune cells’ response in those who had no ...

Genetic variants identified that impact immune cells' functioning 

Researchers have combined genome-wide sequencing and functional profiling of immune cells to understand more about the impact of genetic variants on ...

New genetic drug target for treatment resistant colorectal cancer 

Researchers have identified a new potential drug target for treating some types of advanced colorectal cancers.

‘Patchwork’ tumours prevalent across multiple cancer types

Scientists have confirmed that tumour evolution is driven by changes that benefit the cancer, and these lead to a wide range ...

New DERMATLAS project will create world's most comprehensive public resource of rare skin tumour genomes 

This project will document the genomes of around 70 rare skin tumours to build a map of how these cancers form ...

Genetic link to male infertility identified

Men who carry a certain subtype of Y chromosome are more likely to experience genetic mutations that lead to low sperm ...

Fighting Pathogens with Data and Partnerships

"Data analysis in genomics means that you can work in something that is meaningful."

Salivary gland cells revealed as sites of COVID-19 infection

Human Cell Atlas findings point to role for saliva in SARS-CoV-2 transmission

New addition to COSMIC database will collate available drugs to target cancer mutations

The Actionability resource identifies relationships between types of cancer, specific mutations and available drugs

CRISPR study identifies gene that plays key role in metastasis of cancers to the lungs

Over-expression of LRRN4CL was linked to cancer spread in colon, breast and bladder cancers in humans

Project to understand beginnings of rare childhood cancer awarded innovation funding

Sam Behjati and collaborators at University College London hope to identify new treatment targets by uncovering foetal origins of rhabdomysarcoma.

SARS-CoV-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

These findings offer a molecular explanation for the reported differences in disease severity for COVID-19 patients depending on age, gender and ...

From Scorpions to Skin Cancer

Dr Daniela Robles-Espinoza recently joined the Sanger Institute as an International Fellow. She works on acral melanoma, a deadly form ...

Genomic surveillance – the world’s binoculars focused on infectious diseases

Monitoring the microorganisms that cause COVID-19, malaria, cholera and a whole range of other diseases enables researchers to track outbreaks, ...

Placenta is a dumping ground for genetic defects 

The study is the first high-resolution survey of the genomic architecture of the human placenta, revealing specific patterns of mutation that ...

Full evolutionary journey of hospital superbug mapped for the first time 

Sanger Institute researchers and their collaborators have published the full genetic timeline of the bacterium, Enterococcus faecalis showing the influence of ...

Students invited to create a card game inspired by the Human Cell Atlas

How to build a Human: Design a card game challenge

Virtual event celebrates Equality and Diversity Champions from the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

Reverse mentoring: Promoting diversity and positive culture change

Alice Matimba and Martin Dougherty reflect on their experiences of reverse mentoring, and how it can play a key role ...

Genomics study identifies routes of transmission of coronavirus in care homes

Genome sequencing was combined with detailed epidemiological information to examine the impact of COVID-19 on care homes and to discover how ...

New search engine for single cell atlases

New software tool allows researchers to rapidly search datasets from single-cell sequencing

Origin of childhood cancer malignant rhabdoid tumour discovered

Researchers identified two drugs that could be used to overcome the genetic root of the disease, resuming normal development and bringing ...

Sanger Institute researcher wins Pezcoller Foundation EACR Rising Star Award

Congratulations to Dr Sam Behjati, who receives the Award in recognition of his potential to make significant contributions to cancer research

Open data on malaria genomes will help combat drug resistance

The release represents the world’s largest resource of genomic data on malaria parasite evolution and drug resistance

Gene that helps control egg’s journey sheds light on why ectopic pregnancy may occur

Study details the first evidence of gene regulation in the transit of eggs from the ovaries to the uterus in mammals

Lab-grown ‘mini-bile ducts’ used to repair human livers in regenerative medicine first

For the first time, this new study has successfully created ‘mini-organs’ in the lab, that could help patients with liver damage

Scientists identify over 140,000 virus species in the human gut, half of which are new to science

The results form the basis of the highly-curated Gut Phage Database (GPD) which will be an invaluable resource for those studying ...

New COVID-19 saliva testing strategy could translate into easy-to-use home device

The new testing approach would be easier to collect and simpler to process in the laboratory than the current nasal-swab process.

International Day of Women & Girls in Science 2021

Just 30 per cent of researchers worldwide, only 35 per cent of all students enrolled in STEM-related fields of study ...

New drug targets for childhood cancer neuroblastoma identified

All neuroblastomas arise from developmental cells not normally found in children, making them a promising target for drug development

Sequencing COVID: our latest stats

As the sequencing hub of COG-UK, the Sanger Institute is sequencing the genomes of coronavirus samples from across the country. ...

Sanger Institute joins Wellcome Leap Global Network dedicated to accelerated breakthroughs in human health

Charter group of 21 world-class institutions representing a network of over 150,000 researchers across six continents sign agreement that sets ...

Developmental origins of eczema and psoriasis discovered

Skin Cell Atlas points to new drug targets for inflammatory diseases

Snail hotels, 3D printed robots and custom clips

Engineering solutions to genomic research

20 Things We Learned in 2020

This has been a year that none of us will forget in a hurry. The Institute is immensely proud of ...

Cell atlas of tropical disease parasite may hold key to new treatments

The atlas of 13 distinct cell types at the start of the Schistosoma mansoni's development will aid vaccine and treatment ...

Darwin Tree of Life: Looking back on 2020

Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at ...

Ten artists to create artworks for global research project mapping the human body

Human Cell Atlas explored through art science collaboration

Gut research identifies key cellular changes associated with childhood-onset Crohn’s Disease

Gut Cell Atlas reveals gut development mechanisms

Dr Sam Behjati selected as an EMBO Young Investigator

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work on the developmental origins of ...

COG-UK computing effort wins collaboration award for COVID-19 work

HPCwire award recognises consortium's sequencing of tens of thousands of viral genomes

Wellcome Sanger Institute and COG-UK receive £12.2M UK Government investment for COVID-19 real-time genomic surveillance system

Institute researchers will support the COVID-19 Genomics UK consortium's work by providing high-throughput virus genome sequencing, creating surveillance software to ...

Sanger Faculty to co-lead new Italian Genomics Research Centre

Nicole Soranzo will join the Human Technopole Institute to establish its dual programmes of Population and Medical Genomics and Functional Genomics ...

Stand up science

Join us for an evening of science comedy

Uncovering the origin of rare childhood cancer guides treatment

Bilateral neuroblastoma cancers in a patient can arise independently from each other, at the very earliest stages of life

Why protecting the brain against infection takes guts

Gut microbes educate antibody producing cells that guard the brain

Sequencing COVID – what now?

Helping to track coronavirus outbreaks.

Human Cell Atlas projects increase diversity of sample donors

Funding from the Chan Zuckerberg Initiative enables tissue samples from more diverse ethnic backgrounds

Sanger Institute welcomes Wellcome's new science strategy

Director Mike Stratton outlines the opportunities and continuing support that Wellcome's new strategy provides for Sanger researchers

Sequencing COVID-19 at the Sanger Institute

This photo essay goes behind the scenes of the effort to sequence the genome of the COVID-19 virus at the ...

Study linking 28 genes to developmental disorders will mean diagnoses for around 500 families

Researchers estimate that approximately another 1,000 genes linked to developmental issues have yet to be found

Update to COSMIC drives precision oncology

The Cancer Mutation Census combines biological, biochemical and population data to enable users to understand which DNA mutations drive human cancers

Equity, diversity and inclusion in science

To celebrate Black History Month, Your Digital Mentor Podcast released a special episode. Academics from across the globe discuss inequalities ...

Novel map reveals how immune cells fight and remember infections

Mouse immune study gives pointers for development of vaccines and immune therapies

Comeback of drug-resistant neglected tropical disease tracked through genomic surveillance

Study shows that re-emergence was likely caused by latent infections in untreated asymptomatic people

Song Chen to lead research group in Cellular Genetics Programme

This new group will develop powerful, cutting-edge technologies to map individual cells in the brain and other tissues, to understand how ...

Cause of 1990s Argentina cholera epidemic uncovered

Work influenced Argentine health policy, where the national alert surveillance system now uses whole-genome sequencing to distinguish between pandemic and non-pandemic ...

DNA changes in healthy bladder provide clues on how cancer arises

The research reveals a huge diversity in the number and types of changes between individuals, indicating that a wide range of ...

Xylem, Mentoring, and the Worldwide Fantasy Food Tour

Dr Christine Boinett talks about Black History Month, her new international podcast on mentoring and her research on drug-resistant bacteria.

Highly detailed map of human heart could guide personalised heart treatments

Heart Cell Atlas will illuminate our understanding of heart health and disease

Key genetic clue missing in fight against superbugs

Analysis shows importance of including plasmids when tracking antibiotic resistance in bacterial populations

Ambitious genomics project seeks to understand how aquatic species thrive together

The Aquatic Symbiosis Project will empower researchers to answer important questions about the ecology and evolution of symbiosis

Key discovery in psoriatic arthritis points way for developing targeted treatments

Genetic evidence points to potential single cause for the disease

A day in the life of a cell technician: CRISPR, teamwork, and character cells

Life in the cellular generation and phenotyping labs at the Sanger Institute.

Fire on Wellcome Genome Campus detected and extinguished quickly

The fire was contained to one room and the Campus is safe and fully operational

Future of genomic research at risk without greater public trust in how genetic data is shared

Survey finds lack of familiarity with genomics and how it can benefit society

How Dantu blood group protects against malaria - and how all humans could benefit

Red blood cells have a higher surface tension that prevents them from being invaded by Plasmodium parasite

Genetic information can predict predisposition to blood diseases

Studies identify bulk of genetic variation that influences blood cell traits

Unprecedented national effort by UK immunologists to search for answers on COVID-19 

Sanger Institute researchers join national research projects to investigate the role of our immune system in tackling COVID-19

Mosquito immune system mapped to help fight malaria

Atlas will be valuable resource for understanding and controlling mosquito-borne diseases such as malaria, Dengue and Zika

Inspiring prisoners and their families with genomics

“I want to inspire kids, let them know that though they are having a really tough time now, there ...

The race to sequence SARS-CoV-2

The Sanger Institute is built for high-throughput science – but the project to sequence coronavirus demanded more samples were handled more ...

Former Sanger Institute Head of Pathogens receives the 2020 Albert B. Sabin Gold Medal 

Professor Gordon Dougan awarded Sabin Vaccine Institute prize for his contributions to vaccinology

From locked down to reaching out: re-inventing public engagement for the “new normal”

Since the Campus closed to visitors in March, staff have been finding new ways of engaging with people who want ...

New podcast to provide digital mentoring tips for early career researchers

Your Digital Mentor launches with first episode on the mentoring experience

Genomes within Genomes

Hiding in the genome of a newly-sequenced red colobus monkey, there was a second species - a parasite descended from ...

New drug targets for lethal brain cancer discovered

Researchers engineered a new mouse model for studying glioblastoma, the most aggressive type of brain cancer

Artificial intelligence finds patterns of mutations and survival in tumour images

AI detects patterns of 167 different mutations and predicts patient survival in 28 cancer types

Impact of The Technician Commitment

Kelly Vere, Programme Director of the Technician Commitment, explores the progress of the scheme across the UK.

Chronic inflammation alters the evolution of cells in the colon, study finds

Researchers have compared diseased colon with healthy tissue to better understand how inflammatory bowel disease (IBD) is linked to an increased ...

Building an inclusive culture in all we do

Launching a new Behavioural Competency Framework.

From bacterial behaviours to COVID-19

Sushmita Sridhar has paused her work on a gastroenteritis-causing bacterium to help diagnose the virus that causes COVID-19.

Explore COVID-19 science in action with new Human Cell Atlas animation

Mapping COVID-19: How the Human Cell Atlas enhances our understanding of the disease

International Common Disease Alliance releases action plan to drive next phase of genetic understanding of common disease

Report defines priorities, proposes international collaborations to accelerate progress from genetic maps to biological mechanisms to medical treatments

Launch of virtual Sanger Seminar series

Join us for a new series of virtual seminars, open to all, which will present the latest research from the Sanger ...

Drug screens and CRISPR combine to help make better cancer drugs

Improved understanding of the biological mechanisms underpinning drug response will enable faster, more efficient drug development

Sarah Teichmann, an international pioneer of single cell research

We spoke to the Head of Cellular Genetics at the Sanger Institute about her life, career and the Human Cell ...

The first draft human genome at 20

A revolution powering today’s advances in genomics, biology and medicine

‘It had better be good’

We reflect on what followed the publication of the human genome sequence for the Sanger Institute, and what the future ...

Restarting Science

Staff are starting to return to the Wellcome Genome Campus.

Update to DECIPHER brings power to clinical genomics

Update to rare disease database allows researchers and clinicians to input, interpret and share all types of genomic variants in all ...

Supporting Pride Month at the Wellcome Genome Campus

We are celebrating Pride Month with virtual events, and we are pleased to have joined the Stonewall Diversity Champions programme. ...

Denisovan DNA influences immune system of modern day Oceanian populations

Previously-unknown variations in medically-important genes will be valuable resource for the field of precision medicine

My postdoc and my dad’s dementia

This carers week, postdoctoral fellow Lia Chappell shares her experiences.

Genomic surveillance of antibiotic resistance in the Philippines established

Bacterial resistance to last-line antibiotic mapped in the Philippines

Sanger researcher wins prize from European Society for Human Genetics

Gosia Trynka awarded 2020 Leena Peltonen Prize for her outstanding research into human immune diseases

From cancer, stem cells and organoids to COVID-19

Sanger scientists speak about their new roles in sequencing SARS-CoV-2 genomes.

4,000 years of contact, conflict and cultural change had little genetic impact on Near East

Only three periods had lasting effect on genetics of local people in Beirut

Analysis of COVID-19 Genomes reveals large numbers of introductions to the UK in March

The data reports, published by the COVID-19 Genomics UK Consortium (COG-UK), show the value in mapping COVID-19 lineages across the UK ...

An automated method for cell type discovery

Identifying cell types from single-cell RNA sequencing data is now more efficient than ever

Honour with Athena SWAN Silver Award

The Wellcome Sanger Institute and its associated organisations have been awarded by Athena SWAN for commitment to advancing women's careers ...

Potentially cancerous cells kept in check by competitive neighbours, study of oesophagus finds

Hope that understanding of the 'rules of the game' of clonal competition will lead to new therapies

Welcoming Athena SWAN Silver

"We are deeply committed to our values of equality, diversity and inclusion and these are fundamental to our work."...

Sanger scientists recognised by the Academy of Medical Sciences

Six Sanger researchers – past and present – have been welcomed into Fellowship of the prestigious organisation

‘These lowly organised creatures’: Earthworm sample collecting at the Sanger Institute

Few organisms have, as Darwin himself wrote, played such an important role in the history of the world.

Sanger scientist receives Chan Zuckerberg Initiative support for COVID-19 study

Roser Vento-Tormo will use single-cell technologies to understand human immune response to SARS-CoV-2 infection and the progression of the disease

New computational method unravels single-cell data from multiple people

Souporcell could assist personalised medicine and malaria research

Prising open the scallop genome

As part of the Sanger Institute’s 25 Genomes Project, the king scallop, Pecten maximus, had its genome sequenced.

Head of Cellular Genetics elected Fellow of the Royal Society

Sarah Teichmann is recognised for her pioneering computational biology and genomics work, leading to the Human Cell Atlas initiative

New tools to tackle malaria: translating from cutting edge research to real-world applications

This World Malaria Day we look at three ambitious projects, backed by the Sanger Institute Technology Transfer Office, which are ...

Puzzles and Parasites

Dr Stephen Doyle, in the Sanger Institute’s Parasites and Microbes Programme, has just been awarded a new UKRI Future ...

Sanger researcher backed through flagship fellowship

Dr Stephen Doyle has been awarded a UKRI Future Leaders Fellowship to explore the evolution of drug responses in parasitic worms

Sanger Institute to extend funding for Postdoctoral Fellows affected by COVID-19 shutdown

Funding will be extended for six months, including for those funded by third parties

Key nose cells identified as likely COVID-19 entry points

Study with Human Cell Atlas could help understand transmission of the virus

Normal human uterus is colonised by clones with cancer-driving mutations that arise early in life, study finds

Hope that insights into earliest stages of uterine cancer development will help to tackle one of most common female cancers

Tackling COVID-19 at the Sanger Institute

Staff at the Sanger Institute have joined the fight against the global COVID-19 pandemic.

Experience matters for immune cells - discovery of T cells response spectrum could help understand immune diseases

Study could help find better drug targets for asthma and rheumatoid arthritis

Mapping the Human Cell Atlas – charting the body’s cellular world

The Human Cell Atlas is being used to guide future research into human development, biology, health, and disease.

Raising Awareness of Neurodiversity in the Scientific Workplace

In February, we welcomed Sara Rankin, Professor of Leukocyte and Stem Cell Biology at the National Heart and Lung Institute, ...

Sanger Institute scientist wins 2021 Biochemical Society award

Roser Vento-Tormo awarded an Early Career Research Award

UK launches whole genome sequence alliance to map spread of coronavirus

The Wellcome Sanger Institute will collaborate with expert groups across the country to analyse the genetic code of COVID-19 samples circulating ...

Sanger Institute and Wellcome Genome Campus temporarily closed to all but critical research

In response to the rapidly changing COVID-19 pandemic, the Sanger Institute and its neighbours on the Wellcome Genome Campus will close ...

Global human genomes reveal rich genetic diversity shaped by complex evolutionary history

Study will help identify the susceptibility of different populations to disease

The duty of care: a genetic balancing act?

Genetic testing is becoming a standard part of UK healthcare, with plans to expand its use. But who does this ...

New research on brain structure highlights cells linked to Alzheimer’s and autism

Astrocytes organised into layers in similar way to neurons

Being an LGBT+ Ally and Supporting Diversity

Jim Smith joined us at the Wellcome Genome Campus last year as part of the LGBT+ Network and Equality in ...

Dinosaurs and the high seas

Eugene Gardner is a Postdoctoral Fellow in the Human Genetics Programme. His research focuses on the genetics of developmental disorders.

Equality and Diversity Champions celebrated at the Wellcome Genome Campus

Winners of the Best Practice Awards are announced for International Women’s Day

Origins of immune system mapped, opening doors for new cancer immunotherapies

Cell atlas of human thymus could help engineer improved therapeutic T cells

Otter genome to help understand genetic legacy of pollution crisis and secure species’ future

Genome will unlock wealth of data stored in DNA archives in bid to understand response to environmental changes

Gut bacteria’s interactions with immune system mapped

Cell atlas could reveal why some gut diseases affect specific areas

Cancer across the animal kingdom

Cancer, ageing and somatic mutation rates across species.

Sepsis and precision medicine: is it all in your genes?

Using gene expression data to stratify patients.

Sequencing and the Tree of Life

Progress and promise of the Earth Biogenome Project - a mission to sequence all known eukaryotic species.

The Human Cell Atlas: Understanding health to combat disease

Dr Kerstin Meyer, Principal Staff Scientist at the Sanger Institute, explains what it’s like to work on a such ...

Background information about the ICGC/TCGA Pan-Cancer Project

Overview of the Pan-Cancer Project

Cancer-causing culprits will be caught by their DNA fingerprints

Study within Pan-Cancer Project will help research into cancer prevention, diagnosis and treatments

Comprehensive study finds mutations in non-coding genome are infrequent drivers of cancer

Findings suggest efforts to develop new cancer treatments should primarily focus on protein-coding genes

Genomics in the cloud

The huge, international Pan-Cancer project is the first large-scale use of distributed cloud computing in genomics. As genomics becomes a ...

Unprecedented exploration generates most comprehensive map of cancer genomes charted to date

Pan-Cancer Project discovers causes of previously unexplained cancers, pinpoints cancer-causing events and zeroes in on mechanisms of development

Red and grey squirrel genomes could hold the key to the survival of reds in Britain and Ireland

Susceptibility to squirrel pox and genetic fitness of fragmented populations are key questions for red squirrel researchers

Tailor-made vaccines could almost halve rates of serious bacterial disease

Innovative study points the way to more effective vaccine design

Statement on Brexit by the Wellcome Sanger Institute, the European Molecular Biology Laboratory (EMBL) and the Francis Crick Institute

Statement on Brexit

Never too late to quit: protective cells could cut risk of lung cancer for ex-smokers

Ex-smokers have four times more genetically healthy cells than smokers, helping to protect them against lung cancer

2020 vision: supporting the people behind our science

Read about our ongoing and upcoming work to ensure that all our staff and students from all backgrounds can thrive

“If you know, there is a Nobel prize for you!” – Searching for the causes of cancer in Czechia

In a study spanning five continents, researchers are hunting for tell-tale ‘signatures’ left in DNA by the unknown causes of ...

#SangerAdvent

For our advent calendar on Twitter, this year we celebrated our staff from around the world. Each day, someone told ...

Analysis of CRISPR-Cas9 datasets leads to largest genetic screen resource for cancer research

Study will help narrow down the list of targets for the next generation of cancer treatments

Dr Konstantinos Tzelepis receives ASH–BSH Abstract Achievement Award for leukaemia target research

Award-winning abstract on METTL3 presented at American Society of Hematology meeting

Researchers identify over 140 genes linked to immune system regulation

First extensive immune profiling of mice reveals a vast catalogue of genes that regulate the immune system and model human disease

Appointments and changes to the Genome Research Limited Board

At the GRL Board meeting on 2 December 2019, David Willetts announced his intention to step down as Chair because of ...

Researchers identify new possibilities for the treatment of inflammatory bowel disease

Two molecular pathways found to be integral to maintaining balance in the digestive system

Root of childhood kidney cancer discovered

Pre-cancerous signatures found in healthy tissue point the way towards new treatment options

Causality and the genetic thesaurus

Manuel Tardaguila is a postdoctoral research scientist in Nicole Soranzo’s group. The group focuses on the application of large-scale ...

Best of both worlds

A degree apprenticeship offers the opportunity to earn whilst studying.

From childhood cancer to mapping human development: Pioneering scientist awarded 2019 Foulkes Foundation medal

Congratulations to Professor Muzlifah Haniffa, who has been recognised for her work on the immune system and childhood cancer

Dr Sam Behjati wins Liddy Shriver Early Career Research Award

Congratulations to Sanger Institute cancer researcher, Dr Sam Behjati, who has been recognised for his work in sarcoma cancer genomics

New malaria drug targets identified in liver stage of life cycle

Hope that new liver-stage drugs will help to counter the threat of antimicrobial resistance to current blood-stage medicines

Ambitious project to map genomes of all life on British Isles funded by Wellcome

An unprecedented insight to the diverse range of species on the British Isles will be made possible by Wellcome funding to ...

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Research explains why children often catch other infections after measles, and highlights the importance of vaccination

Perfume, jazz and immunogenetics

Dr Velislava Petrova is a Postdoctoral Fellow working in immunogenetics in Dr Carl Anderson’s group at the Sanger Institute. ...

Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

Researchers will examine both healthy and diseased intestinal tissue to identify key cell types involved in Crohn’s disease

Accumulation of DNA mutations found in healthy liver leads to disease

Largest study of its kind seeks to better understand how liver disease and hepatocellular carcinoma develop

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

Science on a bike

One man, one bike, and lots of genomics.

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early ...

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

Pioneering Computer Science

Celebrating Ada Lovelace Day and the achievements of women in science, technology, engineering and maths.

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use ...

A dangerous new Salmonella strain is emerging in sub-Saharan Africa

Researchers have discovered the first extensively drug resistant non-typhoidal Salmonella in the Democratic Republic of the Congo

Human kidney map charts our growing immune defence

New cell atlas reveals immune cells present in zones of human kidney

The biology of the brain

Studying mouse brain development can give insights into human neurodevelopmental and psychiatric disorders, as well as help diagnose rare genetic ...

Scientists hone in on DNA differences behind immune diseases

Search could help find drug targets for developing new treatments

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Strain of dangerous pathogen shown to have developed resistance to last-line-of-defence drug

Babies' gut bacteria affected by delivery method, Baby Biome project shows

Vaginal delivery promotes mother's gut bacteria in baby's gut

Health implications of the baby biome?

The method of a baby’s birth affects its collection of gut microbes – its microbiome. But we still don’t ...

Coding the Future

You’re never too young to start learning about DNA sequencing, software development and 3D printing.

500,000 whole human genomes will be a game-changer for research into human diseases

Following on from a successful pilot at the Sanger Institute, we are leading a project to sequence the genomes of all ...

Powering discovery in blood disorders and depression

The wealth of information available to researchers through UK Biobank is powering studies into human health and disease

Brown trout genome will help explain species' genetic superpowers

Eagerly awaited reference genome will allow conservationists to understand how the fish adapts to marine and freshwater environments

Fishing for answers in the brown trout genome

Brown trout are highly adaptable and its genetic make up may hold key answers to helping species survive climate change

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab has launched an exciting programme of events for Friday 27 and Saturday 28 September 2019, transforming parts of Cambridge, Peterborough ...

Flying to the Future

Dr Sophie Adjalley is a Postdoctoral Fellow in Marcus Lee's research group at the Wellcome Sanger Institute. Her research ...

Decoding first of 60,000 British species as Darwin Tree of Life branches out

The mission to map the genetic code of all known British species is underway

Malaria Cell Atlas: mapping a murderous parasite’s life cycle

Malaria - and the parasite that causes it - is complicated. Not only does the single-celled parasite move between humans ...

Malaria control success in Africa at risk from spread of multi-drug resistance

Regional populations of Plasmodium falciparum parasites in Africa are sharing genetic material in all directions – including genes that can confer resistance ...

Map of malaria behaviour set to revolutionise research

The Malaria Cell Atlas gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites ...

A lasting legacy

Meet the next generation of genomic scientists who are benefiting from our founder's generosity

Diarrhoea-causing bacteria adapted to spread in hospitals

Gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals

The modern rise of an ancient disease

Sanger scientists have sequenced the largest number of Treponema pallidum bacterial genomes to date. The bacterium causes syphilis, a sexually ...

Vaccines: Life savers against infectious diseases

Smallpox has been stamped out and various other diseases are declining, thanks to vaccination. But not all diseases have vaccines ...

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Research emphasises importance of ongoing genomic surveillance and infection control

Outbreaks and Antibiotic Resistance

Sophia David talks about her life as a postdoctoral researcher at the Sanger Institute.

Cancer drug data release set to power next wave of therapeutic discovery

Unique data comparing almost 1,000 cancer cell lines’ responses to 453 licensed and experimental drugs is now freely available to ...

Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

Medical student working in the Cancer Genome Project wins prize for colon cancer research

2019 Chief Medical Officer’s Report published

Sanger Institute researchers contribute to Professor Dame Sally Davies' eleventh annual report

Multi-drug resistant malaria spreading in Asia

Study reveals importance of ongoing genomic surveillance for malaria control strategies

Low doses of radiation promote cancer-capable cells

New research in mice helps to understand the risks around exposure to low doses of radiation, such as CT scans and ...

COSMIC: setting the path for tomorrow’s cancer treatments

From gene discovery, to database, to cancer treatment. COSMIC celebrates 15 years of fuelling cancer research.

Cancer, Caveman and Art

Thoughts on life as a postdoctoral researcher, combining science and art.

DECIPHER: Fuelling Rare Disease Research

More than 15 years ago, a hospital doctor realised that bringing people’s genetic data together could provide answers for ...

Connecting With Science

Staff at the Wellcome Genome Campus are supported to connect people with their science - find out more

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Seed Networks projects will focus on specific tissues, such as the thymus, lung, liver, kidney and immune system

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Genomic analysis shows that a significant number of strains are susceptible to penicillin combined with clavulanic acid

Melanoma, Personalised Medicine and the Middle Ages

Saskia Rudat talks about her life as a postdoctoral researcher at the Sanger Institute.

First lung map uncovers new insights into asthma

Understanding lung cells and their signals could help towards finding new asthma drug targets

What if medicine could be tailored ‘just for you’?

The information in our genomes is helping doctors diagnose and treat disease. But how far can personalised medicine go?

Tracking a deadly shapeshifter

A global child killer constantly changes its coat to evade destruction, but a worldwide network of scientists is using genetics ...

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo becomes an elected member of the European Molecular Biology Organization

Pneumonia mapped in largest genomic survey of any disease-causing bacterium

Study will help predict strains important for new vaccines

Breaking the mould – the story of penicillin

From a contaminated dish in London to saving lives on the D-Day beaches of Normandy (via dedicated scientists in Oxford ...

Day in the life: Software Developer – making research happen

Meet the people building software to enable high-throughput genomics at the Sanger Institute.

Major stem cell discovery to boost research into development and regenerative medicine

Expanded Potential Stem Cell lines of pig and human cells established

Equality and Diversity – not just about fairness

We've come a long way, but the journey isn't finished yet...

We’ve got the power

Running one of the largest biosciences data centres in Europe as efficiently as possible requires cool heads and even cooler ...

Global Strep A vaccine one step closer

Streptococcus genomes reveal potential vaccine targets present in over 20 countries worldwide

Infectious diseases make a comeback in Venezuela following healthcare crisis

The experiences of a friend of a Sanger Institute researcher reveal how parasites and bacteria are now threatening the country'...

CRISPR catches out critical cancer changes

Researchers reveal which gene fusions are critical for the growth of cancer cells and identify a new drug target for multiple ...

Sanger Institute animal research facility to close

Following a full review, the Sanger Institute will be closing its animal research facility

Caring for children with cancer

We explore the world of award-winning cancer scientist, Dr Sam Behjati

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

The 2019 recipient of the Dr Simon Newell Early Career Investigator Award has been announced as Dr Sam Behjati, whose career ...

Lead cancer researcher elected to Academy of Medical Sciences

Dr Peter Campbell receives prestigious Fellowship for his work in cancer genomics

Sanger’s super-sized sequencing scales new heights

We're celebrating: we've just read the same amount of DNA in one year as we achieved in the ...

More than just malaria

Researchers can change children's futures in many more ways than just helping to beat a killer disease...

Crusaders made love and war, genetic study finds

Sanger Institute researchers have produced whole-genome sequences from skeletons discovered in a 13th Century burial pit in Sidon, Lebanon

Rare genetic change provides clues to pancreas development

Understanding pancreas formation could aid research into type 1 diabetes treatments

Head of Human Genetics elected Fellow of the Royal Society

Matthew Hurles is recognised for his pioneering work in identifying the genetic basis of undiagnosed developmental disorders and paving the way ...

Six surprising animal cancer facts

Some creatures never get cancer, while others can catch it from the sea. Find out more in our list of ...

Mice reveal 38 new genes involved in hearing loss

Molecular pathways revealed could identify potential drug targets for restoring hearing

Cracking cancer with CRISPR

How Sanger scientists are using genetic surgery to understand the blueprint of life

Genetic code of WWI soldier's cholera mapped

The bacterium was isolated from a British soldier and stored for over 100 years before being revived and sequenced

New cancer drug targets accelerate path to precision medicine

Researchers discovered thousands of genes essential for cancer’s survival and ranked which ones show the most promise as drug targets ...

CRAM-ming it in

An impending flood of genomic data threatens to overwhelm scientists' abilities to store and share it. Next-generation compression seeks to ...

Sanger Institute scientist wins 2020 Biochemical Society award

Head of Cellular Genetics Programme wins GlaxoSmithKline prize

Tea-time News

Hot tea has been linked to oesophageal cancer - but it's not clear if it's the cause. Studying ...

Darwin Tree of Life sets down roots

Planning for the Darwin Tree of Life Project is underway. We welcome Professor Mark Blaxter, from the University of Edinburgh, who ...

Glass: The Poetry of Science

Dr Kate Carruthers Thomas explores gender in the workplace through the poetry of the Glass Ceiling, Glass Escalator, Glass Cliff ...

Catching pneumonia with caterpillars

Using caterpillars to investigate how human pneumonia works.

Commitment to collaborate on using genomics for pathogen surveillance across Europe

Combining the strengths of the European Centre for Disease Prevention and Control, the Wellcome Sanger Institute and the Centre for Genomic ...

A Day in the Life: Bioinformatician – collaboration, cancer and all life on Earth

Understanding the nature of life on Earth has been revolutionised by DNA sequencing. In the past we could only observe ...

Champions of equality and diversity celebrated

The winners were nominated by staff working at the Wellcome Genome Campus for their actions to advance equality, diversity and inclusion, ...

Major mutation pattern in cancer occurs in bursts

New resource could help understand origins of cancer

Cambridge heart research boosted by £6 million British Heart Foundation Research Excellence Award

Funding will allow Sanger Institute researchers and collaborators to apply cutting-edge genomics to help develop new heart disease diagnostics and treatments

Getting smart about artificial intelligence

Sanger researchers are harnessing the power of AI to extract new knowledge from the ever increasing flood of genomic data. ...

Roser Vento-Tormo leads single-cell research team at the Sanger Institute

The new group will identify the cells involved in the human female reproductive system, how they work, organise and communicate with ...

Improving global surveillance of antibiotic resistance

A WHO Technical Note has been published that will enable health authorities to make informed choices on the most appropriate molecular ...

Establishing the molecular blueprint of early embryo development

By studying the genetic activity of 116,312 single cells from 6.5 to 8.5 days after fertilisation, researchers have ...

Cancer comparison across species highlights new drug target

Scientists discover key genes for mucosal melanoma in humans, dogs and horses that help prioritise targets for new cancer therapies

Almost 2,000 unknown bacteria discovered in the human gut

Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America

I’ve never had chickenpox, what’s your superpower?

Gary Dillon, Business Development Manager at the Sanger Institute gives us his view on some of the powers and pitfalls ...

Sanger Institute steps up commitment to Equality, Diversity and Inclusion in Science

The Institute has joined a new coalition to remove biases in all aspects of life science research, including staff, experiment design, ...

Study reveals how immune cells target different tissues

Tissue-specific receptors and adaptations enable localisation of T regulatory cells

100 cancer organoid models developed by Sanger Institute scientists

The organoids developed by the Sanger Institute lead the UK effort as part of the international Human Cancer Model Initiative (HCMI) ...

More than 100 new gut bacteria discovered in human microbiome

Study will help understand role of microbiome in health and disease

The weird and wonderful world of organoids

Mini organs grown in the lab are boosting cancer research and drug discovery.

Genetic testing gives answers on developmental disorders during pregnancy

Researchers identified new diagnoses of known genetic disorders for 52 of the 610 pregnancies they genome sequenced

Immune master regulator orchestrates responses to parasite infection

Receptor IL-10R is vital to coordinating the body's immune response to whipworms, preventing uncontrolled infection and gut lining damage

GARFIELD classifies disease-relevant changes in the genome

New approach reveals role of genomic changes in a disease, both within and outside genes

Genetic Disability, Experience and the Sorting Society

Our genetic information is more accessible to us than ever before. But what do we want to know? Dr Felicity ...

Huge step forward in decoding genomes of small species

Scientists from the Wellcome Sanger Institute and Pacific Biosciences use just ‘half a mosquito-worth’ of DNA to produce a whole, high ...

Ian Dunham appointed as Open Targets Director

Open Targets is the public-private partnership on the Wellcome Genome Campus that aims to transform drug discovery through the systematic identification ...

Genetic study reveals possible new routes to treating osteoarthritis

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines

The importance of public engagement on antibiotic resistance

Nicole Wheeler talks antibiotics, antibiotic resistance and public engagement - and letting people use real software on real data to ...

Developing a view on Brexit

Sarion Bowers, Policy Lead at the Sanger Institute, reflects on how Brexit will affect science.

Disability, Inclusion and Science

Distinguished disability rights campaigner, David Ruebain, joined us last month at the Wellcome Genome Campus. He spoke on disability and ...

CRISPR study reveals new immune system regulators

Map of T cell regulation could aid development of drugs that could activate the immune system

Mystery of Yemen cholera epidemic solved

Bacteria's genomes reveal that the most likely source of the disease came from Eastern Africa and entered Yemen with the ...

Science in a conflict zone: Investigating cholera in Yemen

In addition to the civil war, Yemen is experiencing the worst epidemic of cholera ever recorded. We spoke to Ankur ...

Bird migration and conservation clues in robin and Turtle dove genomes

The genomes were read by the Sanger Institute and its partners, in celebration of Sanger’s 25th anniversary

Statement from GRL Board accepting the findings of the independent investigation into a whistleblowing claim

Genome Research Limited Chair and Director of the Wellcome Sanger Institute outline steps the Institute will put in place to improve ...

Human genome editing – the issues explored

Hayley Clissold from the Sanger Institute's policy team team explores the issues surrounding gene editing and human embryos

From eye drops to potential leukaemia treatment

Ingredient in pre-clinical treatment for retinal neovascular disease targets gene associated with acute myeloid leukaemia

Hasta la VISA, genomes!

From ragworts that are too common and the tricky toughness of truffles to the trials of getting DNA samples a ...

New strains of hepatitis C found in Africa

Study could inform hepatitis C treatment and vaccine development worldwide

Scientific Evidence in Policy Making

Evidence is a vital part of policy-making - but it's by no means the only part. We look at ...

Chernobyl: chasing a ‘catching’ cancer

Sanger researcher Alex Cagan travelled to Chernobyl’s nuclear exclusion zone for samples of cancer. But he isn’t investigating ...

Claims of genome edited babies shock the world

Our Policy Lead, Sarion Bowers, explores the extraordinary claims that the world’s first genome edited babies have been born.

Sanger’s cloud computing wins award

High performance computing community recognises pioneering work of Sanger’s scientific IT teams

Human Embryo Editing: science fiction or science fact?

Anna Middleton, Head of the Society and Ethics research group at Wellcome Genome Campus Connecting Science, reports on Prof He ...

Wellcome Genome Campus wins silver watermark to recognise its support for public engagement

Award reflects work to nurture a culture where public engagement is supported and encouraged

Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing

Prediction resource could make CRISPR-Cas9 editing more reliable

Dr Cordelia Langford wins BioBeat award

The ‘50 Movers and Shakers in BioBusiness 2018’ report identifies outstanding women who are developing revolutionary bioscience. Dr Cordelia Langford, ...

Human cell atlas study reveal