Immune master regulator orchestrates responses to parasite infection
Receptor IL-10R is vital to coordinating the body's immune response to whipworms, preventing uncontrolled infection and gut lining damage
A new study has identified the master regulator that maintains a healthy gut and limits damage by parasitic whipworms. Researchers from the Wellcome Sanger Institute and collaborators have revealed that the interleukin 10 receptor (IL-10R) is critical to prevent uncontrolled whipworm infection in mice and a damaging immune response in the gut.
The study, published today (31 January) in PLOS Pathogens, helps with understanding the signalling mechanism that maintains a balance between the host, whipworms and gut bacteria. Unravelling this signalling mechanism will help scientists understand immune response to other parasites and will shed light on pathways that could be involved in the control of other diseases such as inflammatory bowel disease and allergies.
The gut is home to millions of bacteria, known as the microbiota, and also to parasites such as whipworms. The human whipworm – Trichuris trichiura – infects approximately 500 million people globally, causing the neglected tropical disease Trichuriasis, and has evolved over millennia to infect the intestines and reproduce there.
The health of the host is important for a parasite, as it needs a live host to survive and reproduce. The researchers found that the worm, the gut, the immune system and the microbiota form a finely balanced ecosystem.
“This work shows how any change in the host or microbiota will also change the response to whipworms. Interactions between the host cells, microbiota and whipworms, enable the whipworms to survive in infected individuals and now we’ve found a master regulator of those interactions.”
Dr Maria Duque-Correa First author from the Wellcome Sanger Institute
Certain immune signalling molecules – called interleukins – had previously been implicated in host immune response to worm infection, regulating inflammation in the gut. To further understand their role in this balanced ecosystem, the researchers studied mice that were missing genes from the interleukin 10 (IL-10) superfamily of receptors to see how they responded to whipworm infection.
The researchers discovered that a specific IL-10R receptor was critical for regulation. They found that lack of IL-10R regulation led to an uncontrolled immune response that damaged the gut lining and failed to produce protective mucus. The worms invading the gut-lining cells, destroyed the barrier between the gut and the host, enabling bacteria to cross over into the rest of the body, causing fatal infection.
“This is the first study revealing the master role of IL-10R in regulating the response to whipworm, and controlling the microbiota. We discovered the absence of this crucial signalling pathway leads to disturbed microbiota and uncontrolled inflammation that destroys the gut lining allowing microbes to invade and cause liver failure.”
Professor Richard Grencis An author from the University of Manchester
“Our discovery of the importance of the IL-10R signalling pathway for gut regulation not only helps us understand the immune response to parasites, it also has implications for other diseases. Further research to better understand this immune signalling pathway could open up new ways of finding treatments for diseases caused by an over-active immune system such as allergies, inflammatory bowel disease or asthma.”
Dr Matt Berriman Senior author from the Wellcome Sanger Institute
Maria Adelaida Duque-Correa et al. (2019) Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection. PLOS Pathogens. DOI: 10.1371/journal.ppat.1007265
The work was supported by Wellcome and the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 656347
The University of Manchester, a member of the prestigious Russell Group, is one of the UK’s largest single-site university with more than 40,000 students – including more than 10,000 from overseas. It is consistently ranked among the world’s elite for graduate employability. The University is also one of the country’s major research institutions, rated fifth in the UK in terms of ‘research power’ (REF 2014). World-class research is carried out across a diverse range of fields including cancer, advanced materials, global inequalities, energy and industrial biotechnology. No fewer than 25 Nobel laureates have either worked or studied here. It is the only UK university to have social responsibility among its core strategic objectives, with staff and students alike dedicated to making a positive difference in communities around the world. Manchester is ranked 29th in the world in the QS World University Rankings 2018 and 6th in the UK.
The Wellcome Sanger Institute is one of the world’s leading genome centres.
Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease.
Wellcome exists to improve health by helping great ideas to thrive.
We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research.
We are a politically and financially independent foundation. wellcome.org
Related blog posts
What are helminths?
Helminths are worm-like parasites that survive by feeding on a living host to gain nourishment and protection, sometimes resulting in illness ...
17 Jun 2021
Study identifies trigger for ‘head-to-tail’ axis development in human embryo
Researchers have mapped, in new detail, the genetic changes that a human embryo goes through as it develops.
14 Jun 2021
Computer method to help predict outcomes and tailor treatments for patients with inherited heart diseases
Clinicians and scientists analysed how individual genetic changes affect the heart muscle and created a new computer tool to integrate genomic ...