Explore our programmes
Cancer, Ageing and Somatic mutation
Provides data aggregation and informatics innovation, develops high-throughput cellular models of cancer for genome-wide functional screens and drug testing, and explores the role somatic mutation plays in clonal evolution, ageing and development. Find out more
Uses single-cell approaches and “cell atlas” technologies to understand human genetics at the cellular level. Combines cutting-edge techniques in wet and dry lab to further understanding of human health, development and disease. Find out more
Drives understanding of genetic causes and biological mechanisms of disease susceptibility and progression, focuses on developmental disorders and diseases of the blood and immune system. Integrates population-scale genetics, longitudinal clinical data, and large-scale genetic perturbation studies in cellular model systems. Aims to transform the clinical utility of human genetic variation. Find out more
Parasites and Microbes
We are using genomics to get at important problems in infectious disease, with a strong desire to translate this into tools for disease control and elimination, but we are also at the forefront of basic research into microbial ecology, evolutionary genetics and the biology of parasitism. Find out more
Genomic Surveillance Unit
The Unit supports partners worldwide with practical tools for pandemic preparedness and local infectious disease control.
We develop, run, support and maintain open products: all the way from sample collection in the field, through high-throughput laboratory sequencing, to the delivery and interrogation of analysis-ready data.
COVID-19 research at the Sanger Institute
We are committed to tracking, understanding and combatting COVID-19. Our staff sequence thousands of virus genomes and use the data to trace transmission, inform public health measures and monitor for new variants of the virus. We also work to understand how the virus interacts with our cells, and to develop new diagnostics
Explore our science
Our research is built upon our Faculty and Associate Faculty research leaders. Each develops his or her own hypothesis-driven research, seeking answers to important biomedical questions. Faculty and Associate Faculty members lead their own groups of postdoctoral fellows, PhD students and support staff.
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Our ability to conduct large-scale, high-throughput genomic studies enables our researchers to play leading roles in national and international projects: spanning cancer, infectious disease, human epidemiology and developmental disorders.
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All our software tools are made available to the research community and comply with our open-access policy, recognising that community improvement is essential to maximising efficiencies in software development.
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Sanger Seminar Series
Throughout the COVID-19 lockdown of 2020-2021 we hosted a series of monthly freely available and open virtual seminars, showcasing how our researchers are tackling some of the greatest challenges in human health and disease. From using genomic approaches to map all cell types in the human body, understand how cancer develops, and track the evolution and spread of global diseases, our senior scientists and faculty presented the latest developments in their field.
26 Jan 2023
‘Collateral damage’ from normal cell function may cause mutations that play a role in cancer
APOBEC1 enzyme likely responsible for two mutational signatures found in many cancers in small intestine
19 Jan 2023
Bowel cancer mutations that impact immunotherapy identified
Researchers used CRISPR and mini tumours to discover more about how cancer develops and responds to the body’s immune response.