Parasites and Microbes

David Goulding, Wellcome Sanger Institute

Overview

We use genomics to study important problems in infectious disease, with a strong desire to develop and refine tools for disease control and elimination. We are also at the forefront of basic research into microbial ecology, evolutionary genetics and the biology of parasitism.

For further information on the work and people within the programme, download the Parasites and Microbes Programme at the Sanger Institute PDF document.

Related groups

Science group

Berriman Group

Parasite Genomics

The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.

Science group

Bryant Group

Lung microbiome

We explore how the bacteria, viruses and fungi present in a person’s lungs affect health. We study how this changes ...

Science group

Genomics of Pneumonia, Meningitis and Neonatal Sepsis

Parasites and Microbes

We study variation in the genomes of major bacterial pathogens to understand their evolution in the context of disease and asymptomatic ...

Science group

Lawley Lab

Host-microbiota interactions

The Host-Microbiota Interactions Lab explores the relationship between humans and their microbiome- the community of microorganisms that live on and in ...

Science group

Lee Group

Malaria Parasite Drug Resistance

The group aims to understand how malaria parasites become resistant to antimalarial compounds. They study drugs in clinical use as well ...

Science group

Parasites and Microbes Administration

Parasites and Microbes

The activities of the team include anything from organising international travel itineraries, servicing multi-million pound collaborative grants and facilitating Faculty management ...

Science group

Parasites and Microbes Informatics

Parasites and Microbes

The Parasites and Microbes Informatics team develop and maintain software applications and systems to support the research activities of the Parasites ...

Science group

Respiratory Virus and Microbiome Initiative

Parasites and Microbes

We develop DNA sequencing and analysis platforms to track the transmission and evolution of respiratory viruses and understand their interactions with ...

Science group

Thomson Group

Bacterial genomics and evolution

The bacterial genomics and evolution team focuses primarily on using whole-genome sequencing approaches to study the patterns and drivers for historical ...

Science group

Aanensen Group

Genomic Epidemiology of Infectious Diseases

Our mission is to inform control strategies and interventions on a local, national and international scale. Our group consists of a ...

Science group

Billker Group

Rodent models of malaria

At the Sanger Institute Oliver Billker's group used experimental genetics in rodent models to study the basic biology of malaria ...

Science group

COVID-19 Genomics Initiative at the Wellcome Sanger Institute

Genomic Surveillance

We provide real-time genomic monitoring of SARS-CoV-2 in the UK to aid public health response. We monitor for genetic mutations which ...

Science group

Dougan Group

Microbial Pathogenesis

The Microbial Pathogenesis team, under the leadership of Professor Gordon Dougan, focused on the genetic analysis of the interactions between ...

Science group

Kwiatkowski Group

Natural genetic variation

The Kwiatkowski group investigates Plasmodium, Anopheles and human genome variation in large clinical and epidemiological studies carried out with partners in ...

Science group

Parkhill Group

Pathogen Genomics

The Pathogen genomics team, headed by Julian Parkhill, used high-throughput genomic and phenotypic analysis of bacteria to understand their virulence, ...

Science group

PlasmoGEM

Parasites and Microbes

PlasmoGEM (the Plasmodium Genetic Modification Project) is an interdisciplinary group at the Wellcome Sanger Institute focussed on changing the scale of ...

Science group

Rayner Group

Human-parasite interactions in malaria

The group uses large-scale experimental approaches to identify and prioritise drug and vaccine targets in malaria. Focusing on the blood stages ...

Science group

Wright Group

Cell Surface Signalling Laboratory

The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic ...

Related International Fellows and Honorary Faculty

International Fellow

Prof Alfred Amambua-Ngwa

Alfred is a Cameroonian Biochemist with experience and research interest in the use of biotechnology and genomics to understand the evolution ...

International Fellow

Dr Claire Chewapreecha

Claire is a computational biologist based in Thailand and committed to improving public health in Southeast Asia through the development of ...

Honorary Faculty

Prof Abdoulaye Djimdé

Abdoulaye Djimdé is a leading malaria researcher based in Mali, working primarily on the genetic epidemiology of antimalarial drug resistance in ...

International Fellow

Dr Gregorio Iraola

Gregorio is a computational microbiologist based in Uruguay. He applies high-throughput sequencing, bioinformatics and culturing to investigate the evolutionary patterns of ...

Honorary Faculty

Dr Samuel Kariuki

Sam utilises molecular tools to investigate the field epidemiology of major enteric infections and antimicrobial resistance ecology and transmission in Kenya ...

International Fellow

Dr Annettee Nakimuli

Annettee Nakimuli is a leading maternal health researcher based in Uganda, focused primarily on investigating the aetiology, treatment, prevention and long ...

International Fellow

Prof Pablo Tsukayama

Pablo is a Peruvian microbiologist with a long-standing interest in infectious diseases affecting Latin American populations. His research combines methods in ...

Associated research

Collaborations

Collaboration

50 Helminth Genomes Project (50HGP)

We are surveying the genomes of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease ...

Collaboration

Genomic Surveillance Unit

The Genomic Surveillance Unit (GSU) improves global human health by accelerating the use and impact of genomic surveillance. We deliver products, ...

Collaboration

MalariaGEN (Malaria Genomic Epidemiology Network)

MalariaGEN is a data-sharing community that creates genetic data resources to support the control and elimination of malaria.

Collaboration

Wellcome Connecting Science Global Training

The Pathogen groups work with Wellcome Connecting Science to develop and deliver a number of training courses on pathogen genomics, surveillance, ...

Collaboration

MRC Centre for Genomics and Global Health (CGGH)

From 2008 until 2021, this hub for collaboration created networks and infrastructure that turned large-scale genomic data into effective tools to ...

Collaboration

The Centre for Genomic Pathogen Surveillance (CGPS)

Our mission is to inform pathogen control strategies and interventions on a local, national and international scale.

Tools & software

Tool

ARNIE - AVEXIS Receptor Network with Integrated Expression

ARNIE is an online database that integrates the extracellular protein interaction network generated in our lab using AVEXIS technology with ...

Tool

Ag1000g

The Anopheles Gambiae 1000 Genome project is a global collaboration using whole genome deep sequencing to provide a high-resolution view of ...

Tool

Malaria Cell Atlas

The Malaria Cell Atlas aims to provide a resource of single cell transcriptomic data across the full lifecycle of the parasite

Tool

Pf3k

The Pf3k project is a global collaboration using the latest sequencing technologies to provide a high-resolution view of the natural variation ...

Tool

Artemis Comparison Tool (ACT)

ACT is a Java application for displaying pairwise comparisons between two or more DNA sequences.

Data

Data set

Helminth Data

All helminth genomes sequenced by the Sanger Institute

Data set

Protozoan Data

All protozoan genomes sequenced by the Sanger Institute

Data set

Virus Data

All viral genomes sequenced by the Sanger Institute

Data set

Bacterial Data

This Archived page provides historical information on the genome sequences of bacteria that were sequenced at the Wellcome Sanger Institute and ...