Open Targets; Cancer, Ageing and Somatic Mutation
Experimental Cancer Genetics
We are a team of cancer biologists, geneticists and computational biologists interested in understanding how cancers develop and the ways of ...
Health Data Research UK (HDR UK); Human Genetics; Open Targets
Genomics of inflammation and immunity
The goal of our research is to use high-throughput screens to gain causal insights into the biological basis of human disease, ...
Cellular Genetics
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Cellular Genetics; Cancer, Ageing and Somatic Mutation
Connecting human development and disease
Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and ...
Parasites and Microbes; Tree of Life
Parasite Genomics
The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.
Tree of Life
Evolutionary Genomics
All life is linked by the common thread of DNA, modified through evolution. We use whole genome sequences to explore the ...
Parasites and Microbes
Lung microbiome
We explore how the bacteria, viruses and fungi present in a person’s lungs affect health. We study how this changes ...
Cancer, Ageing and Somatic Mutation
Cancer Genetics & Genomics
Throughout life, the genome within cells of the human body is exposed to DNA damage and suffers mistakes in replication. These ...
Single-cell multi-omics tissue mapping and organoid-based disease modeling
We work on a range of tissues and employ multiple cutting-edge tools such as CRISPR perturbation and organoid modeling.
Health Data Research UK (HDR UK); Human Genetics
Health Data Research UK Cambridge Hub
The Danesh group works as part of the Health Data Research (HDR) UK Cambridge site, using genomic, molecular and electronic ...
Open Targets; Human Genetics
Functional Genomics
We combine genomic analysis with clinical data to understand how genetics contributes to the variation between patients in their disease severity ...
Translational Cancer Genomics
The Translational Cancer Genomics team investigate how genetic alterations in cancer contribute to disease and impact on response to therapy.
Cellular Genetics Programme
The team’s research applies disruptive cutting-edge techniques to study the genomics of immune cell populations at single-cell resolution and uses ...
Genomic mutation and genetic disease
The Hurles group studies the genetic causes and mechanisms of rare genetic disorders and how DNA mutates as it is pass ...
Evolution of unusual reproductive mechanisms
We explore how evolution is driven by changes in DNA sequence and chromosome structure by analysing and comparing the genomes of ...
Cancer, Ageing and Somatic Mutation; Open Targets
Pre-cancer
Our group studies how normal cell behaviour is altered by mutation in aging and the earliest stages of cancer development. We ...
Host-microbiota interactions
The Host-Microbiota Interactions Lab explores the relationship between humans and their microbiome- the community of microorganisms that live on and in ...
Evolutionary genetics
Our research group uses genomics to investigate insect biodiversity and malaria transmission.
Malaria Parasite Drug Resistance
Marcus Lee’s group is interested in the molecular basis of drug resistance in the human malaria parasite Plasmodium falciparum, and ...
Human Genetics
Programmable biology
We seek to lay the foundations for programmable biology. By combining genomics, biophysics, mechanistic modelling and artificial intelligence at scale, we ...
Medical and population genomics
We analyse large-scale genetic and electronic health record data to explore fine-scale population structure, its impact on disease risk, and the ...
Science group
Somatic evolution
We combine genome sequencing and computational analyses to study somatic mutation in healthy cells, in ageing and in cancer development.
Genomics of rapid speciation and adaptation
Biodiversity is very unevenly distributed across the tree of life. While the evolution of new species typically takes millions of years, ...
Function of human DNA and its variation
Our goal is to understand how genetic background influences outcome of mutations. To do so, we measure, model, and modulate cell ...
Cancer predisposition and Ageing
During the natural process of ageing, somatic mutations accumulate in our genome and can cause cancer and cancer prediposition. However, little ...
Open Targets; Cellular Genetics
Gene expression genomics
We use cutting edge single cell genomics technologies and computational methods to understand genes, proteins and cells in human health and ...
Bacterial genomics and evolution
The bacterial genomics and evolution team focuses primarily on using whole-genome sequencing approaches to study the patterns and drivers for historical ...
Human Genetics; Open Targets
Immune Genomics
The Trynka group combines experimental and computational approaches to study how genetics control the immune system and predispose individuals to autoimmune ...
The Vento Lab uses genomics and computational tools to reconstruct immune environments. The main areas of focus are: Immunogenomics - Immune responses ...
Single-cell genomics
Thierry Voet's group focuses on developing methods that characterise the DNA and RNA in a single cell to enable ...
Genomic Epidemiology of Infectious Diseases
Our mission is to inform control strategies and interventions on a local, national and international scale. Our group consists of a ...
Medical Genomics
The Barrett team studied how genetic variation affects risk for diseases, and finds ways to apply that knowledge to improve ...
Metabolic disease group
We are a multidisciplinary team that combines large-scale genetic and genomic approaches, and studies in model organisms, to understand the ...
Rodent models of malaria
At the Sanger Institute Oliver Billker's group used experimental genetics in rodent models to study the basic biology of malaria ...
Mouse genomics
The Bradley laboratory is a multi-disciplinary environment with a number of parallel research themes. One of our core disciplines is the ...
Microbial Pathogenesis
The Microbial Pathogenesis team, under the leadership of Professor Gordon Dougan, focused on the genetic analysis of the interactions between ...
Health Data Research UK (HDR UK); Cellular Genetics; Open Targets
Genomics of gene regulation
Gene expression involves the transformation of genetic information encoded in DNA sequence into a gene product, such as a protein. Regulation ...
Quantitative models of gene expression
The Hemberg group is interested in developing quantitative models of gene expression. Our approach is theoretical and we strive to develop ...
Natural genetic variation
The Kwiatkowski group investigates Plasmodium, Anopheles and human genome variation in large clinical and epidemiological studies carried out with partners in ...
Mouse cancer genetics
We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such ...
Pathogen Genomics
The Pathogen genomics team, headed by Julian Parkhill, used high-throughput genomic and phenotypic analysis of bacteria to understand their virulence, ...
Human-parasite interactions in malaria
While at the Sanger Institute, Julian Rayner's group investigated the molecular details of human-parasite interactions during the P. falciparum blood ...
Global Health and Populations
At the Sanger Institute, our research focused on global health and populations, assessing human diversity and its impact on the ...
Human evolution
We study variation in the DNA of people from different parts of the world, and also in related species such as ...
Cellular Genetics; Open Targets
Pancreatic genetics
The Vallier laboratory studies the basic mechanisms controlling differentiation of human pluripotent cells into pancreas, lung, gut and liver cells.
Haematological cancer genetics
The Haematological Cancer Genetics team, led by George Vassiliou, studies the genes and genetic pathways involved in the development of blood ...
Cell Surface Signalling Laboratory
The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic ...
Stem Cell Genetics
The Yusa laboratory focuses on the development of genome engineering technologies that allow us to perform unbiased genome-wide genetic screens ...
Analytical Genomics of Complex Traits
Our research aimed to help identify the genetic determinants of complex human traits by using next-generation association studies to detect ...
Using outbred genetic variation to understand basic biology
DNA sequence remains at the heart of molecular biology and bioinformatics. The Birney Associate Faculty Research Group at the Sanger ...
Our research is focused on understanding what type of immune cells live within different organs in humans, and how the special ...
Computational Genomics
Population and evolutionary genomics, novel computational genomics methods, and related mathematical and statistical models.
Single cell genomics
John Marioni's group develop computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression ...
Non-coding RNA and epigenetics
We are interested in all aspects of gene regulation by non-coding RNA. Current research themes include: miRNA biology and pathology, miRNA ...
Epigenetic reprogramming
Single cell epigenomics applied to development and ageing
Human Complex Traits
Our research focuses on the application of large-scale genomic analysis to unravel the spectrum of human genetic variation associated with cardiometabolic ...
We aim to leverage machine learning in the context of single cell genomics to provide a true model-based understanding of the ...
Systems biology of host-pathogen interactions
The group utilises systems biology methods and differentiated mutant embryonic stem (ES) cells to understand the complex inter-relationship between the ...
Regulatory evolution in mammalian tissues
Duncan Odom's Associate Faculty group compared how transcription and transcriptional regulation vary during evolution, and the implications this regulatory ...
Obesity-associated Metabolic Complications
We aim to learn why being obese causes metabolic and cardiovascular problems and to provide the rational for mechanistically driven therapeutic ...
Cancer Genome Project
The COSMIC group combines expert cancer scientists with experienced bioinformaticians to build the world's largest database of somatic mutations in ...
We design algorithms and tools to identify all cancer vulnerabilities and genetic dependencies, paving the way to new therapies
Cellular Operations
Scientific Operations
The Cellular Generation and Cellular Screening groups are core facilities that provides central cell biology support to the Sanger Institute, functioning ...
We enable the Institute to deliver its world-leading, cutting-edge cell atlassing research for the Human Cell Atlas initiative within the Cellular ...
Cellular Operations; Open Targets
We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and ...
The Cytometry Core Facility at the Wellcome Trust Sanger Institute is a dedicated scientific service offering investigators with state-of-the-art flow cytometry ...
Mapping the Clinical Genome
DECIPHER (DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources) is an interactive web-based database which incorporates a suite ...
In collaboration with our colleagues in Cellular Operations and Stem Cell Informatics, our work focuses on supporting and delivering the gene ...
Tree of Life Programme
The Genome Reference Informatics Team analyses genome assemblies to reveal and correct quality issues and to identify and add variation. It ...
We study variation in the genomes of major bacterial pathogens to understand their evolution in the context of disease and asymptomatic ...
Informatics and Software Development
Sequencing Informatics
Many high profile projects such as the Cancer Genome and 1000 Genomes projects need quality assemblies for downstream analysis using 2nd ...
Sanger-EBI Initative for Large-Scale Spatial Genomics
HTSG uses large-scale spatial genomics to map human tissue architecture.
Administrative Support
The HCA Executive Office, in the UK, is based at the Wellcome Sanger Institute, and works with regional offices in the ...
The Human Genetics Administration comprises a five strong team that provides comprehensive support for the smooth running of the Human Genetics ...
Human Genetics; Information Communications Technology
Human Genetics Informatics (HGI) supports the scientific aims of the Human Genetics programme by developing and operating computational analysis workflows, managing ...
The activities of the team include anything from organising international travel itineraries, servicing multi-million pound collaborative grants and facilitating Faculty management ...
We develop DNA sequencing and analysis platforms to track the transmission and evolution of respiratory viruses and understand their interactions with ...
Graduate Training
First year PhD students undertaking rotation projects.
Genome Engine
The Tree of Life assembly team develops and maintains QC, assembly and analysis pipelines as part of the Tree of Life ...
The Core Laboratory team provides molecular biology support for all projects within the Tree of Life Programme.
Programme management, operations management and support team for the Tree of Life Programme
Our team is responsible for writing and maintaining the core software used in the Tree of Life programme. We work closely ...
The Informatics Infrastructure team oversees the implementation and delivery of the genome assembly pipelines in the Tree of Life programme, and ...
The Project Management & Operations team supports and facilitates the cutting-edge science of the Tree of Life programme. This takes many forms: ...
Our team oversees the supply of samples – collected from organisms in the field or from the laboratory – that feed into the ...
Genomic Surveillance
We provide real-time genomic monitoring of SARS-CoV-2 in the UK to aid public health response. We monitor for genetic mutations which ...
The High Throughput Gene Editing team helped to deliver the gene editing requirements of the Institute's faculty and research
Infection Genomics
The activities of the team include anything from organising international travel itineraries, servicing multi-million pound collaboratorive grants and facilitating Faculty ...
Malaria
The Malaria and the Infection Genomics Administration teams merged in December 2017 to become the Parasites and Microbes Administration team.
PlasmoGEM (the Plasmodium Genetic Modification Project) is an interdisciplinary group at the Wellcome Sanger Institute focussed on changing the scale of ...
Scientific Resources
Until the group left the Sanger Institute in 2017, it was interested in solving questions about the biology underlying health ...
We developed algorithms and technologies that enable researchers to discover and share genetic variation using next-generation sequencing technologies. We were ...
This group consists of manual annotators and software developers. The HAVANA team provides the manual annotation of human, mouse, zebrafish and ...
We explore molecular phenotypes through the transcript sequencing of whole vertebrate embryos and tissues either by traditional RNA-seq or 3' end ...
Informatics
The Vertebrate Resequencing (VR) team was responsible for handling the informatics and large scale sequencing projects for the Durbin and Adams ...
Genomic Surveillance Unit
We develop, deploy and support the digital products and infrastructure that enables the Genomic Surveillance Unit (GSU) to carry out its ...
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Information Communications Technology
Pipeline Solutions
Cellular Informatics (CI) develops custom laboratory information systems (LIMS) and computational research tools (WGE) for high-throughput laboratory analysis of human stem ...
Information Communications Technology; Tree of Life; Cancer, Ageing and Somatic Mutation; Human Genetics; Parasites and Microbes
Informatics and Digital Solutions (Web, Web security and Core Bioinformatics)
Core Software Services comprises: Core Web Team; Core Bioinformatics (CoreBio) and; Core Web security.
The Database Services team is primarily responsible for the design, development, implementation and maintenance of diverse relational databases in support of ...
High Performance Computing
Our Informatics support team is responsible for both developing and providing scale out scientific compute platforms that can both meet todays ...
Scientific Computing
Provide World Class High Performance Computing and First Class Production Platforms and Services for genome and biodata research.
As a group the team is involved in the day to day service provision and maintenance of the production Networking, Storage ...
NPG is responsible for the delivery of DNA Pipelines's data products and the provision of informatics expertise and QC systems.
The Parasites and Microbes Informatics team develop and maintain software applications and systems to support the research activities of the Parasites ...
Pipeline Solutions Division - Information and Digital Solutions
Laboratory Information and Management Systems (LIMS) compute and infrastructure
The Production Software Development team is responsible for Laboratory Information Management Systems (LIMS) development in core informatics within the Wellcome Sanger ...
SAM contributes to various software packages for processing DNA sequence data, including samtools, htslib, biobambam and the Staden package. We also ...
The Sequencing Informatics group supports DNA Pipelines in the production of their data products, faculty's use of those products, and ...
In line with the IT Strategy, our aim is to deliver a robust, reliable and repeatable IT service to both the ...
We are part of the wider Illumina sequencing team that generates data for all of the faculty research programmes at the ...
The Wellcome Sanger Institute's technological platforms underpin our ability to carry out biomedical research on a large scale, allowing researchers ...
The team identifies significant opportunities to improve processes across DNA Pipelines, improving the outputs of Operations and adressing key business ...
DNA Sequencing
DNA Pipelines Development
The DNA Pipelines Research and Development group is the entry point for new technologies to the Institute, especially sequencing instruments. The ...
The Data QC team within DNA Pipelines Operations represent the final opportunity to detect and resolve issues with sequencing data ...
The Genotyping, Index Sequence Capture (ISC) & Single-cell Sequencing team within DNA Pipelines Operations is a high throughput Illumina® library creation ...
The High Throughput DNA sequencing team within DNA Pipelines Operations is a highly automated high throughput team specialising in producing libraries ...
The High Throughput RNA and LCMB Sequencing team within DNA Pipelines Operations is a high throughput Illumina® library creation team ...
The long read sequencing team within DNA Pipelines Operations at the Wellcome Sanger Institute provides support for research projects requiring ...
Sample management undertake DNA and RNA extraction from biological materials, provide automated QC and normalisation to the DNA pipelines teams, an ...
The Scientific Customer Support team comprises Scientific Services Representatives (SSRs) who are the first point of contact for the Institute’s ...
Our Faculty work closely with our Scientific Operations teams which are responsible for all data production pipelines at the Institute.
DNA Pipelines provides genome analysis services for the Institute’s Faculty. The Pipelines process DNA, RNA and tissue samples received from ...
Our mission is to provide state-of-the-art molecular cytogenetics services to support the cutting-edge research of the institute.
Model Pipelines
Model Pipelines produced and characterised knock-out mice for large-scale research projects, including the Sanger Mouse Genetics Project, KOMP2, EUCOMMTools, and the ...
Mouse Pipelines
The team provided high-throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells or CRISPR/Cas9 ...
The Mouse Phenotyping team delivered phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompassed a standardised set ...
The Mouse Pipelines team supported biomedical research through the humane and optimized use of genetically-modified mice.
The Transgenic Technologies group produced mutant mice by utilising modified ES cell and Crispr/Cas9. All lines produced were cryopreserved and ...
The Research Support Facility served the Institute and worldwide community by providing and caring for mice and zebrafish used in research ...
Our aim is to offer a high-quality, high-throughput single cell sequencing service that enables Faculty to study and understand cellular heterogeneity ...
