News Archive

News Archive

500,000 whole human genomes will be a game-changer for research into human diseases

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500,000 whole human genomes will be a game-changer for research into human diseases

Following on from a successful pilot at the Sanger Institute, we are leading a project to sequence the genomes of all UK Biobank volunteers to power the next wave of genetic and health research

In a major advance for public health and for the UK’s global leadership in genomics, a £200m project involving the government, charity, researchers and four leading pharmaceutical companies, was announced today (11 September). The Whole Genome Sequencing (WGS) project will become a game-changing resource accessible to the global scientific community to understand, diagnose, treat and prevent life-changing diseases such as cancer and dementia.

Brown trout genome will help explain species' genetic superpowers

Brown trout (Salmo trutta) are one of the most genetically diverse vertebrates, it could comprise up to 50 distinct species. The newly-sequenced brown trout genome will allow scientists and conservationists to better understand the fish's genetic roots

Brown trout genome will help explain species' genetic superpowers

Eagerly awaited reference genome will allow conservationists to understand how the fish adapts to marine and freshwater environments

Better conservation and management of fish stocks is on the horizon, after the completion of the brown trout reference genome by scientists at the Wellcome Sanger Institute and their collaborators. The genome will help settle a longstanding debate about whether the physically-varied brown trout is actually a single species or several, and give insights into their ability to quickly adapt to multiple environments.

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab in action

LifeLab 2019 – discovery on your doorstep with an exciting programme of free events and activities

LifeLab has launched an exciting programme of events for Friday 27 and Saturday 28 September 2019, transforming parts of Cambridge, Peterborough and Ely into discovery zones for the weekend

LifeLab is led by Wellcome Genome Campus Public Engagement, and brings together five of the region’s leading life science research organisations: the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI), the Babraham Institute, the University of Cambridge and the MRC Laboratory of Molecular Biology.

Decoding first of 60,000 British species as Darwin Tree of Life branches out

Speckled wood butterfly

Decoding first of 60,000 British species as Darwin Tree of Life branches out

The mission to map the genetic code of all known British species is underway

A mission to map the genetic code of 60,000 British species is well underway as 150 species are in the process of having their DNA extracted and their entire genetic code read and assembled. Sanger Institute researchers and their collaborators within the Darwin Tree of Life project plan to sequence the genomes of 2,000 British species over the next two years, and then scale up to complete 60,000 species’ genomes with the next 10 years, Professor Mark Blaxter announced this week at a press briefing in New York.

Map of malaria behaviour set to revolutionise research

Malaria Cell Atlas logo. Image credit: Alex Cagan

Map of malaria behaviour set to revolutionise research

The Malaria Cell Atlas gives the highest resolution view of malaria parasite gene expression to date and monitors how individual parasites change as they develop in both the mosquito and human host

The first detailed map of individual malaria parasite behaviour across each stage of its complicated life cycle has been created by scientists. Researchers at the Wellcome Sanger Institute and their collaborators used advanced single-cell technology to isolate individual parasites and measure their gene activity. The result is the Malaria Cell Atlas

Malaria control success in Africa at risk from spread of multi-drug resistance

Effective case management remains one of the cornerstones of malaria prevention and control. Artemisinin-based combination therapies (ACTs) are used for the treatment of uncomplicated malaria. Credit: William Brieger, Jhpiego

Malaria control success in Africa at risk from spread of multi-drug resistance

Regional populations of Plasmodium falciparum parasites in Africa are sharing genetic material in all directions – including genes that can confer resistance to anti-malarial drugs

In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs. This sheds new light on the way that drug resistance is emerging in different locations and moving by various routes across Africa, putting previous success in controlling malaria at risk.

Diarrhoea-causing bacteria adapted to spread in hospitals

Diarrhoea-causing bacteria adapted to spread in hospitals

Diarrhoea-causing bacteria adapted to spread in hospitals

Gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals

Scientists have discovered that the gut-infecting bacterium Clostridium difficile is evolving into two separate species, with one group highly adapted to spread in hospitals. Researchers identified genetic changes in the newly-emerging species that allow it to thrive on the Western sugar-rich diet, evade common hospital disinfectants and spread easily. They estimated this emerging species started to appear thousands of years ago, and accounts for over two thirds of healthcare C. difficile infections.

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Hospitals key in the spread of extremely drug resistant bacteria in Europe Primary tabs. Image credit: Shutterstock

Hospitals key in the spread of extremely drug resistant bacteria in Europe

Research emphasises importance of ongoing genomic surveillance and infection control

New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections in humans, are spreading through hospitals in Europe. Certain strains of K. pneumoniae are resistant to the carbapenem antibiotics that represent the last line of defence in treating infections and are therefore regarded as extremely drug resistant (XDR).

Cancer drug data release set to power next wave of therapeutic discovery

Cancer drug data release set to power next wave of therapeutic discovery

Cancer drug data release set to power next wave of therapeutic discovery

Unique data comparing almost 1,000 cancer cell lines’ responses to 453 licensed and experimental drugs is now freely available to the worldwide research community

The Genomics of Drug Sensitivity in Cancer project (www.cancerrxgene.org) has released the results of four years of intense research to power genetic research into cancer treatment worldwide. The new data set builds on the previous six years’ study, and practically doubles the volume of novel data available on the website – making it the largest public dataset of its kind in the world.

Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

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Sanger Institute researcher, Henry Lee-Six, wins Dr Falk Pharma/Guts UK essay prize

Medical student working in the Cancer Genome Project wins prize for colon cancer research

A medical student who undertook a clinical PhD at the Wellcome Sanger Institute in Cambridge has gained a top prize in the prestigious Dr Falk-Pharma/Guts UK charity national awards. Mr Henry Lee-Six won the  award for his project entitled ‘Mutational Landscape of Normal Colon’ which examined potential causes of the evolution of colon cells from normal to cancerous.

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