News Archive

News Archive

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Human Cell Atlas

Chan Zuckerberg Initiative boosts Human Cell Atlas research at the Sanger Institute

Seed Networks projects will focus on specific tissues, such as the thymus, lung, liver, kidney and immune system

Wellcome Sanger Institute researchers will receive funding from the Chan Zuckerberg Initiative (CZI) for five collaborative projects supporting the Human Cell Atlas (HCA), the global initiative to map every cell type in the human body. These projects will investigate specific tissues in the thymus, lung, liver, kidney and immune system to understand health and what goes wrong in disease.

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA

Genomic analysis shows that a significant number of strains are susceptible to penicillin combined with clavulanic acid

In Nature Microbiology, scientists have identified which gene mutations make MRSA susceptible to a combination of penicillin and clavulanic acid. Analysing the whole-genome sequences of a diverse collection of MRSA strains revealed that a significant number of strains – including USA300 clone, the dominant strain in the United States – would be treatable with this drug combination.

First lung map uncovers new insights into asthma

First lung map uncovers new insights into asthma

First lung map uncovers new insights into asthma

Understanding lung cells and their signals could help towards finding new asthma drug targets

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. Understanding the cells and their signals could lead to finding new drug targets for treating asthma.

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo has been elected as an EMBO Member

Sanger Institute researcher honoured by EMBO

Professor Nicole Soranzo becomes an elected member of the European Molecular Biology Organization

Professor Nicole Soranzo joins 48 fellow scientists from 17 countries in being elected as Members of the European Molecular Biology Organization (EMBO). An additional eight researchers from Argentina, Australia, Japan and the US have become Associate Members of the organisation whose mission is to promote excellence in European molecular life sciences research.

Major stem cell discovery to boost research into development and regenerative medicine

Pig EPSCs (expanded potential stem cells) Image credit: Xuefei Gao

Major stem cell discovery to boost research into development and regenerative medicine

Expanded Potential Stem Cell lines of pig and human cells established

The research from the Wellcome Sanger Institute and collaborators offers incredible potential for studying human development and regenerative medicine. It is the first time scientists have been able to derive stem cells from early pig embryos and will also be beneficial for animal health and food production.

Global Strep A vaccine one step closer

Currently there is no global vaccine for Group A streptococcal bacteria

Global Strep A vaccine one step closer

Streptococcus genomes reveal potential vaccine targets present in over 20 countries worldwide

The search for a global Strep A vaccine has narrowed after researchers sequenced the DNA of more than 2,000 Group A Streptococcus samples from around the world. Researchers identified potential vaccine targets present in strains from all the countries sampled, pointing to the possibility of developing an effective global vaccine against Strep A, one of the top 10 causes of death from infectious diseases worldwide.

Sanger Institute animal research facility to close

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Sanger Institute animal research facility to close

Following a full review, the Sanger Institute will be closing its animal research facility

The difficult decision has been made after consultation with the Sanger Institute board and the Genome Research Limited board, which has representation from Wellcome. The facility is expected to close over the next few years.

CRISPR catches out critical cancer changes

Pancreatic cancer cells: one of 43 types of cancer studied by the Wellcome Sanger Institute for gene fusions

CRISPR catches out critical cancer changes

Researchers reveal which gene fusions are critical for the growth of cancer cells and identify a new drug target for multiple cancers

In the first large-scale analysis of cancer gene fusions, researchers at the Wellcome Sanger Institute and their collaborators used CRISPR to uncover which gene fusions are critical for the growth of cancer cells. The team also identified a new gene fusion that presents a novel drug target for multiple cancers, including brain and ovarian cancers. The results give more certainty for the use of specific gene fusions to diagnose and guide the treatment of patients.

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

Dr Sam Behjati has received the Royal College of Paediatrics and Child Health (RCPH) Dr Simon Newell Early Career Investigator Award

Honouring research excellence: Dr Sam Behjati wins award for work to unravel the identity and origin of childhood cancers

The 2019 recipient of the Dr Simon Newell Early Career Investigator Award has been announced as Dr Sam Behjati, whose career to date has focused on the developmental origins of childhood cancers

This annual honour is open to outstanding clinician researchers early in their academic career, and is named in memory of Dr Simon Newell – a renowned and widely respected neonatologist and paediatrician who had a passion for encouraging the next generation of paediatric clinicians and researchers.

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