News Archive

News Archive

Takeda joins drug target discovery initiative

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Takeda joins drug target discovery initiative

Takeda will expand the skills and scientific background of Open Target's existing partners by bringing expertise in gastroenterology, central nervous system and oncology

Takeda is a global, research and development-driven pharmaceutical company with expertise in oncology, gastroenterology (GI) and central nervous system (CNS) disease that will complement the offerings of GSK, Biogen, the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI), and build on the initiative’s success.

Largest genetic study of mosquitoes reveals spread of insecticide resistance across Africa

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Largest genetic study of mosquitoes reveals spread of insecticide resistance across Africa

Genetic resource will help develop new tools to support the campaign against malaria in Africa

The largest-ever genetic study of mosquitoes reveals the movement of insecticide resistance between different regions of Africa and finds several rapidly evolving insecticide resistance genes. Malaria is transmitted by mosquitoes and rising resistance to insecticides is hampering efforts to control the disease. Reported in Nature, this genetic resource will help to develop new tools for monitoring resistance and managing insecticide use, and for designing novel control methods.

Unforeseen new drug target discovered for acute myeloid leukaemia (AML)

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Unforeseen new drug target discovered for acute myeloid leukaemia (AML)

Scientists find that inhibiting the METTL3 gene destroys AML cells without harming non-cancerous blood cells

A study has found an unexpected new drug target for acute myeloid leukaemia (AML) that could open new avenues to develop effective treatments against this potentially lethal disease. Researchers from the Wellcome Trust Sanger Institute, the Gurdon Institute and their collaborators show that inhibiting the METTL3 gene destroys human and mouse AML cells without harming non-leukaemic blood cells.

Risk of cholera epidemics estimated with new rule book

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Risk of cholera epidemics estimated with new rule book

Researchers from across the world have studied cholera outbreaks in Africa, Latin America and the Caribbean from the last 60 years

In two new studies focussing on Africa and Latin America, scientists analysed historical cholera samples to trace their transmission across the globe. They found that cholera repeatedly traveled out of south Asia to cause epidemics in Africa and Latin America.

25 new genomes to celebrate 25 years of the Sanger Institute

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25 new genomes to celebrate 25 years of the Sanger Institute

Blackberry to robin, bush cricket to brown trout - the 25 species all reside in the UK

To commemorate the Wellcome Trust Sanger Institute turning 25 in 2018, the Institute and collaborators are sequencing 25 new genomes. From the blackberry to the robin, bush cricket to brown trout, all the species reside in the UK. Twenty species have already been decided, and the remaining five will be voted for by the public and school children.

Professor Sharon Peacock to be awarded the 2018 Microbiology Society Unilever Colworth Prize

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Professor Sharon Peacock to be awarded the 2018 Microbiology Society Unilever Colworth Prize

This Prize is awarded for significant contributions in the field of microbiology

Professor Peacock uses whole genome sequencing technology in public health, helping to increase the speed of outbreak analysis. She has been working with local hospitals and regional microbiology services to implement sequence-based approaches to clinical microbiology. Her latest study showed that routine genomic surveillance of MRSA can detect unsuspected outbreaks.

Study shows routine genomic surveillance of MRSA can detect unsuspected outbreaks

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Study shows routine genomic surveillance of MRSA can detect unsuspected outbreaks

Catching outbreaks early could prevent further spread and reduce the number of people involved

Genomic surveillance has revealed the first complete picture of MRSA spread across the east of England. By tracking all MRSA-positive people in the area, researchers saw the transmission within and between hospitals, and in GPs surgeries and communities. The study showed that routine genomic surveillance could catch outbreaks earlier, which could help prevent further transmission.

Five new malaria targets that could lead to an effective vaccine

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Five new malaria targets that could lead to an effective vaccine

Scientists have identified five targets that reduce the parasite’s ability to invade red blood cells

In the largest study of its kind, five new malaria vaccine targets have been discovered by scientists at the Wellcome Trust Sanger Institute and their collaborators. Researchers studied the malaria parasite at its most vulnerable stage – when invading human red blood cells – and identified five targets that lead to a reduction in the parasite’s ability to enter red blood cells.

Thermo Fisher Scientific and Wellcome Trust Sanger Institute Announce the Axiom Africa Array for Medical and Population Genomics

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Thermo Fisher Scientific and Wellcome Trust Sanger Institute Announce the Axiom Africa Array for Medical and Population Genomics

The array tags at least 90 per cent of common genetic variation in 12 diverse African populations

The AGR whole-genome sequencing effort encompassed populations from across Africa, including from Ethiopia (Gumuz, Wolayta, Amhara, Oromo, Somali), Egypt, Namibia (Nama/Khoesan) and South Africa (Zulu). The genomes of 2,000 individuals from Uganda (Baganda, Banyarwanda, Barundi and others) were also included. The AGR resource now contains 94.5M SNPs of which 21.7M are unique to AGR.

1 to 10 mutations are needed to drive cancer, scientists find

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1 to 10 mutations are needed to drive cancer, scientists find

The results show the number of mutations driving cancer varies considerably across different cancer types

For the first time, scientists have provided unbiased estimates of the number of mutations needed for cancers to develop, in a study of more than 7,500 tumours across 29 cancer types. Researchers from the Wellcome Trust Sanger Institute and their collaborators adapted a technique from the field of evolution to confirm that, on average, 1 to 10 driver mutations are needed for cancer to emerge. The results are published today (19th October) in Cell.

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