News Archive

News Archive

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Measles infection wipes our immune system's memory, leaving us vulnerable to other diseases

Research explains why children often catch other infections after measles, and highlights the importance of vaccination

Researchers from the Wellcome Sanger Institute, University of Amsterdam and their collaborators revealed that the measles virus deletes part of the immune system’s memory, removing previously existing immunity to other infections, in both humans and ferrets. Importantly, the team showed for the first time that measles resets the human immune system back to an immature baby-like state with only limited ability to respond to new infections.

Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

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Scientists to Create a “Gut Cell Atlas” With Funding from the Helmsley Charitable Trust

Researchers will examine both healthy and diseased intestinal tissue to identify key cell types involved in Crohn’s disease

The Leona M. and Harry B. Helmsley Charitable Trust announced $13 million in new grants to create a Gut Cell Atlas, cataloguing the many cell types in the small and large intestines. The initiative aims to understand distinct cell functions and interactions in human health and Crohn’s disease. Helmsley’s Gut Cell Atlas initiative is part of the larger international Human Cell Atlas collaboration

Accumulation of DNA mutations found in healthy liver leads to disease

Microscope image of liver tissue affected by cirrhosis

Accumulation of DNA mutations found in healthy liver leads to disease

Largest study of its kind seeks to better understand how liver disease and hepatocellular carcinoma develop

New insights into the journey from health to disease in the human liver have been made by scientists at the Wellcome Sanger Institute, Cancer Research UK Cambridge Institute, the University of Cambridge and their collaborators. In the largest study of its kind, the team documented in unprecedented detail how the accumulation of changes in our DNA over time, known as mutations, evolves during the development of chronic liver disease and liver cancer.

Uncovering the pathway to colon cancer

Using laser capture microscopy to take samples from colon tissue

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

The hidden world of genetic changes, or mutations, in healthy colon tissue has been uncovered by scientists at the Wellcome Sanger Institute and their collaborators. The team developed technology to sequence the genomes of small numbers of colon cells, allowing them to study genetic mutations in unprecedented detail. Researchers found complex patterns of mutations, including changes in cancer genes, and a huge variability of mutations both within and between people.

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

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Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

The inaccurate allegations refer to specific research that aimed to support scientific discovery with partners working in Africa. The Sanger Institute has not commercialised any products based on this research and it has not received and will not financially benefit from any revenues.

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

For the first time, scientists have uncovered the likely series of events that led to the world’s deadliest malaria parasite being able to jump from gorillas to humans. Researchers at the Wellcome Sanger Institute and the University of Montpellier reconstructed an approximately 50,000-year-old gene sequence that was acquired by the ancestor of Plasmodium falciparum, giving it the ability to infect human red blood cells. 

Jumping genes can cause rare developmental disorders in children

Jumping genes can cause rare developmental disorders in children. Image credit: Pixabay

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

The largest study of its kind into childhood developmental disorders has discovered that jumping genes cause genetic changes in some patients with undiagnosed neurodevelopmental diseases. The research has provided genetic diagnoses for three children enrolled in the Deciphering Developmental Disorders project, which will help the families access support and understand the disease risks for any future children.

First cell map of developing human liver reveals how blood and immune systems develop

First cell map of developing human liver reveals how blood and immune system develops

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early life

In a world first, scientists have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the foetus. It maps changes in the cellular landscape of the developing liver between the first and second trimesters of pregnancy, including how stem cells from the liver seed other tissues to support the high demand for oxygen needed for growth.
 

Fresh insights could lead to new treatments for liver disease

Liver fibrosis. Image credit: Neil Henderson, University of Edinburgh

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

Scientists have identified new sub-types of cells that, when they interact, accelerate the scarring process in diseased livers.

Sanger Institute cancer researcher’s innovation recognised

Mathew Garnett has received a National Cancer Research Institute Excellence Award

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use of next-generation organoid models of cancer

Dr Mathew Garnett has received one of the first Excellence Awards given by the National Cancer Research Institute (NCRI). The Innovation Award highlights the work of Dr Garnett and his team in producing hundreds of patient-derived 3D organoid cultures as a community resource to accelerate cancer research.

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