News Archive

News Archive

Uncovering the pathway to colon cancer

Using laser capture microscopy to take samples from colon tissue

Uncovering the pathway to colon cancer

Scientists identify patterns of genetic changes in healthy colon tissue, giving insight into the very earliest stages of cancer

The hidden world of genetic changes, or mutations, in healthy colon tissue has been uncovered by scientists at the Wellcome Sanger Institute and their collaborators. The team developed technology to sequence the genomes of small numbers of colon cells, allowing them to study genetic mutations in unprecedented detail. Researchers found complex patterns of mutations, including changes in cancer genes, and a huge variability of mutations both within and between people.

Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

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Sanger Institute refutes allegations of misuse of African DNA data from partner institutions

Two investigations by two separate experts found that no wrongdoing took place

The inaccurate allegations refer to specific research that aimed to support scientific discovery with partners working in Africa. The Sanger Institute has not commercialised any products based on this research and it has not received and will not financially benefit from any revenues.

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Resurrection of over 50,000-year-old gene reveals how malaria parasite jumped from gorillas to humans

Discovery of molecular pathway is valuable example of how a pathogen can switch from one host species to another

For the first time, scientists have uncovered the likely series of events that led to the world’s deadliest malaria parasite being able to jump from gorillas to humans. Researchers at the Wellcome Sanger Institute and the University of Montpellier reconstructed an approximately 50,000-year-old gene sequence that was acquired by the ancestor of Plasmodium falciparum, giving it the ability to infect human red blood cells. 

Jumping genes can cause rare developmental disorders in children

Jumping genes can cause rare developmental disorders in children. Image credit: Pixabay

Jumping genes can cause rare developmental disorders in children

Diagnoses achieved for three more children in the Deciphering Developmental Disorders project

The largest study of its kind into childhood developmental disorders has discovered that jumping genes cause genetic changes in some patients with undiagnosed neurodevelopmental diseases. The research has provided genetic diagnoses for three children enrolled in the Deciphering Developmental Disorders project, which will help the families access support and understand the disease risks for any future children.

First cell map of developing human liver reveals how blood and immune systems develop

First cell map of developing human liver reveals how blood and immune system develops

First cell map of developing human liver reveals how blood and immune systems develop

Resource improves understanding of normal development and will support efforts to tackle diseases, such as leukaemia, that can form during early life

In a world first, scientists have created the human developmental liver cell atlas that provides crucial insights into how the blood and immune systems develop in the foetus. It maps changes in the cellular landscape of the developing liver between the first and second trimesters of pregnancy, including how stem cells from the liver seed other tissues to support the high demand for oxygen needed for growth.
 

Fresh insights could lead to new treatments for liver disease

Liver fibrosis. Image credit: Neil Henderson, University of Edinburgh

Fresh insights could lead to new treatments for liver disease

The fight against liver disease could be helped by the discovery of cells that cause liver scarring

Scientists have identified new sub-types of cells that, when they interact, accelerate the scarring process in diseased livers.

Sanger Institute cancer researcher’s innovation recognised

Mathew Garnett has received a National Cancer Research Institute Excellence Award

Sanger Institute cancer researcher’s innovation recognised

Congratulations to Dr Mathew Garnett who has received a National Cancer Research Institute Excellence Award for his research into the use of next-generation organoid models of cancer

Dr Mathew Garnett has received one of the first Excellence Awards given by the National Cancer Research Institute (NCRI). The Innovation Award highlights the work of Dr Garnett and his team in producing hundreds of patient-derived 3D organoid cultures as a community resource to accelerate cancer research.

Human kidney map charts our growing immune defence

Section of human kidney cortex

Human kidney map charts our growing immune defence

New cell atlas reveals immune cells present in zones of human kidney

The first cell atlas of the human kidney’s immune system has been created after scientists mapped nearly 70,000 individual kidney cells from early life and adults. Researchers generated the atlas and used it to map immune cells in the kidney. This shows for the first time how the kidney’s immune system develops during early life, and strengthens after birth and as we mature into adults, with implications for tackling kidney disease and transplant rejection

Scientists hone in on DNA differences behind immune diseases

Scientists hone in on DNA differences behind immune diseases. Image credit: Shutterstock

Scientists hone in on DNA differences behind immune diseases

Search could help find drug targets for developing new treatments

Scientists are one step closer to discovering the causes of immune diseases such as asthma, multiple sclerosis and arthritis. Research from the Wellcome Sanger Institute, GSK and Biogen, under the Open Targets initiative, has shown that thousands of differences in DNA between individuals, associated with immune diseases, are linked with the switching-on of a specific subtype of immune cells.

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Salmonella responsible for bloodstream infections in central Africa resistant to nearly all drugs

Strain of dangerous pathogen shown to have developed resistance to last-line-of-defence drug

The first extensively drug-resistant (XDR) strains of Salmonella Typhimurium, a pathogen which is responsible for millions of bloodstream infections per year in sub-Saharan Africa, have been identified in the Democratic Republic of Congo (DRC). Drug-resistance has increased in successive groups of S. Typhimurium over time. These new strains are resistant to all but one of the commonly available drugs in the DRC, with one sample showing reduced susceptibility to this final antibiotic.

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