News Archive - 2014

News Archive - 2014

Agreement will accelerate genetic disease research worldwide

Agreement will accelerate genetic disease research worldwide

Licence provides access to more than 9,500 knock-out EUCOMM mouse resources

Academic and industry researchers worldwide will be able to carry out research and development into human disease more rapidly due to a non-exclusive partnership between European Conditional Mouse Mutational Program (EUCOMM) members Wellcome Trust Sanger Institute and Helmholtz Zentrum München, and genOway, a specialist producer and distributer of modified mouse resources.

Reconstructing the life history of a single cell

Reconstructing the life history of a single cell

Cell's unique mutations used to trace history back to its origins in the embryo

Researchers have developed new methods to trace the life history of individual cells back to their origins in the fertilised egg. By looking at the copy of the human genome present in healthy cells, they were able to build a picture of each cell's development from the early embryo on its journey to become part of an adult organ.

Mosquitos swap insecticide-resistance genes

Mosquitos swap insecticide-resistance genes

Genome sequences of Anopheles gambiae sister species help to investigate insecticide resistance

Researchers have exploited a natural experiment created by our use of insecticides to show that large regions of DNA can move between the two types of mosquito that are most important in spread of malaria. The work is important for infection control because it suggests that these mosquitoes can remain distinct species even as they acquire resistance to insecticides from one another.

Exploring a parasitic tunnel-boring machine

Exploring a parasitic tunnel-boring machine

Parasitic worm genome and biology provides a solid basis for the development of new interventions

Researchers have deduced essential biological and genetic information from the genome sequence of the whipworm, an intestinal parasitic worm that infects hundreds of millions of people in developing countries. This information acts as the foundation for the development of new strategies and treatments against this debilitating parasite.

Sanger Institute launches return-to-research fellowship

Sanger Institute launches return-to-research fellowship

Sanger Institute Fellowship will help scientists who have taken a career gap

The Wellcome Trust Sanger Institute has launched the Sanger Institute Fellowship; a postdoctoral fellowship designed to help scientists to return to scientific research after a career break of 12 months or more, for any reason. One fellowship will be awarded each year after a competitive selection process. Successful candidates will join one of the Sanger Institute's research programmes for three years.

Pathway between gut and liver regulates bone mass

Pathway between gut and liver regulates bone mass

Biological process behind role of vitamin B12 in bone formation unravelled

Researchers have uncovered a previously unknown biological process involving vitamin B12 and taurine that regulates the production of new bone cells. This pathway could be a potential new target for osteoporosis treatment.

Clonal heterogeneity is hidden in the mix

Clonal heterogeneity is hidden in the mix

Algorithm reconstructs lineages of competing cancer cells within individual tumours

Researchers at the Wellcome Trust Sanger Institute have developed a method to characterise the main lineages of cells that are present in a tumour and their prevalence over time following chemotherapy. Aiming to reconstruct the genetic profiles of cellular lineages within the tumour, the team created a new computational algorithm named cloneHD which makes use of whole-genome DNA sequencing from mixed populations.

Beneath the skin

Beneath the skin

A genetic microscope on skin development

Researchers report the first comprehensive analysis of genes that affect a single tissue. Genes don't act in isolation and it is only by studying the effects of many genes that scientists can gain a more accurate and holistic view of the complex biology of tissues.

Atlas shows how genes affect our metabolism

Atlas shows how genes affect our metabolism

New atlas of molecules paves the way for improved understanding of metabolic diseases

In the most comprehensive exploration of the association between genetic variation and human metabolism, researchers have provided unprecedented insights into how genetic variants influence complex disease and drug response through metabolic pathways.

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