Genome damage from CRISPR/Cas9 gene editing higher than thought
Roots of leukaemia reveal possibility of predicting people at risk
Wellcome Sanger Institute researchers and collaborators found that patients with acute myeloid leukaemia (AML) had genetic changes in their blood years before they suddenly developed the disease. The study published in Nature shows that further research could allow earlier detection and monitoring of people at risk of AML in the future.
Cholera spread tracked at household level
For the first time, the transmission of cholera has been tracked at the household level across Dhaka, Bangladesh, a city with a ‘hyper-endemic’ level of the disease. Researchers from the Wellcome Sanger Institute and their collaborators found that nearly 80 per cent of the cholera transmission in Dhaka occurred between people who shared a household. The results of the large-scale genomic study could be used by public health officials to improve cholera control strategies.
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Loose ends: almost one in five human genes still have unresolved coding status.
Nucleic acids research 2018
Prediction of acute myeloid leukaemia risk in healthy individuals.
Crumble: reference free lossy compression of sequence quality values.
Bioinformatics (Oxford, England) 2018
Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.
Microbial genomics 2018
A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.
Scientific reports 2018;8;1;10439
Detection and removal of barcode swapping in single-cell RNA-seq data.
Nature communications 2018;9;1;2667
No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice.
PLoS genetics 2018;14;7;e1007503
BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells.
Brain : a journal of neurology 2018
Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution.
Cell reports 2018;24;2;489-502
The prehistoric peopling of Southeast Asia.
Science (New York, N.Y.) 2018;361;6397;88-92
ESBL-plasmid carriage in <i>E. coli</i> enhances in vitro bacterial competition fitness and serum resistance in some strains of pandemic sequence types without overall fitness cost.
Gut pathogens 2018;10;24
Single-cell biology: resolving biological complexity, one cell at a time.
Development (Cambridge, England) 2018;145;13
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Nature medicine 2018