Milestone reached in major developmental disorders project
Genetics allows personalised disease predictions for chronic blood cancers
Scientists have developed a successful method to make truly personalised predictions of future disease outcomes for patients with certain types of chronic blood cancers. Wellcome Sanger Institute researchers and collaborators combined extensive genetic and clinical information to predict the prognosis for patients with myeloproliferative neoplasms. Published in the New England Journal of Medicine, the research identified eight different genetic subgroups of the disease and could lead to personalised medicine for patients with these blood cancers.
25 UK species' genomes sequenced for first time
The genomes of 25 UK species have been read for the first time by scientists at the Wellcome Sanger Institute and their collaborators. The 25 completed genome sequences, announced today (4 October) on the Sanger Institute’s 25th anniversary, will lead to future studies to understand the biodiversity of the UK and aid the conservation and understanding of our species.
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A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.
BACTOME-a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates.
Nucleic acids research 2018
KAT6A Syndrome: genotype-phenotype correlation in 76 patients with pathogenic KAT6A variants.
Genetics in medicine : official journal of the American College of Medical Genetics 2018
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.
Nature genetics 2018
Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal <i>Salmonella</i>.
Proceedings of the National Academy of Sciences of the United States of America 2018
Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.
Cell stem cell 2018
Common genetic variants contribute to risk of rare severe neurodevelopmental disorders.
Effect of vaccination on pneumococci isolated from the nasopharynx of healthy children and the middle ear of children with otitis media in Iceland.
Journal of clinical microbiology 2018
Population genetic analysis of Chadian Guinea worms reveals that human and non-human hosts share common parasite populations.
PLoS neglected tropical diseases 2018;12;10;e0006747
Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models.
Nucleic acids research 2018
An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis.
Molecular microbiology 2018