Analysis of CRISPR-Cas9 datasets leads to largest genetic screen resource for cancer research
Researchers identify over 140 genes linked to immune system regulation
Researchers have analysed over 500 genetically modified mouse lines to explore the effect of disrupting single genes on the immune system. The study by researchers from the Wellcome Sanger Institute and Kings College London identified more than 140 genes involved in regulating the immune system and the response to infection with pathogens such as salmonella and the flu.
Dr Konstantinos Tzelepis receives ASH–BSH Abstract Achievement Award for leukaemia target research
Congratulations to Dr Konstantinos Tzelepis, Sir Henry Wellcome Fellow and Visiting Scientist at the Wellcome Sanger Institute, who has been awarded the ASH–BSH Abstract Achievement Award for his work on the leukaemia target, METTL3. This work was carried out in collaboration with the University of Cambridge, and with STORM Therapeutics, and revealed the work on targeting RNA modifying enzymes for cancer treatment
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The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata.
PLoS neglected tropical diseases 2019;13;9;e0007013
Voices in methods development.
Nature methods 2019;16;10;945-951
Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants.
Human mutation 2020;41;1;277-290
The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.
Molecular microbiology 2019;112;6;1831-1846
A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.
EMBO reports 2019;20;11;e47967
Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.
Clinical dysmorphology 2020;29;1;10-16
Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients.
Scientific reports 2019;9;1;14042
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.
Nature medicine 2019;25;10;1526-1533
Bayesian localization of CNV candidates in WGS data within minutes.
Algorithms for molecular biology : AMB 2019;14;20