Origins of immune system mapped, opening doors for new cancer immunotherapies
Otter genome to help understand genetic legacy of pollution crisis and secure species’ future
One of Britain’s best-loved mammals is set to receive a boost with the sequencing and release of the first high-quality Eurasian otter (Lutra lutra) genome by scientists at the Wellcome Sanger Institute, in partnership with the Cardiff University Otter Project.
Gut bacteria’s interactions with immune system mapped
The first detailed cell atlas of the immune cells and gut bacteria within the human colon has been created by researchers. The study from the Wellcome Sanger Institute and collaborators revealed different immune niches, showing changes in the bacterial microbiome and immune cells throughout the colon.
Contact the Press Office
Emily Mobley, Media Manager
Tel +44 (0)1223 496 851
Dr Samantha Wynne, Media Officer
Tel +44 (0)1223 492 368
Dr Matthew Midgley, Media Officer
Tel +44 (0)1223 494 856
Wellcome Sanger Institute,
Mobile +44 (0) 7748 379849
The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata.
PLoS neglected tropical diseases 2019;13;9;e0007013
Voices in methods development.
Nature methods 2019;16;10;945-951
Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants.
Human mutation 2020;41;1;277-290
The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre.
Molecular microbiology 2019;112;6;1831-1846
A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.
EMBO reports 2019;20;11;e47967
Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.
Clinical dysmorphology 2020;29;1;10-16
Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients.
Scientific reports 2019;9;1;14042
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.
Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.
Nature medicine 2019;25;10;1526-1533
Bayesian localization of CNV candidates in WGS data within minutes.
Algorithms for molecular biology : AMB 2019;14;20