Cancer comparison across species highlights new drug target
Sanger Institute steps up commitment to Equality, Diversity and Inclusion in Science
Building on its ongoing work with Athena SWAN to address equality imbalances, the Institute is seeking to further address the wider issues of equality and diversity that can affect both the makeup of its scientific staff and the ability of its scientific samples to represent a diversity of ethnicities and gender.
Almost 2,000 unknown bacteria discovered in the human gut
Researchers at the Wellcome Sanger Institute and EMBL’s European Bioinformatics Institute have identified almost 2,000 bacterial species living in the human gut. These species are yet to be cultured in the lab. The team used a range of computational methods to analyse samples from individuals worldwide.
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Metastasis in the wild: investigating metastasis in non-laboratory animals.
Clinical & experimental metastasis 2019
A new genomic blueprint of the human gut microbiota.
Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2019
Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment.
PLoS genetics 2019;15;2;e1007905
Genome-wide Approaches to Investigate Anthelmintic Resistance.
Trends in parasitology 2019
Antigen Receptor Sequence Reconstruction and Clonality Inference from scRNA-Seq Data.
Methods in molecular biology (Clifton, N.J.) 2019;1935;223-249
Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity.
Genome biology 2019;20;1;30
Clonal approaches to understanding the impact of mutations on hematologic disease development.
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
American journal of medical genetics. Part A 2019
Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.
Cell death & disease 2019;10;2;108
Dysregulations of sonic hedgehog signaling in MED12-related X-linked intellectual disability disorders.
Molecular genetics & genomic medicine 2019;e569
Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa.
Tracing outbreaks with machine learning.
Nature reviews. Microbiology 2019