We start with the production and analysis of high quality reference genomes. The malaria parasite P. falciparum is the gold standard for this – we have curated its genome for more than a decade – but the approach is being extended to other more neglected parasites including schistosomes and whipworms.
We then use comparisons between genomes, performed over different evolutionary scales, to address questions about parasite biology. We use draft genomes across diverse clades to survey the broad differences between parasites and finer grained comparisons between more closely related species to study the evolution of genes associated with specific clades of parasites or parasite traits.
For two exemplar helminth species – Schistosoma mansoni and Trichuris muris, representing flatworms and nematodes, we use full infection lifecycles established at the Institute to facilitate phenotyping and in-depth functional genomics studies, from which genes or proteins can be selected for detailed investigation.
Dr Matt Berriman
Senior Group Leader
Matt leads the parasite genomics group who study the parasites that cause malaria and neglected tropical diseases. He uses large-scale comparative and functional genomics approaches to discover and study genes associated with major biological traits of parasites or with potential for exploitation as targets for intervention.
Previous team members
50 Helminth Genomes Project (50HGP)
We are surveying the genomes of the parasitic worms that have the greatest impact on human, agricultural and veterinary disease ...
A BBSRC-funded consortium exploiting genomic approaches to understand anthelminthic drug resistance in GI nematodes of small ruminants
Flatworm Functional Genomics Initiative (FUGI)
A consortium funded by a Wellcome Trust Strategic Award to develop game-changing research tools for the study and manipulation of parasitic ...
The Pf3k project is a global collaboration using the latest sequencing technologies to provide a high-resolution view of the natural ...
Production and Curation of Parasite Reference Genomes
The Parasite Genomics Group is working on the assembly, annotation and manual curation of several different reference genomes.
All life is linked by the common thread of DNA, modified through evolution. We use whole genome sequences to explore the ...
Natural genetic variation
The Kwiatkowski group investigates Plasmodium, Anopheles and human genome variation in large clinical and epidemiological studies carried out with partners in ...
Programmes and Facilities
Parasites and Microbes
We are using genomics to get at important problems in infectious disease, with a strong desire to translate this into tools ...
We develop and enhance high-throughput tools and technologies for malaria research to enable us to understand specific biological problems relevant for ...