The genomics of gene regulation group is interested in understanding the role of gene regulatory variation in human disease and evolution.

Headed by Daniel Gaffney, the group combines computational and statistical methods with high-throughput experimental techniques to understand the role played by changes in gene regulation in disease susceptibility and human evolution. A major focus of our group is the use of human induced pluripotent stem cells as models to study the functions of regulatory variation, as part of the Human Induced Pluripotent Stem Cells Initiative (HipSci) (Kilpinen, Goncalves et al, 2017). Recent publications and preprints from our group have focussed on IPSCs as models for context-specific specific changes in regulation in immune response (Alasoo et al, 2018), and in hard-to-access cells like neurons (Schwartzentruber et al, 2018). We also work on statistical methods development for genetic mapping of gene regulatory variants (Kumasaka et al, 2016) and of interactions between regulatory regions (Kumasaka et al, 2018)

We welcome applications from prospective postdocs and PhD students. Projects are available in the areas of genomics of gene regulation, molecular evolution and on population genomics of gene regulation. All our work involves data analysis, but there is also scope for projects with a component of laboratory work. Interested applicants should send a CV to Dan (see profile page for contact details), with information on your research and publications.

Much of our work applies the principles of association mapping to cell phenotypes, such as RNA levels or chromatin status. Association mapping is a powerful, unbiased approach for identifying genetic loci (sometimes referred to as quantitative trait loci, QTLs) that change a phenotype. Many maps of expression QTLs (eQTLs) have now been created, both as individual studies (for some recent reviews see here or here) and, more recently, as part of large consortia such as the GTEX project. Our current work is focussed on using this approach in Induced Pluripotent Stem Cells (IPSCs) and cells derived from IPSCs, as part of our ongoing involvement in HIPSCI.

Core team

Previous team members

Photo of Dr Maria Nascimento Primo

Dr Maria Nascimento Primo

Postdoctoral Fellow

Photo of Jeremy Schwartzentruber

Jeremy Schwartzentruber

Former PhD Student at the Sanger Institute

Photo of Sebastian Lukasiak

Sebastian Lukasiak

Postdoctoral Fellow

Photo of Nicoletta Bruno

Nicoletta Bruno

Former Research Assistant at the Sanger Institute

Photo of Kaur Alasoo

Kaur Alasoo

PhD Student

Partners

We work with the following groups

External

Wellcome Trust

External

Medical Research Council

We are generously funded by the MRC to pursue research on human IPSCs.

External

The Stegle group at EBI

We collaborate closely with Oliver Stegle's group at EBI on the HIPSCI project.

External

OpenTargets

OpenTargets is a unique public-private initiative to apply cutting edge genetics research to the problem of drug taregt identification and validation. They have generously funded several projects in our lab on the application of CRISPR technology to human IPS-derived model systems

 

Publications

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