Stem Cell Genetics
This page is maintained as a historical record and is no longer being updated.
Kosuke Yusa left the Sanger Institute in 2018, to join the Institute of Frontier Life and Medical Sciences, Kyoto University. This page is being maintained as historical record of the research group’s work at the Sanger Institute and is no longer being updated.
The Yusa laboratory focuses on the development of genome engineering technologies that allow us to perform unbiased genome-wide genetic screens in mammalian cells. We have recently adopted the CRISPR-Cas9 technology as a screening tool and generated genome-scale lentiviral CRISPR libraries. The current focus of the laboratory is further development and improvement of the CRISPR screening methodology and application of the screening technology in stem cell and oncology research.
Stem cell biology: Maintenance of and exit from pluripotency in mouse and human ES/iPS cells. Differentiation. Lineage reprogramming.
Oncology: Genetic vulnerabilities in cancer cells. The mechanisms of drug resistance. Sensitisation to targeted therapies.
Dr Kosuke Yusa
Former Group Leader
Kosuke developed and applied novel genome engineering techniques in mouse and human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells to screen for disease-causing variations. His group's focus included development of genome-wide CRISPR-based genetic screening and its applications in stem cell and oncology research.
Cancer Dependency Map Analytics
Cancer, Ageing and Somatic Mutation
We design algorithms and tools to identify all cancer vulnerabilities and genetic dependencies, paving the way to new therapies
Translational Cancer Genomics
The Translational Cancer Genomics team investigate how genetic alterations in cancer contribute to disease and impact on response to therapy.
Function of human DNA and its variation
We share many interests with Dr. Kosuke Yusa's group, and collaborate with them on internal projects.