Mouse Phenotyping

Mouse Pipelines

Archive Page

This page is maintained as a historical record and is no longer being updated.

The Mouse Phenotyping team delivered phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompassed a standardised set of more than 600 clinical parameters, and covered key biomedical areas such as reproduction, development, infection and immunity, musculoskeletal system, metabolism and endocrinology.

Characterisation was completed for over 1000 mutant mouse lines, with an additional 160 strains processed annually. All the data was made freely available to the scientific community.

We found many unexpected phenotypes, which were detected only because we screened for them, emphasizing the value of screening all mutants for a wide range of traits. The pipeline of knockout mouse generation and phenotyping was world-leading in its effectiveness, sophistication and throughput.

Our mouse strains and data continue to be used by scientists throughout the world, reducing the amount of unnecessary experimental duplication and ensuring a ‘gold standard’ of models for research groups to study.