Gene expression genomics
Sarah Teichmann is co-founder and principal leader of the Human Cell Atlas (HCA) international consortium. The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells to further understand health and disease.
The team’s research focuses on four complementary study areas:
- Transcriptional regulation and gene expression
- Single-cell genomics
- Protein complexes
Transcriptional regulation and gene expression
We study the processes that control cell-specific gene expression in both embryonic stem cells and in T lymphocytes.
This research enables us to ask questions about the mechanisms that maintain stem-cell pluripotency and the ways that cells make fate decisions within the immune system.
It is clear that differences between cells within seemingly homogenous populations can be crucial in many biological processes.
We work with cutting-edge techniques that enable us to study cell populations at single-cell resolution.
We apply these techniques to better understand our areas of interest and we also develop novel computational approaches to analyse single-cell data.
We are fascinated by the mechanisms that control the development, differentiation and fate choices of CD4+ T lymphocytes.
We study these cells at the single-cell level to understand their behaviour during immune responses and also the role of the cells’ specific T cell receptors.
We investigate the principles that govern the folding and assembly of protein complexes. Most recently, by analysing the tens of thousands of protein complexes for which three-dimensional structures have already been experimentally determined, we found repeating patterns in the assembly transitions that occur, which could be organized into a periodic table.
Previous team members
Cellular Generation and Phenotyping
The Cellular Generation and Phenotyping (CGaP) core facility provides central cell biology support to the Sanger Institute, functioning as a contract ...
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Cytometry Core Facility
The Cytometry Core Facility at the Wellcome Trust Sanger Institute is a dedicated scientific service offering investigators with state-of-the-art flow cytometry ...
The Wellcome Sanger Institute's technological platforms underpin our ability to carry out biomedical research on a large scale, allowing researchers ...
DNA Pipelines Research and Development
DNA Pipelines Development
The DNA Pipelines Research and Development group is the entry point for new technologies to the Institute, especially sequencing instruments. The ...
Human Cell Atlas - Executive Office (UK)
The HCA Executive Office, in the UK, is based at the Wellcome Sanger Institute, and works with regional offices in the ...
Programmes and Facilities
Open Targets is an innovative, public-private partnership that uses human genetics and genomics data at large scale for systematic drug target ...