Gene expression genomics
The teams are using single-cell approaches, so called “cell atlas” technologies to combined with human genetics at the cellular level. We combine cutting-edge techniques in wet and dry lab and are applying these methodologies for further understanding of human health, development and disease.
Sarah Teichmann is co-founder and principal leader of the Human Cell Atlas (HCA) international consortium. The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells to further understand health and disease.
The team's research focuses on four complementary study areas:
- Transcriptional regulation and gene expression
- Single-cell genomics
- Protein complexes
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Transcriptional regulation and gene expression
We study the processes that control cell-specific gene expression in both embryonic stem cells and in T lymphocytes.
This research enables us to ask questions about the mechanisms that maintain stem-cell pluripotency and the ways that cells make fate decisions within the immune system.
It is clear that differences between cells within seemingly homogenous populations can be crucial in many biological processes.
We work with cutting-edge techniques that enable us to study cell populations at single-cell resolution.
We apply these techniques to better understand our areas of interest and we also develop novel computational approaches to analyse single-cell data.
We are fascinated by the mechanisms that control the development, differentiation and fate choices of CD4+ T lymphocytes.
We study these cells at the single-cell level to understand their behaviour during immune responses and also the role of the cells’ specific T cell receptors.
We investigate the principles that govern the folding and assembly of protein complexes. Most recently, by analysing the tens of thousands of protein complexes for which three-dimensional structures have already been experimentally determined, we found repeating patterns in the assembly transitions that occur, which could be organized into a periodic table.
Dr Sarah Teichmann, FMedSci
Head of Cellular Genetics and Senior Group Leader
Sarah Teichmann is interested in global principles of protein interactions and gene expression. In particular, her research now focuses on genomics and immunity. From 2016, Sarah is the Head of Cellular Genetics at the Wellcome Sanger Institute.
Previous team members
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DNA Pipelines Research and Development
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Single Cell Genomics Core Facility
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Programmes and Facilities
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