Wellcome Sanger Institute

Teichmann Group

Gene expression genomics

The teams are using single-cell approaches, so called “cell atlas” technologies to combined with human genetics at the cellular level. We combine cutting-edge techniques in wet and dry lab and are applying these methodologies for further understanding of human health, development and disease.

Sarah Teichmann is co-founder and principal leader of the Human Cell Atlas (HCA) international consortium. The International Human Cell Atlas initiative aims to create comprehensive reference maps of all human cells to further understand health and disease.

The team’s research focuses on four complementary study areas:

  • Transcriptional regulation and gene expression
  • Single-cell genomics
  • Immunology
  • Protein complexes

Transcriptional regulation and gene expression

We study the processes that control cell-specific gene expression in both embryonic stem cells and in T lymphocytes.

This research enables us to ask questions about the mechanisms that maintain stem-cell pluripotency and the ways that cells make fate decisions within the immune system.

Single-cell genomics

It is clear that differences between cells within seemingly homogenous populations can be crucial in many biological processes.

We work with cutting-edge techniques that enable us to study cell populations at single-cell resolution.

We apply these techniques to better understand our areas of interest and we also develop novel computational approaches to analyse single-cell data.

Immunology

We are fascinated by the mechanisms that control the development, differentiation and fate choices of CD4+ T lymphocytes.

We study these cells at the single-cell level to understand their behaviour during immune responses and also the role of the cells’ specific T cell receptors.

Protein complexes

We investigate the principles that govern the folding and assembly of protein complexes. Most recently, by analysing the tens of thousands of protein complexes for which three-dimensional structures have already been experimentally determined, we found repeating patterns in the assembly transitions that occur, which could be organized into a periodic table.

Core team

Photo of Dr Cecilia Domínguez Conde

Dr Cecilia Domínguez Conde

Postdoctoral Fellow

Photo of Elo Madissoon

Elo Madissoon

Postdoctoral Fellow

Photo of Rasa Elmentaite

Rasa Elmentaite

PhD Student

Photo of Veronika Kedlian

Veronika Kedlian

PhD Student

Photo of Lira Mamanova

Lira Mamanova

Scientific Manager

Photo of Monika Litvinukova

Monika Litvinukova

Visiting Scientist

Photo of Jongeun Park

Jongeun Park

Postdoctoral Fellow

Photo of Mirjana Efremova

Mirjana Efremova

Postdoctoral Fellow

Photo of Dr Kylie James

Dr Kylie James

Postdoctoral Fellow

Photo of Daniel J. Kunz

Daniel J. Kunz

PhD Student

Photo of Chenqu Suo

Chenqu Suo

PhD Student

Photo of Dr Kelvin Tuong

Dr Kelvin Tuong

Visiting Scientist

Photo of Krzysztof Polanski

Krzysztof Polanski

Computational Biologist

Photo of Dr Peng He

Dr Peng He

Visiting Scientist

Photo of Tracey Andrew

Tracey Andrew

Executive Administrator Human Cell Atlas

Photo of Dr Kerstin Meyer

Dr Kerstin Meyer

Principal Staff Scientist

Photo of Dr Carlos Talavera-Lopez

Dr Carlos Talavera-Lopez

Computational Biologist

Photo of Dr Waradon SUNGNAK

Dr Waradon SUNGNAK

Postdoctoral Fellow

Previous team members

Photo of Dr Helena Kilpinen

Dr Helena Kilpinen

Career Development Fellow

Photo of Xi Chen

Xi Chen

Senior Staff Scientist

Photo of Dr Angela Goncalves

Dr Angela Goncalves

Former Postdoctoral Fellow at the Sanger Institute

Photo of Dr Kedar Natarajan

Dr Kedar Natarajan

Postdoctoral Fellow

Photo of Dr Emmanouil Athanasiadis

Dr Emmanouil Athanasiadis

Visiting Worker - Research Associate

Photo of Angela Macharia

Angela Macharia

Project Manager

Photo of Raghd Rostom

Raghd Rostom

PhD Student

Photo of Adrian Bird

Adrian Bird

Former Associate Faculty

Photo of Dr Michael Stubbington

Dr Michael Stubbington

Principal Staff Scientist

Related groups

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