Understanding human DNA function by engineering
The following four statements describe our approach:
1) We get things done. We start projects with clearly defined goals, and publish both positive and negative results of the ones that pass the pilot stage. We deliver to our collaborators.
2) We work on important problems. We pick projects based on how much they impact our understanding of human cells, characterize the variation of gene function across individuals, or influence how others work.
3) We succeed as a team. We have a diverse mix of backgrounds and skillsets, complementing each other with our strenghts.
4) We are excited about science. We read broadly, discuss latest developments, and keep up to date both with the depth of our field, and the entire breadth of genomics.
Dr Leopold Parts
Leo is focuses on figuring out most important features to measure in individual cells, creating accurate computational models for their readouts, and finding out how they are changed by variation in genomes and surrounding context. Trained in maths and computer science, he now spends his time pondering about statistics and high throughput cell biology.
Previous team members
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Cancer Dependency Map Analytics
Cancer, Ageing and Somatic Mutation
We design algorithms and tools to identify all cancer vulnerabilities and genetic dependencies, paving the way to new therapies
Cellular Generation and Cellular Screening
The Cellular Generation and Cellular Screening groups are core facilities that provides central cell biology support to the Sanger Institute, functioning ...
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Cellular and Gene Editing Research
We develop novel genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and ...
Translational Cancer Genomics
The Translational Cancer Genomics team investigate how genetic alterations in cancer contribute to disease and impact on response to therapy.
In collaboration with our colleagues in Cellular Operations and Stem Cell Informatics, our work focuses on supporting and delivering the gene ...
Human Cell Atlas - Executive Office (UK)
The HCA Executive Office, in the UK, is based at the Wellcome Sanger Institute, and works with regional offices in the ...
Human Genetics Administration
The Human Genetics Administration comprises a five strong team that provides comprehensive support for the smooth running of the Human Genetics ...
Human Genetics Informatics (HGI)
Human Genetics Informatics (HGI) supports the scientific aims of the Human Genetics programme by developing and operating computational analysis workflows, managing ...
Rodent models of malaria
We help create models for high throughput genetic screens carried out in Dr. Billker's group.
High throughput gene editing
The High Throughput Gene Editing team helped to deliver the gene editing requirements of the Institute's faculty and research
Programmes and Facilities
Founded in 2014, Open Targets is an innovative public-private partnership that uses human genetics and genomics data for systematic drug target ...
The Human Genetics Programme is driving a step-change in our understanding of genetic causes and biological mechanisms of disease susceptibility and ...