Tree of Life Core Laboratory Team
Tree of Life Programme
The Tree of Life Core Laboratory provides the wet lab molecular biology heart of the Tree of Life Genome Assembly Engine. The team works across all of the projects within the Tree of Life Programme, supporting Faculty Teams, providing secure sample flow into Scientific Operations, and continuously improving processes via R&D projects large and small.
The team is responsible for working with samples that have been collected by all of the varied partners and collaborators, extracting high molecular weight DNA and RNA, providing robust quality control and processing, and feeding this through to various sequencing platforms in order to generate the data required for reference level genome assembly.
The team has developed routine processes that can be applied at scale to an extremely large range of organisms, and are continuing to develop ever more refined methods for those taxonomic groups that provide more challenge.
Dr Caroline Howard
Senior Scientific Manager
Caroline is responsible for overseeing the management of the wet lab processing of samples that come to Sanger to fulfil the scientific aims of the Tree of Life programme. This work involves developing and embedding processes, research and development of new protocols and equipment, developing systems to track work and samples, and working with colleagues and collaborators.
Previous team members
Aquatic Symbiosis Genomics Project
An ambitious project to read the genomes of 1,000 freshwater and marine species that represent more than 500 symbiotic relationships, ...
All life is linked by the common thread of DNA, modified through evolution. We use whole genome sequences to explore the ...
The Wellcome Sanger Institute's technological platforms underpin our ability to carry out biomedical research on a large scale, allowing researchers ...
Population and evolutionary genomics, novel computational genomics methods, and related mathematical and statistical models.
Evolution of unusual reproductive mechanisms
We explore how evolution is driven by changes in DNA sequence and chromosome structure by analysing and comparing the genomes of ...
Our research group uses genomics to investigate insect biodiversity and malaria transmission.
Long Read Sequencing
The long read sequencing team within DNA Pipelines Operations at the Wellcome Sanger Institute provides support for research projects requiring ...