Hurles Group

Genomic mutation and genetic disease

We study the genetic causes and biological mechanisms of rare conditions resulting from severely impaired development.

We use experimental model systems, especially cells, to understand the biology of these conditions in greater detail. We also study how DNA mutates as it is passed from one generation to the next, and the factors that influence the number and type of mutations that arise. We are a multi-disciplinary group of molecular biologists, bioinformaticians and computational geneticists.