Hurles Group

Genomic mutation and genetic disease

We study the genetic causes and biological mechanisms of rare conditions resulting from severely impaired development.

We use experimental model systems, especially cells, to understand the biology of these conditions in greater detail. We also study how DNA mutates as it is passed from one generation to the next, and the factors that influence the number and type of mutations that arise. We are a multi-disciplinary group of molecular biologists, bioinformaticians and computational geneticists.

Core team

Photo of Mohamed Almarri

Mohamed Almarri

PhD Student

Previous team members

Photo of Dr Nadia Akawi

Dr Nadia Akawi

Postdoctoral Fellow

Photo of Christina Dias

Christina Dias

Visiting Scientist

Photo of Dr Giuseppe Gallone

Dr Giuseppe Gallone

Former Senior Computer Biologist at the Sanger Institute

Photo of Dr Eugene Gardner

Dr Eugene Gardner

Postdoctoral Fellow

Photo of Sophie Hackinger

Sophie Hackinger

PhD Student

Photo of Liu He

Liu He

Postdoctoral Fellow

Photo of Phil Jones

Phil Jones

DDD Informatics Team Manager

Photo of Dr Ro (Rosemary) Kelsell

Dr Ro (Rosemary) Kelsell

Project Administrator

Photo of Dr Helena Kilpinen

Dr Helena Kilpinen

Career Development Fellow

Photo of Darren Logan

Darren Logan

Former CDF Group Leader

Photo of Dr Jenny Lord

Dr Jenny Lord

Postdoctoral Fellow

Photo of Jeremy McRae

Jeremy McRae

Statistical Geneticist

Photo of Dr Joshua C. Randall

Dr Joshua C. Randall

Senior Scientific Manager

Photo of Dr Gabriele Rinck

Dr Gabriele Rinck

Project Manager

Photo of Dr Kaitlin Samocha

Dr Kaitlin Samocha

Postdoctoral Fellow

Photo of Patrick Short

Patrick Short

PhD Student, Wellcome Trust PhD in Mathematical Genomics and Medicine

Photo of Dr Jawahar Swaminathan

Dr Jawahar Swaminathan

Senior Scientific Manager (DECIPHER Project Manager)

Photo of Dr Caroline Wright

Dr Caroline Wright

Senior Scientific Manager

Photo of Elizabeth Wynn

Elizabeth Wynn

Advanced Research Assistant

Photo of Eleftheria Zeggini

Eleftheria Zeggini

Former Group Leader

Related groups

Partners

We work with the following groups

External

Health Innovation Challenge Fund

The DDD and PAGE studies are funded by the Health Innovation Challenge Fund, a parallel funding partnership between the Wellcome Trust and the Department of Health to stimulate the creation of innovative healthcare products, technologies and interventions and to facilitate their development for the benefit of patients in the NHS and beyond.

External

Wellcome Trust

Biomedical charity that funds most of our science

 

Publications

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