New Pipeline Group (NPG)
Illumina Sequencing forms the majority of DNA Pipelines’ products and NPG provides the tracking, QC, and analysis systems to process the output. Our automated high-throughput analysis systems provide analyses appropriate for the study, sample, and type of library being sequenced. When requested, the team may also provide bespoke or tailored analysis for our faculty customers (for example, 10X processing using other experimental data).
DNA Pipelines typically uses PacBio Sequencing to provide high base quality long-read sequencing in up to 15 kb fragments. NPG wraps around the analysis systems provided by PacBio to ensure data delivery and QC reporting. We also provide local informatics expertise concerning this data.
DNA Pipelines also provide a variety of other sequence assay products: ONT sequencing offers unique capabilities, Bionano a non-sequencing method of studying structure, and small panel genotyping using Fluidigm. NPG wraps around these to ensure automated delivery of suitable data products to the customer.
NPG provides consistent delivery of all the varied data products with appropriate metadata and access control.
The NPG team liaises with DNA Pipelines and faculty informatics to gather requirements and best practices. DNA Pipelines ensure we’re aware of changes in the nature of the product and demand e.g. new instruments, new instrument types, and new projects with expected throughput and processing requirements.
NPG continuously reviews its systems with an eye to product trends and implements long rolling projects to accommodate them.
The NPG team has to maintain informatics, Illumina sequencing, and genotyping knowledge sufficient to anticipate and understand DNA Pipelines customer requirements so that requests can be anticipated, evaluated, and rejected or implemented appropriately.
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
The Wellcome Sanger Institute's technological platforms underpin our ability to carry out biomedical research on a large scale, allowing researchers ...
DNA Pipelines Research and Development
DNA Pipelines Development
The latest and greatest stuff from DNA Pipelines R&D often requires custom analysis or changes to our pipelines and services.
Data Quality Control (QC)
NPG provide interfaces for sequencing run creation and sequencing run QC to the operations teams. We also provide training and advice ...
Genome Reference Informatics Team
Tree of Life Programme
The Genome Reference Informatics Team analyses genome assemblies to reveal and correct quality issues and to identify and add variation. It ...
High Performance Algorithm Group (HPAG)
HPA has created tools which are essential components of NPG's current analysis pipelines and leads on developing and testing software ...
Human Genetics Informatics (HGI)
Human Genetics Informatics (HGI) supports the scientific aims of the Human Genetics programme by developing and operating computational analysis workflows, managing ...
Informatics Support Group
High Performance Computing
NPG are reliant on the Sanger systems teams for providing solid compute and storage.
Production Software Development
Laboratory Information and Management Systems (LIMS) compute and infrastructure
We work closely with PSD as their systems provide us with all the LIMS information required to run our analysis pipelines ...