Health Data Research UK Cambridge Hub
The Danesh group works as part of the Health Data Research (HDR) UK Cambridge site, using genomic, molecular and electronic health record data at population scale to understand disease at a deeper than ever biological level.
Work in this area aims to advance understanding of disease prediction, causation, and progression through the integration of molecular data and other intermediate phenotypes with routine clinical data. We seek to gain novel insights into biology and disease aetiology by integration of information, at scale, on genomics, other biomolecular traits, and high-resolution electronic health records (EHRs). This multi-dimensional framework should afford an aetiological “systems genomics” approach to address complex biomedical problems. Our ultimate vision, therefore, is to create new informatics infrastructures and data science methods that help achieve a deep integration of biology, biomedicine, and population health science.
The Danesh group also combines clinical epidemiology and genomics to focus on understanding the underlying biology of cardiovascular disease and health. This work will help clinicans and researchers to better understand the roots and progression of heart- and blood system-related diseases, paving the way for more effective, personalised treatment for individual patients.
Professor John Danesh
As a Faculty member Danesh works to further understand cardiometabolic traits through combining cardiovascular epidemiology with genomic research techniques. Danesh is Director of HDR UK Cambridge, a consortium comprising the Wellcome Sanger Institute, EMBL-EBI, the University of Cambridge and its hospitals, which aims to understand disease at a deeper than ever biological level, to enable us to better predict the onset and progression of ill-health and tailor medicines for sub-types of disease, as well as predict patients’ reaction to medicines.
Programmes and Facilities
Health Data Research UK (HDR UK)
The Health Data Research (HDR) UK Cambridge site is part of the national institute for health data science (HDR UK) ...