Rahbari Group

Cancer predisposition and Ageing

Our group aims to provide a detailed description of the genetic changes in normal and precancerous tissues, and to understand how mutations acquired during ageing may contribute to the germline predisposition to cancer for future offspring.

During the natural process of ageing, somatic mutations accumulate in our genome and can cause cancer and cancer prediposition. However, little is known about mutagenesis or factors that influence rates of accumulation of mutations in normal tissue and their impact.

Our group aims to provide a detailed description of the genetic changes in normal and precancerous tissues, and to understand how mutations acquired during ageing may contribute to the germline predisposition to cancer for future offspring.