Proteomic Mass Spectrometry
This page is maintained as a historical record and is no longer being updated.
The Proteomic Mass Spectrometry team left the Sanger Institute in 2017. This page is being maintained as a historical record of the work of the group and is no longer being updated.
The Proteomic mass spectrometry team complemented the research programmes of the Sanger Institute to further understanding of the relationship between the genome and the proteome (entire set of expressed proteins). Through its research and collaborations the group explored protein-protein interactions, cell signalling and protein expression in a range of human, pathogen and model organisms.
Our research portfolio encompassed all levels of proteome complexity: from whole organism characterisation to subcellular organelles, from protein complexes to post-translation modifications.
- Proteome Characterisation and Quantification
- Post-Translational Modifications
- Protein Interactions
Technology and Instrumentation
We had a long-standing expertise in sample preparation, peptide and protein separation and purification technologies, mass spectrometry and proteomics data analysis. Our well-equipped laboratory featured a range of state-of-the-art high-resolution mass spectrometers that we combined with innovative tools and software to precisely identify and quantify proteins and their modifications in the proteome.
Previous team members
The following were also members of this team:
|Aidan Walker||Now PhD student in the Wellcome Trust DPhil Programme in Chromosomal and Developmental Biology at Oxford University|
|Ana Luisa Toribio|
|Daniel Bode||Now in his final year of BSci degree in Biological Sciences at Dundee University|
|Evelyn Hillner||Now doing an MSci placement at Cellzome, Heidelberg (Germany)|
|Francois Demais||Now PhD student at Cambridge University|
|Mark Collins||Now Lecturer at the University of Sheffield|
|Markus Brosch||Now Head of Marketing & Business Development at Genedata|
|Nikki Royle||Now Protein Analytical Scientist at Crescendo Biologicals Ltd. (Cambridge)|
|Rachael Coyle||Now Advanced Research Assistant in Julian Rayner's group|
|Rebecca Ohra||Now MSci student in Biochemistry (Immunology) at University of Aberdeen|
|Shan Chong||Now PhD student at the Wellcome Trust Sanger Institute|
|Tannia Gracia||Now Research Associate at the Cambridge Institute for Medical Research|
DecoyPYrat - Fast Hybrid Decoy Sequence Database Creation for Proteomic Mass Spectromtery Analyses
MascotPercolator is a software package that interfaces the database search algorithm Mascot with Percolator, a well-performing machine learning algorithm for rescoring ...
We work with the following groups
Seth Grant, University of Edinburgh
We worked with Seth on the project "Defining the human synapse proteome", funded by the MRC
Gitta Stockinger, NIMR
We worked with Gita on the project "Physiological functions of the arylhydrocarbon receptor in innate and adaptive immune responses", funded by Wellcome Trust (WT-OOE)
Gad Frankel, Imperial College
We worked with Gad on the project "The ubiquitin ligase NleG type III secretion system effectors of E. coli O157", funded by the BBSRC