Proteomic Mass Spectrometry

Scientific Resources

Archive Page

This page is maintained as a historical record and is no longer being updated.

The Proteomic Mass Spectrometry team left the Sanger Institute in 2017. This page is being maintained as a historical record of the work of the group and is no longer being updated.

Until the group left the Sanger Institute in 2017, it was interested in solving questions about the biology underlying health and disease by studying molecular processes and pathways. To do this the team used a range of techniques including mass spectrometry, biochemistry, molecular biology and informatics, to study protein function, proteome composition and organisation.

The Proteomic mass spectrometry team complemented the research programmes of the Sanger Institute to further understanding of the relationship between the genome and the proteome (entire set of expressed proteins). Through its research and collaborations the group explored protein-protein interactions, cell signalling and protein expression in a range of human, pathogen and model organisms.

Our research portfolio encompassed all levels of proteome complexity: from whole organism characterisation to subcellular organelles, from protein complexes to post-translation modifications.

• Proteome Characterisation and Quantification
• Proteogenomics
• Post-Translational Modifications
• Protein Interactions

Technology and Instrumentation

We had a long-standing expertise in sample preparation, peptide and protein separation and purification technologies, mass spectrometry and proteomics data analysis. Our well-equipped laboratory featured a range of state-of-the-art high-resolution mass spectrometers that we combined with innovative tools and software to precisely identify and quantify proteins and their modifications in the proteome.