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Sanger Projects

 

Research project

Antarctic notothenioids fish genomes project

Genome assemblies for 25 species across the Notothenioid radiation.

The notothenioids (suborder: Notothenioidei), are a group of Percomorph fish and one of the best characterized marine adaptive radiations. Notothenioids consist ...

 

Research project

Cellular Genetics Portals

Open-access data portals

The Cellular Genetics Programme is committed to making cell atlasing data analysis and visualisation tools available to the scientific community

 

Research project

Cellular Genetics Software

Open access tools

Computational tools developed by the research groups and scientific teams of the Cellular Genetics Programme

 

Research project

Cellular Genetics scRNA-seq analysis course

originally developed in Martin Hemberg's group

Cellular Genetics scRNA-seq analysis course

 

Research project

Combinatorial drug screens in mesothelioma for novel targets.

Combinatorial screen in a panel of mesothelioma cell lines

We have carried out a combinatorial screen in a panel of mesothelioma cell lines of 2,697 2-drug combinations and ...

 

Research project

EXPRESs- EXtracellular Plasmid RESource on Addgene

Our plasmid collections can be browsed and ordered from our EXtracellular Plasmid RESource (EXPRESs) at Addgene.

 

Research project

Genetic and epigenetic determinants of hematopoiesis

The hematopoietic system provides a good model system to inform interpretation of association studies owing to simple phenotypes at the ...

 

Research project

Genome Reference Informatics

As the impact of the human reference genome assembly on biomedical research has shown, the availability of a high quality ...

 

Research project

Genome-wide mutagenesis screens for drug resistance in cancer.

The use of genome-wide forward genetic screens to define the landscape of drug resistance drivers in cancer.

 

Research project

Genomic characterization of Colorectal Patient-derived Xenografts

Cancer Ageing and Somatic Mutation research

In collaboration with the Andrea Bertotti lab at University of Turin we plan to sequence 500 human colorectal PDX models.

 

Research project

Genomics of Rare Cancers - Anaplastic Meningiomas

Whole genome and targeted gene screens in primary and recurrent anaplastic meningiomas.

 

Research project

Identification of novel drug targets in colorectal cancer.

We are using siKinome and genome-wide CRISPR/Cas9 lethality screens in colorectal cancer cell lines to identify novel vulnerabilities.

 

Research project

Malawi cichlid genome project

The genomics of rapid speciation in Lake Malawi cichlids

Genome sequences of cichlid fish for studies in speciation and evolutionary genomics

 

Research project

Manual Annotation

HAVANA team

The HAVANA team manually annotate the human, mouse, zebrafish and other vertebrate genomes.

 

Research project

Microenvironment of kidney cancer

Mapping single cell transcriptomes in the intra-tumoural and associated territories of kidney cancer

This project charts the heterogeneity in the microenvironment in kidney cancer using single cell RNA sequencing, spatial transcriptomics, and whole exome ...

 

Research project

OME-Zarr

This is a collection of OME-Zarr backed visualizations for bioimaging data

This is a collection of datasets from the Sanger Institute that have been converted to OME-Zarr to test and encourage the ...

 

Research project

PlasmoGEM - The Plasmodium Genetic Modification Project

PlasmoGEM provides the malaria research community with a variety of resources currently focusing on P.berghei , P falciparum and P. ...

 

Research project

Transgenerational epigenetic inheritance

Miska Lab

This line of research pursues the identification of major molecular players involved in epigenetic inheritance in mammals. We are especially interested ...

 

Research project

Trynka group data and code

Datasets and code from Trynka group

Links to codes, data visualisation and datasets

 

Research project

Vertebrate Genomes Project

The Vertebrate Genomes Project

The Vertebrate Genomes Project (VGP) at the Sanger Institute aims to provide reference quality assemblies for hundreds of fish, rodents ...

 

Research project

Wellcome Sanger Institute COVID-19 Surveillance Team

 COVID-19 Surveillance Team

The SARS-CoV2 genome sequences produced by the Wellcome Sanger Institute are the result of a team effort by many people from ...

 

Research project

Wellcome Trust Strategic Award - The Homunculus in our Thymus: A Cellular Genomics Approach

Wellcome Trust Strategic Award - The Homunculus in our Thymus: A Cellular Genomics Approach

We have been granted a strategic award from the Wellcome Trust 'The Homunculus in our Thymus: A Cellular Genomics Approach' that ...

 

Research project

piRNA biology and germline genome stability

Miska Lab

This project aims at elucidating the function of piRNAs - small germline-specific non-coding RNAs - in different vertebrates.

 

Research project

Artemis

Visualising, analysing and browsing next generation sequence data

Examples and use cases for Artemis are shown below.

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