Human Cell Atlas
About the Human Cell Atlas
The Human Cell Atlas aims to chart the types and properties of all human cells, across all tissues and organs, to build a reference map of the healthy human body. The human body is made of trillions of cells – the fundamental units of life – which divide, grow and acquire distinct functions in the embryo, eventually leading to different cell types (such as skin cells, neurons or fat cells) that form the various tissues of the body. These tissues come together to form organs such as the lungs and the brain. Previous knowledge of cells has come from looking at them under a microscope, or more recently by analysing clumps of hundreds or thousands of cells and finding the average properties. However, to see the true picture for every cell type, it is necessary to first separate the cells and then find out what molecules are produced in each. These molecules include sets of RNA messages, called the transcriptome, which help give each cell its own identity and distinguish it from the many other cell types found in the body. A few years ago, measuring this complex and extensive information would have been impossible, but recent technological advances in the field of single-cell genomics can separate individual cells from different tissues and organs, and measure the transcriptome or other important molecules from each of them.
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Connecting human development and disease
Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and ...
Cellular Generation and Cellular Screening
The Cellular Generation and Cellular Screening groups are core facilities that provides central cell biology support to the Sanger Institute, functioning ...
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Our research is focused on understanding what type of immune cells live within different organs in humans, and how the special ...
Genomics of immune cell populations at single-cell resolution
Based at the Wellcome Sanger Institute and Newcastle University Biosciences Institute, we study the human immune system at single-cell resolution using ...
Human Cell Atlas - Executive Office (UK)
The HCA Executive Office, in the UK, is based at the Wellcome Sanger Institute, and works with regional offices in the ...
Single cell genomics
John Marioni's group develop computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression ...
Stegle and Theis Group
Cellular Genetics Programme
We aim to leverage machine learning in the context of single cell genomics to provide a true model-based understanding of the ...