Human Cell Atlas
About the Human Cell Atlas
The Human Cell Atlas aims to chart the types and properties of all human cells, across all tissues and organs, to build a reference map of the healthy human body. The human body is made of trillions of cells – the fundamental units of life – which divide, grow and acquire distinct functions in the embryo, eventually leading to different cell types (such as skin cells, neurons or fat cells) that form the various tissues of the body. These tissues come together to form organs such as the lungs and the brain. Previous knowledge of cells has come from looking at them under a microscope, or more recently by analysing clumps of hundreds or thousands of cells and finding the average properties. However, to see the true picture for every cell type, it is necessary to first separate the cells and then find out what molecules are produced in each. These molecules include sets of RNA messages, called the transcriptome, which help give each cell its own identity and distinguish it from the many other cell types found in the body. A few years ago, measuring this complex and extensive information would have been impossible, but recent technological advances in the field of single-cell genomics can separate individual cells from different tissues and organs, and measure the transcriptome or other important molecules from each of them.
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Origins of Human Cancer
Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and ...
Cellular Generation and Phenotyping
The Cellular Generation and Phenotyping (CGaP) core facility provides central cell biology support to the Sanger Institute, functioning as a contract ...
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Our research is focused on understanding what type of immune cells live within different organs in humans, and how the special ...
Cellular Genetics Programme
The team’s research applies disruptive cutting-edge techniques to study the genomics of immune cell populations at single-cell resolution and uses ...
Quantitative models of gene expression
The Hemberg group is interested in developing quantitative models of gene expression. Our approach is theoretical and we strive to develop ...
Human Cell Atlas Group
We are undertaking research to develop, optimise and assess the performance of key enabling experimental and computational technologies that will underly ...
Single cell genomics
John Marioni's group develop computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression ...
Stegle and Theis Group
Cellular Genetics Programme
We aim to leverage machine learning in the context of single cell genomics to provide a true model-based understanding of the ...