GBM-space: spatial genomic atlas of glioblastoma
About Glioblastoma multiforme (GBM)
Glioblastoma multiforme (GBM) is an aggressive type of brain tumour that is currently incurable. It is the most common type of primary malignant brain tumour in adults. The tumours are very varied – they contain a mixture of different cell types, and there is high heterogeneity in the genetic, transcriptional and epigenetic activity of the cells. In addition, different states are highly dynamic in GBM, with cells transitioning from one state to another throughout tumour development as well as in disease relapse after therapy.
The GBM-space: spatial genomic atlas of glioblastoma Project
The project is part of the Wellcome Leap ‘Delta Tissue’ or ‘tissue time machine’ project. It will use high throughput spatial genomic techniques to profile the state of cells and tissues to unprecedented detail about the states of these cancer cells and their tissue microenvironment. It is hoped that this information will help to uncover new targets for treatment development.
The collaboration draws together researchers at the Wellcome Sanger Institute, the University of Cambridge, the German Cancer Research Centre (DKFZ) and The Francis Crick Institute. It will characterise and catalogue cell type, developmental trajectory, interactions, features, form and functions to enable prediction of the transition between states.
To understand the forces that drive the cell changes seen in GBM tumours, the team comprehensively characterise the cells and molecules of the tumour tissue in 2D and 3D.
Sanger Institute scientists use spatial genomic methods to can map the intracellular signals and interactions that influence the tumour cells. The initial focus is to understand immune cells and their role in GBM by profiling neurosurgery samples from 50 patients receiving treatment at Addenbrooke’s Hospital in Cambridge.
Computational Postdoctoral Fellow in GBM Spatial Multi-omics:
Postdoctoral Fellow in GBM Spatial Multi-omics:
Staff scientist in GBM Spatial Multi-omics:
Prof David Rowitch, FMedSci
Head of Paediatrics at the University of Cambridge and Honorary Faculty at the Wellcome Sanger Institute
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Connecting human development and disease
Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and ...
High Throughput Spatial Genomics
Sanger-EBI Initative for Large-Scale Spatial Genomics
HTSG uses large-scale spatial genomics to map human tissue architecture.