Genomic characterization of Colorectal Patient-derived Xenografts

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  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
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  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
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  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
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  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
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  About Us
  We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
  Read more
About
We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
About Us
We tackle some of the most difficult challenges in genomic research. This demands science at scale; a visionary and creative approach to research that pushes the boundaries of our understanding in ever new and exciting ways.
Read more
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Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease or analytic focus. In all cases, the studies provide insights into human, pathogen, cellular evolution, the phenotypic and hence biological consequences of genome variation and the processes which cause mutations.
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Our science is organised into six Scientific Programmes, each defining a major area of research with a particular biological, disease, analytic or generative focus.
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Almost 1,000 scientists, developers, engineers and skilled professionals work together to deliver the Sanger Institute’s cutting-edge genomic research.
Join us
Our science is founded on the talents, imagination and curiosity of our people. Our wet-lab scientists, bioinformaticians, developers, engineers and skilled administrators work together to deliver cutting-edge research. Join us
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We deliver therapeutic, diagnostic and production benefits in areas as diverse as cancer, immunology, public health and personalised treatment.
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We apply our science to benefit society by empowering innovators and engaging with businesses and investors - driven by Sanger Genomics Innovation
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Latest News

15 Jan 2025

DNA damage can last unrepaired for years, changing our view of mutations
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13 Jan 2025

Bacterial survival genes uncovered using evolutionary map
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8 Jan 2025

Human ‘Domainome’ reveals root cause of inherited conditions
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News and Blogs
News and stories Announcements, articles and blogs from the cutting edge of genomic research.
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Wellcome Sanger Institute

Sanger Institute Science Collaboration

Cancer, Ageing and Somatic Mutation

Genomic characterization of Colorectal Patient-derived Xenografts

In collaboration with the Andrea Bertotti lab at University of Turin we plan to sequence 500 human colorectal PDX models.

About the project

Using a targeted gene screen for 116 colorectal cancer genes, 50 regions recurrently amplified or deleted as well as MSI regions, we will Illumina sequence approx. 500 human colorectal patient-derived xenografts to enable the rapid translation of gene-drug associations observed in the Sanger Institute cell line drug screen or the siKinome and CRISPR/Cas9 lethality screens we are currently undertaking.

Sanger people

Photo of Dr Howard Lightfoot

Dr Howard Lightfoot

Principal Bioinformatician

External Contributors

Photo of Prof Andrea Bertotti MD PhD

Prof Andrea Bertotti MD PhD

Related groups

Science group

McDermott Group

Cancer Functional Genomics

Our work is in the understanding of how cancer genomes affect drug sensitivity and resistance.

Wellcome Sanger Institute

Programmes and Facilities

Programme

Cancer, Ageing and Somatic Mutation

The Cancer, Ageing and Somatic Mutation Programme pioneers data aggregation and informatics innovation, develops high-throughput cellular models of cancer for genome-wide ...