Plasmodium vivax

P. vivax causes severe disease in humans but unlike P. falciparum it is rarely fatal. This project is part of a study to compare the genomes of the two organisms in an attempt to understand differences in their pathology.

Data Downloads

The Sanger Institute sequenced a single P. vivax YAC mapping to a telomere, in collaboration with Hernando A. del Portillo at the at the Universidade de Sao Paulo and Michael Lanzer of the Universitat Heidelberg.

Published Genome Data

The complete IVD10 YAC clone 155,711 bp in length has now been sequenced, finished and annotated. 32 predicted genes and four pseudogenes have been identified, the majority being members of a novel gene family, termed vir, encoding putative transmembrane proteins.

The predicted genes and pseudogenes from the vir family have similar structure. The majority have three exons, a short first exon followed by a longer second exon containing a predicted transmembrain domain at its 3' end and a third exon of uniform length. The vir genes family can be divided into subfamilies based on homology. To date 6 families have been identified, termed A to F.

Bibliography

  • Comparative genomics of the neglected human malaria parasite Plasmodium vivax.

    Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang'a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW and Fraser-Liggett CM

    Nature 2008;455;7214;757-63

    PUBMED: 18843361; PMC: 2651158; DOI: 10.1038/nature07327

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

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