AMELIA - Allele Matching Empirical Locus-specific Integrated Association

AMELIA is a program that employs allele matching to analyse the effects of rare variants within a specific locus.

There is increasing evidence that rare variants play a role in some complex traits, but their analysis is not straightforward. Locus-based tests become necessary due to low power in rare variant single-point association analyses. In addition, variant quality scores are available for sequencing data, but are rarely taken into account.

To enable this analysis, AMELIA (Allele Matching Empirical Locus-specific Integrated Association test) has been developed as an allele-matching approach that is robust to the presence of both directions of effect for variants within the locus analysed. An allele-matching approach for the analysis of imputed data is also available.

Downloads

System requirements

The software should run on any UNIX or GNU/Linux system.

Download AMELIA

• amelia.tar.gz
• AMELIA_README.txt
• AMELIA_impute.tar.gz
• AMELIA_impute_README.txt
• ariel-amelia_build_37_genelist.txt.gz

After downloading the files, please read the AMELIA_README.txt file to set up and run the files.