Time course changes in gene expression in naive and memory CD4 T cells after activation

How gene expression changes after activation of CD4 naive and memory T cells

Do you want to know how your favourite gene(s) expression changes in activated CD4 T cells? Check it in our dataset!

We isolated memory and naive CD4 T cells from 119 individuals, activated them and analysed their gene expression by scRNAseq. We examined these two types of CD4 T cells before (0h) and at several time points (16h, 40h, 5days) after activation.

Visualise and download expression values, averaged by cell type, experimental time point and activation trajectory bin.

You can also visualise and download gene expression on single cell  level.

Full description of the experiment in our paper:
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation Read paper

Study authors:

Blagoje Soskic1,2*, Eddie Cano-Gamez1,2*,

Deborah J. Smyth1,2*, Kirsty Ambridge1, Ziying Ke1, Lara Bossini-Castillo1, Joanna Kaplanis 1,2, Lucia Ramirez-Navarro1,Julie Matte 1, Anna Lorenc1, Nikolina Nakic3, Jorge Esparza-Gordillo3, Wendy Rowan3, David Wille3, David F. Tough3, Paola G. Bronson4, Gosia Trynka1,2

1. Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK
2. Open Targets, Wellcome Genome Campus, Hinxton, UK
3. GSK, R&D, Stevenage, UK
4. R&D Translational Biology, Biogen, Cambridge, MA, USA

* These authors contributed equally to this work


Sanger Institute Contributors

Photo of Ziying Ke

Ziying Ke

PhD Student

Photo of Dr Blagoje Soskic

Dr Blagoje Soskic

Postdoctoral Fellow

Photo of Dr Gosia Trynka

Dr Gosia Trynka

Group Leader at the Sanger Institute and Experimental Science Director at Open Targets

Previous contributors

Photo of Dr Lara Bossini-Castillo

Dr Lara Bossini-Castillo

Postdoctoral Fellow

Photo of Joanna Kaplanis

Joanna Kaplanis

Post doctoral fellow

Photo of Dr Anna (Ania) Lorenc

Dr Anna (Ania) Lorenc

Principal Bioinformatician