Treg Colocalisation

Colocalisation plots between Treg QTLs and immune disease GWAS signals

We profiled gene expression (RNA-seq) and chromatin activity (using ATAC-seq, H3K4me3 and H3K27ac assays)inCD4+regulatory T cells isolated from XXX healthy individuals. We identified between XXX and YYY QTL effects across the different assays. We performed colocalisation of these QTL signals with variants associated with different immune diseases.

This tool provides a visualisation of the colocalisation plots between Treg QTLs and immune disease GWAS signals. It includes correlation plots between p-values of GWAS variants and QTL SNPs and locus zoom plots to examine the LD structure within the associated loci. 

Colocalisation plots between Treg QTLs and immune disease GWAS signals


Sanger Institute Contributors

Photo of Dr Lara Bossini-Castillo

Dr Lara Bossini-Castillo

Postdoctoral Fellow

Previous contributors

Photo of Dafni Glinos

Dafni Glinos

PhD Student