Plasmodium reichenowi

The chimpanzee malaria parasite P. reichenowi is phylogenetically close to the human parasite P. falciparum and whole genome comparisons should reveal crucial information about the evolution of host specificity.

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BLAST server

A low (1-2x) coverage draft genome sequence was previously produced by Sanger sequencing from the only known source of P. reichenowi genomic DNA (CDC strain) provided by Alan Thomas (BPRC, Netherlands). Following the discovery of an additional aliquot of the same DNA source, a full genome sequence has been produced using Illumina Sequence-by-Synthesis. The complete and annotated genome, compared with that of P. falciparum has been published (PMID:25203297).

Bibliography

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.

Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C and Berriman M

Nature communications 2014;5;4754

PUBMED: 25203297; PMC: 4166903; DOI: 10.1038/ncomms5754

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk