P. chabaudi is one of the four malaria species that infect murine rodents from Central Africa that are infectious to laboratory rodents and easily maintained and transmitted by Anopheles stephensi in the laboratory. It serves as a good model for the human parasites with which it shares high homology in most essential aspects of structure, biochemistry and life cycle. Genome organisation is conserved between rodent and human parasites and the two share detailed synteny.
An initial analysis of a low-coverage (3x) draft genome produced by Sanger-sequencing was published by Hall et al. in 2005. From these data P. chabaudi has an estimated genome size of 18-20 Mb, with 14 chromosomes in the size range of 0.6 Mb to 3.8 Mb. DNA for this sequencing project was obtained from bloodstages of clone AS of of P. chabaudi.
Further sequencing of P. chabaudi AS and several other strains has been completed using Illumina Sequence-by-synthesis technology. The re-assembly and annotation has been published (PMID:25359557).
A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
BMC biology 2014;12;86
Data Use Statement
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
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