Leishmania donovani

Leishmania donovani is a protozoan parasite belonging to the Trypanosomatid group. As a major human tropical disease causing debilitating visceral and dermal leishmaniasis, examining genomic variation in strains infecting patients can illuminate the molecular mechanisms of its pathogenicity and resistance to drugs.

Data Downloads

This project is ongoing and and data for this organism will be made available in due course.

Work exploring the genome-level variablility in Leishmania donovani at the Sanger is funded under European Framework Project 7 through two consortia, Kaladrug-r and Gemini, created to evaluate the biology of the parasite. More information on Kaladrug-r and on Gemini is available.

Published Genome Data

The genome sequence of Leishmania donovani has not yet been published.

Bibliography

  • Domestic animals and epidemiology of visceral leishmaniasis, Nepal.

    Bhattarai NR, Van der Auwera G, Rijal S, Picado A, Speybroeck N, Khanal B, De Doncker S, Das ML, Ostyn B, Davies C, Coosemans M, Berkvens D, Boelaert M and Dujardin JC

    Emerging infectious diseases 2010;16;2;231-7

    PUBMED: 20113552; PMC: 2958000; DOI: 10.3201/eid1602.090623

  • The potential of metabolomics for Leishmania research in the post-genomics era.

    Scheltema RA, Decuypere S, T'kindt R, Dujardin JC, Coombs GH and Breitling R

    Parasitology 2010;137;9;1291-302

    PUBMED: 20109253; DOI: 10.1017/S0031182009992022

  • Spread of vector-borne diseases and neglect of Leishmaniasis, Europe.

    Dujardin JC, Campino L, Cañavate C, Dedet JP, Gradoni L, Soteriadou K, Mazeris A, Ozbel Y and Boelaert M

    Emerging infectious diseases 2008;14;7;1013-8

    PUBMED: 18598618; PMC: 2600355; DOI: 10.3201/eid1407.071589

  • Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy.

    Lukes J, Mauricio IL, Schönian G, Dujardin JC, Soteriadou K, Dedet JP, Kuhls K, Tintaya KW, Jirků M, Chocholová E, Haralambous C, Pratlong F, Oborník M, Horák A, Ayala FJ and Miles MA

    Proceedings of the National Academy of Sciences of the United States of America 2007;104;22;9375-80

    PUBMED: 17517634; PMC: 1890502; DOI: 10.1073/pnas.0703678104

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

Short-link