Leishmania braziliensis

The Leishmania parasite is an intracellular pathogen of the immune system targeting macrophages and dendritic cells. The disease Leishmaniasis affects the populations of 88 counties worldwide with symptoms ranging from disfiguring cutaneous and muco-cutaneous lesions that can cause widespread destruction of mucous membranes to visceral disease affecting the haemopoetic organs.

Data Downloads

Unlike previous species sequenced, Leishmania braziliensis is a New World pathogen and currently the only Leishmania genome from the Viannia species group. As well as causing localised cutaneous lesions in affected people, Leishmania braziliensis can also result in a more destructive, progressive infection in mucosal tissue in a proportion of patients.

We have generated a whole genome shotgun, to approximately 5x coverage, of Leishmania braziliensis clone MHOM/BR/75M2904. This project is a collaboration with Universidade de Sao Paulo - FMRP - USP and Debbie Smith (Imperial College).

Published Genome Data

A whole genome shotgun, to approximately 5x coverage, of Leishmania braziliensis clone MHOM/BR/75M2904 was generated. This project is a collaboration with Angela Cruz (Universidade de São Paulo - FMRP - USP) and Debbie Smith (University of York).

Bibliography

  • Comparative genomic analysis of three Leishmania species that cause diverse human disease.

    Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF and Berriman M

    Nature genetics 2007;39;7;839-47

    PUBMED: 17572675; PMC: 2592530; DOI: 10.1038/ng2053

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

Short-link