Entamoeba

Entamoeba histolytica is the causal agent of amoebic dysentery and amoebic liver abscess. With an estimated 40 million cases worldwide and 100,000 deaths, it is responsible for agreat deal of suffering, particularly in the developing world.

Data Downloads

The Wellcome Trust Sanger Institute Pathogen Genomics Group, in collaboration with Graham Clark (London School of Hygiene and Tropical Medicine), sequenced the genome of E. histolytica HM-1:IMSS strain.

Published Genome Data

The E. histolytica genome is ~24 Mb in size and split into 14 chromosomes. A whole genome shotgun sequence (8X coverage) was produced in collaboration with The Institute of Genome Research and assembled into 888 scaffolds.

Additionally, for comparative purposes, the Wellcome Trust Sanger Institute Pathogen Genomics Group sequenced 20000 sequence reads each of Entamoeba dispar, Entamoeba invadens, Entamoeba moshkovskii and Entamoeba terrapinae.

Bibliography

  • The genome of the protist parasite Entamoeba histolytica.

    Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillén N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA, Clark CG, Embley TM, Barrell B, Fraser CM and Hall N

    Nature 2005;433;7028;865-8

    PUBMED: 15729342; DOI: 10.1038/nature03291

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

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