Hymenolepis microstoma

Hymenolepis microstoma is a member of the Cyclophyllidea, which comprises the majority of tapeworms that are of medical importance. H. microstoma is a rodent tapeworm which is used as a laboratory model organism. Much of the basic understanding of tapeworm biology stems from work on Hymenolepis species.

Data Downloads

This is a pilot project to sequence the genome of H. microstoma. Shotgun sequencing will be performed using 454 pyrosequencing and illumina sequencing. The draft genome will be used to assess levels of polymorphism and to evaluate prospects for further sequencing. The draft will be used for comparative genomics against other tapeworms such as Echinococcus multilocularis and Echinococcus granulosus and as a reference for gene finding using RNA-seq.

This work is being done in collaboration with Dr. Pete Olson from the Natural History Museum.

Bibliography

  • The genomes of four tapeworm species reveal adaptations to parasitism.

    Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sánchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Bennett HM, Cai X, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernández C, Holland PWH, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Pouchkina-Stantcheva N, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y, Taenia solium Genome Consortium, Cai J, Soberón X, Olson PD, Laclette JP, Brehm K and Berriman M

    Nature 2013;496;7443;57-63

    PUBMED: 23485966; PMC: 3964345; DOI: 10.1038/nature12031

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

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