A. fumigatus causes more infections worldwide than any other mould. Four percent of all patients dying in tertiary care hospitals in Europe have invasive aspergillosis. The fungus causes allergic deseases in asthmatics and patients suffering from cystic fibrosis. Invasive aspergillosis can occur in individuals with cavities caused by tuberculosis or other cystic lung diseases.
Published Genome Data
The Sanger Institute and its collaborators, Dr. David Denning and Dr. Andrew Brass at the University of Manchester, were initially funded to carry out a pilot genomic analysis of Aspergillus fumigatus . This involved preparing a bacterial artificial chromosome (BAC) library, to fingerprint 3000 BAC clones generating a physical map and then sequencing 10 physically linked BAC clones.
The Sanger Institute was then funded to carry our a whole genome shotgun of A. fumigatus in collaboration with The Institute of Genome Research (TIGR).
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
PUBMED: 16372009; DOI: 10.1038/nature04332
Data Use Statement
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
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