Streptococcus suis
Streptococcus suis is a Gram-positive bacterium that infects pigs and can occasionally cause serious infections in humans. Zoonotic infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality.
Data Downloads
We have sequenced the whole genome sequences of three Streptococcus suis strains from the same lineage: one from European pigs, and two from human cases from China and Vietnam.
The strains are:
- P1/7 was isolated from an ante-mortem blood culture from a pig dying with meningitis, and is sequence type (ST)1 by MLST
- BM407 was isolated from CSF from a human case of meningitis in Ho Chi Minh City, Vietnam in 2004, and is is ST1
- SC84 was isolated from a case of streptococcal toxic shock-like syndrome in Sichuan Province, China in 2005, and is is ST7, a single locus varient of ST1
We have also undertaken some deep sequencing within the ST1 lineages, examining human and pig isolates from in and around Ho Chi Minh City, Vietnam
Collaborators
Stephen Baker, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
Constance Schultsz, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
Published Genome Data
The sequences and annotations of the Streptococcus suis P1/7, SC84 and BM407 genomes have been deposited in the EMBL database under accession numbers AM946016, FM252031, FM252032 and FM252033 respectively.
Shotgun and assembly data from these projects are available from our FTP site.
Studies
- Discovery of sequence diversity in Streptococcus suis (Vietnam)
- Identification of Streptococcus suis genes required for infection of pig nasal septum IVOC using TraDIS
- Haemophilus parasuis genome comparisons
- Streptococcus suis genome comparisons
- Streptococcus suis in the pig meat supply chain
- NCTC 3000
- Streptococcus suis in the pig meat supply chain
- TraDIS study of a multivalent vaccine and single platform diagnostic for bacterial respiratory diseases of pigs
- PacBio sequencing of bacteria causing respiratory diseases of pigs
- Evolution of pathogenesis in Streptococcus suis
Discovery of sequence diversity in Streptococcus suis (Vietnam)
Identification of Streptococcus suis genes required for infection of pig nasal septum IVOC using TraDIS
Haemophilus parasuis genome comparisons
| Sample | Strain | Run Accession |
|---|---|---|
| SS_Mb | P1/7 | ERR225612 |
| SS_Ma | P1/7 | ERR225611 |
Streptococcus suis genome comparisons
Streptococcus suis in the pig meat supply chain
Streptococcus suis in the pig meat supply chain
Bibliography
-
Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.
PloS one 2009;4;7;e6072
PUBMED: 19603075; PMC: 2705793; DOI: 10.1371/journal.pone.0006072
Related links
Data Use Statement
This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.
Sequencing enquiries
Please address all sequencing enquiries to: pathinfo@sanger.ac.uk
