Ruminococcus flavefaciens is an anaerobic, cellulolytic bacterium found in the rumen and in the hindgut of monogastric domestic and wild mammals. These and other cellulolytic bacteria play an important role in the digestion of hemicellulose and cellulose plant cell walls. They possess "cellulosomes," which are surface structures anchored to the bacterial cell wall and consist of a scaffold to which attach several different carbohydrate binding modules possessing cellulase and hemicellulase activities (Bayer et al 2008 The Chemical Record 8: 364-377; Fontes and Gilbert 2010 Ann Rev Biochem 79:23.1-23.27). Ruminococcus flavefaciens strain 007C was isolated from the rumen of a cow (Stewart et al., J Appl Bacteriol 1990 68:349-56) and possesses a novel cell surface-anchored cellulose binding protein. (Rincon et al., J. Bacteriol 2007 Jul; 189(13):4774-83).
The Ruminococcus flavefaciens strain 007C genome was sequenced in collaboration with Prof. Harry Flint of the Rowett Institute of Nutrition and Health, Aberdeen.
Cellulosomes: highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates.
Annual review of biochemistry 2010;79;655-81
PUBMED: 20373916; DOI: 10.1146/annurev-biochem-091208-085603
From cellulosomes to cellulosomics.
Chemical record (New York, N.Y.) 2008;8;6;364-77
PUBMED: 19107866; DOI: 10.1002/tcr.20160
A novel cell surface-anchored cellulose-binding protein encoded by the sca gene cluster of Ruminococcus flavefaciens.
Journal of bacteriology 2007;189;13;4774-83
PUBMED: 17468247; PMC: 1913464; DOI: 10.1128/JB.00143-07
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