The genus Neisseria comprises a number of species associated with colonisation in humans and animals mostly as harmless commensals. Two species, Neisseria meningitidis and Neisseria gonorrhoeae are associated with respiratory and genital disease respectively.
Neisseria meningitidis is a causative agent of meningitis, and is responsible for considerable morbidity and mortality throughout the world. Most disease-causing N. meningitidis strains belong to serogroups A, B and C. Serogroup A strains are responsible for epidemic disease in developing countries, and serogroup B and C strains are responsible for outbreaks of menigitis in the developed world.
The Sanger Institute has been funded by the Wellcome Trust/Beowulf Genomics to sequence the genomes of strains from serogroups A and C:
N. meningitidis serogroup A strain Z2491, in collaboration with Brian Spratt (Imperial College, UK) and Mark Achtman (University of Cork, Ireland)
N. meningitidis serogroup C strain FAM18, in collaboration with Mark Achtman (University of Cork, Ireland)
We also have a broad ranging collaboration with Martin Maiden (University of Oxford) looking at diversity across the genus, within species, within clones and within infections.
Published Genome Data
The genomes of The genome of Neisseria meningitidis serogroup A strain Z2491, Neisseria meningitidis serogroup C strain FAM18 and Neisseria lactamica 020-06 are all available in the EMBL/GenBank databases with accession numbers AL157959, AM421808 and FN995097respectively.
Shotgun and assembly data from these projects are available from the our FTP site.
- Neisseria meningitidis variation during infection
- Discovery of sequence diversity in Neisseria spp.
- Genome sequencing of Neisseria gonorrhoeae isolates
- Neisseria meningitidis transformation study
- Neisseria lactamica Colonisation
- Neisseria meningitidis diversity
- Neisseria meningitidis study
- Emergence and spread of antibiotic resistant Neisseria gonorrhoeae in the US
- Global dataset of Neisseria gonorrhoeae spanning 2 decades to study global spread through the dissemination of drug resistant clones
- Microevolution of Neisseria meningitidis during clonal waves of colonization and disease - phase 2
- Neisseria meningitidis causing invasive disease in South Africa, 2003-2012
- Integration of the host and pathogen genetics in bacterial meningitis
- NCTC 3000
- Understanding the Molecular Epidemiology of Scottish Meningococci through Genome Sequencing
- Extended genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to extended spectrum cephalosporins and azithromycin in the US
- Genomic characterization of bladder bacteria from healthy and infected women
- Molecular epidemiology and microbial ecology of Neisseria gonorrhoeae in Singapore
- SureSelect analysis to study molecular epidemiology and microbial ecology of Neisseria gonorrhoeae in Singapore
- Using genomics to understand transmission networks of Neisseria gonorrhoeae in New York City
- sRNAs from Neisseria extracellular vesicles
- Repeated cross-sectional survey of meningococcal carriage in Burkina Faso
- Ecology and molecular epidemiology of the genus Neisseria in the African meningitis belt
- Neisseria meningitidis carriage studies
- Sequencing ESKAPE pathogens in Malawi