Klebsiella

Klebsiella is a genus of non-motile, Gram-negative, oxidase-negative, rod-shaped bacteria of the family Enterobacteriaceae.

Amnogst it's species is Klebsiella pneumoniae which has a world-wide distribution causing disease in a highly diverse group of hosts including humans, animals and plants. Relatively little is known about the evolution of K. pneumoniae. K. pneumoniae is an important cause of human disease resulting in significant morbidity and mortality in the developed world and one of the most common causes of community acquired infections in Asia, causing diseases including pneumonia, liver abscess and septicemia. In developed countries, K. pneumoniae is typically a nosocomial pathogen responsible for sepsis, urinary tract infections and pneumonia K. pneumoniae is also a common veterinary pathogen, causing mastitis in dairy cows and an infection of the uterus in horses. Furthermore, K. pneumoniae is a plant endophyte, illustrating the broad host range of this bacterium. We are aiming to capture a snap shot of the global diversity held within this species and have put together a strain collection for sequencing accordingly.

Data Downloads

This project is ongoing and data for this organism will be made available in due course.

Collaborators

Dick Strugnell Ph.D. (Prof) The Department of Microbiology & Immunology, The University of Melbourne, VIC AUSTRALIA

Heiman F.L. Wertheim, M.D. Ph.D. Oxford University Clinical Research Unit, National Institute of Infectious and Tropical Diseases, Bach Mai Hospital, Hanoi Viet Nam.

Kathryn Holt Ph.D. The Department of Microbiology & Immunology, The University of Melbourne, VIC AUSTRALIA

Stephen Baker Ph.D. OAK Leadership Fellow Wellcome Trust Major Overseas Programme Oxford University Clinical Research Unit The Hospital for Tropical Diseases 190 Ben Ham Tu, Quan 5 Ho Chi Minh City Vietnam

Ruth N. Zadoks, DVM, PhD Moredun Chair of Veterinary Epidemiology, Moredun Research Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh

Published Genome Data

The Sanger Institute has sequenced the genome of Klebsiella pneumoniae subsp. pneumoniae Ecl8. The chromosomal genome is available from EMBL/GenBank with accession number HF536482. Similarly, the plasmid is available with accession number HF536483.