Corynebacterium diphtheriae

Corynebacterium diphtheriae produces a potent bacteriophage-encoded protein exotoxin, diphtheria toxin, which causes the symptoms of diphtheria. This potentially fatal infectious disease is controlled in many developed countries by an effective immunisation programme. However, the disease has made a dramatic return in recent years, in particular within the Eastern European region.

Data Downloads

FTP site

BLAST server

C. diphtheriae biotype gravis strain NCTC13129 was isolated in 1997 from a 72-year-old female with clinical diphtheria who had returned to the UK from a Baltic cruise.

Published Genome Data

The C. diphtheriae NCTC 13129 genome is composed of a single circular chromosome of 2,488,635 bp, and was sequenced in collaboration with Dr. Androulla Efstratiou of the W.H.O. collaborating centre for diphtheria, Respiratory and Systemic Infection Laboratory, at the Health Protection Agency.

The fully annotated genome is available from the EMBL/GenBank databases with accession number BX248353.

Shotgun and assembly data from this project are available from our FTP site.

Studies

Discovery of sequence diversity in Corynebacterium diphtheriae

Sample	Strain	Run Accession
93-78	Unknown	ERR034142
97-278	Unknown	ERR034146
97-225	Unknown	ERR034143
99-194	Unknown	ERR034144
RR_0800_1513	Unknown	ERR034145

NCTC 3000

Sample	Strain	Run Accession
3012STDY5814528	NCTC11397	ERR550493
3012STDY5814528	NCTC11397	ERR550508
3012STDY5814528	NCTC11397	ERR550510
3012STDY7122766	NCTC380	ERR2432869
3012STDY7103889	NCTC3529	ERR2496359
3012STDY7103890	NCTC7838	ERR2496360

PacBio sequencing of Corynebacterium diphtheriae

Sample	Strain	Run Accession
3156STDY5854174	Unknown	ERR654510

Bibliography

The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.

Cerdeño-Tárraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG and Parkhill J

Nucleic acids research 2003;31;22;6516-23

PUBMED: 14602910; PMC: 275568; DOI: 10.1093/nar/gkg874

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk