Citrobacter

Citrobacter is a genus of Gram-negative enteric bacteria. It include Citrobacter rodentium whose cognate host is mice where it causes transmissible murine colonic hyperplasia, and is responsible for high mortality in suckling mice (Barthold et al., 1978; Schauer & Falkow, 1993; Schauer et al., 1995). Citrobacter species are widely distributed in nature, frequently present in soil and water, and can be readily isolated from human and animal faeces. However, unlike the host-adapted C. rodentium that causes gastrointestinal disease, the other Citrobacter species are opportunistic pathogens that cause a variety of extraintestinal infections (Luperchio & Schauer, 2001). Although disease caused by C. rodentium has been observed primarily in mice, this bacterium has also been reported to cause disease with a high rate of fatality in other rodents (de la Puente-Redondo et al., 1999). There are no reports of C. rodentium being pathogenic to humans.

Data downloads

Citrobacter rodentium

C. rodentium is a member of the attaching and effacing (A/E) family of bacterial pathogens, which is characterised by intimate bacterial adherence to host intestinal epithelial cells, effacement of microvilli, and reorganisation of the host actin cytoskeleton to form pedestal-like extensions of epithelial cells beneath the adherent bacteria called A/E lesions (Wales et al., 2005). Gastrointestinal colonisation and formation of A/E lesions is mediated by a pathogenicity island called the locus of enterocyte effacement (LEE), which is conserved among A/E bacteria (Deng et al., 2001; Wales et al., 2005). C. rodentium is unique amongst Citrobacter species in possessing the LEE (Schauer & Falkow, 1993; Schauer et al., 1995). As the only known A/E pathogen to naturally infect mice, it is a valuable model organism for the study of pathogenesis of the clinically significant human pathogens, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC).

Collaborators

Gad Frankel Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK.

Nicola Petty School of Chemistry and Molecular Biosciences University of Queensland Brisbane QLD 4072 Australia

Published Data

We have reported the fully annotated genome sequence of a murine virulent strain of C. rodentium, ICC168. The genome is 5,346,659 bp in length, with an average G+C content of 54.72 % and is deposited in the EMBL/GenBank databases with accession number FN543502. Additionaly, three plasmids are also deposited in EMBL/GenBank with accession numbers FN543503, FN543504 and FN543505.

Shotgun and assembly data from this project are available from our FTP site.

Citrobacter freundii

The Sanger Institute has been funded by the Wellcome Trust to sequence the genome of Citrobacter freundii ballerup 7851.

The DNA sequence of Citrobacter freundii ballerup 7851 was obtained by 454 FLX pyrosequencing, assembled using the 454/Roche Newbler assembly program.

357 contigs (N50 contig size 60,237 bp) were obtained from 410,057 sequence reads with an average read length of 177 bp, to give a total sequence length of 4,904,659 bp. The data are available in the European Nucleotide Archive with accession ERA000106.

Studies

TraDIS Citrobacter rodentium
SampleStrainRun Accession
1_CR_TraDISUnknownERR349744
1_CR_TraDISUnknownERR349741
1_CR_TraDISUnknownERR374323
1_CR_TraDISUnknownERR374399
1_CR_TraDISUnknownERR374551
1_CR_TraDISUnknownERR374475
2_CR_TraDISUnknownERR349743
2_CR_TraDISUnknownERR349742
2_CR_TraDISUnknownERR374324
2_CR_TraDISUnknownERR374400
2_CR_TraDISUnknownERR374552
2_CR_TraDISUnknownERR374476
pH7_2UnknownERR374322
pH7_2UnknownERR374398
pH52_2UnknownERR374321
pH52_2UnknownERR374397
pH4_2UnknownERR374320
pH4_2UnknownERR374396
pH3_2UnknownERR374319
pH3_2UnknownERR374395
H2O2_2UnknownERR374318
H2O2_2UnknownERR374394
Anae_2UnknownERR374317
Anae_2UnknownERR374393
MUCIN_2UnknownERR374316
MUCIN_2UnknownERR374392
BILE_2UnknownERR374315
BILE_2UnknownERR374391
BILE_2UnknownERR1045484
DRM_G_2UnknownERR374314
DRM_G_2UnknownERR374390
DRM_G_2UnknownERR1045482
DRM_2UnknownERR374313
DRM_2UnknownERR374389
DRM_2UnknownERR1045480
CAE_10P2AUnknownERR374312
CAE_10P2AUnknownERR374388
CAE_10P1AUnknownERR374311
CAE_10P1AUnknownERR374387
CAE_10113UnknownERR374310
CAE_10113UnknownERR374386
CAE_10112UnknownERR374385
CAE_10112UnknownERR374309
CAE_10111UnknownERR374308
CAE_10111UnknownERR374384
CAE_1093UnknownERR374307
CAE_1093UnknownERR374383
CAE_1092UnknownERR374306
CAE_1092UnknownERR374382
CAE_1091UnknownERR374305
CAE_1091UnknownERR374381
COL_10P2AUnknownERR374304
COL_10P2AUnknownERR374380
COL_10P1AUnknownERR374303
COL_10P1AUnknownERR374379
COL_10113UnknownERR374302
COL_10113UnknownERR374378
COL_10112UnknownERR374301
COL_10112UnknownERR374377
COL_10111UnknownERR374300
COL_10111UnknownERR374376
COL_1093UnknownERR374375
COL_1093UnknownERR374299
COL_1092UnknownERR374298
COL_1092UnknownERR374374
COL_1091UnknownERR374297
COL_1091UnknownERR374373
CL_10P2AUnknownERR374296
CL_10P2AUnknownERR374372
CL_10P1AUnknownERR374295
CL_10P1AUnknownERR374371
CL_10113UnknownERR374294
CL_10113UnknownERR374370
CL_10112UnknownERR374293
CL_10112UnknownERR374369
CL_10111UnknownERR374292
CL_10111UnknownERR374368
CL_1093UnknownERR374291
CL_1093UnknownERR374367
CL_1092UnknownERR374290
CL_1092UnknownERR374366
CL_1091UnknownERR374289
CL_1091UnknownERR374365
FAE_10P2AUnknownERR374288
FAE_10P2AUnknownERR374364
FAE_10P1AUnknownERR374287
FAE_10P1AUnknownERR374363
FAE_10113UnknownERR374286
FAE_10113UnknownERR374362
FAE_10112UnknownERR374285
FAE_10112UnknownERR374361
FAE_10111UnknownERR374360
FAE_10111UnknownERR374284
FAE_1093UnknownERR374283
FAE_1093UnknownERR374359
FAE_1092UnknownERR374358
FAE_1092UnknownERR374282
FAE_1091UnknownERR374281
FAE_1091UnknownERR374357
CAE_7P2AUnknownERR374280
CAE_7P2AUnknownERR374356
CAE_7P1AUnknownERR374279
CAE_7P1AUnknownERR374355
CAE_781UnknownERR374278
CAE_781UnknownERR374354
CAE_772UnknownERR374277
CAE_772UnknownERR374353
CAE_771UnknownERR374276
CAE_771UnknownERR374352
CAE_761UnknownERR374275
CAE_761UnknownERR374351
CAE_752UnknownERR374274
CAE_752UnknownERR374350
CAE_751UnknownERR374273
CAE_751UnknownERR374349
COL_7P2AUnknownERR374272
COL_7P2AUnknownERR374348
COL_7P1AUnknownERR374271
COL_7P1AUnknownERR374347
COL_781UnknownERR374270
COL_781UnknownERR374346
COL_772UnknownERR374269
COL_772UnknownERR374345
COL_771UnknownERR374344
COL_771UnknownERR374268
COL_761UnknownERR374267
COL_761UnknownERR374343
COL_752UnknownERR374266
COL_752UnknownERR374342
COL_751UnknownERR374341
COL_751UnknownERR374265
CL_7P2AUnknownERR374264
CL_7P2AUnknownERR374340
CL_7P1AUnknownERR374263
CL_7P1AUnknownERR374339
CL_781UnknownERR374262
CL_781UnknownERR374338
CL_772UnknownERR374261
CL_772UnknownERR374337
CL_771UnknownERR374336
CL_771UnknownERR374260
CL_761UnknownERR374259
CL_761UnknownERR374335
CL_752UnknownERR374258
CL_752UnknownERR374334
CL_751UnknownERR374333
CL_751UnknownERR374257
FAE_7P2AUnknownERR374332
FAE_7P2AUnknownERR374256
FAE_7P1AUnknownERR374255
FAE_7P1AUnknownERR374331
FAE_781UnknownERR374254
FAE_781UnknownERR374330
FAE_772UnknownERR374253
FAE_772UnknownERR374329
FAE_771UnknownERR374252
FAE_771UnknownERR374328
FAE_761UnknownERR374251
FAE_761UnknownERR374327
FAE_752UnknownERR374250
FAE_752UnknownERR374326
FAE_751UnknownERR374325
FAE_751UnknownERR374249
pH7_1UnknownERR374474
pH7_1UnknownERR374550
pH52_1UnknownERR374473
pH52_1UnknownERR374549
pH4_1UnknownERR374472
pH4_1UnknownERR374548
pH3_1UnknownERR374471
pH3_1UnknownERR374547
H2O2_1UnknownERR374470
H2O2_1UnknownERR374546
Anae_1UnknownERR374545
Anae_1UnknownERR374469
MUCIN_1UnknownERR374468
MUCIN_1UnknownERR374544
MUCIN_1UnknownERR1045485
BILE_1UnknownERR374467
BILE_1UnknownERR374543
BILE_1UnknownERR1045483
DRM_G_1UnknownERR374466
DRM_G_1UnknownERR374542
DRM_G_1UnknownERR1045481
DRM_1UnknownERR374465
DRM_1UnknownERR374541
DRM_1UnknownERR1045479
CAE_4P2AUnknownERR374464
CAE_4P2AUnknownERR374540
CAE_4P1AUnknownERR374539
CAE_4P1AUnknownERR374463
CAE_441UnknownERR374538
CAE_441UnknownERR374462
CAE_432UnknownERR374537
CAE_432UnknownERR374461
CAE_431UnknownERR374536
CAE_431UnknownERR374460
CAE_421UnknownERR374535
CAE_421UnknownERR374459
CAE_412UnknownERR374458
CAE_412UnknownERR374534
CAE_411UnknownERR374457
CAE_411UnknownERR374533
COL_4P2AUnknownERR374456
COL_4P2AUnknownERR374532
COL_4P1AUnknownERR374531
COL_4P1AUnknownERR374455
COL_441UnknownERR374454
COL_441UnknownERR374530
COL_432UnknownERR374453
COL_432UnknownERR374529
COL_431UnknownERR374528
COL_431UnknownERR374452
COL_421UnknownERR374451
COL_421UnknownERR374527
COL_412UnknownERR374450
COL_412UnknownERR374526
COL_411UnknownERR374449
COL_411UnknownERR374525
CL_4P2AUnknownERR374448
CL_4P2AUnknownERR374524
CL_4P1AUnknownERR374523
CL_4P1AUnknownERR374447
CL_441UnknownERR374446
CL_441UnknownERR374522
CL_432UnknownERR374445
CL_432UnknownERR374521
CL_431UnknownERR374444
CL_431UnknownERR374520
CL_421UnknownERR374443
CL_421UnknownERR374519
CL_412UnknownERR374442
CL_412UnknownERR374518
CL_411UnknownERR374441
CL_411UnknownERR374517
FAE_4P2AUnknownERR374440
FAE_4P2AUnknownERR374516
FAE_4P1AUnknownERR374439
FAE_4P1AUnknownERR374515
FAE_441UnknownERR374514
FAE_441UnknownERR374438
FAE_432UnknownERR374437
FAE_432UnknownERR374513
FAE_431UnknownERR374436
FAE_431UnknownERR374512
FAE_421UnknownERR374435
FAE_421UnknownERR374511
FAE_412UnknownERR374434
FAE_412UnknownERR374510
FAE_411UnknownERR374509
FAE_411UnknownERR374433
CAE_1P2AUnknownERR374432
CAE_1P2AUnknownERR374508
CAE_1P1AUnknownERR374507
CAE_1P1AUnknownERR374431
CAE_123UnknownERR374506
CAE_123UnknownERR374430
CAE_122UnknownERR374429
CAE_122UnknownERR374505
CAE_121UnknownERR374428
CAE_121UnknownERR374504
CAE_113UnknownERR374427
CAE_113UnknownERR374503
CAE_112UnknownERR374426
CAE_112UnknownERR374502
CAE_111UnknownERR374425
CAE_111UnknownERR374501
COL_1P2AUnknownERR374424
COL_1P2AUnknownERR374500
COL_1P1AUnknownERR374423
COL_1P1AUnknownERR374499
COL_123UnknownERR374422
COL_123UnknownERR374498
COL_122UnknownERR374421
COL_122UnknownERR374497
COL_121UnknownERR374420
COL_121UnknownERR374496
COL_113UnknownERR374495
COL_113UnknownERR374419
COL_112UnknownERR374494
COL_112UnknownERR374418
COL_111UnknownERR374417
COL_111UnknownERR374493
CL_1P2AUnknownERR374416
CL_1P2AUnknownERR374492
CL_1P1AUnknownERR374415
CL_1P1AUnknownERR374491
CL_123UnknownERR374414
CL_123UnknownERR374490
CL_122UnknownERR374413
CL_122UnknownERR374489
CL_121UnknownERR374412
CL_121UnknownERR374488
CL_113UnknownERR374411
CL_113UnknownERR374487
CL_112UnknownERR374410
CL_112UnknownERR374486
CL_111UnknownERR374409
CL_111UnknownERR374485
FAE_1P2AUnknownERR374408
FAE_1P2AUnknownERR374484
FAE_1P1AUnknownERR374407
FAE_1P1AUnknownERR374483
FAE_123UnknownERR374406
FAE_123UnknownERR374482
FAE_122UnknownERR374481
FAE_122UnknownERR374405
FAE_121UnknownERR374480
FAE_121UnknownERR374404
FAE_113UnknownERR374479
FAE_113UnknownERR374403
FAE_112UnknownERR374402
FAE_112UnknownERR374478
FAE_111UnknownERR374401
FAE_111UnknownERR374477
55_H2O2_1_D2ICC168ERR842418
55_H2O2_1_D2ICC168ERR842361
54_H2O2_1_D2ICC168ERR842417
54_H2O2_1_D2ICC168ERR842360
53_CTRL1_DRM_D2ICC168ERR842416
53_CTRL1_DRM_D2ICC168ERR842359
52_H2O2_2_D1ICC168ERR842415
52_H2O2_2_D1ICC168ERR842358
51_H2O2_1_D1ICC168ERR842414
51_H2O2_1_D1ICC168ERR842357
50_CTRL2_DRM_D1ICC168ERR842413
50_CTRL2_DRM_D1ICC168ERR842356
49_CTRL1_DRM_D1ICC168ERR842412
49_CTRL1_DRM_D1ICC168ERR842355
48_Anae2_D2ICC168ERR842411
48_Anae2_D2ICC168ERR842354
47_Anae1_D2ICC168ERR842410
47_Anae1_D2ICC168ERR842353
46_CTRL2_D2ICC168ERR842409
46_CTRL2_D2ICC168ERR842352
45_CTRL1_D2ICC168ERR842408
45_CTRL1_D2ICC168ERR842351
44_Anae2_D1ICC168ERR842407
44_Anae2_D1ICC168ERR842350
43_Anae1_D1ICC168ERR842406
43_Anae1_D1ICC168ERR842349
42_CTRL2_D1ICC168ERR842405
42_CTRL2_D1ICC168ERR842348
41_CTRL1_D1ICC168ERR842404
41_CTRL1_D1ICC168ERR842347
40_CL_425ICC168ERR842403
40_CL_425ICC168ERR842346
39_CL_424ICC168ERR842402
39_CL_424ICC168ERR842345
38_CL_423ICC168ERR842401
38_CL_423ICC168ERR842344
37_CL_422ICC168ERR842400
37_CL_422ICC168ERR842343
36_CL_421ICC168ERR842399
36_CL_421ICC168ERR842342
35_CL_415ICC168ERR842398
35_CL_415ICC168ERR842341
34_CL_414ICC168ERR842397
34_CL_414ICC168ERR842340
33_CL_413ICC168ERR842396
33_CL_413ICC168ERR842339
32_CL_412ICC168ERR842395
32_CL_412ICC168ERR842338
31_CL_411ICC168ERR842394
31_CL_411ICC168ERR842337
30_FAE_425ICC168ERR842393
30_FAE_425ICC168ERR842336
29_FAE_424ICC168ERR842392
29_FAE_424ICC168ERR842335
28_FAE_423ICC168ERR842391
28_FAE_423ICC168ERR842334
27_FAE_422ICC168ERR842390
27_FAE_422ICC168ERR842333
26_FAE_421ICC168ERR842389
26_FAE_421ICC168ERR842332
25_FAE_415ICC168ERR842388
25_FAE_415ICC168ERR842331
24_FAE_414ICC168ERR842387
24_FAE_414ICC168ERR842330
23_FAE_413ICC168ERR842386
23_FAE_413ICC168ERR842329
22_FAE_412ICC168ERR842385
22_FAE_412ICC168ERR842328
21_FAE_411ICC168ERR842384
21_FAE_411ICC168ERR842327
20_CAE_425ICC168ERR842383
20_CAE_425ICC168ERR842326
19_CAE_424ICC168ERR842382
19_CAE_424ICC168ERR842325
18_CAE_423ICC168ERR842381
18_CAE_423ICC168ERR842324
17_CAE_422ICC168ERR842380
17_CAE_422ICC168ERR842323
16_CAE_421ICC168ERR842379
16_CAE_421ICC168ERR842322
15_CAE_415ICC168ERR842378
15_CAE_415ICC168ERR842321
14_CAE_414ICC168ERR842377
14_CAE_414ICC168ERR842320
13_CAE_413ICC168ERR842376
13_CAE_413ICC168ERR842319
12_CAE_412ICC168ERR842375
12_CAE_412ICC168ERR842318
11_CAE_411ICC168ERR842374
11_CAE_411ICC168ERR842317
10_Col_425ICC168ERR842373
10_Col_425ICC168ERR842316
9_Col_424ICC168ERR842372
9_Col_424ICC168ERR842315
8_Col_423ICC168ERR842371
8_Col_423ICC168ERR842314
7_Col_422ICC168ERR842370
7_Col_422ICC168ERR842313
6_Col_421ICC168ERR842369
6_Col_421ICC168ERR842312
5_Col_415ICC168ERR842368
5_Col_415ICC168ERR842311
4_Col_414ICC168ERR842367
4_Col_414ICC168ERR842310
3_Col_413ICC168ERR842366
3_Col_413ICC168ERR842309
2_Col_412ICC168ERR842365
2_Col_412ICC168ERR842308
1_Col_411ICC168ERR842364
1_Col_411ICC168ERR842307
2_pH3_CRICC168ERR909359
1_pH3_CRICC168ERR909358
2_pH5point2_CRICC168ERR909357
1_pH5point2_CRICC168ERR909356
2_pH7_CRICC168ERR909355
1_pH7_CRICC168ERR909354
Unable to read file: /resources/downloads/bacteria/inc/citrobacter3454.inc
Lung Culturomics
SampleStrainRun Accession
7_Run_RUnknownERR968251
Unable to read file: /resources/downloads/bacteria/inc/citrobacter3773.inc
Unable to read file: /resources/downloads/bacteria/inc/citrobacter4186.inc
Unable to read file: /resources/downloads/bacteria/inc/citrobacter4237.inc
Unable to read file: /resources/downloads/bacteria/inc/citrobacter4530.inc

Bibliography

  • The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.

    Petty NK, Bulgin R, Crepin VF, Cerdeño-Tárraga AM, Schroeder GN, Quail MA, Lennard N, Corton C, Barron A, Clark L, Toribio AL, Parkhill J, Dougan G, Frankel G and Thomson NR

    Journal of bacteriology 2009;192;2;525-38

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

Short-link