Burkholderia cenocepacia

Burkholderia cenocepacia (formerly Burkholderia cepacia genomovar III, and before that Pseudomonas cepacia) is a Gram negative bacterium which is ubiquitous in the environment and may cause a number of diseases in plants. Human infection can be caused by B. cepacia, especially in patients with cystic fibrosis and chronic granulomatous disease, and is often fatal.

Data Downloads

The Sanger Institute has completed the sequencing of and published the 8.06 Mb genome of Burkholderia cenocepacia strain J2315, in collaboration with Dr. Eshwar Mahenthiralingham of the School of Biosciences, Cardiff University, Prof. John Govan of the Department of Medical Microbiology, University of Edinburgh, Prof. C.A. Hart of the Department of Medical Microbiology, University of Liverpool, and Prof. Peter Vandamme of the Laboratorium voor Microbiologie, Universiteit Gent, Belgium.

Note that B. cenocepacia J2315 has recently been renamed from B. cepacia J2315

Published Genome Data

The sequenced strain, J2315, is a genomovar III strain of the ET12 lineage, and is the index strain for transmission of this strain among CF patients in the UK. Strain J2315 has been deposited as LMG 16656 in the Belgium Coordinated Collection of Microorganisms.

The sequence and annotation of the Burkholderia cenocepacia strain J2315 genome have been deposited in the EMBL database under accession numbers AM747720, AM747721, AM747722 and AM747723

Shotgun and assembly data from this project are available from our FTP site.

Studies

Unable to read file: inc/burkholderia-cenocepacia.inc

Bibliography

  • The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.

    Holden MT, Seth-Smith HM, Crossman LC, Sebaihia M, Bentley SD, Cerdeño-Tárraga AM, Thomson NR, Bason N, Quail MA, Sharp S, Cherevach I, Churcher C, Goodhead I, Hauser H, Holroyd N, Mungall K, Scott P, Walker D, White B, Rose H, Iversen P, Mil-Homens D, Rocha EP, Fialho AM, Baldwin A, Dowson C, Barrell BG, Govan JR, Vandamme P, Hart CA, Mahenthiralingam E and Parkhill J

    Journal of bacteriology 2008;191;1;261-77

    PUBMED: 18931103; PMC: 2612433; DOI: 10.1128/JB.01230-08

  • Burkholderia cenocepacia sp. nov.--a new twist to an old story.

    Vandamme P, Holmes B, Coenye T, Goris J, Mahenthiralingam E, LiPuma JJ and Govan JR

    Research in microbiology 2003;154;2;91-6

    PUBMED: 12648723; DOI: 10.1016/S0923-2508(03)00026-3

Related links

Data Use Statement

This sequencing centre plans on publishing the completed and annotated sequences in a peer-reviewed journal as soon as possible. Permission of the principal investigator should be obtained before publishing analyses of the sequence/open reading frames/genes on a chromosome or genome scale. See our data sharing policy.

Sequencing enquiries

Please address all sequencing enquiries to: pathinfo@sanger.ac.uk

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