GENCODE

In‭ ‬2007‭ ‬the US National Human Genome Research Institute‭ (‬NHGRI‭) ‬provided funding for‭ ‬the‭ ‬GENCODE sub-project,‭ ‬part of a programme to expand the ENCylcopedia Of DNA Elements‭ (‬ENCODE‭) ‬project.‭ ‬In‭ ‬2013,‭ ‬after‭ ‬successfully‭ ‬delivering‭ ‬the definitive annotation of functional elements in the human genome,‭ ‬the GENCODE group‭ ‬was awarded a second grant to continue their human genome annotation work and expand GENCODE to include annotation of the mouse genome.

The aim of GENCODE is to annotate all evidence-based gene features in the entire human genome at a high accuracy.‭ ‬The result will be a set of annotations including all protein-coding loci with alternatively transcribed variants,‭ ‬non-coding loci with transcript evidence and pseudogenes.‭ ‬The process to create this annotation involves manual curation,‭ ‬different computational analysis and targeted experimental approaches.‭ ‬Putative loci can be verified by wet-lab experiments and computational predictions are analysed manually.

The international team working in the GENCODE project is headed by Professor Tim Hubbard,‭ ‬Honorary Faculty at the Wellcome Trust Sanger Institute and includes members from Centre de RegulacióGenòmica,‭ ‬The University of Lausanne,‭ ‬Massachusetts Institute of Technology,‭ ‬Yale University and The University of California,‭ ‬Santa Cruz.

www.gencodegenes.org

[Genome Research Limited]

Information about the Gencode project and its data can be found at:

* quick link - http://q.sanger.ac.uk/wpi9iw10