Cellular Genetics

Cellular Genetics

Cellular Genetics

Our Approach

The Cellular Genetics programme is focused on cell-atlasing and cellular genetics. The programme uses these approaches to map cells in the human body combining cutting-edge methodologies and computational approaches. This enables us to understand what the identity of cells are, how they are regulated, relationships between them and, importantly, how this can change during development, health disease and ageing. 

Our Work

The future outlook for the programme is to build on current scientific and funding success with expansion of expertise in cell-atlasing approaches, spatial genomics and computational approaches and use of cell-atlasing technologies to understand in vitro systems such as IPSCs and organoids. This will be coupled with increasing focus on using cell-atlasing to understand disease.

The Cellular Genetic’s Programme jointly lead the “Human Cell Atlas” (HCA) global consortium alongside the Broad Institute, with Sarah Teichmann as co-lead and co-founder, together with Aviv Regev (MIT/Broad). The HCA vision is to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease.

The “resolution revolution” in genomics has enabled the study of single cells, so-called “single cell genomics”, such that we can now sequence millions of individual cells in unprecedented detail. On a similar scale to the Human Genome Project, the Human Cell Atlas aims to create a 3D ‘Google map’ of the 37 trillion cells of the human body which will allow scientists to zoom into organs, tissues and cells to reveal the location and gene activity patterns of each cell type.

The Human Cell Atlas was launched in London in 2016 with a kick-off meeting attended by an interdisciplinary community of biomedical experts, genomics technologists and computational biologists at an international meeting to discuss how to create a Human Cell Atlas. Three years later, the global Human Cell Atlas initiative has over 1,500 researchers from more than 60 countries and has achieved success in fundamental areas of basic and translational research including oncology, immunology, respiratory disease, human development and reproductive biology.

 

Research

Groups

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