The future outlook for the programme is to build on current scientific and funding success with expansion of expertise in cell-atlasing approaches, spatial genomics and computational approaches and use of cell-atlasing technologies to understand in vitro systems such as IPSCs and organoids. This will be coupled with increasing focus on using cell-atlasing to understand disease.
The Cellular Genetic’s Programme jointly lead the “Human Cell Atlas” (HCA) global consortium alongside the Broad Institute, with Sarah Teichmann as co-lead and co-founder, together with Aviv Regev (MIT/Broad). The HCA vision is to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human health and diagnosing, monitoring, and treating disease.
The “resolution revolution” in genomics has enabled the study of single cells, so-called “single cell genomics”, such that we can now sequence millions of individual cells in unprecedented detail. On a similar scale to the Human Genome Project, the Human Cell Atlas aims to create a 3D ‘Google map’ of the 37 trillion cells of the human body which will allow scientists to zoom into organs, tissues and cells to reveal the location and gene activity patterns of each cell type.
The Human Cell Atlas was launched in London in 2016 with a kick-off meeting attended by an interdisciplinary community of biomedical experts, genomics technologists and computational biologists at an international meeting to discuss how to create a Human Cell Atlas. Three years later, the global Human Cell Atlas initiative has over 1,500 researchers from more than 60 countries and has achieved success in fundamental areas of basic and translational research including oncology, immunology, respiratory disease, human development and reproductive biology.
Cellular Genetics Leadership
Our Faculty Group Leaders conceive and deliver ambitious, world-leading science at a scale. They and their research teams (listed below) collaborate with their peers across all the Institute’s scientific Programmes to create innovative approaches to explore new areas of genomic science.
Our Associate Faculty bring knowledge and approaches that enrich and diversify our science. Their satellite research groups (listed below) benefit from the Institute’s data-generation/data analysis infrastructure and scientific expertise, supplementing our Core Faculty groups’ scientific portfolio.
Our International Fellows work closely with our Core Faculty to advance their research into diseases prevalent in their country by leveraging the Institute’s research environment. We are delighted to be collaborating with Dr Annettee Nakimuli, a leading maternal health researcher in Uganda. She is partnering with Dr Roser Vento-Tormo’s group to apply genomic techniques to understand maternal and neonatal health in Sub-Saharan Africa
We seek to explore the vast cellular diversity in the human brain using large-scale spatial transcriptomics, imaging and functional screens.
Cancer genomics & single cell transcriptomics
Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and ...
Cellular Genetics Informatics
Our team provides efficient access to cutting-edge analysis methods, environments and pipelines for Cellular Genetics programme, which leads and is involved ...
Our research is focused on understanding what type of immune cells live within different organs in humans, and how the special ...
Genomics of gene regulation
Gene expression involves the transformation of genetic information encoded in DNA sequence into a gene product, such as a protein. Regulation ...
Cellular Genetics Programme
The team’s research applies disruptive cutting-edge techniques to study the genomics of immune cell populations at single-cell resolution and uses ...
Quantitative models of gene expression
The Hemberg group is interested in developing quantitative models of gene expression. Our approach is theoretical and we strive to develop ...
Human Cell Atlas Group
We are undertaking research to develop, optimise and assess the performance of key enabling experimental and computational technologies that will underly ...
Single cell genomics
John Marioni's group develop computational and statistical tools to exploit high-throughput genomics data to understand the regulation of gene expression ...
Stegle and Theis Group
Cellular Genetics Programme
We aim to leverage machine learning in the context of single cell genomics to provide a true model-based understanding of the ...
Gene expression genomics
We use cutting edge single cell genomics technologies and computational methods to understand genes, proteins and cells in human health and ...
The Trynka group combines experimental and computational approaches to study how genetics control the immune system and predispose individuals to autoimmune ...
The Vento Lab uses genomics and computational tools to reconstruct immune environments. The main areas of focus are: Immunogenomics - Immune responses ...
Epigenetic mechanisms in health and disease
Adrian's group is investigating "The function of long non-coding RNAs originating at CpG island promoters" and "The effects of ...
The Bradley laboratory is a multi-disciplinary environment with a number of parallel research themes. One of our core disciplines is ...
Stem cell engineering
The Stem cell engineering team employed high-throughput gene-targeting strategies to study the function of mammalian genes.
The Vallier laboratory studies the basic mechanisms controlling differentiation of human pluripotent cells into pancreas, lung, gut and liver cells.
Cellular Genetics Portals
Open-access data portals
The Cellular Genetics Programme is committed to making cell atlasing data analysis and visualisation tools available to the scientific community
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Launch of virtual Sanger Seminar series
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18 May 2020
An automated method for cell type discovery
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