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The Malaria Programme joined with the Infection Genomics Programme to form the new Parasites and Microbes Programme in 2018
- Conduct large-scale, high-resolution analysis of Plasmodium and Anopheles genome variation to understand how they are evolving
- Investigate genetic interactions between human, parasite and vector populations
- Use molecular, cellular and organismal model systems to investigate how genetic variation affects host-parasite interactions
- Developing scalable technologies and resources for Plasmodium experimental genetics using both in vitro and in vivo model systems
- Develop new methods to investigate extracellular low-affinity interactions between P. falciparum extracellular proteins and host receptors
Malaria is a debilitating and sometimes fatal illness that is caused by infection with Plasmodium parasites that are passed between people by Anopheles mosquitoes. Despite progress in fighting the illness, nearly half the world’s population – 3.4 billion people in 97 countries – are at risk. In 2012, there were 207 million reported cases and 627,000 deaths, with the majority of deaths among African children under the age of five (WHO Malaria Report, 2013). Developing an effective malaria vaccine and fighting antimalarial drug resistance remain major global public health challenges.
By integrating genomics with experimental research and operating both at scale, the Malaria programme is uniquely placed to tackle key challenges in malaria control, including the development of effective genomic surveillance of drug and insecticide resistance, and identifying and validating new drug and vaccine targets.
The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.
Rodent models of malaria
At the Sanger Institute Oliver Billker's group used experimental genetics in rodent models to study the basic biology of malaria ...
Natural genetic variation
The Kwiatkowski group investigates Plasmodium, Anopheles and human genome variation in large clinical and epidemiological studies carried out with partners in ...
Malaria Parasite Drug Resistance
Marcus Lee’s group is interested in the molecular basis of drug resistance in the human malaria parasite Plasmodium falciparum, and ...
Malaria Administration Support Team
The Malaria and the Infection Genomics Administration teams merged in December 2017 to become the Parasites and Microbes Administration team.
Human-parasite interactions in malaria
While at the Sanger Institute, Julian Rayner's group investigated the molecular details of human-parasite interactions during the P. falciparum blood ...
ARNIE - AVEXIS Receptor Network with Integrated Expression
ARNIE is an online database that integrates the extracellular protein interaction network generated in our lab using AVEXIS technology with ...
The Anopheles Gambiae 1000 Genome project is a global collaboration using whole genome deep sequencing to provide a high-resolution view of ...